Chronic Granulomatous Disease: The European Experience
Publication Date
April 21, 2009
Journal
PLOS ONE
Authors
J. Merlijn Van Den Berg, Elsbeth Van Koppen, Anders Åhlin, Bernd H. Belohradsky, et al
Volume
4
Issue
4
Pages
e5234
DOI
https://dx.plos.org/10.1371/journal.pone.0005234
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0005234
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/19381301
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668749
Europe PMC
http://europepmc.org/abstract/MED/19381301
Web of Science
000265513800010
Scopus
65349179624
Mendeley
http://www.mendeley.com/research/chronic-granulomatous-disease-european-experience-8
Events
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Mendeley | Further Information

{"title"=>"Chronic granulomatous disease: The European experience", "type"=>"journal", "authors"=>[{"first_name"=>"J. Merlijn", "last_name"=>"van den Berg", "scopus_author_id"=>"7201551173"}, {"first_name"=>"Elsbeth", "last_name"=>"van Koppen", "scopus_author_id"=>"15744846800"}, {"first_name"=>"Anders", "last_name"=>"Åhlin", "scopus_author_id"=>"7003588761"}, {"first_name"=>"Bernd H.", "last_name"=>"Belohradsky", "scopus_author_id"=>"7007001582"}, {"first_name"=>"Ewa", "last_name"=>"Bernatowska", "scopus_author_id"=>"35465947600"}, {"first_name"=>"Lucien", "last_name"=>"Corbeel", "scopus_author_id"=>"7005169859"}, {"first_name"=>"Teresa", "last_name"=>"Espanñol", "scopus_author_id"=>"26532706600"}, {"first_name"=>"Alain", "last_name"=>"Fischer", "scopus_author_id"=>"36047665000"}, {"first_name"=>"Magdalena", "last_name"=>"Kurenko-Deptuch", "scopus_author_id"=>"6506938812"}, {"first_name"=>"Richard", "last_name"=>"Mouy", "scopus_author_id"=>"6701815859"}, {"first_name"=>"Theoni", "last_name"=>"Petropoulou", "scopus_author_id"=>"6602872932"}, {"first_name"=>"Joachim", "last_name"=>"Roesler", "scopus_author_id"=>"7006323503"}, {"first_name"=>"Reinhard", "last_name"=>"Seger", "scopus_author_id"=>"7101798532"}, {"first_name"=>"Marie José", "last_name"=>"Stasia", "scopus_author_id"=>"6701661130"}, {"first_name"=>"Niels H.", "last_name"=>"Valerius", "scopus_author_id"=>"7003421788"}, {"first_name"=>"Ron S.", "last_name"=>"Weening", "scopus_author_id"=>"7004426487"}, {"first_name"=>"Baruch", "last_name"=>"Wolach", "scopus_author_id"=>"7006567926"}, {"first_name"=>"Dirk", "last_name"=>"Roos", "scopus_author_id"=>"36079296100"}, {"first_name"=>"Taco W.", "last_name"=>"Kuijpers", "scopus_author_id"=>"7005692728"}], "year"=>2009, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-65349179624", "pui"=>"354520369", "doi"=>"10.1371/journal.pone.0005234", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"65349179624", "pmid"=>"19381301"}, "id"=>"822be8f6-9234-338f-a7d3-24e94b90e249", "abstract"=>"CGD is an immunodeficiency caused by deletions or mutations in genes that encode subunits of the leukocyte NADPH oxidase complex. Normally, assembly of the NADPH oxidase complex in phagosomes of certain phagocytic cells leads to a “respiratory burst”, essential for the clearance of phagocytosed micro-organisms. CGD patients lack this mechanism, which leads to life-threatening infections and granuloma formation. However, a clear picture of the clinical course of CGD is hampered by its low prevalence (∼1∶250,000). Therefore, extensive clinical data from 429 European patients were collected and analyzed. Of these patients 351 were males and 78 were females. X-linked (XL) CGD (gp91phox deficient) accounted for 67% of the cases, autosomal recessive (AR) inheritance for 33%. AR-CGD was diagnosed later in life, and the mean survival time was significantly better in AR patients (49.6 years) than in XL CGD (37.8 years), suggesting a milder disease course in AR patients. The disease manifested itself most frequently in the lungs (66% of patients), skin (53%), lymph nodes (50%), gastrointestinal tract (48%) and liver (32%). The most frequently cultured micro-organisms per episode were Staphylococcus aureus (30%), Aspergillus spp. (26%), and Salmonella spp. (16%). Surprisingly, Pseudomonas spp. (2%) and Burkholderia cepacia (<1%) were found only sporadically. Lesions induced by inoculation with BCG occurred in 8% of the patients. Only 71% of the patients received antibiotic maintenance therapy, and 53% antifungal prophylaxis. 33% were treated with γ-interferon. 24 patients (6%) had received a stem cell transplantation. The most prominent reason of death was pneumonia and pulmonary abscess (18/84 cases), septicemia (16/84) and brain abscess (4/84). These data provide further insight in the clinical course of CGD in Europe and hopefully can help to increase awareness and optimize the treatment of these patients.", "link"=>"http://www.mendeley.com/research/chronic-granulomatous-disease-european-experience-8", "reader_count"=>69, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>8, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>3, "Student > Master"=>15, "Other"=>12, "Student > Bachelor"=>8, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>8, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>3, "Student > Master"=>15, "Other"=>12, "Student > Bachelor"=>8, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>14, "Medicine and Dentistry"=>41, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>41}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>1, "Japan"=>1, "Denmark"=>1, "Mexico"=>1, "Italy"=>1, "Kenya"=>1, "Germany"=>1}, "group_count"=>0}

CrossRef

Scopus | Further Information

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  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"32", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"41", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"48"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"460", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"44"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/900996"], "description"=>"<p>Prevalence of liver abscess and causative micro-organisms.</p>", "links"=>[], "tags"=>["abscess", "causative"], "article_id"=>571433, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t010", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prevalence_of_liver_abscess_and_causative_micro_organisms_/571433", "title"=>"Prevalence of liver abscess and causative micro-organisms.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:12:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/901532"], "description"=>"*<p>Female X-linked patients are extremely lyonized heterozygous carrriers.</p>", "links"=>[], "tags"=>["subtypes", "cgd"], "article_id"=>571966, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t002", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_different_subtypes_of_CGD_according_to_sex_/571966", "title"=>"Distribution of different subtypes of CGD according to sex.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:15:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/900804"], "description"=>"<p><i>*Log rank statistics for difference in survival between X-linked and AR: 7.01 (p = 0.0081)</i>.</p>", "links"=>[], "tags"=>["ar", "patients", "compared", "xl"], "article_id"=>571235, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.g003", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cumulative_survival_of_AR_patients_compared_to_XL_patients_/571235", "title"=>"Cumulative survival of AR patients compared to XL patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 06:11:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/901643"], "description"=>"<p>Prevalence and causes of osteomyelitis.</p>", "links"=>[], "tags"=>["causes"], "article_id"=>572076, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t013", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prevalence_and_causes_of_osteomyelitis_/572076", "title"=>"Prevalence and causes of osteomyelitis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:16:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/901479"], "description"=>"*<p>AR = autosomal recessive.</p>", "links"=>[], "tags"=>["cohort", "cgd", "patients", "divided"], "article_id"=>571913, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t001", "stats"=>{"downloads"=>1, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_cohort_of_CGD_patients_divided_according_to_nationality_ethnic_background_and_type_of_CGD_/571913", "title"=>"The cohort of CGD patients divided according to nationality/ ethnic background and type of CGD.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:15:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/901423"], "description"=>"*<p>n.o.s. = not otherwise specified.</p>", "links"=>[], "tags"=>["immunology", "Infectious diseases", "pediatrics and child health", "immunology/immunity to infections", "immunology/leukocyte development", "infectious diseases/fungal infections"], "article_id"=>571847, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t017", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cause_of_death_/571847", "title"=>"Cause of death.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:15:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/900933"], "description"=>"<p>Percentages of patients who received above-mentioned therapies at one point during their lives.</p>", "links"=>[], "tags"=>["curative"], "article_id"=>571366, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t016", "stats"=>{"downloads"=>5, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prophylactic_and_curative_treatment_/571366", "title"=>"Prophylactic and curative treatment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:12:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/900477"], "description"=>"<p>Each column represents 2.5 years.</p>", "links"=>[], "tags"=>["irrespective"], "article_id"=>570887, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.g001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_age_at_diagnosis_of_CGD_irrespective_of_the_subtype_/570887", "title"=>"The age at diagnosis of CGD, irrespective of the subtype.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 06:09:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/901883"], "description"=>"*<p>including three episodes of renal abscess.</p>", "links"=>[], "tags"=>["kidneys", "urinary", "tract"], "article_id"=>572318, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t011", "stats"=>{"downloads"=>3, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Involvement_of_kidneys_and_urinary_tract_UT_/572318", "title"=>"Involvement of kidneys and urinary tract (UT).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:17:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/901827"], "description"=>"<p>Prevalence and causes of brain abscess.</p>", "links"=>[], "tags"=>["causes"], "article_id"=>572257, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t014", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prevalence_and_causes_of_brain_abscess_/572257", "title"=>"Prevalence and causes of brain abscess.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:17:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/901055"], "description"=>"<p>Lymphadenitis and cultured micro-organisms (in total 622 episodes in 213 patients). Percentages are the number of episodes with a positive culture of a certain pathogen divided by the total number of reported episodes.</p>", "links"=>[], "tags"=>["immunology", "Infectious diseases", "pediatrics and child health", "immunology/immunity to infections", "immunology/leukocyte development", "infectious diseases/fungal infections"], "article_id"=>571479, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t008", "stats"=>{"downloads"=>5, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lymphadenitis_/571479", "title"=>"Lymphadenitis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:13:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/901579"], "description"=>"<p>Different subtypes of autosomal recessive CGD.</p>", "links"=>[], "tags"=>["subtypes", "autosomal", "recessive"], "article_id"=>572011, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t003", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Different_subtypes_of_autosomal_recessive_CGD_/572011", "title"=>"Different subtypes of autosomal recessive CGD.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:16:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/901308"], "description"=>"<p>Pulmonary involvement and cultured microorganisms (in total 634 episodes in 284 patients). Percentages are the number of episodes with a positive culture of a certain pathogen divided by the total number of reported episodes.</p>", "links"=>[], "tags"=>["cultured"], "article_id"=>571740, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t006", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pulmonary_involvement_and_cultured_microorganisms_/571740", "title"=>"Pulmonary involvement and cultured microorganisms.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:14:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/901360"], "description"=>"<p>Diseases of the skin in CGD and causative pathogens.</p>", "links"=>[], "tags"=>["cgd", "causative"], "article_id"=>571799, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t007", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Diseases_of_the_skin_in_CGD_and_causative_pathogens_/571799", "title"=>"Diseases of the skin in CGD and causative pathogens.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:14:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/901114"], "description"=>"<p>Gastrointestinal manifestations of CGD.</p>", "links"=>[], "tags"=>["manifestations"], "article_id"=>571544, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t009", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gastrointestinal_manifestations_of_CGD_/571544", "title"=>"Gastrointestinal manifestations of CGD.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:13:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/900649"], "description"=>"<p>Average Age at Establishment of Diagnosis “CGD”.</p>", "links"=>[], "tags"=>["immunology", "Infectious diseases", "pediatrics and child health", "immunology/immunity to infections", "immunology/leukocyte development", "infectious diseases/fungal infections"], "article_id"=>571077, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.g002", "stats"=>{"downloads"=>2, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Average_Age_at_Establishment_of_Diagnosis_8220_CGD_8221_/571077", "title"=>"Average Age at Establishment of Diagnosis “CGD”.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 06:10:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/901174"], "description"=>"<p>Clinical course in CGD patients is milder in AR patients, as reflected by a later age at diagnosis and longer survival.</p>+<p>a.n. = antenatal.</p>¶<p>14 out of 429 patients were excluded because reliable data on survival were lacking.</p>", "links"=>[], "tags"=>["immunology", "Infectious diseases", "pediatrics and child health", "immunology/immunity to infections", "immunology/leukocyte development", "infectious diseases/fungal infections"], "article_id"=>571599, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t004", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_course_in_CGD_/571599", "title"=>"Clinical course in CGD.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:13:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/901707"], "description"=>"<p>Most frequently isolated micro-organisms.</p>", "links"=>[], "tags"=>["immunology", "Infectious diseases", "pediatrics and child health", "immunology/immunity to infections", "immunology/leukocyte development", "infectious diseases/fungal infections"], "article_id"=>572129, "categories"=>["Immunology", "Medicine", "Infectious Diseases"], "users"=>["J. Merlijn van den Berg", "Elsbeth van Koppen", "Anders Åhlin", "Bernd H. Belohradsky", "Ewa Bernatowska", "Lucien Corbeel", "Teresa Español", "Alain Fischer", "Magdalena Kurenko-Deptuch", "Richard Mouy", "Theoni Petropoulou", "Joachim Roesler", "Reinhard Seger", "Marie-José Stasia", "Niels H. Valerius", "Ron S. Weening", "Baruch Wolach", "Dirk Roos", "Taco W. Kuijpers"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0005234.t015", "stats"=>{"downloads"=>2, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Most_frequently_isolated_micro_organisms_/572129", "title"=>"Most frequently isolated micro-organisms.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 06:16:52"}
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PMC Usage Stats | Further Information

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