A Comprehensive Analysis of the Structure-Function Relationship in Proteins Based on Local Structure Similarity
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Mendeley | Further Information

{"title"=>"A Comprehensive Analysis of the Structure-Function Relationship in Proteins Based on Local Structure Similarity", "type"=>"journal", "authors"=>[{"first_name"=>"Torgeir R.", "last_name"=>"Hvidsten"}, {"first_name"=>"Astrid", "last_name"=>"Lægreid"}, {"first_name"=>"Andriy", "last_name"=>"Kryshtafovych"}, {"first_name"=>"Gunnar", "last_name"=>"Andersson"}, {"first_name"=>"Krzysztof", "last_name"=>"Fidelis"}, {"first_name"=>"Jan", "last_name"=>"Komorowski"}], "year"=>2009, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0006266"}, "id"=>"2dfc8a54-09a0-34fb-950c-1719b8a375c1", "abstract"=>"Sequence similarity to characterized proteins provides testable functional hypotheses for less than 50% of the proteins identified by genome sequencing projects. With structural genomics it is believed that structural similarities may give functional hypotheses for many of the remaining proteins.\\r\\n\\r\\n\\r\\n\\r\\nWe provide a systematic analysis of the structure-function relationship in proteins using the novel concept of local descriptors of protein structure. A local descriptor is a small substructure of a protein which includes both short- and long-range interactions. We employ a library of commonly reoccurring local descriptors general enough to assemble most existing protein structures. We then model the relationship between these local shapes and Gene Ontology using rule-based learning. Our IF-THEN rule model offers legible, high resolution descriptions that combine local substructures and is able to discriminate functions even for functionally versatile folds such as the frequently occurring TIM barrel and Rossmann fold. By evaluating the predictive performance of the model, we provide a comprehensive quantification of the structure-function relationship based only on local structure similarity. Our findings are, among others, that conserved structure is a stronger prerequisite for enzymatic activity than for binding specificity, and that structure-based predictions complement sequence-based predictions. The model is capable of generating correct hypotheses, as confirmed by a literature study, even when no significant sequence similarity to characterized proteins exists.\\r\\n\\r\\n\\r\\n\\r\\nOur approach offers a new and complete description and quantification of the structure-function relationship in proteins. By demonstrating how our predictions offer higher sensitivity than using global structure, and complement the use of sequence, we show that the presented ideas could advance the development of meta-servers in function prediction.", "link"=>"http://www.mendeley.com/research/comprehensive-analysis-structurefunction-relationship-proteins-based-local-structure-similarity-4", "reader_count"=>8, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Materials Science"=>1, "Agricultural and Biological Sciences"=>3, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Materials Science"=>{"Materials Science"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"United Kingdom"=>1, "Germany"=>2}, "group_count"=>0}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/441572", "https://ndownloader.figshare.com/files/441704", "https://ndownloader.figshare.com/files/441832", "https://ndownloader.figshare.com/files/441911", "https://ndownloader.figshare.com/files/441950", "https://ndownloader.figshare.com/files/442052"], "description"=>"<div><h3>Background</h3><p>Sequence similarity to characterized proteins provides testable functional hypotheses for less than 50% of the proteins identified by genome sequencing projects. With structural genomics it is believed that structural similarities may give functional hypotheses for many of the remaining proteins.</p><h3>Methodology/Principal Findings</h3><p>We provide a systematic analysis of the structure-function relationship in proteins using the novel concept of local descriptors of protein structure. A local descriptor is a small substructure of a protein which includes both short- and long-range interactions. We employ a library of commonly reoccurring local descriptors general enough to assemble most existing protein structures. We then model the relationship between these local shapes and Gene Ontology using rule-based learning. Our IF-THEN rule model offers legible, high resolution descriptions that combine local substructures and is able to discriminate functions even for functionally versatile folds such as the frequently occurring TIM barrel and Rossmann fold. By evaluating the predictive performance of the model, we provide a comprehensive quantification of the structure-function relationship based only on local structure similarity. Our findings are, among others, that conserved structure is a stronger prerequisite for enzymatic activity than for binding specificity, and that structure-based predictions complement sequence-based predictions. The model is capable of generating correct hypotheses, as confirmed by a literature study, even when no significant sequence similarity to characterized proteins exists.</p><h3>Conclusions/Significance</h3><p>Our approach offers a new and complete description and quantification of the structure-function relationship in proteins. By demonstrating how our predictions offer higher sensitivity than using global structure, and complement the use of sequence, we show that the presented ideas could advance the development of meta-servers in function prediction.</p></div>", "links"=>[], "tags"=>["structure-function", "proteins", "based"], "article_id"=>147043, "categories"=>["Biological Sciences", "Medicine", "Cancer"], "users"=>["Torgeir R. Hvidsten", "Astrid Lægreid", "Andriy Kryshtafovych", "Gunnar Andersson", "Krzysztof Fidelis", "Jan Komorowski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006266.s001", "https://dx.doi.org/10.1371/journal.pone.0006266.s002", "https://dx.doi.org/10.1371/journal.pone.0006266.s003", "https://dx.doi.org/10.1371/journal.pone.0006266.s004", "https://dx.doi.org/10.1371/journal.pone.0006266.s005", "https://dx.doi.org/10.1371/journal.pone.0006266.s006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_Comprehensive_Analysis_of_the_Structure_Function_Relationship_in_Proteins_Based_on_Local_Structure_Similarity/147043", "title"=>"A Comprehensive Analysis of the Structure-Function Relationship in Proteins Based on Local Structure Similarity", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2009-07-15 01:57:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/891335"], "description"=>"<p>Descriptors are named: ‘PDB protein domain name’#‘central amino acid’. A) Cartoon of the secondary structure of the central descriptor and its structural alignment with the ten closest descriptors in the group. B) The sequence alignment resulting from the structural alignment in A. C) Location in Gene Ontology of the significantly overrepresented (FDR controlled at 0.05 <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006266#pone.0006266-Benjamini1\" target=\"_blank\">[39]</a>) molecular functions annotated to the 68 proteins matching the local substructure in A (marked in red). In total, 28 molecular functions were annotated to the 68 proteins. D) The rule IF (1qama_#37 AND 1xvaa_#68) THEN (GO:0008757 OR GO:0000287) combining the substructure 1qama_#37 in A with the substructure 1xvaa_#68 to uniquely describe 12 of the proteins annotated with GO:0008757: <i>S-adenosylmethionine-dependent methyltransferase activity</i>. Two of these proteins are additionally annotated with GO:0000287: <i>magnesium ion binding</i>. The rule thus effectively combines local substructures to address only one of the three statistically significant GO classes related to 1qama_#37.</p>", "links"=>[], "tags"=>["substructure", "descriptor"], "article_id"=>561793, "categories"=>["Biological Sciences", "Medicine", "Infectious Diseases"], "users"=>["Torgeir R. Hvidsten", "Astrid Lægreid", "Andriy Kryshtafovych", "Gunnar Andersson", "Krzysztof Fidelis", "Jan Komorowski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006266.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Local_substructure_group_with_central_descriptor_1qama_37_/561793", "title"=>"Local substructure group with central descriptor 1qama_#37.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-15 00:29:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/891442"], "description"=>"<p>A) List of the ten best predicted GO molecular function classes as measured by the AUC and its standard error <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006266#pone.0006266-Hanley1\" target=\"_blank\">[34]</a>. We also report sensitivity (SENS), specificity (SPEC), and the number of true positives (TP), false positives (FP), true negatives (TN), and false negatives (FN) at one specific decision threshold (THR). See <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006266#s4\" target=\"_blank\">Materials and Methods</a> for details. (B, C and D) Performance for all GO classes and all three GO subontologies using local substructures or CATH folds at different decision thresholds (resulting from varying the costs on false positives, see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006266#s4\" target=\"_blank\">Materials and Methods</a> for details). <i>Coverage</i> is the percentage of <i>proteins</i> with at least one correct prediction or the percentage of <i>annotations</i> correctly predicted, and <i>precision</i> is the percentage of predictions that are correct. Numbers corresponding to the decision thresholds in A are circled.</p>", "links"=>[], "tags"=>["cross-validation", "roc"], "article_id"=>561902, "categories"=>["Biological Sciences", "Medicine", "Infectious Diseases"], "users"=>["Torgeir R. Hvidsten", "Astrid Lægreid", "Andriy Kryshtafovych", "Gunnar Andersson", "Krzysztof Fidelis", "Jan Komorowski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006266.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Model_prediction_performance_using_cross_validation_and_ROC_analysis_/561902", "title"=>"Model prediction performance using cross-validation and ROC analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-15 00:31:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/891539"], "description"=>"<p>A) Structure of CypA (PDB id: 1aka). The loop region represented by Phe 67 is correlated with the dynamics of the core represented by the hydrophobic cluster including Leu 39, Phe 46, Phe 48 and Ile 78 <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006266#pone.0006266-Eisenmesser1\" target=\"_blank\">[36]</a>. The rule combining local substructures 1elva1#604 and 1bif_2#398 describes exactly this mechanism. 1elva1#604 (yellow) matches the loop region including Phe 67 (space filled yellow), while 1bif_2#398 (blue) matches parts of the core including Leu 39 (space filled blue). The overlap between the two local substructures is in green. Although all the residues in the hydrophobic cluster are described in our local substructure library, the minimal IF-THEN rule only needs one residue in the cluster to discriminate the function. B) Two local substructures in the rule in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006266#pone-0006266-g001\" target=\"_blank\">Figure 1D</a> matching the enzyme Cytosine-N4-Specific (PDB id: 1boo): 1qama_#37 in yellow, 1xvaa_#68 in blue, the overlap in green and the residues in contact as space filled. The combined local substructures have a very similar number of residues in contact in the 12 matching proteins (the average contact surface included 25% of the non-overlapping residues in the two local substructures with standard deviation 6.4).</p>", "links"=>[], "tags"=>["combining", "substructures", "connected"], "article_id"=>561993, "categories"=>["Biological Sciences", "Medicine", "Infectious Diseases"], "users"=>["Torgeir R. Hvidsten", "Astrid Lægreid", "Andriy Kryshtafovych", "Gunnar Andersson", "Krzysztof Fidelis", "Jan Komorowski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006266.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rules_combining_local_substructures_into_connected_complexes_/561993", "title"=>"Rules combining local substructures into connected complexes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-15 00:33:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/891606"], "description"=>"<p>A library of local descriptors of protein structure is built from a representative subset of PDB (i.e. training set). The library is used to represent protein structures, and a model that discriminates classes of Gene Ontology annotations is induced using combinations of local substructures. The model is evaluated both internally and on an external test set.</p>", "links"=>[], "tags"=>["Computational biology", "computational biology/genomics", "computational biology/macromolecular structure analysis"], "article_id"=>562061, "categories"=>["Biological Sciences", "Medicine", "Infectious Diseases"], "users"=>["Torgeir R. Hvidsten", "Astrid Lægreid", "Andriy Kryshtafovych", "Gunnar Andersson", "Krzysztof Fidelis", "Jan Komorowski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006266.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overview_of_the_function_prediction_method_/562061", "title"=>"Overview of the function prediction method.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-15 00:34:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/891691"], "description"=>"<p>The second column gives the number of annotated proteins and the number of annotations for these proteins. The third column gives the number of GO classes selected and the related numbers of proteins and annotations.</p>", "links"=>[], "tags"=>["ontology", "annotations", "molecular", "cellular"], "article_id"=>562147, "categories"=>["Biological Sciences", "Medicine", "Infectious Diseases"], "users"=>["Torgeir R. Hvidsten", "Astrid Lægreid", "Andriy Kryshtafovych", "Gunnar Andersson", "Krzysztof Fidelis", "Jan Komorowski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006266.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gene_Ontology_annotations_for_molecular_function_biological_process_and_cellular_component_/562147", "title"=>"Gene Ontology annotations for molecular function, biological process and cellular component.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-15 00:35:47"}

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  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
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  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
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  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"8"}
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  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
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  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
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  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
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  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
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  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"23", "full-text"=>"34", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
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  • {"unique-ip"=>"17", "full-text"=>"22", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
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  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
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  • {"unique-ip"=>"27", "full-text"=>"23", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"42", "full-text"=>"42", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"42", "full-text"=>"43", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"67", "full-text"=>"75", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"50", "full-text"=>"66", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"57", "full-text"=>"66", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"48", "full-text"=>"58", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"47", "full-text"=>"52", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"75", "full-text"=>"98", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"76", "full-text"=>"89", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
  • {"unique-ip"=>"73", "full-text"=>"81", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
  • {"unique-ip"=>"57", "full-text"=>"65", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
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Relative Metric

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