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{"title"=>"Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease", "type"=>"journal", "authors"=>[{"first_name"=>"Diego", "last_name"=>"Mastroeni", "scopus_author_id"=>"8988585000"}, {"first_name"=>"Ann", "last_name"=>"McKee", "scopus_author_id"=>"56763649300"}, {"first_name"=>"Andrew", "last_name"=>"Grover", "scopus_author_id"=>"7201683683"}, {"first_name"=>"Joseph", "last_name"=>"Rogers", "scopus_author_id"=>"35433647900"}, {"first_name"=>"Paul D.", "last_name"=>"Coleman", "scopus_author_id"=>"7201455663"}], "year"=>2009, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"68949096744", "doi"=>"10.1371/journal.pone.0006617", "pui"=>"355113814", "pmid"=>"19672297", "scopus"=>"2-s2.0-68949096744", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"8b8499a4-5c4d-3ede-aed6-8af27e794e00", "abstract"=>"DNA methylation is capable of modulating coordinate expression of large numbers of genes across many different pathways, and may therefore warrant investigation for their potential role between genes and disease phenotype. In a rare set of monozygotic twins discordant for Alzheimer's disease (AD), significantly reduced levels of DNA methylation were observed in temporal neocortex neuronal nuclei of the AD twin. These findings are consistent with the hypothesis that epigenetic mechanisms may mediate at the molecular level the effects of life events on AD risk, and provide, for the first time, a potential explanation for AD discordance despite genetic similarities.", "link"=>"http://www.mendeley.com/research/epigenetic-differences-cortical-neurons-pair-monozygotic-twins-discordant-alzheimers-disease", "reader_count"=>122, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>9, "Librarian"=>1, "Researcher"=>28, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>31, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>13, "Student > Bachelor"=>19, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>9, "Librarian"=>1, "Researcher"=>28, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>31, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>13, "Student > Bachelor"=>19, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>10, "Biochemistry, Genetics and Molecular Biology"=>11, "Materials Science"=>1, "Agricultural and Biological Sciences"=>55, "Medicine and Dentistry"=>25, "Neuroscience"=>9, "Chemistry"=>2, "Psychology"=>7, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>25}, "Neuroscience"=>{"Neuroscience"=>9}, "Chemistry"=>{"Chemistry"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>7}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>55}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>11}, "Unspecified"=>{"Unspecified"=>10}}, "reader_count_by_country"=>{"Hong Kong"=>1, "United States"=>2, "Japan"=>1, "Mexico"=>1, "Germany"=>2}, "group_count"=>4}

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• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/b0b338ff-ba26-4693-b215-52402353c110", "title"=>"The complexity of Alzheimer Disease", "body"=>"Sirs,\nthis really fascinating paper conclusion sounds:\"Since epigenetic patterns can be passed on to subsequent generations, epigenetics may also constitute a mechanism by which AD in a first degree relative confers increased risk of “sporadic” disease\". As a consequence, both n-Dna and mit-DNA are involved by alterations, since AD patients are \"ALL\" positive fo a particular mitochondrial cytopathology, I discovered about 30 years before and termed Congenital Acidosic Enzyme Metabolic Histangiopathy, every biophysical semeiotic constitution is based on (1-5). In fact, such as differences, Authors illustrated in the article, may be observed in some, but not in all monozygotic twin, so that they are discordant for AD, could indicate really the presence of some specific \"genetic\" modifications, perhaps mitochondrial in origin, facilitating the first one.\n\n1) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica condizione necessaria non sufficiente della oncogenesi. XI Congr. Naz. Soc. It. di Microangiologia e Microcircolaz. Abstracts, pg 38, 28 Settembre-1 Ottobre, Bellagio 1983\n2) Stagnaro-Neri Marina, Stagnaro Sergio. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico\". Travel Factory SRL., Roma, 2004. \n3) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica. Una Patologia Mitocondriale Ignorata. Gazz Med. It. - Arch. Sci. Med. 144, 423 (Infotrieve) 1985\n4) Stagnaro S. Pre-Metabolic Syndrome: Locus primary prevention. NYAS web site. \n5) Stagnaro-Neri M., Stagnaro S., Sindrome di Reaven, classica e variante, in evoluzione diabetica. Il ruolo della Carnitina (Medline)", "isRemoved"=>false, "created"=>"2009-08-12T21:11:40Z", "lastModified"=>"2009-08-12T21:11:40Z", "creator"=>{"userId"=>"55997"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0006617", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2009-08-12T21:11:40Z", "replies"=>[]}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/887841"], "description"=>"<p>AD pathology was remarkably rare in the non-demented twin and abundant in the AD twin.</p>", "links"=>[], "tags"=>["plaques", "phf1", "neurofibrillary", "tangle", "pathology", "temporal", "gyrus", "non-demented"], "article_id"=>558285, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Diego Mastroeni", "Ann McKee", "Andrew Grover", "Joseph Rogers", "Paul D. Coleman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006617.g001", "stats"=>{"downloads"=>2, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Thioflavin_S_plaques_and_PHF1_neurofibrillary_tangle_pathology_in_middle_temporal_gyrus_MTG_of_non_demented_and_AD_twin_/558285", "title"=>"Thioflavin S plaques and PHF1 neurofibrillary tangle pathology in middle temporal gyrus (MTG) of non-demented and AD twin.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-12 02:18:05"}
• {"files"=>["https://ndownloader.figshare.com/files/888100"], "description"=>"<p>Note extensive co-localization of 5-methylcytosine in ND twin with all three cell specific markers, and the lack of co-localization with 5-methylcytosine in the AD twin.</p>", "links"=>[], "tags"=>["immunoreactivity", "5-methylcytosine", "neuron", "rca1", "non-demented"], "article_id"=>558555, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Diego Mastroeni", "Ann McKee", "Andrew Grover", "Joseph Rogers", "Paul D. Coleman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006617.g003", "stats"=>{"downloads"=>1, "page_views"=>135, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Co_localization_of_immunoreactivity_for_5_methylcytosine_with_neuron_specific_enolase_GFAP_RCA1_microglial_marker_in_non_demented_and_Alzheimer_s_disease_twin_/558555", "title"=>"Co-localization of immunoreactivity for 5-methylcytosine with neuron specific enolase, GFAP, RCA1 (microglial marker) in non-demented and Alzheimer's disease twin.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-12 02:22:35"}
• {"files"=>["https://ndownloader.figshare.com/files/440111", "https://ndownloader.figshare.com/files/440134"], "description"=>"<div><p>DNA methylation <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006617#pone.0006617-Adcock1\">[1]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006617#pone.0006617-Suzuki1\">[2]</a> is capable of modulating coordinate expression of large numbers of genes across many different pathways, and may therefore warrant investigation for their potential role between genes and disease phenotype. In a rare set of monozygotic twins discordant for Alzheimer's disease (AD), significantly reduced levels of DNA methylation were observed in temporal neocortex neuronal nuclei of the AD twin. These findings are consistent with the hypothesis that epigenetic mechanisms may mediate at the molecular level the effects of life events on AD risk, and provide, for the first time, a potential explanation for AD discordance despite genetic similarities.</p></div>", "links"=>[], "tags"=>["epigenetic", "differences", "cortical", "neurons", "monozygotic", "twins", "discordant"], "article_id"=>146756, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Diego Mastroeni", "Ann McKee", "Andrew Grover", "Joseph Rogers", "Paul D. Coleman"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006617.s001", "https://dx.doi.org/10.1371/journal.pone.0006617.s002"], "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Epigenetic_Differences_in_Cortical_Neurons_from_a_Pair_of_Monozygotic_Twins_Discordant_for_Alzheimer_s_Disease/146756", "title"=>"Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2009-08-12 01:52:36"}
• {"files"=>["https://ndownloader.figshare.com/files/888236"], "description"=>"<p>Antibodies.</p>", "links"=>[], "tags"=>["cell biology/neuronal and glial cell biology", "neuroscience/neurobiology of disease and regeneration", "neuroscience/neuronal and glial cell biology"], "article_id"=>558691, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Diego Mastroeni", "Ann McKee", "Andrew Grover", "Joseph Rogers", "Paul D. Coleman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006617.t001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antibodies_/558691", "title"=>"Antibodies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-08-12 02:24:51"}
• {"files"=>["https://ndownloader.figshare.com/files/887961"], "description"=>"<p>a) Anterior temporal neocortex (left and right top panels) and cerebellum (left and right bottom panels) immunoreactivity for DNA methylation marker in a pair of monozygotic twins discordant for Alzheimer's disease. Sections were processed in parallel using identical antibody concentrations to 5-methylcytosine (1∶1000) with nickel intensification. Note similarity of immunoreactivity in cerebellar granule cell layer of both twins in this brain region that is relatively unaffected in Alzheimer's disease. b) Integrated fluorescence intensities of DAPI-counterstained anterior temporal neocortex layer II and layer III neuronal nuclei in a set of monozygotic twins discordant for AD. Sections were processed at the same time using identical immunohistochemical methods <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006617#pone.0006617-Mastroeni1\" target=\"_blank\">[4]</a> and antibody concentrations. Nuclei of NSE+ cells (N = 20/brain) were randomly selected and traced from coded slides by an investigator blind to subject condition. The appropriate detection fluorescence bandwidth (488 nm) for 5-methylcytosine indicator was then set, and the integrated fluorescence intensity within the traced area was taken. Highly significant decrements in the pathologically-vulnerable entorhinal cortex was observed in the AD twin (p<3.51E-08 for layer II and p<3.71E-06 for layer III), whereas readings for the cerebellum were nearly identical in the AD and ND twin (data not shown).</p>", "links"=>[], "tags"=>["cell biology/neuronal and glial cell biology", "neuroscience/neurobiology of disease and regeneration", "neuroscience/neuronal and glial cell biology"], "article_id"=>558415, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Diego Mastroeni", "Ann McKee", "Andrew Grover", "Joseph Rogers", "Paul D. Coleman"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006617.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Figure_2_/558415", "title"=>"Figure 2", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-12 02:20:15"}

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Relative Metric

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F1000Prime