Naturopathic Care for Anxiety: A Randomized Controlled Trial ISRCTN78958974
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Mendeley | Further Information

{"title"=>"Naturopathic care for anxiety: A randomized controlled trial ISRCTN78958974", "type"=>"journal", "authors"=>[{"first_name"=>"Kieran", "last_name"=>"Cooley", "scopus_author_id"=>"23018079800"}, {"first_name"=>"Orest", "last_name"=>"Szczurko", "scopus_author_id"=>"14030675900"}, {"first_name"=>"Dan", "last_name"=>"Perri", "scopus_author_id"=>"6602399768"}, {"first_name"=>"Edward J.", "last_name"=>"Mills", "scopus_author_id"=>"7102584704"}, {"first_name"=>"Bob", "last_name"=>"Bernhardt", "scopus_author_id"=>"23986930100"}, {"first_name"=>"Qi", "last_name"=>"Zhou", "scopus_author_id"=>"55722142200"}, {"first_name"=>"Dugald", "last_name"=>"Seely", "scopus_author_id"=>"8527304400"}], "year"=>2009, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-69949168009", "sgr"=>"69949168009", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0006628", "pmid"=>"19718255", "isbn"=>"1932-6203", "pui"=>"355219361"}, "id"=>"7b403eaf-92c5-3e7b-9715-5734045ef856", "abstract"=>"BACKGROUND: Anxiety is a serious personal health condition and represents a substantial burden to overall quality of life. Additionally anxiety disorders represent a significant cost to the health care system as well as employers through benefits coverage and days missed due to incapacity. This study sought to explore the effectiveness of naturopathic care on anxiety symptoms using a randomized trial.\\n\\nMETHODS: Employees with moderate to severe anxiety of longer than 6 weeks duration were randomized based on age and gender to receive naturopathic care (NC) (n = 41) or standardized psychotherapy intervention (PT) (n = 40) over a period of 12 weeks. Blinding of investigators and participants during randomization and allocation was maintained. Participants in the NC group received dietary counseling, deep breathing relaxation techniques, a standard multi-vitamin, and the herbal medicine, ashwagandha (Withania somnifera) (300 mg b.i.d. standardized to 1.5% with anolides, prepared from root). The PT intervention received psychotherapy, and matched deep breathing relaxation techniques, and placebo. The primary outcome measure was the Beck Anxiety Inventory (BAI) and secondary outcome measures included the Short Form 36 (SF-36), Fatigue Symptom Inventory (FSI), and Measure Yourself Medical Outcomes Profile (MY-MOP) to measure anxiety, mental health, and quality of life respectively. Participants were blinded to the placebo-controlled intervention.\\n\\nRESULTS: Seventy-five participants (93%) were followed for 8 or more weeks on the trial. Final BAI scores decreased by 56.5% (p<0.0001) in the NC group and 30.5% (p<0.0001) in the PT group. BAI group scores were significantly decreased in the NC group compared to PT group (p = 0.003). Significant differences between groups were also observed in mental health, concentration, fatigue, social functioning, vitality, and overall quality of life with the NC group exhibiting greater clinical benefit. No serious adverse reactions were observed in either group.\\n\\nRELEVANCE: Many patients seek alternatives and/or complementary care to conventional anxiety treatments. To date, no study has evaluated the potential of a naturopathic treatment protocol to effectively treat anxiety. Knowledge of the efficacy, safety or risk of natural health products, and naturopathic treatments is important for physicians and the public in order to make informed decisions.\\n\\nINTERPRETATION: Both NC and PT led to significant improvements in patients' anxiety. Group comparison demonstrated a significant decrease in anxiety levels in the NC group over the PT group. Significant improvements in secondary quality of life measures were also observed in the NC group as compared to PT. The whole system of naturopathic care for anxiety needs to be investigated further including a closer examination of the individual components within the context of their additive effect.\\n\\nTRIAL REGISTRATION: Controlled-Trials.com ISRCTN78958974.", "link"=>"http://www.mendeley.com/research/naturopathic-care-anxiety-randomized-controlled-trial-isrctn78958974", "reader_count"=>264, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Librarian"=>2, "Researcher"=>20, "Student > Doctoral Student"=>10, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>18, "Student > Master"=>21, "Other"=>14, "Student > Bachelor"=>149, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>3, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Librarian"=>2, "Researcher"=>20, "Student > Doctoral Student"=>10, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>18, "Student > Master"=>21, "Other"=>14, "Student > Bachelor"=>149, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>3, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Agricultural and Biological Sciences"=>54, "Philosophy"=>1, "Business, Management and Accounting"=>1, "Computer Science"=>2, "Nursing and Health Professions"=>20, "Biochemistry, Genetics and Molecular Biology"=>3, "Materials Science"=>2, "Medicine and Dentistry"=>142, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>4, "Sports and Recreations"=>2, "Psychology"=>15, "Social Sciences"=>11, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>142}, "Social Sciences"=>{"Social Sciences"=>11}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Psychology"=>{"Psychology"=>15}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>4}, "Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>54}, "Computer Science"=>{"Computer Science"=>2}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>20}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"Sweden"=>1, "United States"=>6, "Ireland"=>2, "Malaysia"=>1, "Australia"=>4, "Spain"=>1, "India"=>1}, "group_count"=>17}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/886218"], "description"=>"<p>Week 12<sup>*</sup> - the value at week 8 was used for week 12 If the missing value was occurred.</p><p>NC = Naturopathic Care; PT = Psychotherapy.</p>", "links"=>[], "tags"=>["evidence-based healthcare", "Mental health", "nutrition", "mental health/anxiety disorders", "public health and epidemiology/occupational and industrial medicine"], "article_id"=>556667, "categories"=>["Infectious Diseases", "Mental Health", "Medicine"], "users"=>["Kieran Cooley", "Orest Szczurko", "Dan Perri", "Edward J. Mills", "Bob Bernhardt", "Qi Zhou", "Dugald Seely"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006628.t004", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SF_36_results_/556667", "title"=>"SF-36 results.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-08-31 01:51:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/886097"], "description"=>"<p>Week 12<sup>*</sup> - the week 8 value was used for week 12 if the week 12 data was missing.</p><p>NC = Naturopathic Care; PT = Psychotherapy.</p>", "links"=>[], "tags"=>["bmi"], "article_id"=>556552, "categories"=>["Infectious Diseases", "Mental Health", "Medicine"], "users"=>["Kieran Cooley", "Orest Szczurko", "Dan Perri", "Edward J. Mills", "Bob Bernhardt", "Qi Zhou", "Dugald Seely"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006628.t002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fatigue_questionnaire_Weight_and_BMI_results_/556552", "title"=>"Fatigue questionnaire, Weight and BMI results.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-08-31 01:49:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/886135"], "description"=>"<p>Week 12<sup>*</sup> - the week 8 value will be used for week 12 If missing value is occurred at week 12.</p>**<p>- week 4 was considered baseline for these outcome measures.</p><p>NC = Naturopathic Care; PT = Psychotherapy.</p>", "links"=>[], "tags"=>["my-mop"], "article_id"=>556582, "categories"=>["Infectious Diseases", "Mental Health", "Medicine"], "users"=>["Kieran Cooley", "Orest Szczurko", "Dan Perri", "Edward J. Mills", "Bob Bernhardt", "Qi Zhou", "Dugald Seely"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006628.t003", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_BAI_MY_MOP_and_Perceived_Benefit_questionnaire_results_/556582", "title"=>"BAI, MY-MOP and Perceived Benefit questionnaire results.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-08-31 01:49:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/886002"], "description"=>"<p>MYMOP – Symptom 2 results.</p>", "links"=>[], "tags"=>["evidence-based healthcare", "Mental health", "nutrition", "mental health/anxiety disorders", "public health and epidemiology/occupational and industrial medicine"], "article_id"=>556450, "categories"=>["Infectious Diseases", "Mental Health", "Medicine"], "users"=>["Kieran Cooley", "Orest Szczurko", "Dan Perri", "Edward J. Mills", "Bob Bernhardt", "Qi Zhou", "Dugald Seely"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006628.g004", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MYMOP_8211_Symptom_2_results_/556450", "title"=>"MYMOP – Symptom 2 results.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-31 01:47:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/885853"], "description"=>"<p>MYMOP – Symptom 1 results.</p>", "links"=>[], "tags"=>["evidence-based healthcare", "Mental health", "nutrition", "mental health/anxiety disorders", "public health and epidemiology/occupational and industrial medicine"], "article_id"=>556302, "categories"=>["Infectious Diseases", "Mental Health", "Medicine"], "users"=>["Kieran Cooley", "Orest Szczurko", "Dan Perri", "Edward J. Mills", "Bob Bernhardt", "Qi Zhou", "Dugald Seely"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006628.g003", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MYMOP_8211_Symptom_1_results_/556302", "title"=>"MYMOP – Symptom 1 results.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-31 01:45:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/885612"], "description"=>"<p>Flowchart of participants through trial.</p>", "links"=>[], "tags"=>["evidence-based healthcare", "Mental health", "nutrition", "mental health/anxiety disorders", "public health and epidemiology/occupational and industrial medicine"], "article_id"=>556059, "categories"=>["Infectious Diseases", "Mental Health", "Medicine"], "users"=>["Kieran Cooley", "Orest Szczurko", "Dan Perri", "Edward J. Mills", "Bob Bernhardt", "Qi Zhou", "Dugald Seely"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006628.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flowchart_of_participants_through_trial_/556059", "title"=>"Flowchart of participants through trial.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-31 01:40:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/438726", "https://ndownloader.figshare.com/files/438804"], "description"=>"<div><h3>Background</h3><p>Anxiety is a serious personal health condition and represents a substantial burden to overall quality of life. Additionally anxiety disorders represent a significant cost to the health care system as well as employers through benefits coverage and days missed due to incapacity. This study sought to explore the effectiveness of naturopathic care on anxiety symptoms using a randomized trial.</p><h3>Methods</h3><p>Employees with moderate to severe anxiety of longer than 6 weeks duration were randomized based on age and gender to receive naturopathic care (NC) (n = 41) or standardized psychotherapy intervention (PT) (n = 40) over a period of 12 weeks. Blinding of investigators and participants during randomization and allocation was maintained. Participants in the NC group received dietary counseling, deep breathing relaxation techniques, a standard multi-vitamin, and the herbal medicine, ashwagandha (<em>Withania somnifera</em>) (300 mg b.i.d. standardized to 1.5% withanolides, prepared from root). The PT intervention received psychotherapy, and matched deep breathing relaxation techniques, and placebo. The primary outcome measure was the Beck Anxiety Inventory (BAI) and secondary outcome measures included the Short Form 36 (SF-36), Fatigue Symptom Inventory (FSI), and Measure Yourself Medical Outcomes Profile (MY-MOP) to measure anxiety, mental health, and quality of life respectively. Participants were blinded to the placebo-controlled intervention.</p><h3>Results</h3><p>Seventy-five participants (93%) were followed for 8 or more weeks on the trial. Final BAI scores decreased by 56.5% (p<0.0001) in the NC group and 30.5% (p<0.0001) in the PT group. BAI group scores were significantly decreased in the NC group compared to PT group (p = 0.003). Significant differences between groups were also observed in mental health, concentration, fatigue, social functioning, vitality, and overall quality of life with the NC group exhibiting greater clinical benefit. No serious adverse reactions were observed in either group.</p><h3>Relevance</h3><p>Many patients seek alternatives and/or complementary care to conventional anxiety treatments. To date, no study has evaluated the potential of a naturopathic treatment protocol to effectively treat anxiety. Knowledge of the efficacy, safety or risk of natural health products, and naturopathic treatments is important for physicians and the public in order to make informed decisions.</p><h3>Interpretation</h3><p>Both NC and PT led to significant improvements in patients' anxiety. Group comparison demonstrated a significant decrease in anxiety levels in the NC group over the PT group. Significant improvements in secondary quality of life measures were also observed in the NC group as compared to PT. The whole system of naturopathic care for anxiety needs to be investigated further including a closer examination of the individual components within the context of their additive effect.</p><h3>Trial Registration</h3><p>Controlled-Trials.com <a href=\"http://www.controlled-trials.com/ISRCTN78958974/78958974\">ISRCTN78958974</a></p></div>", "links"=>[], "tags"=>["naturopathic", "randomized", "controlled", "isrctn78958974"], "article_id"=>146520, "categories"=>["Cancer", "Mental Health", "Medicine"], "users"=>["Kieran Cooley", "Orest Szczurko", "Dan Perri", "Edward J. Mills", "Bob Bernhardt", "Qi Zhou", "Dugald Seely"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006628.s001", "https://dx.doi.org/10.1371/journal.pone.0006628.s002"], "stats"=>{"downloads"=>2, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Naturopathic_Care_for_Anxiety_A_Randomized_Controlled_Trial_ISRCTN78958974/146520", "title"=>"Naturopathic Care for Anxiety: A Randomized Controlled Trial ISRCTN78958974", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2009-08-31 01:48:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/886180"], "description"=>"*<p>Caffeine doses were calculated based on reported consumption level of caffeinated drinks; 7 oz.Coffee = 1.0; 1 serving cola = 1, tea = 0.5.</p><p>Values are shown±Std Deviation.</p>", "links"=>[], "tags"=>["evidence-based healthcare", "Mental health", "nutrition", "mental health/anxiety disorders", "public health and epidemiology/occupational and industrial medicine"], "article_id"=>556630, "categories"=>["Infectious Diseases", "Mental Health", "Medicine"], "users"=>["Kieran Cooley", "Orest Szczurko", "Dan Perri", "Edward J. Mills", "Bob Bernhardt", "Qi Zhou", "Dugald Seely"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006628.t001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_participant_characteristics_/556630", "title"=>"Baseline participant characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-08-31 01:50:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/886253"], "description"=>"<p>NC = Naturopathic Care; PT = Psychotherapy.</p>", "links"=>[], "tags"=>["evidence-based healthcare", "Mental health", "nutrition", "mental health/anxiety disorders", "public health and epidemiology/occupational and industrial medicine"], "article_id"=>556705, "categories"=>["Infectious Diseases", "Mental Health", "Medicine"], "users"=>["Kieran Cooley", "Orest Szczurko", "Dan Perri", "Edward J. Mills", "Bob Bernhardt", "Qi Zhou", "Dugald Seely"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006628.t005", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adverse_reactions_/556705", "title"=>"Adverse reactions.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-08-31 01:51:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/885761"], "description"=>"<p>Beck Anxiety Inventory results.</p>", "links"=>[], "tags"=>["evidence-based healthcare", "Mental health", "nutrition", "mental health/anxiety disorders", "public health and epidemiology/occupational and industrial medicine"], "article_id"=>556210, "categories"=>["Infectious Diseases", "Mental Health", "Medicine"], "users"=>["Kieran Cooley", "Orest Szczurko", "Dan Perri", "Edward J. Mills", "Bob Bernhardt", "Qi Zhou", "Dugald Seely"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0006628.g002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Beck_Anxiety_Inventory_results_/556210", "title"=>"Beck Anxiety Inventory results.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-31 01:43:30"}

PMC Usage Stats | Further Information

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Relative Metric

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