The Relationship of DNA Methylation with Age, Gender and Genotype in Twins and Healthy Controls
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{"title"=>"The relationship of DNA methylation with age, gender and genotype in twins and healthy controls", "type"=>"journal", "authors"=>[{"first_name"=>"Marco P.", "last_name"=>"Boks", "scopus_author_id"=>"6603260738"}, {"first_name"=>"Eske M.", "last_name"=>"Derks", "scopus_author_id"=>"6602753396"}, {"first_name"=>"Daniel J.", "last_name"=>"Weisenberger", "scopus_author_id"=>"6602748296"}, {"first_name"=>"Erik", "last_name"=>"Strengman", "scopus_author_id"=>"6506197520"}, {"first_name"=>"Esther", "last_name"=>"Janson", "scopus_author_id"=>"35110491900"}, {"first_name"=>"Iris E.", "last_name"=>"Sommer", "scopus_author_id"=>"7006338234"}, {"first_name"=>"René S.", "last_name"=>"Kahn", "scopus_author_id"=>"56720467600"}, {"first_name"=>"Roel A.", "last_name"=>"Ophoff", "scopus_author_id"=>"7004321340"}], "year"=>2009, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"69449084444", "doi"=>"10.1371/journal.pone.0006767", "pui"=>"355176542", "pmid"=>"19774229", "scopus"=>"2-s2.0-69449084444", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "arxiv"=>"arXiv:1002.1600v2"}, "id"=>"b056882c-efac-3c49-97d3-d59182f1d83e", "abstract"=>"Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of epigenetic influence on human traits and disease. In addition to influences of age and gender, genetic control of DNA methylation levels has recently been described. We used whole blood genomic DNA in a twin set (23 MZ twin-pairs and 23 DZ twin-pairs, N = 92) as well as healthy controls (N = 96) to investigate heritability and relationship with age and gender of selected DNA methylation profiles using readily commercially available GoldenGate bead array technology. Despite the inability to detect meaningful methylation differences in the majority of CpG loci due to tissue type and locus selection issues, we found replicable significant associations of DNA methylation with age and gender. We identified associations of genetically heritable single nucleotide polymorphisms with large differences in DNA methylation levels near the polymorphism (cis effects) as well as associations with much smaller differences in DNA methylation levels elsewhere in the human genome (trans effects). Our results demonstrate the feasibility of array-based approaches in studies of DNA methylation and highlight the vast differences between individual loci. The identification of CpG loci of which DNA methylation levels are under genetic control or are related to age or gender will facilitate further studies into the role of DNA methylation and disease.", "link"=>"http://www.mendeley.com/research/relationship-dna-methylation-age-gender-genotype-twins-healthy-controls", "reader_count"=>221, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>20, "Student > Doctoral Student"=>15, "Researcher"=>44, "Student > Ph. D. Student"=>62, "Student > Postgraduate"=>4, "Other"=>9, "Student > Master"=>28, "Student > Bachelor"=>25, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>3, "Professor"=>7}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>20, "Student > Doctoral Student"=>15, "Researcher"=>44, "Student > Ph. D. Student"=>62, "Student > Postgraduate"=>4, "Other"=>9, "Student > Master"=>28, "Student > Bachelor"=>25, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>3, "Professor"=>7}, "reader_count_by_subject_area"=>{"Unspecified"=>12, "Agricultural and Biological Sciences"=>108, "Business, Management and Accounting"=>1, "Chemistry"=>1, "Computer Science"=>8, "Economics, Econometrics and Finance"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>28, "Materials Science"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>39, "Neuroscience"=>4, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Sports and Recreations"=>2, "Psychology"=>6, "Social Sciences"=>4, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>39}, "Social Sciences"=>{"Social Sciences"=>4}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Psychology"=>{"Psychology"=>6}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>12}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Neuroscience"=>{"Neuroscience"=>4}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>108}, "Computer Science"=>{"Computer Science"=>8}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>28}}, "reader_count_by_country"=>{"New Zealand"=>2, "Canada"=>2, "Netherlands"=>1, "United States"=>5, "Uruguay"=>3, "Poland"=>1, "United Kingdom"=>4, "Thailand"=>1, "Germany"=>2, "Iceland"=>1, "Spain"=>1}, "group_count"=>10}

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  • {"files"=>["https://ndownloader.figshare.com/files/439447", "https://ndownloader.figshare.com/files/439461", "https://ndownloader.figshare.com/files/439471", "https://ndownloader.figshare.com/files/439481", "https://ndownloader.figshare.com/files/439489", "https://ndownloader.figshare.com/files/439504", "https://ndownloader.figshare.com/files/439521"], "description"=>"<div><p>Cytosine-5 methylation within CpG dinucleotides is a potentially important mechanism of epigenetic influence on human traits and disease. In addition to influences of age and gender, genetic control of DNA methylation levels has recently been described. We used whole blood genomic DNA in a twin set (23 MZ twin-pairs and 23 DZ twin-pairs, N = 92) as well as healthy controls (N = 96) to investigate heritability and relationship with age and gender of selected DNA methylation profiles using readily commercially available GoldenGate bead array technology. Despite the inability to detect meaningful methylation differences in the majority of CpG loci due to tissue type and locus selection issues, we found replicable significant associations of DNA methylation with age and gender. We identified associations of genetically heritable single nucleotide polymorphisms with large differences in DNA methylation levels near the polymorphism (<em>cis effects)</em> as well as associations with much smaller differences in DNA methylation levels elsewhere in the human genome (<em>trans effects)</em>. Our results demonstrate the feasibility of array-based approaches in studies of DNA methylation and highlight the vast differences between individual loci. The identification of CpG loci of which DNA methylation levels are under genetic control or are related to age or gender will facilitate further studies into the role of DNA methylation and disease.</p></div>", "links"=>[], "tags"=>["dna", "methylation", "genotype", "twins", "controls"], "article_id"=>146635, "categories"=>["Molecular Biology", "Genetics", "Cancer", "Medicine", "Developmental Biology"], "users"=>["Marco P. Boks", "Eske M. Derks", "Daniel J. Weisenberger", "Erik Strengman", "Esther Janson", "Iris E. Sommer", "René S. Kahn", "Roel A. Ophoff"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006767.s001", "https://dx.doi.org/10.1371/journal.pone.0006767.s002", "https://dx.doi.org/10.1371/journal.pone.0006767.s003", "https://dx.doi.org/10.1371/journal.pone.0006767.s004", "https://dx.doi.org/10.1371/journal.pone.0006767.s005", "https://dx.doi.org/10.1371/journal.pone.0006767.s006", "https://dx.doi.org/10.1371/journal.pone.0006767.s007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_Relationship_of_DNA_Methylation_with_Age_Gender_and_Genotype_in_Twins_and_Healthy_Controls/146635", "title"=>"The Relationship of DNA Methylation with Age, Gender and Genotype in Twins and Healthy Controls", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2009-08-26 01:50:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/885856"], "description"=>"<p>Sample plot of DNA methylation levels at probe ALOX12_P223_R by genotype of SNP rs434473.</p>", "links"=>[], "tags"=>["dna", "methylation", "levels", "probe", "alox12_p223_r", "genotype", "snp"], "article_id"=>556301, "categories"=>["Molecular Biology", "Genetics", "Infectious Diseases", "Medicine", "Developmental Biology"], "users"=>["Marco P. Boks", "Eske M. Derks", "Daniel J. Weisenberger", "Erik Strengman", "Esther Janson", "Iris E. Sommer", "René S. Kahn", "Roel A. Ophoff"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006767.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sample_plot_of_DNA_methylation_levels_at_probe_ALOX12_P223_R_by_genotype_of_SNP_rs434473_/556301", "title"=>"Sample plot of DNA methylation levels at probe ALOX12_P223_R by genotype of SNP rs434473.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-26 01:45:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/885974"], "description"=>"<p>Sample description.</p>", "links"=>[], "tags"=>["computational biology/genomics", "developmental biology/aging", "developmental biology/developmental molecular mechanisms", "genetics and genomics/epigenetics", "genetics and genomics/genomics", "molecular biology/dna methylation"], "article_id"=>556423, "categories"=>["Molecular Biology", "Genetics", "Infectious Diseases", "Medicine", "Developmental Biology"], "users"=>["Marco P. Boks", "Eske M. Derks", "Daniel J. Weisenberger", "Erik Strengman", "Esther Janson", "Iris E. Sommer", "René S. Kahn", "Roel A. Ophoff"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006767.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sample_description_/556423", "title"=>"Sample description.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-08-26 01:47:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/886021"], "description"=>"<p>DNA methylation probes with significant effects of age and gender (listed are genes for which significance was detected in both series independently).</p>", "links"=>[], "tags"=>["methylation", "probes", "genes", "was"], "article_id"=>556469, "categories"=>["Molecular Biology", "Genetics", "Infectious Diseases", "Medicine", "Developmental Biology"], "users"=>["Marco P. Boks", "Eske M. Derks", "Daniel J. Weisenberger", "Erik Strengman", "Esther Janson", "Iris E. Sommer", "René S. Kahn", "Roel A. Ophoff"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006767.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_DNA_methylation_probes_with_significant_effects_of_age_and_gender_listed_are_genes_for_which_significance_was_detected_in_both_series_independently_/556469", "title"=>"DNA methylation probes with significant effects of age and gender (listed are genes for which significance was detected in both series independently).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-08-26 01:47:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/886059"], "description"=>"<p>Heritability of probes (top 25 only).</p>", "links"=>[], "tags"=>["probes", "25"], "article_id"=>556513, "categories"=>["Molecular Biology", "Genetics", "Infectious Diseases", "Medicine", "Developmental Biology"], "users"=>["Marco P. Boks", "Eske M. Derks", "Daniel J. Weisenberger", "Erik Strengman", "Esther Janson", "Iris E. Sommer", "René S. Kahn", "Roel A. Ophoff"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006767.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heritability_of_probes_top_25_only_/556513", "title"=>"Heritability of probes (top 25 only).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-08-26 01:48:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/886095"], "description"=>"<p>Genetic associations with DNA methylation levels.</p>", "links"=>[], "tags"=>["associations", "dna", "methylation"], "article_id"=>556550, "categories"=>["Molecular Biology", "Genetics", "Infectious Diseases", "Medicine", "Developmental Biology"], "users"=>["Marco P. Boks", "Eske M. Derks", "Daniel J. Weisenberger", "Erik Strengman", "Esther Janson", "Iris E. Sommer", "René S. Kahn", "Roel A. Ophoff"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0006767.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genetic_associations_with_DNA_methylation_levels_/556550", "title"=>"Genetic associations with DNA methylation levels.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-08-26 01:49:10"}

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