Opiate-Induced Suppression of Rat Hypoglossal Motoneuron Activity and Its Reversal by Ampakine Therapy
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{"title"=>"Opiate-induced suppression of rat hypoglossal motoneuron activity and its reversal by ampakine therapy", "type"=>"journal", "authors"=>[{"first_name"=>"Amanda R.", "last_name"=>"Lorier", "scopus_author_id"=>"8054930800"}, {"first_name"=>"Gregory D.", "last_name"=>"Funk", "scopus_author_id"=>"7102117115"}, {"first_name"=>"John J.", "last_name"=>"Greer", "scopus_author_id"=>"7202258432"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"358442474", "sgr"=>"77949402344", "issn"=>"19326203", "pmid"=>"20098731", "scopus"=>"2-s2.0-77949402344", "doi"=>"10.1371/journal.pone.0008766"}, "id"=>"a375e67e-e479-39f7-8ad0-332719282835", "abstract"=>"Hypoglossal (XII) motoneurons innervate tongue muscles and are vital for maintaining upper-airway patency during inspiration. Depression of XII nerve activity by opioid analgesics is a significant clinical problem, but underlying mechanisms are poorly understood. Currently there are no suitable pharmacological approaches to counter opiate-induced suppression of XII nerve activity while maintaining analgesia. Ampakines accentuate alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptor responses. The AMPA family of glutamate receptors mediate excitatory transmission to XII motoneurons. Therefore the objectives were to determine whether the depressant actions of mu-opioid receptor activation on inspiratory activity includes a direct inhibitory action at the inspiratory premotoneuron to XII motoneuron synapse, and to identify underlying mechanism(s). We then examined whether ampakines counteract opioid-induced depression of XII motoneuron activity.", "link"=>"http://www.mendeley.com/research/opiateinduced-suppression-rat-hypoglossal-motoneuron-activity-reversal-ampakine-therapy", "reader_count"=>8, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>3, "Veterinary Science and Veterinary Medicine"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Spain"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/866749"], "description"=>"<p>A) Integrated (∫) XII nerve activity recorded from a medullary slice preparation illustrating that bath application of DAMGO (500 nM) depresses inspiratory activity. B) Group data (n = 12) showing the effect of bath-applied DAMGO (500 nM) on XII inspiratory burst frequency amplitude, area and duration relative to control. *  =  significantly different from control (p<0.05).</p>", "links"=>[], "tags"=>["damgo", "depresses", "inspiratory"], "article_id"=>537202, "categories"=>["Physiology", "Neuroscience"], "users"=>["Amanda R. Lorier", "Gregory D. Funk", "John J. Greer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0008766.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bath_application_of_DAMGO_depresses_inspiratory_activity_/537202", "title"=>"Bath application of DAMGO depresses inspiratory activity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 03:00:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/866830"], "description"=>"<p>A) ∫XII nerve activity recorded from a medullary slice preparation demonstrating that local application of DAMGO (5 µM, 30s) into the XII nucleus decreases inspiratory burst amplitude. B) Group data (n = 5) show that local application of DAMGO (5 µM, 30 s) significantly reduces XII inspiratory burst amplitude, area and duration. C) ∫XII nerve activity recorded from a medullary slice preparation demonstrating that local application of DAMGO (5 µM, 10s) into the preBötC decreases inspiratory burst amplitude and frequency. D) Group data (n = 10) show that local application of DAMGO (5 µM, 10 s) significantly reduces XII inspiratory burst amplitude and frequency. *  =  significantly different from control (p<0.05).</p>", "links"=>[], "tags"=>["damgo", "xii", "nucleus", "depresses", "inspiratory"], "article_id"=>537287, "categories"=>["Physiology", "Neuroscience"], "users"=>["Amanda R. Lorier", "Gregory D. Funk", "John J. Greer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0008766.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Local_application_of_DAMGO_to_the_XII_nucleus_depresses_inspiratory_burst_amplitude_area_and_duration_/537287", "title"=>"Local application of DAMGO to the XII nucleus depresses inspiratory burst amplitude, area and duration.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 03:00:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/866900"], "description"=>"<p>A) ∫XII nerve activity recorded from a medullary slice preparation illustrating that local application of muscarine (100 µM, 30 s) into the XII motor nucleus (top trace) evokes tonic discharge and increases inspiratory burst amplitude and that this response is inhibited by atropine (bath, 1 µM, bottom trace.) B) ∫XII nerve activity recorded from the same slice preparation as in (A) showing that the inhibition of XII inspiratory burst amplitude evoked by local application of DAMGO (5 µM, 30 s) in the XII nucleus (top and bottom traces) is not reduced by bath-applied atropine (1 µM, bottom trace). C) Group data (n = 4) showing that the magnitude of DAMGO-mediated inhibition of XII inspiratory burst amplitude is not affected by bath-applied atropine.</p>", "links"=>[], "tags"=>["receptors", "damgo-evoked", "xii", "inspiratory"], "article_id"=>537356, "categories"=>["Physiology", "Neuroscience"], "users"=>["Amanda R. Lorier", "Gregory D. Funk", "John J. Greer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0008766.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Muscarinic_receptors_do_not_contribute_to_the_DAMGO_evoked_depression_of_XII_inspiratory_activity_/537356", "title"=>"Muscarinic receptors do not contribute to the DAMGO-evoked depression of XII inspiratory activity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 03:01:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/866989"], "description"=>"<p>A) ∫XII nerve activity and voltage-clamp (V<sub>hold</sub> = −60 mV) recording of membrane current (I<sub>m</sub>) from an inspiratory XII MN illustrating the response to locally-applied DAMGO (5 µM, 30 s). B) Group data (n = 9) show that locally-applied DAMGO (5 µM, 30 s) significantly reduces the amplitude of inspiratory synaptic currents. C) Whole-cell I/V relationships obtained before (control) and during application of DAMGO application to an inspiratory XII MN. Subtraction of the control I/V from that obtained in DAMGO produces the I/V relationship for the DAMGO current (DAMGO – control). D) Group data (n = 9) showing that DAMGO had no effect on the R<sub>N</sub> of inspiratory XII MNs. * = significantly different from control (p<0.05). ψ = transients resulting from delivery of the I/V ramp.</p>", "links"=>[], "tags"=>["damgo", "xii", "mns", "inspiratory", "synaptic"], "article_id"=>537445, "categories"=>["Physiology", "Neuroscience"], "users"=>["Amanda R. Lorier", "Gregory D. Funk", "John J. Greer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0008766.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Local_application_of_DAMGO_to_XII_MNs_reduces_inspiratory_synaptic_current_amplitude_/537445", "title"=>"Local application of DAMGO to XII MNs reduces inspiratory synaptic current amplitude.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 03:01:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/867079"], "description"=>"<p>A) Voltage-clamp (V<sub>hold</sub> = −60 mV) recording of membrane current (I<sub>m</sub>) from an inspiratory XII MN in the presence of TTX (1 µM), strychnine (10 µM) and bicuculline (10 µM) before (right trace) and after (left trace) bath application of DAMGO (500 nM). B) Cumulative frequency histogram for one XII MN showing that DAMGO increased the inter-event interval of mEPSCs. C and D) Group data (n = 6) illustrate that DAMGO evokes a significant increase in the mEPSC inter-event interval but not the mEPSC amplitude. *  =  significantly different from control (p<0.05).</p>", "links"=>[], "tags"=>["damgo", "mepscs", "inspiratory", "xii"], "article_id"=>537539, "categories"=>["Physiology", "Neuroscience"], "users"=>["Amanda R. Lorier", "Gregory D. Funk", "John J. Greer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0008766.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bath_application_of_DAMGO_reduces_the_frequency_of_mEPSCs_in_inspiratory_XII_MNs_/537539", "title"=>"Bath application of DAMGO reduces the frequency of mEPSCs in inspiratory XII MNs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 03:02:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/867184"], "description"=>"<p>∫XII nerve activity recorded from a medullary slice preparation and group data illustrating that the depression of respiratory activity evoked by bath-applied DAMGO (500 nM) was significantly attenuated by bath application of (A) CX614 (5–20 µM, n = 5) or (B) CX717 (50–100 µM, n = 6). Expanded time scale excerpts from control, DAMGO and AMPAKINE conditions are shown on the right hand side of the continuous time trace in (A) and (B). *  =  significantly different from control, #  =  significantly different from DAMGO (p<0.05).</p>", "links"=>[], "tags"=>["cx614", "cx717", "counters", "damgo-induced", "inspiratory"], "article_id"=>537638, "categories"=>["Physiology", "Neuroscience"], "users"=>["Amanda R. Lorier", "Gregory D. Funk", "John J. Greer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0008766.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bath_application_of_CX614_or_CX717_counters_DAMGO_induced_inspiratory_depression_/537638", "title"=>"Bath application of CX614 or CX717 counters DAMGO-induced inspiratory depression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 03:02:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/867273"], "description"=>"<p>∫XII nerve activity from a medullary slice preparation and group data illustrating that the depression of inspiratory burst amplitude, duration and area evoked by bath application of DAMGO (500 nM) was significantly reduced by local application of (A) CX614 (200 µM, n = 6) or (B) CX717 (2 mM, n = 5) into the XII nucleus. #  =  significantly different from DAMGO (p<0.05).</p>", "links"=>[], "tags"=>["cx614", "cx717", "xii", "nucleus", "counters", "damgo-induced", "inspiratory"], "article_id"=>537725, "categories"=>["Physiology", "Neuroscience"], "users"=>["Amanda R. Lorier", "Gregory D. Funk", "John J. Greer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0008766.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Local_application_of_CX614_or_CX717_to_the_XII_nucleus_counters_DAMGO_induced_depression_of_XII_inspiratory_burst_amplitude_/537725", "title"=>"Local application of CX614 or CX717 to the XII nucleus counters DAMGO-induced depression of XII inspiratory burst amplitude.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 03:03:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/867395"], "description"=>"<p>∫XII nerve activity and voltage-clamp (V<sub>hold</sub> = −60 mV) recording of membrane current (I<sub>m</sub>) from an inspiratory XII MN illustrating the effects of bath-applying first DAMGO (500 nM) and then (A) CX614 (20 µM) or (C) CX717 (200 µM). Middle traces show an inspiratory synaptic current envelope averaged from five inspiratory cycles in each condition. Group data showing the effects of DAMGO and, in the continued presence of DAMGO, the effects of CX614 (B, n = 7) or CX717 (D, n = 8) on the amplitude and area of inspiratory synaptic currents. #  =  significantly different from DAMGO (p<0.05).</p>", "links"=>[], "tags"=>["cx717", "potentiate", "xii", "mn", "inspiratory", "synaptic", "currents", "damgo-induced"], "article_id"=>537848, "categories"=>["Physiology", "Neuroscience"], "users"=>["Amanda R. Lorier", "Gregory D. Funk", "John J. Greer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0008766.g008"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CX614_and_CX717_potentiate_XII_MN_inspiratory_synaptic_currents_following_a_DAMGO_induced_depression_of_inspiratory_activity_/537848", "title"=>"CX614 and CX717 potentiate XII MN inspiratory synaptic currents following a DAMGO-induced depression of inspiratory activity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 03:03:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/867514"], "description"=>"<p>A) Voltage-clamp (V<sub>hold</sub> = −60 mV) recording of membrane current (I<sub>m</sub>) from an inspiratory XII MN before (left most trace, note different amplitude scale) and during bath application of TTX (1 µM). Brief pulses of AMPA or glutamate (indicated by short horizontal bar above current trace) were delivered before, during and after bath application of CX614 (20 µM). B) Group data (n = 5) showing the relative amplitude, area and duration of the AMPA/glutamate currents in control and during CX614. C) Voltage-clamp (V<sub>hold</sub> = −60 mV) recording of membrane current (I<sub>m</sub>) from two different inspiratory XII MNs in the presence of TTX (1 µM), strychnine (10 µM), bicuculline (10 µM) and DAMGO (500 nM) illustrating the effect of CX614 (bath, 20 µM) on the shape of the mEPSCs. Each trace represents the average of 20–30 individual mEPSCs. *  =  significantly different from control (p<0.05).</p>", "links"=>[], "tags"=>["acts", "postsynaptically", "potentiate", "ampa", "glutamate-evoked", "currents", "xii"], "article_id"=>537966, "categories"=>["Physiology", "Neuroscience"], "users"=>["Amanda R. Lorier", "Gregory D. Funk", "John J. Greer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0008766.g009"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CX614_acts_postsynaptically_to_potentiate_AMPA_or_glutamate_evoked_currents_in_XII_MNs_/537966", "title"=>"CX614 acts postsynaptically to potentiate AMPA or glutamate-evoked currents in XII MNs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 03:04:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/867630"], "description"=>"<p>A) Voltage-clamp (V<sub>hold</sub> = −60 mV) recording of membrane current (I<sub>m</sub>) from an inspiratory XII MN during bath application of TTX (1 µM). Brief pulses of AMPA (indicated by short horizontal bar above current trace) were delivered before, during and after bath application of CX717 (200 µM). B) Group data (n = 5) showing the relative amplitude, area and duration of the AMPA currents in control and during CX717. C) Voltage-clamp (V<sub>hold</sub> = −60 mV) recording of membrane current (I<sub>m</sub>) from an inspiratory XII MN in the presence of TTX (1 µM), strychnine (10 µM), bicuculline (10 µM) and DAMGO (500 nM) illustrating the shape of the mEPSC in control (DAMGO) and CX717 (bath, 200 µm). Each trace represents the average of 20–30 individual mEPSCs. *  =  significantly different from control (p<0.05).</p>", "links"=>[], "tags"=>["acts", "postsynaptically", "potentiate", "ampa", "glutamate-evoked", "currents", "xii"], "article_id"=>538086, "categories"=>["Physiology", "Neuroscience"], "users"=>["Amanda R. Lorier", "Gregory D. Funk", "John J. Greer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0008766.g010"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CX717_acts_postsynaptically_to_potentiate_AMPA_or_glutamate_evoked_currents_in_XII_MNs_/538086", "title"=>"CX717 acts postsynaptically to potentiate AMPA or glutamate-evoked currents in XII MNs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 03:05:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/867716"], "description"=>"<p>* =  significantly different from control (DAMGO) (p<0.05).</p>", "links"=>[], "tags"=>["cx614", "mepsc"], "article_id"=>538184, "categories"=>["Physiology", "Neuroscience"], "users"=>["Amanda R. Lorier", "Gregory D. Funk", "John J. Greer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0008766.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_CX614_on_mEPSC_kinetics_/538184", "title"=>"Effects of CX614 on mEPSC kinetics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 03:05:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/867744"], "description"=>"<p>Effects of CX717 on mEPSC kinetics.</p>", "links"=>[], "tags"=>["cx717", "mepsc"], "article_id"=>538205, "categories"=>["Physiology", "Neuroscience"], "users"=>["Amanda R. Lorier", "Gregory D. Funk", "John J. Greer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0008766.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_CX717_on_mEPSC_kinetics_/538205", "title"=>"Effects of CX717 on mEPSC kinetics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 03:05:56"}

PMC Usage Stats | Further Information

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Relative Metric

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