The Impact of Vitamin D on Dendritic Cell Function in Patients with Systemic Lupus Erythematosus
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{"title"=>"The impact of vitamin D on dendritic cell function in patients with systemic lupus erythematosus", "type"=>"journal", "authors"=>[{"first_name"=>"Ilan", "last_name"=>"Ben-Zvi", "scopus_author_id"=>"57198042245"}, {"first_name"=>"Cynthia", "last_name"=>"Aranow", "scopus_author_id"=>"6603739260"}, {"first_name"=>"Meggan", "last_name"=>"Mackay", "scopus_author_id"=>"35472776200"}, {"first_name"=>"Anfisa", "last_name"=>"Stanevsky", "scopus_author_id"=>"13605481400"}, {"first_name"=>"Diane L.", "last_name"=>"Kamen", "scopus_author_id"=>"11838940900"}, {"first_name"=>"L. Manuela", "last_name"=>"Marinescu", "scopus_author_id"=>"22950918700"}, {"first_name"=>"Christopher E.", "last_name"=>"Collins", "scopus_author_id"=>"8976041700"}, {"first_name"=>"Gary S.", "last_name"=>"Gilkeson", "scopus_author_id"=>"7005802718"}, {"first_name"=>"Betty", "last_name"=>"Diamond", "scopus_author_id"=>"7102254621"}, {"first_name"=>"John A.", "last_name"=>"Hardin", "scopus_author_id"=>"7202729664"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"20169063", "doi"=>"10.1371/journal.pone.0009193", "sgr"=>"77949538186", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "scopus"=>"2-s2.0-77949538186", "issn"=>"19326203", "pui"=>"358466942"}, "id"=>"5219a357-cbca-371f-8abe-62b69c0687ba", "abstract"=>"BACKGROUND: Excessive activity of dendritic cells (DCs) is postulated as a central disease mechanism in Systemic Lupus Erythematosus (SLE). Vitamin D is known to reduce responsiveness of healthy donor DCs to the stimulatory effects of Type I IFN. As vitamin D deficiency is reportedly common in SLE, we hypothesized that vitamin D might play a regulatory role in the IFNalpha amplification loop in SLE. Our goals were to investigate the relationship between vitamin D levels and disease activity in SLE patients and to investigate the effects of vitamin D on DC activation and expression of IFNalpha-regulated genes in vitro.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: In this study, 25-OH vitamin D (25-D) levels were measured in 198 consecutively recruited SLE patients. Respectively, 29.3% and 11.8% of African American and Hispanic SLE patient had 25-D levels <10 ng/ml. The degree of vitamin D deficiency correlated inversely with disease activity; R = -.234, p = .002. In 19 SLE patients stratified by 25-D levels, there were no differences between circulating DC number and phenotype. Monocyte-derived DCs (MDDCs) of SLE patients were normally responsive to the regulatory effects of vitamin D in vitro as evidenced by decreased activation in response to LPS stimulation in the presence of 1,25-D. Additionally, vitamin D conditioning reduced expression of IFNalpha-regulated genes by healthy donor and SLE MDDCs in response to factors in activating SLE plasma.\\n\\nCONCLUSIONS/SIGNIFICANCE: We report on severe 25-D deficiency in a substantial percentage of SLE patients tested and demonstrate an inverse correlation with disease activity. Our results suggest that vitamin D supplementation will contribute to restoring immune homeostasis in SLE patients through its inhibitory effects on DC maturation and activation. We are encouraged to support the importance of adequate vitamin D supplementation and the need for a clinical trial to assess whether vitamin D supplementation affects IFNalpha activity in vivo and, most importantly, improves clinical outcome.", "link"=>"http://www.mendeley.com/research/impact-vitamin-d-dendritic-cell-function-patients-systemic-lupus-erythematosus", "reader_count"=>67, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>6, "Researcher"=>10, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>6, "Student > Master"=>16, "Other"=>5, "Student > Bachelor"=>10, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>6, "Researcher"=>10, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>6, "Student > Master"=>16, "Other"=>5, "Student > Bachelor"=>10, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>6, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>33, "Agricultural and Biological Sciences"=>15, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>2, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>33}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1, "India"=>1}, "group_count"=>8}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/862398"], "description"=>"<p>The distribution and median blood level for 25-D (+/− 1 SD) is shown for each ethnic group (A). Severe vitamin D deficiency (defined as a blood level of 25-D less than 10 ng/ml) is most prevalent among African American and Hispanic patients (B). Disease activity scores (SLEDAI) exhibited an inverse correlation with 25-D levels (C).</p>", "links"=>[], "tags"=>["25-d", "levels", "patients"], "article_id"=>532841, "categories"=>["Immunology", "Medicine"], "users"=>["Ilan Ben-Zvi", "Cynthia Aranow", "Meggan Mackay", "Anfisa Stanevsky", "Diane L. Kamen", "L. Manuela Marinescu", "Christopher E. Collins", "Gary S. Gilkeson", "Betty Diamond", "John A. Hardin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009193.g001", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Assessment_of_25_D_levels_in_patients_with_SLE_/532841", "title"=>"Assessment of 25-D levels in patients with SLE.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 02:36:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/862475"], "description"=>"<p>DCs were prepared from monocytes of 3 African American patients with SLE (C8, C25, and C26) in the presence or absence of a 10 nM concentration of 1, 25-D and exposed to LPS as a maturation stimulus. Cells were analyzed for expression of HLA-DR II, CD40, and CD86 using flow cytometry. Composite results are shown as the relative value for mean fluorescent index compared to cells not exposed to vitamin D or LPS (A). The histogram data for one representative patient is shown (B). C8 was taking cellcept 3 gm/day and prednisone 5 mg/day, C25 was taking azathioprine 150 mg/day and prednisone 5 mg/day and C26 was taking methylprednisolone 8 mg/day. SLEDAI scores for C8 and C25 were 0 and the SLEDAI score for C26 was 4.</p>", "links"=>[], "tags"=>["patients", "lupus", "responsive", "suppressive"], "article_id"=>532923, "categories"=>["Immunology", "Medicine"], "users"=>["Ilan Ben-Zvi", "Cynthia Aranow", "Meggan Mackay", "Anfisa Stanevsky", "Diane L. Kamen", "L. Manuela Marinescu", "Christopher E. Collins", "Gary S. Gilkeson", "Betty Diamond", "John A. Hardin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009193.g002", "stats"=>{"downloads"=>2, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MDDCs_from_patients_with_lupus_are_responsive_to_the_suppressive_effects_of_vitamin_D_/532923", "title"=>"MDDCs from patients with lupus are responsive to the suppressive effects of vitamin D.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 02:36:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/862662"], "description"=>"<p>Except where indicated otherwise, values are the mean (range). MMC  =  Montefiore Medical Center, NIH  =  National Institutes of Health.</p><p>MUSC  =  Medical University of South Carolina; SLEDAI  =  Systemic Lupus Erythematosus Disease Activity Index.</p><p>dsDNA  =  anti-double-stranded DNA.</p>", "links"=>[], "tags"=>["characteristics"], "article_id"=>533118, "categories"=>["Immunology", "Medicine"], "users"=>["Ilan Ben-Zvi", "Cynthia Aranow", "Meggan Mackay", "Anfisa Stanevsky", "Diane L. Kamen", "L. Manuela Marinescu", "Christopher E. Collins", "Gary S. Gilkeson", "Betty Diamond", "John A. Hardin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009193.t001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_and_clinical_characteristics_of_the_patients_/533118", "title"=>"Demographic and clinical characteristics of the patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 02:37:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/862594"], "description"=>"<p>Relative expression of three IFN inducible genes, compared to the housekeeping gene HPRT1, is shown in MDDC from 2 healthy donors cultured in the presence or absence of 1, 25-D at a concentration of 10 nM followed by exposure to activating SLE plasma or healthy donor plasma (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009193#pone-0009193-g003\" target=\"_blank\">Figure 3A</a>). MDDC from 2 SLE subjects were subjected to an identical sequence of events (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009193#pone-0009193-g003\" target=\"_blank\">Figure 3B</a>). One of these patients was an African American female with active renal disease, a SLEDAI of 10 and a serum 25-D level of 24. The other was a Hispanic female with SLEDAI score of 0 and a serum 25-D level of 19. Although expression of the 3 IFNα targeted genes appears to differ between healthy MDDC and SLE MDDC, overall expression is reduced with the addition of physiologic levels of Vitamin D during MDDC culture.</p>", "links"=>[], "tags"=>["inhibits", "induction", "ifn", "mddcs", "exposed", "activating", "sle"], "article_id"=>533041, "categories"=>["Immunology", "Medicine"], "users"=>["Ilan Ben-Zvi", "Cynthia Aranow", "Meggan Mackay", "Anfisa Stanevsky", "Diane L. Kamen", "L. Manuela Marinescu", "Christopher E. Collins", "Gary S. Gilkeson", "Betty Diamond", "John A. Hardin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009193.g003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Vitamin_D_inhibits_the_induction_of_an_IFN_signature_in_MDDCs_exposed_to_activating_SLE_plasma_/533041", "title"=>"Vitamin D inhibits the induction of an IFN signature in MDDCs exposed to activating SLE plasma.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 02:37:15"}

PMC Usage Stats | Further Information

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