The Influence of IS1301 in the Capsule Biosynthesis Locus on Meningococcal Carriage and Disease
Publication Date
February 25, 2010
Journal
PLOS ONE
Authors
Elisabeth Kugelberg, Bridget Gollan, Christopher Farrance, Holly Bratcher, et al
Volume
5
Issue
2
Pages
e9413
DOI
https://dx.plos.org/10.1371/journal.pone.0009413
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0009413
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/20195528
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828469
Europe PMC
http://europepmc.org/abstract/MED/20195528
Web of Science
000274924300005
Scopus
77949676658
Mendeley
http://www.mendeley.com/research/influence-1301-capsule-biosynthesis-locus-meningococcal-carriage-disease
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Mendeley | Further Information

{"title"=>"The influence of IS 1301 in the capsule biosynthesis locus on meningococcal carriage and disease", "type"=>"journal", "authors"=>[{"first_name"=>"Elisabeth", "last_name"=>"Kugelberg", "scopus_author_id"=>"55959273600"}, {"first_name"=>"Bridget", "last_name"=>"Gollan", "scopus_author_id"=>"24830376100"}, {"first_name"=>"Christopher", "last_name"=>"Farrance", "scopus_author_id"=>"36086120100"}, {"first_name"=>"Holly", "last_name"=>"Bratcher", "scopus_author_id"=>"36086061800"}, {"first_name"=>"Jay", "last_name"=>"Lucidarme", "scopus_author_id"=>"35174790500"}, {"first_name"=>"Ana Belén", "last_name"=>"Ibarz-Pavón", "scopus_author_id"=>"23972812900"}, {"first_name"=>"Martin C J", "last_name"=>"Maiden", "scopus_author_id"=>"7006019693"}, {"first_name"=>"Ray", "last_name"=>"Borrow", "scopus_author_id"=>"7005410023"}, {"first_name"=>"Christoph M.", "last_name"=>"Tang", "scopus_author_id"=>"7404394038"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"358497301", "sgr"=>"77949676658", "scopus"=>"2-s2.0-77949676658", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "pmid"=>"20195528", "doi"=>"10.1371/journal.pone.0009413", "issn"=>"19326203"}, "id"=>"0642c32f-9072-3eca-af91-4e19dafb8163", "abstract"=>"Previously we have shown that insertion of IS1301 in the sia/ctr intergenic region (IGR) of serogroup C Neisseria meningitidis (MenC) isolates from Spain confers increased resistance against complement-mediated killing. Here we investigate the significance of IS1301 in the same location in N. meningitidis isolates from the UK. PCR and sequencing was used to screen a collection of more than 1500 meningococcal carriage and disease isolates from the UK for the presence of IS1301 in the IGR. IS1301 was not identified in the IGR among vaccine failure strains but was frequently found in serogroup B isolates (MenB) from clonal complex 269 (cc269). Almost all IS1301 insertions in cc269 were associated with novel polymorphisms, and did not change capsule expression or resistance to human complement. After excluding sequence types (STs) distant from the central genotype within cc269, there was no significant difference for the presence of IS1301 in the IGR of carriage isolates compared to disease isolates. Isolates with insertion of IS1301 in the IGR are not responsible for MenC disease in UK vaccine failures. Novel polymorphisms associated with IS1301 in the IGR of UK MenB isolates do not lead to the resistance phenotype seen for IS1301 in the IGR of MenC isolates.", "link"=>"http://www.mendeley.com/research/influence-1301-capsule-biosynthesis-locus-meningococcal-carriage-disease", "reader_count"=>13, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>3, "Student > Master"=>1, "Student > Bachelor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>3, "Student > Master"=>1, "Student > Bachelor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>7, "Social Sciences"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Colombia"=>1, "United Kingdom"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/861520"], "description"=>"a<p>P-value was calculated using Fischer's exact test.</p>b<p>NG, non-groupable.</p>", "links"=>[], "tags"=>["igr", "uk", "carriage", "isolates"], "article_id"=>531970, "categories"=>["Infectious Diseases", "Medicine", "Microbiology"], "users"=>["Elisabeth Kugelberg", "Bridget Gollan", "Christopher Farrance", "Holly Bratcher", "Jay Lucidarme", "Ana Belén Ibarz-Pavón", "Martin C. J. Maiden", "Ray Borrow", "Christoph M. Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009413.t001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Presence_of_IS_1301_in_the_IGR_of_UK_disease_and_carriage_isolates_from_South_East_England_/531970", "title"=>"Presence of IS<i>1301</i> in the IGR of UK disease and carriage isolates from South East England.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 02:31:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/861330"], "description"=>"<p>Neighbor-net constructed from the concatenation of the seven MLST housekeeping genes of <i>N. meningitidis </i><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009413#pone.0009413-Maiden1\" target=\"_blank\">[4]</a>. The major groupings (indicated with green, black, and yellow circles) represent the number of allelic differences (1, 2 and 3 respectively) from the core ST-269 allelic profile. The tree was made using the Split-Tree4 software <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009413#pone.0009413-Huson1\" target=\"_blank\">[29]</a>.</p>", "links"=>[], "tags"=>["relatedness", "sts"], "article_id"=>531780, "categories"=>["Infectious Diseases", "Medicine", "Microbiology"], "users"=>["Elisabeth Kugelberg", "Bridget Gollan", "Christopher Farrance", "Holly Bratcher", "Jay Lucidarme", "Ana Belén Ibarz-Pavón", "Martin C. J. Maiden", "Ray Borrow", "Christoph M. Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009413.g004", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genetic_relatedness_between_STs_within_cc269_/531780", "title"=>"Genetic relatedness between STs within cc269.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 02:30:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/861598"], "description"=>"<p>Presence of IS1301 in the IGR of MenB and MenC isolates from different clonal complexes.</p>", "links"=>[], "tags"=>["is1301", "igr", "menb", "menc", "isolates", "clonal"], "article_id"=>532042, "categories"=>["Infectious Diseases", "Medicine", "Microbiology"], "users"=>["Elisabeth Kugelberg", "Bridget Gollan", "Christopher Farrance", "Holly Bratcher", "Jay Lucidarme", "Ana Belén Ibarz-Pavón", "Martin C. J. Maiden", "Ray Borrow", "Christoph M. Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009413.t002", "stats"=>{"downloads"=>9, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Presence_of_IS1301_in_the_IGR_of_MenB_and_MenC_isolates_from_different_clonal_complexes_/532042", "title"=>"Presence of IS1301 in the IGR of MenB and MenC isolates from different clonal complexes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 02:31:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/861554"], "description"=>"<p>Details of IS-8 and iIS+69 are shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009413#pone-0009413-g001\" target=\"_blank\">Fig. 1</a>. iIS refers to IS<i>1301</i> inserted in the IGR in the opposite orientation and +72 indicates IS<i>1301</i> with an additional 72 bp compared with Spanish ST-11 isolates.</p>", "links"=>[], "tags"=>["igrs", "44", "menb", "isolates"], "article_id"=>532002, "categories"=>["Infectious Diseases", "Medicine", "Microbiology"], "users"=>["Elisabeth Kugelberg", "Bridget Gollan", "Christopher Farrance", "Holly Bratcher", "Jay Lucidarme", "Ana Belén Ibarz-Pavón", "Martin C. J. Maiden", "Ray Borrow", "Christoph M. Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009413.t003", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_IGRs_with_IS_1301_in_44_MenB_isolates_from_South_East_England_/532002", "title"=>"Characteristics of IGRs with IS<i>1301</i> in 44 MenB isolates from South East England.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 02:31:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/860936"], "description"=>"<p>A: The transcription initiation site (Ti) is indicated <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009413#pone.0009413-Swartley1\" target=\"_blank\">[28]</a> as well as the insertion of IS<i>1301</i> in the IGR. The two most common polymorphic IGR with IS<i>1301</i>, IS-8 and iIS+69, are also illustrated. B: Isogenic strains with and without the polymorphisms associated with IS<i>1301</i> were constructed by tagging the <i>nmb76</i> gene downstream of the <i>ctr</i> operon with a kanamycin resistance (kan<sup>R</sup>) cassette. C: The 8 bp deletion associated with IS<i>1301</i> in the IGR; i) wild-type sequence, and ii) to iv) shows the 8 bp deletion with associated base pair changes (indicated in bold and lower case). * Refers to the most common type of IS-8, which was used for phenotypic analysis. The sequence denotes the base pairs from the insertion site of IS<i>1301</i> up to the <i>siaA</i> translational start (underlined).</p>", "links"=>[], "tags"=>["intergenic", "operons", "capsule", "biosynthesis"], "article_id"=>531379, "categories"=>["Infectious Diseases", "Medicine", "Microbiology"], "users"=>["Elisabeth Kugelberg", "Bridget Gollan", "Christopher Farrance", "Holly Bratcher", "Jay Lucidarme", "Ana Belén Ibarz-Pavón", "Martin C. J. Maiden", "Ray Borrow", "Christoph M. Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009413.g001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_intergenic_region_IGR_between_the_operons_for_capsule_transport_ctr_and_biosynthesis_sia_/531379", "title"=>"The intergenic region (IGR) between the operons for capsule transport (<i>ctr</i>) and biosynthesis (<i>sia</i>).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 02:28:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/861028"], "description"=>"<p>A: Relative levels of <i>siaA</i> (black bars) and <i>ctrA</i> (white bars) mRNA transcripts measured by qrtRT-PCR. P<0.005 (*) for differences in <i>ctrA</i> mRNA levels in IS-8+ and iIS+69+ versus the controls, using Student's <i>t</i> test. B: β-galactosidase activity was determined for <i>siaA</i> translational fusions. C denotes a control without an IGR. Results are average of three independent experiments, and error bars indicate the standard deviation (SD).</p>", "links"=>[], "tags"=>["capsule", "biosynthesis"], "article_id"=>531480, "categories"=>["Infectious Diseases", "Medicine", "Microbiology"], "users"=>["Elisabeth Kugelberg", "Bridget Gollan", "Christopher Farrance", "Holly Bratcher", "Jay Lucidarme", "Ana Belén Ibarz-Pavón", "Martin C. J. Maiden", "Ray Borrow", "Christoph M. Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009413.g002", "stats"=>{"downloads"=>5, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_capsule_biosynthesis_genes_/531480", "title"=>"Expression of capsule biosynthesis genes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 02:28:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/861444"], "description"=>"<p>Carriage (C) and disease (D) isolates were analysed for the presence of IS<i>1301</i> in the IGR depending on the numbers of loci the STs share with ST-269. Black bars represent strains with IS<i>1301</i> in the IGR and white bars show the frequency of isolates without IS<i>1301</i> in the IGR. Numbers above bars indicate the total number of isolates.</p>", "links"=>[], "tags"=>["igr", "carriage", "isolates"], "article_id"=>531899, "categories"=>["Infectious Diseases", "Medicine", "Microbiology"], "users"=>["Elisabeth Kugelberg", "Bridget Gollan", "Christopher Farrance", "Holly Bratcher", "Jay Lucidarme", "Ana Belén Ibarz-Pavón", "Martin C. J. Maiden", "Ray Borrow", "Christoph M. Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009413.g005", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Presence_of_IS_1301_in_the_IGR_of_carriage_isolates_and_disease_isolates_/531899", "title"=>"Presence of IS<i>1301</i> in the IGR of carriage isolates and disease isolates.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 02:30:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/861229"], "description"=>"<p>A: Relative amount of capsule detected by FACS. Results are shown as mean fluorescense index (MFI; calculated as the geometric mean multiplied by the percentage of positive cells). B: Survival in 8.33% human serum after 1 hour incubation at 37(C. Experiments were performed in duplicate on at least three independent occasions, and error bars indicate the SD. White bars represent isogenic control strains without IS<i>1301</i> in the IGR.</p>", "links"=>[], "tags"=>["igrs", "capsule", "complement"], "article_id"=>531678, "categories"=>["Infectious Diseases", "Medicine", "Microbiology"], "users"=>["Elisabeth Kugelberg", "Bridget Gollan", "Christopher Farrance", "Holly Bratcher", "Jay Lucidarme", "Ana Belén Ibarz-Pavón", "Martin C. J. Maiden", "Ray Borrow", "Christoph M. Tang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0009413.g003", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Polymorphic_IGRs_do_not_influence_capsule_expression_or_complement_resistance_/531678", "title"=>"Polymorphic IGRs do not influence capsule expression or complement resistance.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 02:29:45"}

PMC Usage Stats | Further Information

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