An Odorant Receptor from the Southern House Mosquito Culex pipiens quinquefasciatus Sensitive to Oviposition Attractants
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{"title"=>"An odorant receptor from the Southern house mosquito Culex pipiens quinquefasciatus sensitive to oviposition attractants", "type"=>"journal", "authors"=>[{"first_name"=>"Julien", "last_name"=>"Pelletier", "scopus_author_id"=>"14065312300"}, {"first_name"=>"David T.", "last_name"=>"Hughes", "scopus_author_id"=>"55727461400"}, {"first_name"=>"Charles W.", "last_name"=>"Luetje", "scopus_author_id"=>"7006729983"}, {"first_name"=>"Walter S.", "last_name"=>"Leal", "scopus_author_id"=>"35569644800"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"77952679883", "doi"=>"10.1371/journal.pone.0010090", "pui"=>"359482124", "pmid"=>"20386699", "scopus"=>"2-s2.0-77952679883", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"b541d422-028e-3c79-97a4-e42ecff6bc15", "abstract"=>"BACKGROUND: Insect odorant receptors (ORs) are heteromers comprised of highly variable odorant-binding subunits associated with one conserved co-receptor. They are potential molecular targets for the development of novel mosquito attractants and repellents. ORs have been identified in the malaria mosquito, Anopheles gambiae, and in the yellow fever mosquito, Aedes aegypti. However, they are still unknown in the Southern house mosquito, Culex quinquefasciatus, which transmits pathogens that cause human diseases throughout the world, including West Nile Virus in the United States.\\n\\nMETHODOLOGY: We have employed a combination of bioinformatics, molecular cloning and electrophysiology approaches to identify and characterize the response profile of an OR in Cx. quinquefasciatus. First, we have unveiled a large multigenic family of one-hundred-fifty-eight putative ORs in this species, including a subgroup of conserved ORs in three mosquito species. Using the Xenopus oocytes expression system, we have determined the response profile of CquiOR2, an antennae-specific OR, which shares high identity with putative orthologs in Anopheles gambiae (AgamOR2) and Aedes aegypti (AaegOR2).\\n\\nCONCLUSION: We show that CquiOR2 is highly sensitive to indole, an oviposition attractant for Cx. quinquefasciatus. The response profile of CquiOR2 expressed in Xenopus oocytes resembles that of an olfactory receptor neuron housed in the antennal short blunt-tipped sensilla (A2) of Cx. quinquefasciatus, which are natural detectors for oviposition attractants. This first Culex OR de-orphanized is, therefore, a potential molecular target for screening oviposition attractants.", "link"=>"http://www.mendeley.com/research/odorant-receptor-southern-house-mosquito-culex-pipiens-quinquefasciatus-sensitive-oviposition-attrac", "reader_count"=>76, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>22, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>6, "Student > Master"=>15, "Other"=>3, "Student > Bachelor"=>5, "Lecturer"=>4, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>22, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>6, "Student > Master"=>15, "Other"=>3, "Student > Bachelor"=>5, "Lecturer"=>4, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>56, "Medicine and Dentistry"=>2, "Neuroscience"=>2, "Arts and Humanities"=>1, "Veterinary Science and Veterinary Medicine"=>2, "Chemistry"=>3, "Social Sciences"=>1, "Immunology and Microbiology"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>2}, "Chemistry"=>{"Chemistry"=>3}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>56}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}, "Environmental Science"=>{"Environmental Science"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"United States"=>1, "China"=>1, "United Kingdom"=>1, "Madagascar"=>1, "Kenya"=>1, "Chile"=>1, "Portugal"=>1, "Germany"=>4, "India"=>1}, "group_count"=>3}

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  • {"files"=>["https://ndownloader.figshare.com/files/855395"], "description"=>"<p>Olfactory tissues: antennae (FA); maxillary palps (FMp); proboscis (FPr). Non olfactory tissues: legs (FL); bodies (FB). CquiRpL8 was used as control gene.</p>", "links"=>[], "tags"=>["profiles", "ors", "tissues"], "article_id"=>525851, "categories"=>["Medicine", "Neuroscience", "Molecular Biology"], "users"=>["Julien Pelletier", "David T. Hughes", "Charles W. Luetje", "Walter S. Leal"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010090.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_profiles_of_two_ORs_in_Cx_quinquefasciatus_female_tissues_by_RT_PCR_/525851", "title"=>"Expression profiles of two ORs in <i>Cx. quinquefasciatus</i> female tissues by RT-PCR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-04-08 01:37:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/855465"], "description"=>"<p><i>Xenopus</i> oocytes expressing CquiOR2 + CquiOR7 were challenged with a panel of odorant compounds, each applied for 20 s at 10 µM. <b>A</b>) <i>Upper left trace</i>, an oocyte expressing CquiOR2 + CquiOR7 is challenged with 1-methylindole (1MI), 2-methylindole (2MI), 3-methylindole (3MI), 4-methylindole (4MI) and indole (IND). <i>Upper right trace</i>, an oocyte expressing CquiOR2 + CquiOR7 is challenged with 5-methylindole (5MI), 6-methylindole (6MI), 7-methylindole (7MI) and indole (IND). <i>Lower left trace</i>, an oocyte expressing CquiOR2 + CquiOR7 is challenged with phenol (Phe), 2-methylphenol (2MP), 3-methylphenol (3MP), 4-methylphenol (4MP), 4-ethylphenol (4EP), 2-butoxyethanol (2BE), geranylacetone (GA), 6-methyl-5-hepten-2-one (MHO), mosquito oviposition pheromone (MOP) and indole (IND). <i>Lower right trace</i>, an oocyte expressing CquiOR2 + CquiOR7 is challenged with octanal (OCT), nonanal (NON), decanal (DEC), 2-undecanone (2UD), 2-tridecanone (2TD), trimethylamine (TME) and indole (IND). <b>B</b>) Quantification of current responses of CquiOR2 + CquiOR7 expressing receptors. All responses are normalized to the response of the same oocyte to 10 µM indole (mean ± SEM, n = 3–4).</p>", "links"=>[], "tags"=>["cquior7", "responds", "methylindoles"], "article_id"=>525927, "categories"=>["Medicine", "Neuroscience", "Molecular Biology"], "users"=>["Julien Pelletier", "David T. Hughes", "Charles W. Luetje", "Walter S. Leal"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010090.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CquiOR2_CquiOR7_responds_to_indole_various_methylindoles_and_2_methylphenol_/525927", "title"=>"CquiOR2 + CquiOR7 responds to indole, various methylindoles and 2-methylphenol.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-04-08 01:38:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/855693"], "description"=>"<p>EC<sub>50</sub> and Hill coefficient (n<sub>H</sub>) values were derived by fitting the data in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010090#pone-0010090-g005\" target=\"_blank\">Figure 5</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010090#pone.0010090.s001\" target=\"_blank\">Figure S1</a> to a Hill equation (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010090#s3\" target=\"_blank\">Materials and Methods</a>). Relative efficacies are the maximum values derived from fitting the data and are expressed as a percentage of the maximum value for indole. Values are the mean ± SEM derived from concentration-response data from 5–16 separate oocytes.</p>", "links"=>[], "tags"=>["potencies", "efficacies", "activation", "cquior2"], "article_id"=>526150, "categories"=>["Medicine", "Neuroscience", "Molecular Biology"], "users"=>["Julien Pelletier", "David T. Hughes", "Charles W. Luetje", "Walter S. Leal"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010090.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Functional_potencies_and_relative_efficacies_for_activation_of_CquiOR2_CquiOR7_/526150", "title"=>"Functional potencies and relative efficacies for activation of CquiOR2 + CquiOR7.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-04-08 01:42:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/855307"], "description"=>"<p>Dark grey and light grey shading indicate residues conserved among three species and between two of the three species, respectively.</p>", "links"=>[], "tags"=>["mosquito", "or2", "or10", "amino"], "article_id"=>525763, "categories"=>["Medicine", "Neuroscience", "Molecular Biology"], "users"=>["Julien Pelletier", "David T. Hughes", "Charles W. Luetje", "Walter S. Leal"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010090.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Alignment_of_mosquito_OR2_and_OR10_amino_acid_sequences_/525763", "title"=>"Alignment of mosquito OR2 and OR10 amino acid sequences.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-04-08 01:36:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/855603"], "description"=>"<p><b>A</b>) <i>Upper trace</i>, an oocyte expressing CquiOR2 + CquiOR7 is challenged with 20 s applications of a range of concentrations of indole. <i>Middle trace</i>, an oocyte expressing CquiOR2 + CquiOR7 is challenged with 20 s applications of a range of concentrations of 3-methylindole. <i>Lower trace</i>, an oocyte expressing CquiOR2 + CquiOR7 is challenged with 20 s applications of a range of concentrations of 2-methylphenol. <b>B</b>) Concentration-response relationships for CquiOR2 + CquiOR7 expressing oocytes when activated with a range of indole, 3-methylindole and 2-methylphenol concentrations. All data are normalized to the response of each oocyte to 300 nM indole and the curves were fit as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010090#s3\" target=\"_blank\">Materials and Methods</a> (means ± SEM; n = 5–16). EC<sub>50</sub> and n<sub>H</sub> values are provided in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010090#pone-0010090-t001\" target=\"_blank\">Table 1</a>.</p>", "links"=>[], "tags"=>["cquior7", "responsive"], "article_id"=>526065, "categories"=>["Medicine", "Neuroscience", "Molecular Biology"], "users"=>["Julien Pelletier", "David T. Hughes", "Charles W. Luetje", "Walter S. Leal"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010090.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CquiOR2_CquiOR7_is_highly_responsive_to_indole_/526065", "title"=>"CquiOR2 + CquiOR7 is highly responsive to indole.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-04-08 01:41:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/855131"], "description"=>"<p><i>Culex</i> ORs are in black, <i>Anopheles</i> ORs are in blue and <i>Aedes</i> ORs are in red. Filled circles and empty circles represent 94–100% and 79–93% bootstrap support, respectively. The green box represents relationships in the conserved OR2-OR10 subgroup. CquiOR2 corresponds to (XM_001864509/XP_001864544), CquiOR9 to (XM_001864508/XP_001864543) and CquiOR10 to (XM_001844036/XP_001844088). Major species-specific expansions and conserved OR7 and OR8 subgroups are indicated.</p>", "links"=>[], "tags"=>["relationships", "mosquito"], "article_id"=>525595, "categories"=>["Medicine", "Neuroscience", "Molecular Biology"], "users"=>["Julien Pelletier", "David T. Hughes", "Charles W. Luetje", "Walter S. Leal"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010090.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phylogenetic_relationships_of_mosquito_ORs_/525595", "title"=>"Phylogenetic relationships of mosquito ORs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-04-08 01:33:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/425015", "https://ndownloader.figshare.com/files/425058", "https://ndownloader.figshare.com/files/425101"], "description"=>"<div><h3>Background</h3><p>Insect odorant receptors (ORs) are heteromers comprised of highly variable odorant-binding subunits associated with one conserved co-receptor. They are potential molecular targets for the development of novel mosquito attractants and repellents. ORs have been identified in the malaria mosquito, <em>Anopheles gambiae</em>, and in the yellow fever mosquito, <em>Aedes aegypti</em>. However, they are still unknown in the Southern house mosquito, <em>Culex quinquefasciatus</em>, which transmits pathogens that cause human diseases throughout the world, including West Nile Virus in the United States.</p><h3>Methodology</h3><p>We have employed a combination of bioinformatics, molecular cloning and electrophysiology approaches to identify and characterize the response profile of an OR in <em>Cx. quinquefasciatus</em>. First, we have unveiled a large multigenic family of one-hundred-fifty-eight putative ORs in this species, including a subgroup of conserved ORs in three mosquito species. Using the <em>Xenopus</em> oocytes expression system, we have determined the response profile of CquiOR2, an antennae-specific OR, which shares high identity with putative orthologs in <em>Anopheles gambiae</em> (AgamOR2) and <em>Aedes aegypti</em> (AaegOR2).</p><h3>Conclusion</h3><p>We show that CquiOR2 is highly sensitive to indole, an oviposition attractant for <em>Cx. quinquefasciatus</em>. The response profile of CquiOR2 expressed in <em>Xenopus</em> oocytes resembles that of an olfactory receptor neuron housed in the antennal short blunt-tipped sensilla (A2) of <em>Cx. quinquefasciatus</em>, which are natural detectors for oviposition attractants. This first <em>Culex</em> OR de-orphanized is, therefore, a potential molecular target for screening oviposition attractants.</p></div>", "links"=>[], "tags"=>["odorant", "receptor", "mosquito", "pipiens", "oviposition", "attractants"], "article_id"=>143900, "categories"=>["Medicine", "Neuroscience", "Molecular Biology"], "users"=>["Julien Pelletier", "David T. Hughes", "Charles W. Luetje", "Walter S. Leal"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010090.s001", "https://dx.doi.org/10.1371/journal.pone.0010090.s002", "https://dx.doi.org/10.1371/journal.pone.0010090.s003"], "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/An_Odorant_Receptor_from_the_Southern_House_Mosquito_Culex_pipiens_quinquefasciatus_Sensitive_to_Oviposition_Attractants/143900", "title"=>"An Odorant Receptor from the Southern House Mosquito <em>Culex pipiens quinquefasciatus</em> Sensitive to Oviposition Attractants", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-04-08 01:05:00"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
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  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
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  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
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  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"20", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
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Relative Metric

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