Artemisinin-Derived Dimers Have Greatly Improved Anti-Cytomegalovirus Activity Compared to Artemisinin Monomers
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{"title"=>"Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomers", "type"=>"journal", "authors"=>[{"first_name"=>"Ravit", "last_name"=>"Arav-Boger", "scopus_author_id"=>"6602846645"}, {"first_name"=>"Ran", "last_name"=>"He", "scopus_author_id"=>"36610187900"}, {"first_name"=>"Chuang Jiun", "last_name"=>"Chiou", "scopus_author_id"=>"7202682681"}, {"first_name"=>"Jianyong", "last_name"=>"Liu", "scopus_author_id"=>"8657060500"}, {"first_name"=>"Lauren", "last_name"=>"Woodard", "scopus_author_id"=>"36785618600"}, {"first_name"=>"Andrew", "last_name"=>"Rosenthal", "scopus_author_id"=>"13006730600"}, {"first_name"=>"Lorraine", "last_name"=>"Jones-Brando", "scopus_author_id"=>"6507951715"}, {"first_name"=>"Michael", "last_name"=>"Forman", "scopus_author_id"=>"35406931400"}, {"first_name"=>"Gary", "last_name"=>"Posner", "scopus_author_id"=>"7004518556"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"77956397844", "doi"=>"10.1371/journal.pone.0010370", "scopus"=>"2-s2.0-77956397844", "pui"=>"359494304", "pmid"=>"20442781"}, "id"=>"c03aa94b-8f17-373d-a282-387b4be235a2", "abstract"=>"Artesunate, an artemisinin-derived monomer, was reported to inhibit Cytomegalovirus (CMV) replication. We aimed to compare the in-vitro anti-CMV activity of several artemisinin-derived monomers and newly synthesized artemisinin dimers.", "link"=>"http://www.mendeley.com/research/artemisininderived-dimers-greatly-improved-anticytomegalovirus-activity-compared-artemisinin-monomer", "reader_count"=>16, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Other"=>4, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Other"=>4, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>8, "Agricultural and Biological Sciences"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Chemistry"=>{"Chemistry"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Italy"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/853066"], "description"=>"<p>EC<sub>50</sub>, CC<sub>50</sub> and selectivity index (SI) for monomers, dimers and GCV.</p>", "links"=>[], "tags"=>["selectivity", "dimers"], "article_id"=>523519, "categories"=>["Infectious Diseases", "Medicine", "Virology"], "users"=>["Ravit Arav-Boger", "Ran He", "Chuang-Jiun Chiou", "Jianyong Liu", "Lauren Woodard", "Andrew Rosenthal", "Lorraine Jones-Brando", "Michael Forman", "Gary Posner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010370.t001", "stats"=>{"downloads"=>8, "page_views"=>246, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_EC_50_CC_50_and_selectivity_index_SI_for_monomers_dimers_and_GCV_/523519", "title"=>"EC<sub>50</sub>, CC<sub>50</sub> and selectivity index (SI) for monomers, dimers and GCV.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:43:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/852527"], "description"=>"<p>Luciferase assay was performed 72 hr after HFF were treated with monomers or dimers and infected with luciferase-expressing CMV. Values on Y axis adjusted to 0–1 scale. Mean±SD values are presented.</p>", "links"=>[], "tags"=>["artemisinin", "monomers", "dimers", "luciferase", "cmv-infected"], "article_id"=>522970, "categories"=>["Infectious Diseases", "Medicine", "Virology"], "users"=>["Ravit Arav-Boger", "Ran He", "Chuang-Jiun Chiou", "Jianyong Liu", "Lauren Woodard", "Andrew Rosenthal", "Lorraine Jones-Brando", "Michael Forman", "Gary Posner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010370.g003", "stats"=>{"downloads"=>1, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_artemisinin_monomers_and_artemisinin_dimers_on_luciferase_expression_in_CMV_infected_HFF_/522970", "title"=>"Effect of artemisinin monomers and artemisinin dimers on luciferase expression in CMV-infected HFF.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:40:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/852679"], "description"=>"<p>HFF were infected with SB clinical isolate (MOI = 1) and treated with artemisinin (<b>1</b>), artefanilide (<b>3</b>), and two dimers (<b>4</b>, and <b>6</b>). Ten days following infection DNA was extracted from cells and real-time PCR performed.</p>", "links"=>[], "tags"=>["10", "days", "monomers"], "article_id"=>523124, "categories"=>["Infectious Diseases", "Medicine", "Virology"], "users"=>["Ravit Arav-Boger", "Ran He", "Chuang-Jiun Chiou", "Jianyong Liu", "Lauren Woodard", "Andrew Rosenthal", "Lorraine Jones-Brando", "Michael Forman", "Gary Posner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010370.g004", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CMV_copies_mL_at_10_days_post_infection_in_the_presence_of_monomers_and_dimers_/523124", "title"=>"CMV copies/mL at 10 days post infection in the presence of monomers and dimers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:41:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/852419"], "description"=>"<p>Luciferase assay was performed 72 hr after HFF were treated with compounds and infected with the recombinant luciferase-expressing CMV. Values on Y axis adjusted to 0–1 scale. Mean±SD values are presented.</p>", "links"=>[], "tags"=>["lucifersae", "cmv-infected", "hff", "treated", "artemisinin"], "article_id"=>522865, "categories"=>["Infectious Diseases", "Medicine", "Virology"], "users"=>["Ravit Arav-Boger", "Ran He", "Chuang-Jiun Chiou", "Jianyong Liu", "Lauren Woodard", "Andrew Rosenthal", "Lorraine Jones-Brando", "Michael Forman", "Gary Posner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010370.g002", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relative_lucifersae_activity_in_CMV_infected_HFF_treated_with_four_artemisinin_monomers_/522865", "title"=>"Relative lucifersae activity in CMV-infected HFF treated with four artemisinin monomers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:39:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/852903"], "description"=>"<p>Mean±SD values are presented.</p>", "links"=>[], "tags"=>["cmv", "inhibition", "monomers", "dimers", "90", "minutes"], "article_id"=>523347, "categories"=>["Infectious Diseases", "Medicine", "Virology"], "users"=>["Ravit Arav-Boger", "Ran He", "Chuang-Jiun Chiou", "Jianyong Liu", "Lauren Woodard", "Andrew Rosenthal", "Lorraine Jones-Brando", "Michael Forman", "Gary Posner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010370.g006", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_CMV_inhibition_with_monomers_and_dimers_before_infection_and_90_minutes_after_virus_inoculation_/523347", "title"=>"Comparison of CMV inhibition with monomers and dimers before infection and 90 minutes after virus inoculation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:42:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/852313"], "description"=>"<p>Artemisinin monomers (top) and dimers (bottom) used in this study.</p>", "links"=>[], "tags"=>["monomers", "dimers"], "article_id"=>522751, "categories"=>["Infectious Diseases", "Medicine", "Virology"], "users"=>["Ravit Arav-Boger", "Ran He", "Chuang-Jiun Chiou", "Jianyong Liu", "Lauren Woodard", "Andrew Rosenthal", "Lorraine Jones-Brando", "Michael Forman", "Gary Posner"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010370.g001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Artemisinin_monomers_top_and_dimers_bottom_used_in_this_study_/522751", "title"=>"Artemisinin monomers (top) and dimers (bottom) used in this study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:38:49"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
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