Effects of Long-Term Pioglitazone Treatment on Peripheral and Central Markers of Aging
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Effects of long-term pioglitazone treatment on peripheral and central markers of aging", "type"=>"journal", "authors"=>[{"first_name"=>"Eric M.", "last_name"=>"Blalock", "scopus_author_id"=>"6603208118"}, {"first_name"=>"Jeremiah T.", "last_name"=>"Phelps", "scopus_author_id"=>"26633177700"}, {"first_name"=>"Tristano", "last_name"=>"Pancani", "scopus_author_id"=>"12775448200"}, {"first_name"=>"James L.", "last_name"=>"Searcy", "scopus_author_id"=>"26633282500"}, {"first_name"=>"Katie L.", "last_name"=>"Anderson", "scopus_author_id"=>"55455161200"}, {"first_name"=>"John C.", "last_name"=>"Gant", "scopus_author_id"=>"12798433700"}, {"first_name"=>"Jelena", "last_name"=>"Popovic", "scopus_author_id"=>"36610639800"}, {"first_name"=>"Margarita G.", "last_name"=>"Avdiushko", "scopus_author_id"=>"6507712709"}, {"first_name"=>"Don A.", "last_name"=>"Cohen", "scopus_author_id"=>"7404418105"}, {"first_name"=>"Kuey Chu", "last_name"=>"Chen", "scopus_author_id"=>"36851400100"}, {"first_name"=>"Nada M.", "last_name"=>"Porter", "scopus_author_id"=>"7102053624"}, {"first_name"=>"Olivier", "last_name"=>"Thibault", "scopus_author_id"=>"6701368477"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-77956402617", "pmid"=>"20454453", "sgr"=>"77956402617", "doi"=>"10.1371/journal.pone.0010405", "isbn"=>"1932-6203", "issn"=>"19326203", "pui"=>"359494274"}, "id"=>"c03a3a61-7a3f-3a35-af73-e97212fee066", "abstract"=>"BACKGROUND: Thiazolidinediones (TZDs) activate peroxisome proliferator-activated receptor gamma (PPARgamma) and are used clinically to help restore peripheral insulin sensitivity in Type 2 diabetes (T2DM). Interestingly, long-term treatment of mouse models of Alzheimer's disease (AD) with TZDs also has been shown to reduce several well-established brain biomarkers of AD including inflammation, oxidative stress and Abeta accumulation. While TZD's actions in AD models help to elucidate the mechanisms underlying their potentially beneficial effects in AD patients, little is known about the functional consequences of TZDs in animal models of normal aging. Because aging is a common risk factor for both AD and T2DM, we investigated whether the TZD, pioglitazone could alter brain aging under non-pathological conditions.\\n\\nMETHODS AND FINDINGS: We used the F344 rat model of aging, and monitored behavioral, electrophysiological, and molecular variables to assess the effects of pioglitazone (PIO-Actos(R) a TZD) on several peripheral (blood and liver) and central (hippocampal) biomarkers of aging. Starting at 3 months or 17 months of age, male rats were treated for 4-5 months with either a control or a PIO-containing diet (final dose approximately 2.3 mg/kg body weight/day). A significant reduction in the Ca(2+)-dependent afterhyperpolarization was seen in the aged animals, with no significant change in long-term potentiation maintenance or learning and memory performance. Blood insulin levels were unchanged with age, but significantly reduced by PIO. Finally, a combination of microarray analyses on hippocampal tissue and serum-based multiplex cytokine assays revealed that age-dependent inflammatory increases were not reversed by PIO.\\n\\nCONCLUSIONS: While current research efforts continue to identify the underlying processes responsible for the progressive decline in cognitive function seen during normal aging, available medical treatments are still very limited. Because TZDs have been shown to have benefits in age-related conditions such as T2DM and AD, our study was aimed at elucidating PIO's potentially beneficial actions in normal aging. Using a clinically-relevant dose and delivery method, long-term PIO treatment was able to blunt several indices of aging but apparently affected neither age-related cognitive decline nor peripheral/central age-related increases in inflammatory signaling.", "link"=>"http://www.mendeley.com/research/effects-longterm-pioglitazone-treatment-peripheral-central-markers-aging", "reader_count"=>48, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Student > Doctoral Student"=>1, "Researcher"=>15, "Student > Ph. D. Student"=>7, "Student > Master"=>6, "Other"=>1, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Student > Doctoral Student"=>1, "Researcher"=>15, "Student > Ph. D. Student"=>7, "Student > Master"=>6, "Other"=>1, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>12, "Agricultural and Biological Sciences"=>19, "Arts and Humanities"=>1, "Neuroscience"=>6, "Social Sciences"=>2, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Neuroscience"=>{"Neuroscience"=>6}, "Social Sciences"=>{"Social Sciences"=>2}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>19}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>4}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Japan"=>1, "Brazil"=>1, "France"=>1, "Spain"=>1, "India"=>1}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/77956402617"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/77956402617?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77956402617&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=77956402617&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/77956402617", "dc:identifier"=>"SCOPUS_ID:77956402617", "eid"=>"2-s2.0-77956402617", "dc:title"=>"Effects of long-term pioglitazone treatment on peripheral and central markers of aging", "dc:creator"=>"Blalock E.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"5", "prism:issueIdentifier"=>"4", "prism:pageRange"=>nil, "prism:coverDate"=>"2010-09-14", "prism:coverDisplayDate"=>"2010", "prism:doi"=>"10.1371/journal.pone.0010405", "citedby-count"=>"30", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"UK Albert B. Chandler Hospital", "affiliation-city"=>"Lexington", "affiliation-country"=>"United States"}], "pubmed-id"=>"20454453", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e10405", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0010405", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"97"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"86", "xml_views"=>"0", "html_views"=>"275"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"39", "xml_views"=>"1", "html_views"=>"107"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"60"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"3", "html_views"=>"41"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"34"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"5", "html_views"=>"34"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"4"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"37"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"4"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"0"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/851986"], "description"=>"<p>(<b>A</b>) and (<b>B</b>) Total insulin receptor levels (IR) were measured in liver (left) and cortex (right) as a function of age and diet (CTRL <i>vs.</i> PIO). In liver, the significant age-dependent increase in IR levels was significantly reduced by PIO treatment. (<b>C</b>) and (<b>D</b>) Phosphorylated IR levels (pIR) were also measured in liver (left) and cortex (right). While PIO treatment significant reduced pIR levels in both tissues and both age groups, only liver levels appeared to be sensitive to age. (<b>E</b>) and (<b>F</b>) Measures of signaling through IR, based on the ratio of pIR (C and D) to total IR (A and B) revealed no effects of aging or PIO treatment. * indicates significant aging effects (two-way ANOVA, p<0.05). <sup>#</sup> indicates significant PIO effects (two-way ANOVA, p<0.05). Data represent mean ± SEM in 5–8 samples per group.</p>", "links"=>[], "tags"=>["receptor"], "article_id"=>522433, "categories"=>["Computational Biology", "Neuroscience", "Virology", "Physiology"], "users"=>["Eric M. Blalock", "Jeremiah T. Phelps", "Tristano Pancani", "James L. Searcy", "Katie L. Anderson", "John C. Gant", "Jelena Popovic", "Margarita G. Avdiushko", "Don A. Cohen", "Kuey-Chu Chen", "Nada M. Porter", "Olivier Thibault"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010405.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Insulin_Receptor_signaling_/522433", "title"=>"Insulin Receptor signaling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-04-29 00:40:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/851609"], "description"=>"<p>(<b>A</b>) Body weights measured across age during the 14-week long study (YC = young control, YP = young PIO, AC = aged control and AP = aged PIO; 7–12 animals per group). (<b>B</b>) Heart weight normalized to body weight in 6–8 animals per group fed either control diet (CTRL) and PIO-enriched diet (PIO). (<b>C</b>) Blood glucose levels measured over the course of the study in 3–11 animals per group. Data represent mean ± SEM.</p>", "links"=>[], "tags"=>["weights", "glucose"], "article_id"=>522050, "categories"=>["Computational Biology", "Neuroscience", "Virology", "Physiology"], "users"=>["Eric M. Blalock", "Jeremiah T. Phelps", "Tristano Pancani", "James L. Searcy", "Katie L. Anderson", "John C. Gant", "Jelena Popovic", "Margarita G. Avdiushko", "Don A. Cohen", "Kuey-Chu Chen", "Nada M. Porter", "Olivier Thibault"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010405.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Growth_curves_heart_weights_and_blood_glucose_levels_/522050", "title"=>"Growth curves, heart weights and blood glucose levels.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-04-29 00:34:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/851863"], "description"=>"<p>(<b>A</b>) Representative examples of AHPs recorded in CA1 pyramidal cells from young (left) and aged (right) animals fed either control (CTRL) or PIO-enriched (PIO) diet. Both amplitude (<b>B</b>) and duration (<b>C</b>) of the sAHP were significantly enhanced in the aged group. In aged animals, however, long-term PIO treatment significantly reduced the sAHP (red traces in A). * indicates significant aging and PIO effects (two-way ANOVA, p<0.05). Data represent mean ± SEM in 12–21 recorded neurons from 6–7 animals per group.</p>", "links"=>[], "tags"=>["afterhyperpolarization"], "article_id"=>522309, "categories"=>["Computational Biology", "Neuroscience", "Virology", "Physiology"], "users"=>["Eric M. Blalock", "Jeremiah T. Phelps", "Tristano Pancani", "James L. Searcy", "Katie L. Anderson", "John C. Gant", "Jelena Popovic", "Margarita G. Avdiushko", "Don A. Cohen", "Kuey-Chu Chen", "Nada M. Porter", "Olivier Thibault"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010405.g004", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Measures_of_the_Ca_2_dependent_slow_afterhyperpolarization_sAHP_/522309", "title"=>"Measures of the Ca<sup>2+</sup>-dependent slow afterhyperpolarization (sAHP).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-04-29 00:38:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/852087"], "description"=>"<p>P-value histogram derived from the results of the two-way ANOVA (age and drug) reveals robust aging, but not drug or interaction effects. Changes in hippocampal microarray gene signatures were separated according to main effects of age, drug, or interaction (age×drug). While more genes than expected by chance (dashed horizontal line) were shown to be age-sensitive (819, bold line), fewer than expected by chance were found to be PIO-sensitive (189, dotted line), or associated with the interaction (125, gray line) (median FDRs for age = 0.21; for drug = 2.3; for interaction = 3.8). Dataset was derived from hippocampal tissue isolated from 6–8 animals per group. <b>Inset:</b> Agreement of age-related hippocampal gene expression across this and prior studies. Genes found to be present and annotated across four studies (3906) were subjected to overlap analysis for common age-related transcriptional profiles. Unified aging list includes genes found to change three studies <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010405#pone.0010405-Rowe1\" target=\"_blank\">[47]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010405#pone.0010405-Kadish1\" target=\"_blank\">[48]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010405#pone.0010405-Blalock2\" target=\"_blank\">[50]</a>. Here, the number of genes expected to overlap by chance (94 up, 36 down) was significantly greater (151 up and 61 down; p<0.01). * indicates p<1.7E-8 for up and p<2.7E-4 for downregulated genes.</p>", "links"=>[], "tags"=>["microarray", "analyses", "comparisons", "aging"], "article_id"=>522530, "categories"=>["Computational Biology", "Neuroscience", "Virology", "Physiology"], "users"=>["Eric M. Blalock", "Jeremiah T. Phelps", "Tristano Pancani", "James L. Searcy", "Katie L. Anderson", "John C. Gant", "Jelena Popovic", "Margarita G. Avdiushko", "Don A. Cohen", "Kuey-Chu Chen", "Nada M. Porter", "Olivier Thibault"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010405.g006", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hippocampal_microarray_analyses_and_comparisons_to_prior_aging_studies_/522530", "title"=>"Hippocampal microarray analyses and comparisons to prior aging studies.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-04-29 00:42:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/423766"], "description"=>"<div><h3>Background</h3><p>Thiazolidinediones (TZDs) activate peroxisome proliferator-activated receptor gamma (PPARγ) and are used clinically to help restore peripheral insulin sensitivity in Type 2 diabetes (T2DM). Interestingly, long-term treatment of mouse models of Alzheimer's disease (AD) with TZDs also has been shown to reduce several well-established brain biomarkers of AD including inflammation, oxidative stress and Aβ accumulation. While TZD's actions in AD models help to elucidate the mechanisms underlying their potentially beneficial effects in AD patients, little is known about the functional consequences of TZDs in animal models of normal aging. Because aging is a common risk factor for both AD and T2DM, we investigated whether the TZD, pioglitazone could alter brain aging under non-pathological conditions.</p><h3>Methods and Findings</h3><p>We used the F344 rat model of aging, and monitored behavioral, electrophysiological, and molecular variables to assess the effects of pioglitazone (PIO-Actos® a TZD) on several peripheral (blood and liver) and central (hippocampal) biomarkers of aging. Starting at 3 months or 17 months of age, male rats were treated for 4–5 months with either a control or a PIO-containing diet (final dose approximately 2.3 mg/kg body weight/day). A significant reduction in the Ca<sup>2+</sup>-dependent afterhyperpolarization was seen in the aged animals, with no significant change in long-term potentiation maintenance or learning and memory performance. Blood insulin levels were unchanged with age, but significantly reduced by PIO. Finally, a combination of microarray analyses on hippocampal tissue and serum-based multiplex cytokine assays revealed that age-dependent inflammatory increases were not reversed by PIO.</p><h3>Conclusions</h3><p>While current research efforts continue to identify the underlying processes responsible for the progressive decline in cognitive function seen during normal aging, available medical treatments are still very limited. Because TZDs have been shown to have benefits in age-related conditions such as T2DM and AD, our study was aimed at elucidating PIO's potentially beneficial actions in normal aging. Using a clinically-relevant dose and delivery method, long-term PIO treatment was able to blunt several indices of aging but apparently affected neither age-related cognitive decline nor peripheral/central age-related increases in inflammatory signaling.</p></div>", "links"=>[], "tags"=>["effects", "pioglitazone", "peripheral", "markers", "aging"], "article_id"=>143664, "categories"=>["Biological Sciences", "Neuroscience", "Cancer", "Physiology"], "users"=>["Eric M. Blalock", "Jeremiah T. Phelps", "Tristano Pancani", "James L. Searcy", "Katie L. Anderson", "John C. Gant", "Jelena Popovic", "Margarita G. Avdiushko", "Don A. Cohen", "Kuey-Chu Chen", "Nada M. Porter", "Olivier Thibault"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010405", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Effects_of_Long_Term_Pioglitazone_Treatment_on_Peripheral_and_Central_Markers_of_Aging/143664", "title"=>"Effects of Long-Term Pioglitazone Treatment on Peripheral and Central Markers of Aging", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-04-29 01:01:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/851691"], "description"=>"<p>(<b>A</b>) Path length to platform recorded across age and treatment groups (CTRL and PIO) show a significant increase in aged compared to young animals. (<b>B</b>) Latency to platform also was significant for age effect. In (<b>C</b>) Proximity averages representing a scalar index of recall shows a significant age effect. All measures represent animal performance on the probe day taken 24 h after the last training session. No PIO effects were noted. ** Indicates significant aging effect (two-way ANOVA, p<0.01), * indicates significant aging effect (two-way ANOVA, p<0.05). Data represent mean ± SEM in 4–8 animals per group.</p>", "links"=>[], "tags"=>["neuroscience", "physiology", "neuroscience/behavioral neuroscience", "diabetes and endocrinology/obesity", "diabetes and endocrinology/type 2 diabetes", "neurological disorders/alzheimer disease", "neurological disorders/cognitive neurology and dementia", "neurological disorders/neurogenetics", "neurological disorders/neuropharmacology"], "article_id"=>522131, "categories"=>["Computational Biology", "Neuroscience", "Virology", "Physiology"], "users"=>["Eric M. Blalock", "Jeremiah T. Phelps", "Tristano Pancani", "James L. Searcy", "Katie L. Anderson", "John C. Gant", "Jelena Popovic", "Margarita G. Avdiushko", "Don A. Cohen", "Kuey-Chu Chen", "Nada M. Porter", "Olivier Thibault"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010405.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spatial_memory_recall_/522131", "title"=>"Spatial memory recall.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-04-29 00:35:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/852206"], "description"=>"<p>Lists of significantly (p≤0.05, two-way ANOVA main effect of age) down- and up-regulated genes were subjected to overrepresentation analysis using DAVID's clustering function (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010405#s2\" target=\"_blank\">Methods</a>). Representative pathways from each cluster found to have significantly more genes than expected by chance (p≤0.05, modified Fisher's exact test) are shown. The pathway (bold) is followed in parentheses by the number of genes found to be significant in that pathway (#) and the likelihood that such a number could be found by chance (p = ). This is followed by a list of the gene symbols within that pathway.</p>", "links"=>[], "tags"=>["aging-related"], "article_id"=>522648, "categories"=>["Computational Biology", "Neuroscience", "Virology", "Physiology"], "users"=>["Eric M. Blalock", "Jeremiah T. Phelps", "Tristano Pancani", "James L. Searcy", "Katie L. Anderson", "John C. Gant", "Jelena Popovic", "Margarita G. Avdiushko", "Don A. Cohen", "Kuey-Chu Chen", "Nada M. Porter", "Olivier Thibault"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010405.t002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pathway_analysis_for_aging_related_genes_/522648", "title"=>"Pathway analysis for aging-related genes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-04-29 00:44:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/851797"], "description"=>"<p>(<b>A</b>) and (<b>B</b>) Normalized EPSP slopes measured across both age and treatment groups during baseline and following theta burst stimulation (TBS). Representative averaged EPSP traces for each age and treatment group are shown in insets. Post-tetanic potentiation (PTP) of the EPSPS was measured immediately following LTP induction (<b>C</b>). LTP maintenance was measure 25–30 min latter in CTRL and PIO-treated animals (<b>D</b>). (<b>E</b>) EPSP amplitudes taken before TBS reveal a significant effect of aging. No PIO effects were noted, * indicates significant aging effect (two-way ANOVA, p<0.05). Data represent mean ± SEM in 6–9 hippocampal slices from 3–5 animals per group.</p>", "links"=>[], "tags"=>["induced", "synaptic"], "article_id"=>522233, "categories"=>["Computational Biology", "Neuroscience", "Virology", "Physiology"], "users"=>["Eric M. Blalock", "Jeremiah T. Phelps", "Tristano Pancani", "James L. Searcy", "Katie L. Anderson", "John C. Gant", "Jelena Popovic", "Margarita G. Avdiushko", "Don A. Cohen", "Kuey-Chu Chen", "Nada M. Porter", "Olivier Thibault"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010405.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Theta_burst_induced_synaptic_potentiation_/522233", "title"=>"Theta-burst induced synaptic potentiation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-04-29 00:37:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/852166"], "description"=>"<p>Blood serum markers in control (CTRL) and PIO-treated (PIO) young and aged animals. Abbreviations: Cholesterol: CHOL; Triglycerides: TG; Alanine aminotransferase: ALT; High Density Lipoprotein: HDL.</p><p>*, **, and <sup>#</sup> indicate significant PIO effects (two-way ANOVA, p<0.05, p<0.001, and p<0.0005, respectively).</p>†<p>indicates significant aging effect (two-way ANOVA, p<0.05). Data represent mean ± SEM in 7–8 animals per group.</p>", "links"=>[], "tags"=>["neuroscience", "physiology", "neuroscience/behavioral neuroscience", "diabetes and endocrinology/obesity", "diabetes and endocrinology/type 2 diabetes", "neurological disorders/alzheimer disease", "neurological disorders/cognitive neurology and dementia", "neurological disorders/neurogenetics", "neurological disorders/neuropharmacology"], "article_id"=>522597, "categories"=>["Computational Biology", "Neuroscience", "Virology", "Physiology"], "users"=>["Eric M. Blalock", "Jeremiah T. Phelps", "Tristano Pancani", "James L. Searcy", "Katie L. Anderson", "John C. Gant", "Jelena Popovic", "Margarita G. Avdiushko", "Don A. Cohen", "Kuey-Chu Chen", "Nada M. Porter", "Olivier Thibault"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010405.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Blood_chemistry_panel_/522597", "title"=>"Blood chemistry panel.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-04-29 00:43:17"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"7", "full-text"=>"93", "unique-ip"=>"84", "pdf"=>"66", "year"=>"2010", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"84", "year"=>"2010", "pdf"=>"59", "unique-ip"=>"87", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"59", "unique-ip"=>"53", "pdf"=>"36", "year"=>"2010", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"44", "year"=>"2010", "pdf"=>"32", "unique-ip"=>"47", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"40", "unique-ip"=>"43", "pdf"=>"30", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"28", "year"=>"2010", "pdf"=>"16", "unique-ip"=>"27", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"27", "unique-ip"=>"29", "pdf"=>"15", "year"=>"2010", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"28", "year"=>"2010", "pdf"=>"20", "unique-ip"=>"31", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"22", "unique-ip"=>"24", "pdf"=>"13", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"25", "year"=>"2011", "pdf"=>"14", "unique-ip"=>"27", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"22", "unique-ip"=>"24", "pdf"=>"13", "year"=>"2011", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"19", "year"=>"2011", "pdf"=>"16", "unique-ip"=>"25", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"24", "unique-ip"=>"25", "pdf"=>"20", "year"=>"2011", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"21", "year"=>"2011", "pdf"=>"10", "unique-ip"=>"17", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"24", "unique-ip"=>"24", "pdf"=>"14", "year"=>"2011", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"32", "year"=>"2011", "pdf"=>"13", "unique-ip"=>"35", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "unique-ip"=>"21", "pdf"=>"7", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"32", "year"=>"2011", "pdf"=>"9", "unique-ip"=>"26", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"30", "unique-ip"=>"24", "pdf"=>"11", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"13", "year"=>"2011", "pdf"=>"7", "unique-ip"=>"17", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"24", "unique-ip"=>"22", "pdf"=>"12", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"8", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"31", "unique-ip"=>"29", "pdf"=>"17", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "year"=>"2012", "pdf"=>"5", "unique-ip"=>"15", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"1", "abstract"=>"2", "full-text"=>"24", "unique-ip"=>"23", "pdf"=>"15", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "year"=>"2012", "pdf"=>"9", "unique-ip"=>"18", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"8", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"22", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"4", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"7", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"39", "full-text"=>"47", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"25", "full-text"=>"28", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"86", "full-text"=>"118", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"6", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"20", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}

Relative Metric

{"start_date"=>"2010-01-01T00:00:00Z", "end_date"=>"2010-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[276, 544, 702, 826, 936, 1045, 1140, 1222, 1305, 1377, 1453, 1528, 1584, 1661, 1725, 1783, 1848, 1913, 1977, 2038, 2103, 2158, 2223, 2290, 2346, 2406, 2467, 2529, 2588, 2652, 2722, 2779, 2835, 2892, 2943, 2999]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[265, 560, 722, 863, 978, 1083, 1172, 1261, 1345, 1428, 1488, 1559, 1630, 1701, 1764, 1840, 1899, 1965, 2028, 2088, 2150, 2211, 2270, 2348, 2410, 2461, 2531, 2598, 2645, 2719, 2793, 2870, 2923, 2974, 3020, 3080, 3142, 3198, 3259, 3351, 3418, 3471, 3527, 3581, 3637, 3706, 3761, 3817, 3872]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[266, 530, 683, 806, 930, 1032, 1122, 1207, 1292, 1362, 1433, 1495, 1565, 1621, 1680, 1737, 1792, 1851, 1901, 1967, 2022, 2075, 2150, 2203, 2250, 2314, 2367, 2416, 2472, 2531, 2603, 2651, 2707, 2756, 2800, 2877, 2936, 2986, 3036, 3083, 3131, 3191, 3253, 3313, 3376, 3437, 3496, 3556]}, {"subject_area"=>"/Biology and life sciences/Nutrition", "average_usage"=>[333, 622, 806, 950, 1091, 1200, 1320, 1416, 1501, 1597, 1702, 1777, 1853, 1949, 2049, 2127, 2223, 2314, 2439, 2517, 2587, 2739, 2804, 2885, 2967, 3034, 3138, 3236, 3331, 3387, 3485, 3579, 3667, 3745, 3810, 3898, 3955, 4027, 4082, 4134, 4213, 4287, 4369, 4443, 4509, 4575, 4632, 4681, 4796]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[267, 555, 705, 829, 955, 1058, 1158, 1248, 1324, 1404, 1476, 1548, 1626, 1706, 1765, 1821, 1875, 1937, 2010, 2063, 2130, 2192, 2264, 2316, 2359, 2409, 2484, 2546, 2631, 2695, 2752, 2816, 2871, 2935, 2987, 3041, 3095, 3153, 3207, 3286, 3353, 3392, 3439, 3478, 3531, 3584, 3649, 3714]}, {"subject_area"=>"/Medicine and health sciences/Nutrition", "average_usage"=>[319, 609, 799, 941, 1085, 1205, 1316, 1426, 1517, 1615, 1714, 1790, 1859, 1949, 2060, 2153, 2229, 2333, 2423, 2525, 2610, 2698, 2790, 2871, 2956, 3008, 3085, 3153, 3221, 3294, 3410, 3505, 3612, 3682, 3731, 3790, 3865, 3961, 4035, 4101, 4160, 4229, 4283, 4344, 4402, 4459, 4510, 4573, 4677]}, {"subject_area"=>"/Medicine and health sciences/Pharmacology", "average_usage"=>[275, 539, 709, 846, 991, 1098, 1213, 1311, 1390, 1473, 1556, 1638, 1713, 1783, 1859, 1935, 2005, 2083, 2145, 2207, 2275, 2352, 2444, 2514, 2592, 2657, 2732, 2801, 2879, 2947, 3031, 3109, 3181, 3241, 3312, 3385, 3454, 3502, 3600, 3665, 3726, 3782, 3829, 3901, 3967, 4014, 4055, 4156, 4196]}]}
Loading … Spinner
There are currently no alerts