A Glucose BioFuel Cell Implanted in Rats
Publication Date
May 04, 2010
Journal
PLOS ONE
Authors
Philippe Cinquin, Chantal Gondran, Fabien Giroud, Simon Mazabrard, et al
Volume
5
Issue
5
Pages
e10476
DOI
https://dx.plos.org/10.1371/journal.pone.0010476
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0010476
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/20454563
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864295
Europe PMC
http://europepmc.org/abstract/MED/20454563
Web of Science
000277305300011
Scopus
77956420559
Mendeley
http://www.mendeley.com/research/glucose-biofuel-cell-implanted-rats
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Mendeley | Further Information

{"title"=>"A glucose BioFuel cell implanted in Rats", "type"=>"journal", "authors"=>[{"first_name"=>"Philippe", "last_name"=>"Cinquin", "scopus_author_id"=>"7006271915"}, {"first_name"=>"Chantal", "last_name"=>"Gondran", "scopus_author_id"=>"7003759101"}, {"first_name"=>"Fabien", "last_name"=>"Giroud", "scopus_author_id"=>"35336507200"}, {"first_name"=>"Simon", "last_name"=>"Mazabrard", "scopus_author_id"=>"36458621600"}, {"first_name"=>"Aymeric", "last_name"=>"Pellissier", "scopus_author_id"=>"24326945000"}, {"first_name"=>"François", "last_name"=>"Boucher", "scopus_author_id"=>"7006246993"}, {"first_name"=>"Jean Pierre", "last_name"=>"Alcaraz", "scopus_author_id"=>"7102811458"}, {"first_name"=>"Karine", "last_name"=>"Gorgy", "scopus_author_id"=>"6602344131"}, {"first_name"=>"François", "last_name"=>"Lenouvel", "scopus_author_id"=>"56627185800"}, {"first_name"=>"Stéphane", "last_name"=>"Mathé", "scopus_author_id"=>"57188553577"}, {"first_name"=>"Paolo", "last_name"=>"Porcu", "scopus_author_id"=>"36458937200"}, {"first_name"=>"Serge", "last_name"=>"Cosnier", "scopus_author_id"=>"7004489498"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"359494451", "pmid"=>"20454563", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0010476", "sgr"=>"77956420559", "scopus"=>"2-s2.0-77956420559"}, "id"=>"53102644-0471-3254-bccd-840d3f543f69", "abstract"=>"\\n<p>Powering future generations of implanted medical devices will require cumbersome transcutaneous energy transfer or harvesting energy from the human body. No functional solution that harvests power from the body is currently available, despite attempts to use the Seebeck thermoelectric effect, vibrations or body movements. Glucose fuel cells appear more promising, since they produce electrical energy from glucose and dioxygen, two substrates present in physiological fluids. The most powerful ones, Glucose BioFuel Cells (GBFCs), are based on enzymes electrically wired by redox mediators. However, GBFCs cannot be implanted in animals, mainly because the enzymes they rely on either require low pH or are inhibited by chloride or urate anions, present in the Extra Cellular Fluid (ECF). Here we present the first functional implantable GBFC, working in the retroperitoneal space of freely moving rats. The breakthrough relies on the design of a new family of GBFCs, characterized by an innovative and simple mechanical confinement of various enzymes and redox mediators: enzymes are no longer covalently bound to the surface of the electron collectors, which enables use of a wide variety of enzymes and redox mediators, augments the quantity of active enzymes, and simplifies GBFC construction. Our most efficient GBFC was based on composite graphite discs containing glucose oxidase and ubiquinone at the anode, polyphenol oxidase (PPO) and quinone at the cathode. PPO reduces dioxygen into water, at pH 7 and in the presence of chloride ions and urates at physiological concentrations. This GBFC, with electrodes of 0.133 mL, produced a peak specific power of 24.4 µW mL<sup>−1</sup>, which is better than pacemakers' requirements and paves the way for the development of a new generation of implantable artificial organs, covering a wide range of medical applications.</p>\\n", "link"=>"http://www.mendeley.com/research/glucose-biofuel-cell-implanted-rats", "reader_count"=>180, "reader_count_by_academic_status"=>{"Unspecified"=>9, "Professor > Associate Professor"=>18, "Researcher"=>34, "Student > Doctoral Student"=>9, "Student > Ph. D. Student"=>56, "Student > Postgraduate"=>6, "Student > Master"=>25, "Other"=>6, "Student > Bachelor"=>14, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>9, "Professor > Associate Professor"=>18, "Researcher"=>34, "Student > Doctoral Student"=>9, "Student > Ph. D. Student"=>56, "Student > Postgraduate"=>6, "Student > Master"=>25, "Other"=>6, "Student > Bachelor"=>14, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>14, "Agricultural and Biological Sciences"=>36, "Chemical Engineering"=>7, "Chemistry"=>42, "Energy"=>1, "Engineering"=>52, "Environmental Science"=>3, "Biochemistry, Genetics and Molecular Biology"=>7, "Materials Science"=>9, "Medicine and Dentistry"=>4, "Neuroscience"=>1, "Design"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>9}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Unspecified"=>{"Unspecified"=>14}, "Environmental Science"=>{"Environmental Science"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Chemical Engineering"=>{"Chemical Engineering"=>7}, "Design"=>{"Design"=>1}, "Engineering"=>{"Engineering"=>52}, "Chemistry"=>{"Chemistry"=>42}, "Neuroscience"=>{"Neuroscience"=>1}, "Energy"=>{"Energy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>36}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}}, "reader_count_by_country"=>{"United States"=>5, "Japan"=>3, "Poland"=>1, "United Kingdom"=>2, "France"=>3, "Switzerland"=>1, "Germany"=>2}, "group_count"=>10}

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Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/852462"], "description"=>"<p>(A) Schematic representation. In each electrode, the redox species, quinone (Q) and hydroquinone (QH2) are confined close to a carbon felt by a first dialysis bag (nominal cut-off of 100 g mol<sup>−1</sup>). This bag separates the redox species from the enzymes contained in a second dialysis bag with a nominal cut-off of 6–8000 g mol<sup>−1</sup>. This second dialysis bag contains GOX and catalase for the anode, and urease for the cathode. The two electrodes are packed together in a Dacron® sleeve. (B) Electro-chemical reactions at the electrodes. Action of the GOX at the cathode locally decreases the pH, while action of the urease at the anode locally increases pH. Nernst law governs the difference of potential between anode and cathode (subscripts <i>a</i> is used in this equation to identify pH and concentrations of species at the anode, subscript <i>c</i> denoting the cathode). At the cathode, quinone (Q) is reduced into hydroquinone (QH<sub>2</sub>), while at the anode hydroquinone (QH<sub>2</sub>) is oxidised into quinone (Q). (C) Discharge curve under 100 nA. This curve was recorded after implantation in the retroperitoneal space of a rat, for a constant current of 100 nA. It corresponds to a mean power of 3 nW during 45 minutes.</p>", "links"=>[], "tags"=>["ph-based", "glucose", "urea", "biofuel", "mechanically", "confined"], "article_id"=>522901, "categories"=>["Medicine", "Biotechnology", "Immunology", "Physiology", "Chemistry", "Biophysics", "Biochemistry"], "users"=>["Philippe Cinquin", "Chantal Gondran", "Fabien Giroud", "Simon Mazabrard", "Aymeric Pellissier", "François Boucher", "Jean-Pierre Alcaraz", "Karine Gorgy", "François Lenouvel", "Stéphane Mathé", "Paolo Porcu", "Serge Cosnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010476.g005", "stats"=>{"downloads"=>4, "page_views"=>313, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Implantable_8220_Quinhydrone_pH_based_Glucose_and_Urea_BioFuel_Cell_8221_with_mechanically_confined_electrodes_/522901", "title"=>"Implantable “Quinhydrone pH-based Glucose and Urea BioFuel Cell” with mechanically confined electrodes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-04 00:48:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/852318"], "description"=>"<p>(A) Power-voltage profile. A peak power of 6.5 µW is observed at 0.13 V, yielding a maximum specific power of 24.4 µW mL<sup>−1</sup>. (B) Discharge curve. Discharge of the GBFC starts 4 hours after implantation. The chronopotentiometry was recorded for a constant current (10 µA). A stable production of more than 2 µW is observed for several hours.</p>", "links"=>[], "tags"=>["implanted", "wistar"], "article_id"=>522758, "categories"=>["Medicine", "Biotechnology", "Immunology", "Physiology", "Chemistry", "Biophysics", "Biochemistry"], "users"=>["Philippe Cinquin", "Chantal Gondran", "Fabien Giroud", "Simon Mazabrard", "Aymeric Pellissier", "François Boucher", "Jean-Pierre Alcaraz", "Karine Gorgy", "François Lenouvel", "Stéphane Mathé", "Paolo Porcu", "Serge Cosnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010476.g003", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Performance_of_a_8220_Quinone_Ubiquinone_GBFC_8221_implanted_in_a_male_Wistar_rat_514_g_weight_/522758", "title"=>"Performance of a “Quinone-Ubiquinone GBFC” implanted in a male Wistar rat (514 g weight).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-04 00:45:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/423488"], "description"=>"<div><p>Powering future generations of implanted medical devices will require cumbersome transcutaneous energy transfer or harvesting energy from the human body. No functional solution that harvests power from the body is currently available, despite attempts to use the Seebeck thermoelectric effect, vibrations or body movements. Glucose fuel cells appear more promising, since they produce electrical energy from glucose and dioxygen, two substrates present in physiological fluids. The most powerful ones, Glucose BioFuel Cells (GBFCs), are based on enzymes electrically wired by redox mediators. However, GBFCs cannot be implanted in animals, mainly because the enzymes they rely on either require low pH or are inhibited by chloride or urate anions, present in the Extra Cellular Fluid (ECF). Here we present the first functional implantable GBFC, working in the retroperitoneal space of freely moving rats. The breakthrough relies on the design of a new family of GBFCs, characterized by an innovative and simple mechanical confinement of various enzymes and redox mediators: enzymes are no longer covalently bound to the surface of the electron collectors, which enables use of a wide variety of enzymes and redox mediators, augments the quantity of active enzymes, and simplifies GBFC construction. Our most efficient GBFC was based on composite graphite discs containing glucose oxidase and ubiquinone at the anode, polyphenol oxidase (PPO) and quinone at the cathode. PPO reduces dioxygen into water, at pH 7 and in the presence of chloride ions and urates at physiological concentrations. This GBFC, with electrodes of 0.133 mL, produced a peak specific power of 24.4 µW mL<sup>−1</sup>, which is better than pacemakers' requirements and paves the way for the development of a new generation of implantable artificial organs, covering a wide range of medical applications.</p></div>", "links"=>[], "tags"=>["glucose", "biofuel", "implanted", "rats"], "article_id"=>143609, "categories"=>["Medicine", "Biotechnology", "Immunology", "Physiology", "Chemistry", "Biophysics", "Biochemistry"], "users"=>["Philippe Cinquin", "Chantal Gondran", "Fabien Giroud", "Simon Mazabrard", "Aymeric Pellissier", "François Boucher", "Jean-Pierre Alcaraz", "Karine Gorgy", "François Lenouvel", "Stéphane Mathé", "Paolo Porcu", "Serge Cosnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010476", "stats"=>{"downloads"=>13, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_Glucose_BioFuel_Cell_Implanted_in_Rats/143609", "title"=>"A Glucose BioFuel Cell Implanted in Rats", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-05-04 01:00:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/852226"], "description"=>"<p>The GBFC is immersed in 50 mL HEPES buffer (2.5 10<sup>−2</sup> mol L<sup>−1</sup>; pH 7.2) containing 5.5 10<sup>−3</sup> mol L<sup>−1</sup> glucose and 0.15 mol L<sup>−1</sup> NaCl. (A) Power-voltage profile; i) first day, ii) second day, iii) sixth day, iv) twenty fourth day, v) twenty ninth day vi) fortieth day. (B) Maximum power (▪) and OCV (+) as a function of time.</p>", "links"=>[], "tags"=>["vitro", "performances", "quinone-ubiquinone"], "article_id"=>522666, "categories"=>["Medicine", "Biotechnology", "Immunology", "Physiology", "Chemistry", "Biophysics", "Biochemistry"], "users"=>["Philippe Cinquin", "Chantal Gondran", "Fabien Giroud", "Simon Mazabrard", "Aymeric Pellissier", "François Boucher", "Jean-Pierre Alcaraz", "Karine Gorgy", "François Lenouvel", "Stéphane Mathé", "Paolo Porcu", "Serge Cosnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010476.g002", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_vitro_performances_of_a_Quinone_Ubiquinone_GBFC_/522666", "title"=>"In vitro performances of a Quinone-Ubiquinone GBFC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-04 00:44:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/852370"], "description"=>"<p>Implants containing both GOX and catalase, immobilized on barium alginate beads, in dialysis tubing wrapped in an exPTFE coating. (A) Before implantation. (B) After 3 months of implantation. A neo-vascular network can be seen, no sign of inflammation is present, proving the good tolerance of the rat for the implant.</p>", "links"=>[], "tags"=>["containing", "glucose", "oxidase", "implantation"], "article_id"=>522813, "categories"=>["Medicine", "Biotechnology", "Immunology", "Physiology", "Chemistry", "Biophysics", "Biochemistry"], "users"=>["Philippe Cinquin", "Chantal Gondran", "Fabien Giroud", "Simon Mazabrard", "Aymeric Pellissier", "François Boucher", "Jean-Pierre Alcaraz", "Karine Gorgy", "François Lenouvel", "Stéphane Mathé", "Paolo Porcu", "Serge Cosnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010476.g004", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Implants_containing_both_Glucose_Oxidase_and_catalase_before_and_after_implantation_in_a_rat_/522813", "title"=>"Implants containing both Glucose Oxidase and catalase, before and after implantation in a rat.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-04 00:46:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/852101"], "description"=>"<p>(A) GBFC principle. The anode is constituted of a compacted graphite disc containing ubiquinone, glucose oxidase (GOX) and catalase, while the cathode is composed of a compacted graphite disc containing quinhydrone and polyphenol oxidase (PPO). The cathode is inserted in a dialysis bag (cut-off 100 g mol<sup>−1</sup>), in order to prevent quinhydrone diffusion. Both electrodes are packed in an external dialysis bag (cut-off 6-8000 g mol<sup>−1</sup>) that lets glucose and dioxygen flow into the device. The current generated by the GBFC results from the oxidation of ubiquinol combined with the reduction of quinone. Ubiquinol and quinone are enzymatically generated by GOX and PPO respectively. (B) GBFC preparation and implantation. Each electrode measures 0.133 mL, so that the complete device can fit in the abdomen of the animal. The rat is anesthetized, a median laparotomy is performed, and the GBFC is inserted into the retroperitoneal space in left lateral position. The catheters containing the copper wires connected to the anode and cathode are subcutaneously tunnelled from the abdomen up to the back of the head of the animal, and connected to the potentiostat. Finally, the muscular abdominal wall and the skin are separately sutured and the animal is allowed to recover from anesthesia. (C) GBFC operation. 4 hours after implantation, cycles of discharge (at constant current of 10 µA) and of charge are recorded via a potentiostat until sacrifice of the animal.</p>", "links"=>[], "tags"=>["implantation", "implantable", "glucose", "biofuel"], "article_id"=>522542, "categories"=>["Medicine", "Biotechnology", "Immunology", "Physiology", "Chemistry", "Biophysics", "Biochemistry"], "users"=>["Philippe Cinquin", "Chantal Gondran", "Fabien Giroud", "Simon Mazabrard", "Aymeric Pellissier", "François Boucher", "Jean-Pierre Alcaraz", "Karine Gorgy", "François Lenouvel", "Stéphane Mathé", "Paolo Porcu", "Serge Cosnier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010476.g001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_the_principle_preparation_implantation_and_operation_of_an_implantable_8220_Quinone_Ubiquinone_Glucose_BioFuel_Cell_8221_/522542", "title"=>"Summary of the principle, preparation, implantation and operation of an implantable “Quinone-Ubiquinone Glucose BioFuel Cell”.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-04 00:42:22"}

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