Eccentric Exercise Activates Novel Transcriptional Regulation of Hypertrophic Signaling Pathways Not Affected by Hormone Changes
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{"title"=>"Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes", "type"=>"journal", "authors"=>[{"first_name"=>"Lauren G.", "last_name"=>"MacNeil", "scopus_author_id"=>"9045296500"}, {"first_name"=>"Simon", "last_name"=>"Melov", "scopus_author_id"=>"7003859445"}, {"first_name"=>"Alan E.", "last_name"=>"Hubbard", "scopus_author_id"=>"35551340400"}, {"first_name"=>"Steven K.", "last_name"=>"Baker", "scopus_author_id"=>"7403307787"}, {"first_name"=>"Mark A.", "last_name"=>"Tarnopolsky", "scopus_author_id"=>"7005265730"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-77956492423", "pmid"=>"20502695", "sgr"=>"77956492423", "doi"=>"10.1371/journal.pone.0010695", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "issn"=>"19326203", "pui"=>"359505559"}, "id"=>"4b4c3619-98c3-31b6-8285-65de9bc24687", "abstract"=>"Unaccustomed eccentric exercise damages skeletal muscle tissue, activating mechanisms of recovery and remodeling that may be influenced by the female sex hormone 17beta-estradiol (E2). Using high density oligonucleotide based microarrays, we screened for differences in mRNA expression caused by E2 and eccentric exercise. After random assignment to 8 days of either placebo (CON) or E2 (EXP), eighteen men performed 150 single-leg eccentric contractions. Muscle biopsies were collected at baseline (BL), following supplementation (PS), +3 hours (3H) and +48 hours (48H) after exercise. Serum E2 concentrations increased significantly with supplementation (P<0.001) but did not affect microarray results. Exercise led to early transcriptional changes in striated muscle activator of Rho signaling (STARS), Rho family GTPase 3 (RND3), mitogen activated protein kinase (MAPK) regulation and the downstream transcription factor FOS. Targeted RT-PCR analysis identified concurrent induction of negative regulators of calcineurin signaling RCAN (P<0.001) and HMOX1 (P = 0.009). Protein contents were elevated for RND3 at 3H (P = 0.02) and FOS at 48H (P<0.05). These findings indicate that early RhoA and NFAT signaling and regulation are altered following exercise for muscle remodeling and repair, but are not affected by E2.", "link"=>"http://www.mendeley.com/research/eccentric-exercise-activates-novel-transcriptional-regulation-hypertrophic-signaling-pathways-not-af", "reader_count"=>67, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>4, "Student > Doctoral Student"=>3, "Researcher"=>7, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>6, "Student > Master"=>9, "Other"=>2, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>2, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>4, "Student > Doctoral Student"=>3, "Researcher"=>7, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>6, "Student > Master"=>9, "Other"=>2, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>2, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>7, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>24, "Neuroscience"=>1, "Sports and Recreations"=>17, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Neuroscience"=>{"Neuroscience"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>17}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>24}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Brazil"=>3, "Chile"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/848645"], "description"=>"<p>Graph A – RCAN1 (N = 18). Graph B – HMOX1 (N = 18). 3H = 3 hours post exercise, 48H = 48 hours post exercise. Values are mean ± SEM. **Significant difference vs. baseline when collapsed across supplementation (P<0.01). ***Significant difference vs. baseline when collapsed across supplementation (P<0.001).</p>", "links"=>[], "tags"=>["changes", "mrna", "genes", "baseline"], "article_id"=>519101, "categories"=>["Physiology"], "users"=>["Lauren G. MacNeil", "Simon Melov", "Alan E. Hubbard", "Steven K. Baker", "Mark A. Tarnopolsky"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010695.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_fold_changes_in_mRNA_expression_of_genes_in_muscle_from_baseline_after_exercise_protocol_/519101", "title"=>"Expression fold changes in mRNA expression of genes in muscle from baseline after exercise protocol.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:19:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/848724"], "description"=>"<p>3H = 3 hours post exercise, 48H = 48 hours post exercise. N = 18. Values are mean ± SEM. *Significant difference vs. baseline when collapsed across supplementation (P<0.05).</p>", "links"=>[], "tags"=>["changes", "mrna", "capza1", "baseline"], "article_id"=>519175, "categories"=>["Physiology"], "users"=>["Lauren G. MacNeil", "Simon Melov", "Alan E. Hubbard", "Steven K. Baker", "Mark A. Tarnopolsky"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010695.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_fold_changes_in_mRNA_expression_of_CAPZA1_in_muscle_from_baseline_after_exercise_protocol_/519175", "title"=>"Expression fold changes in mRNA expression of CAPZA1 in muscle from baseline after exercise protocol.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:19:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/848855"], "description"=>"<p>BL  =  baseline, 3H  =  3 hours post exercise, 48H = 48 hours post exercise. Graph A – p38MAPK (Thr <sup>180</sup>/Tyr <sup>182</sup>) (N = 18). Graph B – GSK-3β (Ser<sup>9</sup>) (N = 18). Values are mean ± SEM. **Significant difference vs. baseline when collapsed across supplementation (P<0.01).</p>", "links"=>[], "tags"=>["signaling", "pathways", "baseline", "eccentric"], "article_id"=>519306, "categories"=>["Physiology"], "users"=>["Lauren G. MacNeil", "Simon Melov", "Alan E. Hubbard", "Steven K. Baker", "Mark A. Tarnopolsky"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010695.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fold_change_of_phosphorylated_total_ratio_of_signaling_pathways_from_baseline_after_eccentric_exercise_/519306", "title"=>"Fold change of phosphorylated/total ratio of signaling pathways from baseline after eccentric exercise.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:20:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/848947"], "description"=>"<p>BL  =  baseline, 3H = 3 hours post exercise, 48H = 48 hours post exercise. Graph A – RND3 (N = 18). Graph B – FOS (N = 14). Values are mean ± SEM. *Significant difference vs. baseline when collapsed across supplementation (P<0.05).</p>", "links"=>[], "tags"=>["blot", "rnd3", "fos", "skeletal", "eccentric"], "article_id"=>519402, "categories"=>["Physiology"], "users"=>["Lauren G. MacNeil", "Simon Melov", "Alan E. Hubbard", "Steven K. Baker", "Mark A. Tarnopolsky"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010695.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_blot_analysis_of_RND3_and_FOS_in_skeletal_muscle_after_eccentric_exercise_/519402", "title"=>"Western blot analysis of RND3 and FOS in skeletal muscle after eccentric exercise.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:20:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/849038"], "description"=>"<p>Eccentric exercise promoted greater expression of targets within the STARS/RhoA/AP1 and NFAT/AP1 signaling pathways for hypertrophy and actin biogenesis and organization.</p>", "links"=>[], "tags"=>["transcriptionally", "pathways", "induced"], "article_id"=>519499, "categories"=>["Physiology"], "users"=>["Lauren G. MacNeil", "Simon Melov", "Alan E. Hubbard", "Steven K. Baker", "Mark A. Tarnopolsky"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010695.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_representation_of_the_transcriptionally_active_pathways_following_exercise_induced_muscle_damage_/519499", "title"=>"Schematic representation of the transcriptionally active pathways following exercise induced muscle damage.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:21:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/849133"], "description"=>"<p>RCAN – regulator of calcineurin; HMOX1 – hemeoxygenase 1; ARHGEF7 and ARHGEF12 – Rho guanine nucleotide exchange factor 7 and 12; ARHGAP24 – Rho GTPase activating protein 24; RND3 – Rho family GTPase 3; DIAPH1 – diaphanous homologue 1; CORO1C – Coronin, actin binding protein 1; FLNB – Filamin B, beta; CAPZA1 – capping protein (actin filament) muscle Z-line alpha 1; ACTA2 – actin, alpha 2, smooth muscle, aorta; ACTN1 – actinin, alpha 1; AP1 – activator protein 1; FOS – FBJ murine osteosarcoma viral oncogene homologue; FOSB – FBJ murine osteosarcoma viral oncogene homologue B; JUND – Jun D proto-oncogene.</p>", "links"=>[], "tags"=>["downstream", "targets", "stars", "transcriptionally", "bout", "eccentric"], "article_id"=>519584, "categories"=>["Physiology"], "users"=>["Lauren G. MacNeil", "Simon Melov", "Alan E. Hubbard", "Steven K. Baker", "Mark A. Tarnopolsky"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010695.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regulatory_and_downstream_targets_of_STARS_transcriptionally_active_following_a_single_bout_of_eccentric_exercise_/519584", "title"=>"Regulatory and downstream targets of STARS transcriptionally active following a single bout of eccentric exercise.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:21:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/849205"], "description"=>"<p>p38MAPK – p38 mitogen activated protein kinase; GSK-3β – glycogen synthase kinase 3 beta; MAF – v-maf musculoaponeurotic fibrosarcoma oncogene homologue (avian).</p>", "links"=>[], "tags"=>["downstream", "targets", "nfat", "transcriptionally", "bout", "eccentric"], "article_id"=>519661, "categories"=>["Physiology"], "users"=>["Lauren G. MacNeil", "Simon Melov", "Alan E. Hubbard", "Steven K. Baker", "Mark A. Tarnopolsky"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010695.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regulatory_and_downstream_targets_of_NFAT_transcriptionally_active_following_a_single_bout_of_eccentric_exercise_/519661", "title"=>"Regulatory and downstream targets of NFAT transcriptionally active following a single bout of eccentric exercise.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:22:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/849266"], "description"=>"<p>Fold change of gene expression after 3 hours of recovery from eccentric exercise using DNA microarray analysis (n = 18).</p>", "links"=>[], "tags"=>["eccentric", "dna", "microarray"], "article_id"=>519722, "categories"=>["Physiology"], "users"=>["Lauren G. MacNeil", "Simon Melov", "Alan E. Hubbard", "Steven K. Baker", "Mark A. Tarnopolsky"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010695.t005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fold_change_of_gene_expression_after_3_hours_of_recovery_from_eccentric_exercise_using_DNA_microarray_analysis_n_8202_8202_18_/519722", "title"=>"Fold change of gene expression after 3 hours of recovery from eccentric exercise using DNA microarray analysis (n = 18).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:22:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/849304"], "description"=>"<p>Values are mean ± SEM.</p><p>*P<0.05 main effect for group compared to baseline.</p><p>CON (N = 7), EXP (N = 8).</p>", "links"=>[], "tags"=>["lactate", "dehydrogenase", "150", "eccentric", "contractions", "con", "exp"], "article_id"=>519753, "categories"=>["Physiology"], "users"=>["Lauren G. MacNeil", "Simon Melov", "Alan E. Hubbard", "Steven K. Baker", "Mark A. Tarnopolsky"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010695.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_lactate_dehydrogenase_activity_following_150_eccentric_contractions_in_CON_and_EXP_groups_/519753", "title"=>"Serum lactate dehydrogenase activity following 150 eccentric contractions in CON and EXP groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:22:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/849345"], "description"=>"<p>Values are mean ± SEM.</p>**<p>P<0.01.</p>***<p>P<0.001.</p><p>N = 9/group.</p>", "links"=>[], "tags"=>["concentrations", "8d", "supplementation", "placebo", "e2"], "article_id"=>519804, "categories"=>["Physiology"], "users"=>["Lauren G. MacNeil", "Simon Melov", "Alan E. Hubbard", "Steven K. Baker", "Mark A. Tarnopolsky"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010695.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_hormone_concentrations_after_8d_of_supplementation_with_either_placebo_CON_or_E2_EXP_/519804", "title"=>"Serum hormone concentrations after 8d of supplementation with either placebo (CON) or E2 (EXP).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:22:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/849374"], "description"=>"<p>Values are means ± SEM.</p>", "links"=>[], "tags"=>["eccentric"], "article_id"=>519836, "categories"=>["Physiology"], "users"=>["Lauren G. MacNeil", "Simon Melov", "Alan E. Hubbard", "Steven K. Baker", "Mark A. Tarnopolsky"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010695.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subject_and_eccentric_exercise_trial_characteristics_/519836", "title"=>"Subject and eccentric exercise trial characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:23:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/849411"], "description"=>"<p>Primer and probe sequences for calcineurin regulation, actin dynamics and housekeeping genes.</p>", "links"=>[], "tags"=>["probe", "sequences", "calcineurin", "actin", "housekeeping"], "article_id"=>519867, "categories"=>["Physiology"], "users"=>["Lauren G. MacNeil", "Simon Melov", "Alan E. Hubbard", "Steven K. Baker", "Mark A. Tarnopolsky"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010695.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Primer_and_probe_sequences_for_calcineurin_regulation_actin_dynamics_and_housekeeping_genes_/519867", "title"=>"Primer and probe sequences for calcineurin regulation, actin dynamics and housekeeping genes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:23:19"}

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  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
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  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
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  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
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  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"25", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
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Relative Metric

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