microRNA Expression Patterns Reveal Differential Expression of Target Genes with Age
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"microRNA expression patterns reveal differential expression of target genes with age", "type"=>"journal", "authors"=>[{"first_name"=>"Nicole", "last_name"=>"Noren Hooten", "scopus_author_id"=>"6602316612"}, {"first_name"=>"Kotb", "last_name"=>"Abdelmohsen", "scopus_author_id"=>"13006314400"}, {"first_name"=>"Myriam", "last_name"=>"Gorospe", "scopus_author_id"=>"26643133700"}, {"first_name"=>"Ngozi", "last_name"=>"Ejiogu", "scopus_author_id"=>"15755395900"}, {"first_name"=>"Alan B.", "last_name"=>"Zonderman", "scopus_author_id"=>"56921646000"}, {"first_name"=>"Michele K.", "last_name"=>"Evans", "scopus_author_id"=>"7404538531"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"20505758", "doi"=>"10.1371/journal.pone.0010724", "sgr"=>"77956513434", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "scopus"=>"2-s2.0-77956513434", "issn"=>"19326203", "pui"=>"359515576"}, "id"=>"b8aea4a9-b190-3c90-8bae-dafd1980df70", "abstract"=>"Recent evidence supports a role for microRNAs (miRNAs) in regulating the life span of model organisms. However, little is known about how these small RNAs contribute to human aging. Here, we profiled the expression of over 800 miRNAs in peripheral blood mononuclear cells from young and old individuals by real-time RT-PCR analysis. This genome-wide assessment of miRNA expression revealed that the majority of miRNAs studied decreased in abundance with age. We identified nine miRNAs (miR-103, miR-107, miR-128, miR-130a, miR-155, miR-24, miR-221, miR-496, miR-1538) that were significantly lower in older individuals. Among them, five have been implicated in cancer pathogenesis. Predicted targets of several of these miRNAs, including PI3 kinase (PI3K), c-Kit and H2AX, were found to be elevated with advancing age, supporting a possible role for them in the aging process. Furthermore, we found that decreasing the levels of miR-221 was sufficient to cause a corresponding increase in the expression of the predicted target, PI3K. Taken together, these findings demonstrate that changes in miRNA expression occur with human aging and suggest that miRNAs and their predicted targets have the potential to be diagnostic indicators of age or age-related diseases.", "link"=>"http://www.mendeley.com/research/microrna-expression-patterns-reveal-differential-expression-target-genes-age", "reader_count"=>170, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>13, "Researcher"=>49, "Student > Doctoral Student"=>10, "Student > Ph. D. Student"=>51, "Student > Postgraduate"=>2, "Student > Master"=>16, "Other"=>4, "Student > Bachelor"=>12, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>7}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>13, "Researcher"=>49, "Student > Doctoral Student"=>10, "Student > Ph. D. Student"=>51, "Student > Postgraduate"=>2, "Student > Master"=>16, "Other"=>4, "Student > Bachelor"=>12, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>7}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>24, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>103, "Medicine and Dentistry"=>30, "Neuroscience"=>4, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>30}, "Neuroscience"=>{"Neuroscience"=>4}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>103}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>24}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Czech Republic"=>1, "Romania"=>1, "United States"=>3, "Japan"=>1, "China"=>1, "United Kingdom"=>3, "Italy"=>1, "Germany"=>3, "India"=>2, "Russia"=>1}, "group_count"=>8}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/77956513434"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/77956513434?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77956513434&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=77956513434&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/77956513434", "dc:identifier"=>"SCOPUS_ID:77956513434", "eid"=>"2-s2.0-77956513434", "dc:title"=>"microRNA expression patterns reveal differential expression of target genes with age", "dc:creator"=>"Noren Hooten N.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"5", "prism:issueIdentifier"=>"5", "prism:pageRange"=>nil, "prism:coverDate"=>"2010-09-17", "prism:coverDisplayDate"=>"2010", "prism:doi"=>"10.1371/journal.pone.0010724", "citedby-count"=>"249", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"National Institute on Aging (NIA)", "affiliation-city"=>"Bethesda", "affiliation-country"=>"United States"}], "pubmed-id"=>"20505758", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e10724", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0010724", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments | Further Information

Counter

  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"167", "xml_views"=>"6", "html_views"=>"441"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"162", "xml_views"=>"1", "html_views"=>"338"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"84", "xml_views"=>"1", "html_views"=>"198"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"145"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"74", "xml_views"=>"1", "html_views"=>"223"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"71", "xml_views"=>"1", "html_views"=>"193"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"63", "xml_views"=>"0", "html_views"=>"146"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"51", "xml_views"=>"1", "html_views"=>"117"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"48", "xml_views"=>"2", "html_views"=>"112"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"51", "xml_views"=>"0", "html_views"=>"128"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"42", "xml_views"=>"1", "html_views"=>"130"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"51", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"33", "xml_views"=>"1", "html_views"=>"81"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"36", "xml_views"=>"1", "html_views"=>"108"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"103"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"38", "xml_views"=>"1", "html_views"=>"129"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"124"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"44", "xml_views"=>"1", "html_views"=>"109"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"45", "xml_views"=>"0", "html_views"=>"121"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"38", "xml_views"=>"2", "html_views"=>"138"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"45", "xml_views"=>"1", "html_views"=>"140"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"107"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"44", "xml_views"=>"1", "html_views"=>"108"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"45", "xml_views"=>"2", "html_views"=>"123"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"38", "xml_views"=>"1", "html_views"=>"144"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"39", "xml_views"=>"6", "html_views"=>"115"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"118"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"48", "xml_views"=>"0", "html_views"=>"151"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"140"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"99"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"123"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"99"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"132"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"120"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"118"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"207"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"97"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"185"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"113"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"108"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"200"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"108"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"95"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"344", "xml_views"=>"2", "html_views"=>"108"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"470", "xml_views"=>"1", "html_views"=>"102"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"131"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"61"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"104"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"144"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"64"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"72"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"86"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"94"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"48"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"281"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"66"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"116"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"3", "html_views"=>"62"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"57"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"72"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"65"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"72"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"46"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"5", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"27", "xml_views"=>"3", "html_views"=>"31"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"11", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"2", "html_views"=>"7"}
  • {"month"=>"12", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"1", "year"=>"2021", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"2", "year"=>"2021", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"3", "year"=>"2021", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"1"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/848938"], "description"=>"<p>Demographics for individuals in this sub-cohort of the HANDLS study. Age is reported as the mean ± SD. Abbreviations are as follows: W, White; AA, African American; F, Female; M, Male.</p>", "links"=>[], "tags"=>["molecular biology", "cell biology/gene expression", "developmental biology/aging"], "article_id"=>519390, "categories"=>["Cell Biology", "Molecular Biology", "Medicine"], "users"=>["Nicole Noren Hooten", "Kotb Abdelmohsen", "Myriam Gorospe", "Ngozi Ejiogu", "Alan B. Zonderman", "Michele K. Evans"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010724.t001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_demographic_information_/519390", "title"=>"Patient demographic information.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-05-20 02:36:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/422153", "https://ndownloader.figshare.com/files/422178", "https://ndownloader.figshare.com/files/422196", "https://ndownloader.figshare.com/files/422214", "https://ndownloader.figshare.com/files/422268", "https://ndownloader.figshare.com/files/422333"], "description"=>"<div><p>Recent evidence supports a role for microRNAs (miRNAs) in regulating the life span of model organisms. However, little is known about how these small RNAs contribute to human aging. Here, we profiled the expression of over 800 miRNAs in peripheral blood mononuclear cells from young and old individuals by real-time RT-PCR analysis. This genome-wide assessment of miRNA expression revealed that the majority of miRNAs studied decreased in abundance with age. We identified nine miRNAs (miR-103, miR-107, miR-128, miR-130a, miR-155, miR-24, miR-221, miR-496, miR-1538) that were significantly lower in older individuals. Among them, five have been implicated in cancer pathogenesis. Predicted targets of several of these miRNAs, including PI3 kinase (PI3K), c-Kit and H2AX, were found to be elevated with advancing age, supporting a possible role for them in the aging process. Furthermore, we found that decreasing the levels of miR-221 was sufficient to cause a corresponding increase in the expression of the predicted target, PI3K. Taken together, these findings demonstrate that changes in miRNA expression occur with human aging and suggest that miRNAs and their predicted targets have the potential to be diagnostic indicators of age or age-related diseases.</p></div>", "links"=>[], "tags"=>["microrna", "patterns", "differential", "genes"], "article_id"=>143387, "categories"=>["Cell Biology", "Molecular Biology", "Medicine"], "users"=>["Nicole Noren Hooten", "Kotb Abdelmohsen", "Myriam Gorospe", "Ngozi Ejiogu", "Alan B. Zonderman", "Michele K. Evans"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0010724.s001", "https://dx.doi.org/10.1371/journal.pone.0010724.s002", "https://dx.doi.org/10.1371/journal.pone.0010724.s003", "https://dx.doi.org/10.1371/journal.pone.0010724.s004", "https://dx.doi.org/10.1371/journal.pone.0010724.s005", "https://dx.doi.org/10.1371/journal.pone.0010724.s006"], "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/microRNA_Expression_Patterns_Reveal_Differential_Expression_of_Target_Genes_with_Age/143387", "title"=>"microRNA Expression Patterns Reveal Differential Expression of Target Genes with Age", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-05-20 00:56:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/848292"], "description"=>"<p>For each panel, one young 30- year-old participant and one old 64-year-old participant were screened for miRNA expression using a real-time RT-PCR based miRNome miRNA profiler kit as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010724#s4\" target=\"_blank\">Materials and Methods</a>. Different pairs of individuals were used for both miRNome 1 and miRNome 2. The heat map was generated using dChip software and indicates the fold log<sub>10</sub> relative change in expression in young versus old participants<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010724#pone.0010724-Li2\" target=\"_blank\">[49]</a>. The top upregulated and downregulated miRNAs are shown. Blue indicates downregulation of miRNA expression in the old individuals and red indicates upregulation of miRNA expression in the old individuals. Each patient was sex and race matched as indicated in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010724#pone-0010724-t001\" target=\"_blank\">Table 1</a>. A detailed spreadsheet of the data is available as supplementary information (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010724#pone.0010724.s001\" target=\"_blank\">Table S1</a>). * next to the microRNA refers to the minor form of the miRNA.</p>", "links"=>[], "tags"=>["mirna"], "article_id"=>518746, "categories"=>["Cell Biology", "Molecular Biology", "Medicine"], "users"=>["Nicole Noren Hooten", "Kotb Abdelmohsen", "Myriam Gorospe", "Ngozi Ejiogu", "Alan B. Zonderman", "Michele K. Evans"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010724.g001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Downregulation_of_miRNA_expression_in_old_individuals_/518746", "title"=>"Downregulation of miRNA expression in old individuals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-20 02:25:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/848978"], "description"=>"<p>The predicted targets (from Targetscan) were compiled for each respective miRNA and were examined using Ingenuity software. The top two pathways for each parameter are listed.</p>", "links"=>[], "tags"=>["micrornas", "downregulated"], "article_id"=>519427, "categories"=>["Cell Biology", "Molecular Biology", "Medicine"], "users"=>["Nicole Noren Hooten", "Kotb Abdelmohsen", "Myriam Gorospe", "Ngozi Ejiogu", "Alan B. Zonderman", "Michele K. Evans"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010724.t002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ingenuity_analysis_of_microRNAs_significantly_downregulated_with_age_/519427", "title"=>"Ingenuity analysis of microRNAs significantly downregulated with age.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-05-20 02:37:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/848779"], "description"=>"<p>(A) A Venn diagram showing the overlap between predicted targets of cancer-related miRNAs that were found to be downregulated in older participants. All cancer-related miRNAs have in common the predicted targets PIK3R1 and NOVA1. (B) Relative mRNA expression of PI3K, c-Kit and H2AX from 14 young and 14 old participants using real-time RT-PCR. The histograms show the normalized means ± SEM. (C) Representative immunoblots showing protein expression of PI3K, c-Kit and H2AX in a young and old patient. Participant PBMCs were lysed and immunoblotted with anti-PI3K, anti-c-Kit and anti-H2AX antibodies and reprobed with anti-actin and anti-histone H3 antibodies as protein loading controls. The same individuals were used for each representative immunoblot in C. (D) The protein levels of PI3K, c-Kit and H2AX from PBMCs were quantified from immunoblots and normalized to the amount of actin or histone H3. The histogram represents the normalized relative mean ± SEM from 14 young and 14 old individuals for PI3K and 10 young and 10 old individuals for c-Kit and H2AX. **P<0.01, *P<0.05 by Student's t-test.</p>", "links"=>[], "tags"=>["validation", "mirnas", "downregulated"], "article_id"=>519229, "categories"=>["Cell Biology", "Molecular Biology", "Medicine"], "users"=>["Nicole Noren Hooten", "Kotb Abdelmohsen", "Myriam Gorospe", "Ngozi Ejiogu", "Alan B. Zonderman", "Michele K. Evans"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010724.g004", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Putative_target_validation_of_miRNAs_downregulated_by_age_/519229", "title"=>"Putative target validation of miRNAs downregulated by age.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-20 02:33:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/848603"], "description"=>"<p>(A) Expression of miRNAs from the miRNome analysis were further validated in 14 young and 14 old subject PBMCs (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010724#pone-0010724-t001\" target=\"_blank\">Table 1B</a> for detailed demographic data) using real-time RT-PCR as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010724#s4\" target=\"_blank\">Materials and Methods</a>. The histograms show normalized averages ± SEM from duplicate experiments. <b>*</b>P<0.05 by both Student's t-test and three-way ANOVA. (B) miR-24 and miR-221 expression was examined in 14 young and 14 old individuals using a TaqMan microarray assay as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010724#s4\" target=\"_blank\">Materials and Methods</a>. (C)Age-associated miRNAs that have been implicated in various cancers. See recent reviews for details <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010724#pone.0010724-Garzon1\" target=\"_blank\">[4]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010724#pone.0010724-Lee1\" target=\"_blank\">[35]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010724#pone.0010724-Mocellin1\" target=\"_blank\">[50]</a>.</p>", "links"=>[], "tags"=>["rt-pcr", "validation", "changes", "mirna"], "article_id"=>519054, "categories"=>["Cell Biology", "Molecular Biology", "Medicine"], "users"=>["Nicole Noren Hooten", "Kotb Abdelmohsen", "Myriam Gorospe", "Ngozi Ejiogu", "Alan B. Zonderman", "Michele K. Evans"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010724.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Real_time_RT_PCR_validation_of_changes_in_miRNA_expression_in_young_and_old_participants_/519054", "title"=>"Real-time RT-PCR validation of changes in miRNA expression in young and old participants.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-20 02:30:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/848873"], "description"=>"<p>(A) Hela cells were transfected with control (Ctrl) siRNA or (AS)miR-221 and 48 h later mRNA levels of miR-221 and p85 were analyzed by RT-qPCR using U6 and UBC for normalization, respectively. The histogram represents the mean ± SEM from three independent experiments. *P<0.05 by Student's t-test. (B) Forty eight hrs after transfection with the indicated small RNAs, protein lysates were used for Western blot analysis of p85α expression. β-actin signals served as protein loading controls. (C) Schematics of the <i>p85α</i> 3′UTR and the dual-luciferase plasmids used in (E). <i>pLuc</i> control plasmid expresses both the <i>Renilla</i> luciferase (RL) and firefly luciferase (FL). Constructs of the <i>p85α</i> 3′ UTR span either two (<i>pLuc-p85 (2644)</i>) or one (<i>pLuc-p85 (4491)</i>) of the predicted miR-221 sites (black bars). (D) The <i>p85α</i> mRNA was predicted to be targeted by miR-221 using prediction algorithims from Target Scan and microRNA.org. The position of each predicted site within <i>p85α</i> is indicated. (E) Hela cells were transfected with the dual-luciferase plasmids shown and either control siRNA, (Pre)miR-221 or (AS)miR-221. The ratio of the RL/FL activity is shown. *P<0.05 using one-way ANOVA and Tukey's post-hoc test for the indicated comparisons.</p>", "links"=>[], "tags"=>["regulates", "p85"], "article_id"=>519324, "categories"=>["Cell Biology", "Molecular Biology", "Medicine"], "users"=>["Nicole Noren Hooten", "Kotb Abdelmohsen", "Myriam Gorospe", "Ngozi Ejiogu", "Alan B. Zonderman", "Michele K. Evans"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010724.g005", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_miR_221_regulates_p85_expression_/519324", "title"=>"miR-221 regulates p85 expression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-20 02:35:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/848419"], "description"=>"<p>A Venn diagram showing miRNAs that expression was either upregulated >2-fold (A) or downregulated >2-fold (B) in the old participants compared to young participants from the two different miRNome analyses in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010724#pone-0010724-g001\" target=\"_blank\">Figure 1</a>. Listed are the miRNAs that overlapped between these 2 different data sets. The complete miRNome analysis for the listed miRNAs is available (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010724#pone.0010724.s002\" target=\"_blank\">Table S2</a>).</p>", "links"=>[], "tags"=>["downregulated", "mirnas"], "article_id"=>518873, "categories"=>["Cell Biology", "Molecular Biology", "Medicine"], "users"=>["Nicole Noren Hooten", "Kotb Abdelmohsen", "Myriam Gorospe", "Ngozi Ejiogu", "Alan B. Zonderman", "Michele K. Evans"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010724.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Upregulated_and_downregulated_miRNAs_in_young_and_old_individuals_/518873", "title"=>"Upregulated and downregulated miRNAs in young and old individuals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-05-20 02:27:53"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"24", "unique-ip"=>"23", "pdf"=>"19", "year"=>"2010", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"295", "year"=>"2010", "pdf"=>"231", "unique-ip"=>"249", "figure"=>"50", "scanned-summary"=>"0", "supp-data"=>"18"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"146", "unique-ip"=>"112", "pdf"=>"95", "year"=>"2010", "figure"=>"38", "scanned-summary"=>"0", "supp-data"=>"18"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"83", "year"=>"2010", "pdf"=>"60", "unique-ip"=>"79", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"72", "unique-ip"=>"67", "pdf"=>"54", "year"=>"2010", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"80", "year"=>"2010", "pdf"=>"56", "unique-ip"=>"69", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"7"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"61", "unique-ip"=>"61", "pdf"=>"47", "year"=>"2010", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"9"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"63", "year"=>"2010", "pdf"=>"49", "unique-ip"=>"65", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"61", "unique-ip"=>"72", "pdf"=>"48", "year"=>"2011", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"56", "year"=>"2011", "pdf"=>"56", "unique-ip"=>"62", "figure"=>"22", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"68", "unique-ip"=>"55", "pdf"=>"30", "year"=>"2011", "figure"=>"20", "scanned-summary"=>"0", "supp-data"=>"8"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"48", "year"=>"2011", "pdf"=>"32", "unique-ip"=>"55", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"1", "abstract"=>"4", "full-text"=>"28", "unique-ip"=>"39", "pdf"=>"26", "year"=>"2011", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"2", "abstract"=>"2", "full-text"=>"56", "year"=>"2011", "pdf"=>"36", "unique-ip"=>"54", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"28", "unique-ip"=>"28", "pdf"=>"21", "year"=>"2011", "figure"=>"15", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"21", "year"=>"2011", "pdf"=>"8", "unique-ip"=>"26", "figure"=>"15", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"22", "unique-ip"=>"22", "pdf"=>"15", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"53", "year"=>"2011", "pdf"=>"29", "unique-ip"=>"46", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "unique-ip"=>"22", "pdf"=>"14", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"28", "year"=>"2011", "pdf"=>"22", "unique-ip"=>"28", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"47", "unique-ip"=>"41", "pdf"=>"29", "year"=>"2012", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"5"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"2", "full-text"=>"35", "year"=>"2012", "pdf"=>"18", "unique-ip"=>"36", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"35", "unique-ip"=>"43", "pdf"=>"21", "year"=>"2012", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"23", "year"=>"2012", "pdf"=>"17", "unique-ip"=>"22", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"29", "unique-ip"=>"28", "pdf"=>"19", "year"=>"2012", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"24", "year"=>"2012", "pdf"=>"23", "unique-ip"=>"30", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"38", "full-text"=>"40", "pdf"=>"26", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"19", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"29", "full-text"=>"25", "pdf"=>"13", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"24", "full-text"=>"20", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"25", "full-text"=>"24", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"26", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"23", "full-text"=>"20", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"8", "pdf"=>"8", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"24", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"23", "full-text"=>"20", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"42", "full-text"=>"29", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"8", "cited-by"=>"4", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"33", "full-text"=>"21", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"27", "full-text"=>"25", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"16", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"16", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"21", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"25", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"32", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"31", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"24", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}

Relative Metric

{"start_date"=>"2010-01-01T00:00:00Z", "end_date"=>"2010-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[288, 576, 733, 867, 984, 1087, 1182, 1267, 1346, 1424, 1501, 1577, 1646, 1711, 1778, 1841, 1908, 1970, 2034, 2102, 2162, 2227, 2296, 2359, 2422, 2482, 2550, 2610, 2679, 2747, 2820, 2887, 2955, 3009, 3067, 3130, 3200, 3257, 3322, 3379, 3443, 3507, 3571, 3632, 3683, 3753, 3822, 3877]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[283, 565, 720, 852, 970, 1070, 1168, 1258, 1336, 1411, 1487, 1571, 1640, 1709, 1776, 1843, 1906, 1969, 2031, 2086, 2152, 2221, 2286, 2361, 2419, 2480, 2543, 2598, 2665, 2731, 2802, 2868, 2932, 2996, 3053, 3114, 3169, 3232, 3289, 3355, 3413, 3473, 3530, 3595, 3648, 3711, 3764, 3810, 3863]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[280, 562, 725, 863, 974, 1083, 1177, 1268, 1347, 1421, 1489, 1570, 1638, 1706, 1763, 1823, 1890, 1951, 2016, 2076, 2134, 2192, 2257, 2319, 2378, 2438, 2501, 2572, 2634, 2700, 2759, 2825, 2887, 2936, 3007, 3070, 3121, 3184, 3237, 3304, 3363, 3425, 3484, 3531, 3612, 3663, 3718, 3771]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[265, 560, 722, 863, 978, 1083, 1172, 1261, 1345, 1428, 1488, 1559, 1630, 1701, 1764, 1840, 1899, 1965, 2028, 2088, 2150, 2211, 2270, 2348, 2410, 2461, 2531, 2598, 2645, 2719, 2793, 2870, 2923, 2974, 3020, 3080, 3142, 3198, 3259, 3351, 3418, 3471, 3527, 3581, 3637, 3706, 3761, 3817, 3872]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[306, 610, 768, 915, 1043, 1164, 1255, 1349, 1432, 1511, 1592, 1674, 1744, 1817, 1889, 1950, 2028, 2087, 2153, 2217, 2274, 2349, 2418, 2488, 2558, 2616, 2686, 2745, 2809, 2869, 2938, 3008, 3071, 3131, 3189, 3258, 3320, 3389, 3446, 3503, 3552, 3613, 3677, 3744, 3788, 3842, 3907, 3966, 4015]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[275, 545, 699, 818, 931, 1035, 1128, 1212, 1291, 1366, 1439, 1514, 1580, 1649, 1708, 1765, 1826, 1877, 1940, 2009, 2076, 2150, 2215, 2266, 2335, 2395, 2459, 2521, 2596, 2669, 2724, 2787, 2840, 2890, 2961, 3025, 3081, 3142, 3195, 3261, 3314, 3377, 3442, 3491, 3538, 3583, 3649, 3699, 3747]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[277, 558, 715, 845, 963, 1070, 1166, 1258, 1336, 1410, 1485, 1561, 1638, 1707, 1767, 1834, 1896, 1960, 2030, 2096, 2165, 2229, 2300, 2368, 2425, 2489, 2553, 2617, 2679, 2743, 2814, 2873, 2941, 2995, 3050, 3111, 3169, 3235, 3300, 3363, 3428, 3487, 3548, 3605, 3670, 3726, 3785, 3844]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[270, 536, 692, 812, 932, 1037, 1128, 1210, 1293, 1367, 1439, 1514, 1580, 1646, 1711, 1766, 1834, 1902, 1969, 2036, 2106, 2165, 2221, 2285, 2337, 2403, 2459, 2517, 2586, 2644, 2716, 2782, 2842, 2895, 2958, 3017]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[279, 551, 699, 817, 930, 1027, 1124, 1209, 1287, 1362, 1438, 1512, 1582, 1650, 1717, 1772, 1831, 1888, 1948, 2002, 2070, 2138, 2203, 2267, 2331, 2395, 2467, 2523, 2592, 2656, 2718, 2785, 2839, 2892, 2960, 3034, 3087, 3144, 3194, 3254, 3313, 3373, 3446, 3496, 3551, 3607, 3660, 3712, 3773]}]}
Loading … Spinner
There are currently no alerts