Dissecting the Clinical Heterogeneity of Autism Spectrum Disorders through Defined Genotypes
- Publication Date
- May 28, 2010
- Journal
- PLOS ONE
- Authors
- Hilgo Bruining, Leo De Sonneville, Hanna Swaab, Maretha De Jonge, et al
- Volume
- 5
- Issue
- 5
- Pages
- e10887
- DOI
- https://dx.plos.org/10.1371/journal.pone.0010887
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0010887
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/20526357
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878316
- Europe PMC
- http://europepmc.org/abstract/MED/20526357
- Web of Science
- 000278222100016
- Scopus
- 77956503087
- Mendeley
- http://www.mendeley.com/research/dissecting-clinical-heterogeneity-autism-spectrum-disorders-through-defined-genotypes
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Mendeley | Further Information
{"title"=>"Dissecting the clinical heterogeneity of autism spectrum disorders through defined genotypes", "type"=>"journal", "authors"=>[{"first_name"=>"Hilgo", "last_name"=>"Bruining", "scopus_author_id"=>"35432317200"}, {"first_name"=>"Leo", "last_name"=>"de Sonneville", "scopus_author_id"=>"6701913540"}, {"first_name"=>"Hanna", "last_name"=>"Swaab", "scopus_author_id"=>"8296112400"}, {"first_name"=>"Maretha", "last_name"=>"de Jonge", "scopus_author_id"=>"7005631916"}, {"first_name"=>"Martien", "last_name"=>"Kas", "scopus_author_id"=>"6602425807"}, {"first_name"=>"Herman", "last_name"=>"van Engeland", "scopus_author_id"=>"7004512289"}, {"first_name"=>"Jacob", "last_name"=>"Vorstman", "scopus_author_id"=>"12344759400"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-77956503087", "sgr"=>"77956503087", "pui"=>"359515686", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"20526357", "doi"=>"10.1371/journal.pone.0010887"}, "id"=>"f06eb416-19ea-39db-975b-071903cbaae0", "abstract"=>"BACKGROUND: The etiology of autism spectrum disorders (ASD) is largely determined by different genetic factors of variable impact. This genetic heterogeneity could be a factor to explain the clinical heterogeneity of autism spectrum disorders. Here, a first attempt is made to assess whether genetically more homogeneous ASD groups are associated with decreased phenotypic heterogeneity with respect to their autistic symptom profile. METHODOLOGY: The autistic phenotypes of ASD subjects with 22q11 deletion syndrome (22q11DS) and ASD subjects with Klinefelter Syndrome (KS) were statistically compared to the symptom profile of a large (genetically) heterogeneous ASD sample. Autism diagnostic interview-revised (ADI-R) variables were entered in different statistical analyses to assess differences in symptom homogeneity and the feasibility of discrimination of group-specific ASD-symptom profiles. PRINCIPAL FINDINGS: The results showed substantially higher symptom homogeneity in both the genetic disorder ASD groups in comparison to the heterogeneous ASD sample. In addition, a robust discrimination between 22q11-ASD and KS-ASD and idiopathic ASD phenotypes was feasible on the basis of a reduced number of autistic scales and symptoms. The lack of overlap in discriminating subscales and symptoms between KS-ASD and 22q11DS-ASD suggests that their autistic symptom profiles cluster around different points in the total diagnostic space of profiles present in the general ASD population. CONCLUSION: The findings of the current study indicate that the clinical heterogeneity of ASDs may be reduced when subgroups based on a specific genotype are extracted from the idiopathic ASD population. The current strategy involving the widely used ADI-R offers a relatively straightforward possibility for assessing genotype-phenotype ASD relationships. Reverse phenotype strategies are becoming more feasible, given the accumulating evidence for the existence of genetic variants of large effect in a substantial proportion of the ASD population.", "link"=>"http://www.mendeley.com/research/dissecting-clinical-heterogeneity-autism-spectrum-disorders-through-defined-genotypes", "reader_count"=>68, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>17, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>1, "Student > Master"=>8, "Other"=>5, "Student > Bachelor"=>6, "Professor"=>7}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>17, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>1, "Student > Master"=>8, "Other"=>5, "Student > Bachelor"=>6, "Professor"=>7}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Agricultural and Biological Sciences"=>16, "Arts and Humanities"=>3, "Computer Science"=>2, "Earth and Planetary Sciences"=>1, "Energy"=>1, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>17, "Neuroscience"=>5, "Psychology"=>14, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>17}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>14}, "Unspecified"=>{"Unspecified"=>5}, "Arts and Humanities"=>{"Arts and Humanities"=>3}, "Engineering"=>{"Engineering"=>1}, "Neuroscience"=>{"Neuroscience"=>5}, "Energy"=>{"Energy"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"United States"=>3, "Brazil"=>1, "Italy"=>1, "United Kingdom"=>1, "Germany"=>1, "Iceland"=>1, "Russia"=>1}, "group_count"=>3}CrossRef
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Scopus | Further Information
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- {"id"=>"534344976533307392", "text"=>"that's what @DrTempleGrandin wrote in #TheAutisticBrain: consider subtypes of autism instead #autism in general: \n\nhttp://t.co/Ke0EBAFNWd", "created_at"=>"2014-11-17T13:59:04Z", "user"=>"yousitonmyspot", "user_name"=>"InViennaVeritas", "user_profile_image"=>"http://pbs.twimg.com/profile_images/522842845346942976/swFo5Xry_normal.jpeg"}
- {"id"=>"534348937722081280", "text"=>"@virginiahughes that's interesting, too: http://t.co/Ke0EBAFNWd subphenotypes of #autism", "created_at"=>"2014-11-17T14:14:49Z", "user"=>"yousitonmyspot", "user_name"=>"InViennaVeritas", "user_profile_image"=>"http://pbs.twimg.com/profile_images/522842845346942976/swFo5Xry_normal.jpeg"}
- {"id"=>"534482792340791296", "text"=>"Unterschiede im Phänotyp zw. #Autisten mit 22q11 deletion (#DiGeorge-syndrom) & mit #Klinefelter: http://t.co/Jh61AOQoxx #Autismus-relevant", "created_at"=>"2014-11-17T23:06:42Z", "user"=>"47XXYinfo", "user_name"=>"factsabout47XXY", "user_profile_image"=>"http://pbs.twimg.com/profile_images/480773556024774658/F7KhosBm_normal.png"}
- {"id"=>"534483327613693952", "text"=>"Phenotype differences betw. #autists with #22q11 deletion syndrome & with XXY/#Klinefelter http://t.co/Jh61AOQoxx #Bruining #autism-relevant", "created_at"=>"2014-11-17T23:08:50Z", "user"=>"47XXYinfo", "user_name"=>"factsabout47XXY", "user_profile_image"=>"http://pbs.twimg.com/profile_images/480773556024774658/F7KhosBm_normal.png"}
- {"id"=>"534483742786846720", "text"=>"RT @47XXYinfo: Unterschiede im Phänotyp zw. #Autisten mit 22q11 deletion (#DiGeorge-syndrom) & mit #Klinefelter: http://t.co/Jh61AOQoxx #Au…", "created_at"=>"2014-11-17T23:10:29Z", "user"=>"yousitonmyspot", "user_name"=>"InViennaVeritas", "user_profile_image"=>"http://pbs.twimg.com/profile_images/522842845346942976/swFo5Xry_normal.jpeg"}
- {"id"=>"534483784440483840", "text"=>"RT @47XXYinfo: Phenotype differences betw. #autists with #22q11 deletion syndrome & with XXY/#Klinefelter http://t.co/Jh61AOQoxx #Bruining …", "created_at"=>"2014-11-17T23:10:39Z", "user"=>"yousitonmyspot", "user_name"=>"InViennaVeritas", "user_profile_image"=>"http://pbs.twimg.com/profile_images/522842845346942976/swFo5Xry_normal.jpeg"}
- {"id"=>"536915231285706753", "text"=>"@SFARIautismnews similar story here: http://t.co/Ke0EBAFNWd (Bruining et al, 2010)", "created_at"=>"2014-11-24T16:12:21Z", "user"=>"yousitonmyspot", "user_name"=>"InViennaVeritas", "user_profile_image"=>"http://pbs.twimg.com/profile_images/522842845346942976/swFo5Xry_normal.jpeg"}
- {"id"=>"543526457977602048", "text"=>"@QuerDenkender siehe z.B. http://t.co/Ke0EBAFNWd", "created_at"=>"2014-12-12T22:03:00Z", "user"=>"yousitonmyspot", "user_name"=>"InViennaVeritas", "user_profile_image"=>"http://pbs.twimg.com/profile_images/522842845346942976/swFo5Xry_normal.jpeg"}
- {"id"=>"625251918101770240", "text"=>"Noch mehr neue Artikel: \n\nhttp://t.co/Ke0EBzP0y1\n\nhttp://t.co/bgzMT7FU7d", "created_at"=>"2015-07-26T10:30:48Z", "user"=>"yousitonmyspot", "user_name"=>"InViennaVeritas", "user_profile_image"=>"http://pbs.twimg.com/profile_images/623473335125590016/dsHHkcem_normal.jpg"}
- {"id"=>"718001334834823168", "text"=>"@Spectrumgo @DeWeerdt_Sarah you might read a paper about 22q11 deletion and 47XXY with respect to autism diversity: https://t.co/Ke0EBzP0y1", "created_at"=>"2016-04-07T09:03:52Z", "user"=>"yousitonmyspot", "user_name"=>"InViennaVeritas", "user_profile_image"=>"http://pbs.twimg.com/profile_images/711866601751101440/0180Gik__normal.jpg"}
- {"id"=>"757515710071537665", "text"=>"@TaniaAMarshall have a look here ...\n\nhttps://t.co/7Olh8Mw7pr \n\nSimiliarities to autism and comparison with Klinefelter.", "created_at"=>"2016-07-25T09:59:53Z", "user"=>"yousitonmyspot", "user_name"=>"InViennaVeritas", "user_profile_image"=>"http://pbs.twimg.com/profile_images/711866601751101440/0180Gik__normal.jpg"}
- {"id"=>"758008974360711169", "text"=>"RT @yousitonmyspot: @TaniaAMarshall have a look here ...\n\nhttps://t.co/7Olh8Mw7pr \n\nSimiliarities to autism and comparison with Klinefelter.", "created_at"=>"2016-07-26T18:39:57Z", "user"=>"TaniaAMarshall", "user_name"=>"Tania Marshall M.Sc.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/695206352486936576/RVlCJXY-_normal.jpg"}
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- {"month"=>"9", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"32"}
- {"month"=>"10", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"34"}
- {"month"=>"11", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"39"}
- {"month"=>"12", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"47"}
- {"month"=>"1", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"38"}
- {"month"=>"2", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"44"}
- {"month"=>"3", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"45"}
- {"month"=>"4", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"53"}
- {"month"=>"5", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"35"}
- {"month"=>"6", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"44"}
- {"month"=>"7", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"50"}
- {"month"=>"8", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"30"}
- {"month"=>"9", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"31"}
- {"month"=>"10", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"49"}
- {"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"104"}
- {"month"=>"12", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"170"}
- {"month"=>"1", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"187"}
- {"month"=>"2", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"229"}
- {"month"=>"3", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"246"}
- {"month"=>"4", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"221"}
- {"month"=>"5", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"103"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"30"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"33"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"24"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"33"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"49"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"38"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"43"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"29"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"23"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"21"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"25"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"15"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"15"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"25"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"9"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"33"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"15"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"10"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"12"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"18"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"11"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"10"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"10"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"9"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"10"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"14"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"7"}
PMC Usage Stats | Further Information
- {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"71", "year"=>"2010", "pdf"=>"41", "unique-ip"=>"65", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"2"}
- {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"56", "unique-ip"=>"61", "pdf"=>"46", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"37", "year"=>"2010", "pdf"=>"27", "unique-ip"=>"36", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
- {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"47", "unique-ip"=>"45", "pdf"=>"28", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"48", "year"=>"2010", "pdf"=>"27", "unique-ip"=>"49", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"27", "unique-ip"=>"31", "pdf"=>"15", "year"=>"2010", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "year"=>"2010", "pdf"=>"15", "unique-ip"=>"16", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"16", "unique-ip"=>"20", "pdf"=>"16", "year"=>"2011", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "year"=>"2011", "pdf"=>"13", "unique-ip"=>"20", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"10", "pdf"=>"5", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "year"=>"2011", "pdf"=>"19", "unique-ip"=>"24", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
- {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "unique-ip"=>"21", "pdf"=>"14", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"22", "year"=>"2011", "pdf"=>"17", "unique-ip"=>"21", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"6"}
- {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"17", "unique-ip"=>"15", "pdf"=>"8", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"5"}
- {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"11", "year"=>"2011", "pdf"=>"7", "unique-ip"=>"9", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"23", "unique-ip"=>"21", "pdf"=>"11", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"10", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"12", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"8", "pdf"=>"5", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"12", "year"=>"2011", "pdf"=>"5", "unique-ip"=>"10", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"5"}
- {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"5", "pdf"=>"2", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "year"=>"2012", "pdf"=>"8", "unique-ip"=>"12", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"24", "unique-ip"=>"20", "pdf"=>"11", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"8", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"11", "unique-ip"=>"10", "pdf"=>"6", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"8", "year"=>"2012", "pdf"=>"6", "unique-ip"=>"9", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"8", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
- {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
- {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
- {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
- {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
- {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
- {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
- {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
- {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
- {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
- {"unique-ip"=>"11", "full-text"=>"6", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
- {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
- {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
- {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
- {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
- {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
- {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
- {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
- {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
- {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"1", "year"=>"2015", "month"=>"5"}
- {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
- {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
- {"unique-ip"=>"7", "full-text"=>"12", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
- {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
- {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
- {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
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