Targeting the Neurokinin Receptor 1 with Aprepitant: A Novel Antipruritic Strategy
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{"title"=>"Targeting the neurokinin receptor 1 with aprepitant: A novel antipruritic strategy", "type"=>"journal", "authors"=>[{"first_name"=>"Sonja", "last_name"=>"Ständer", "scopus_author_id"=>"7003440723"}, {"first_name"=>"Dorothee", "last_name"=>"Siepmann", "scopus_author_id"=>"25631555400"}, {"first_name"=>"Ilka", "last_name"=>"Herrgott", "scopus_author_id"=>"14630324300"}, {"first_name"=>"Cord", "last_name"=>"Sunderkötter", "scopus_author_id"=>"7006331260"}, {"first_name"=>"Thomas A.", "last_name"=>"Luger", "scopus_author_id"=>"7101711078"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-77956193969", "sgr"=>"77956193969", "pui"=>"359289671", "isbn"=>"1932-6203", "pmid"=>"20532044", "doi"=>"10.1371/journal.pone.0010968"}, "id"=>"963f01e6-6110-3ef8-9804-211b4d17d133", "abstract"=>"BACKGROUND Chronic pruritus is a global clinical problem with a high impact on the quality of life and lack of specific therapies. It is an excruciating and frequent symptom of e.g. uncurable renal, liver and skin diseases which often does not respond to conventional treatment with e.g. antihistamines. Therefore antipruritic therapies which target physiological mechanisms of pruritus need to be developed. Substance P (SP) is a major mediator of pruritus. As it binds to the neurokinin receptor 1 (NKR1), we evaluated if the application of a NKR1 antagonist would significantly decrease chronic pruritus. METHODS AND FINDINGS Twenty hitherto untreatable patients with chronic pruritus (12 female, 8 male; mean age, 66.7 years) were treated with the NKR1 antagonist aprepitant 80 mg for one week. 16 of 20 patients (80%) experienced a considerable reduction of itch intensity, as assessed by the visual analog scale (VAS, range 0 to 10). Considering all patients, the mean value of pruritus intensity was significantly reduced from 8.4 VAS points (SD +/-1.7) before treatment to 4.9 VAS points (SD +/-3.2) (p<0.001, CI 1.913-5.187). Patients with dermatological diseases (e.g. atopic diathesis, prurigo nodularis) had the best profit from the treatment. Side-effects were mild (nausea, vertigo, and drowsiness) and only occurred in three patients. CONCLUSIONS The high response rate in patients with therapy refractory pruritus suggests that the NKR1 antagonist aprepitant may indeed exhibit antipruritic effects and may present a novel, effective treatment strategy based on pathophysiology of chronic pruritus. The results are promising enough to warrant confirming the efficacy of NKR1 antagonists in a randomized, controlled clinical trial.", "link"=>"http://www.mendeley.com/research/targeting-neurokinin-receptor-1-aprepitant-novel-antipruritic-strategy", "reader_count"=>57, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>6, "Researcher"=>13, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>3, "Other"=>11, "Student > Master"=>4, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>6, "Researcher"=>13, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>3, "Other"=>11, "Student > Master"=>4, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>33, "Pharmacology, Toxicology and Pharmaceutical Science"=>4, "Psychology"=>3, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>33}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>4}}, "reader_count_by_country"=>{"Austria"=>1, "Switzerland"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/846350"], "description"=>"<p>Antipruritic effects in patients with or without atopic diathesis.</p>", "links"=>[], "tags"=>["patients", "atopic"], "article_id"=>516811, "categories"=>["Medicine", "Developmental Biology"], "users"=>["Sonja Stander", "Dorothee Siepmann", "Ilka Herrgott", "Cord Sunderkötter", "Thomas A. Luger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010968.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antipruritic_effects_in_patients_with_or_without_atopic_diathesis_/516811", "title"=>"Antipruritic effects in patients with or without atopic diathesis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:06:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/846388"], "description"=>"<p>*CP, chronic pruritus; PN, prurigo nodularis.</p>+<p>Atopic diathesis; +, present; −, not present.</p>", "links"=>[], "tags"=>["dermatology", "dermatology/atopic dermatitis and other forms of eczema", "dermatology/psoriasis and other inflammatory diseases", "dermatology/skin and systemic disease"], "article_id"=>516844, "categories"=>["Medicine", "Developmental Biology"], "users"=>["Sonja Stander", "Dorothee Siepmann", "Ilka Herrgott", "Cord Sunderkötter", "Thomas A. Luger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010968.t001", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Collective_of_patients_demographic_clinical_and_response_parameters_/516844", "title"=>"Collective of patients: demographic, clinical and response parameters.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-21 01:06:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/846290"], "description"=>"<p>Response is shown for all patients (All, n = 20) as well as for several diagnostic subgroups: patients without (<i>No Prurigo</i>) or with (<i>Prurigo</i>) clinical presence of chronic scratch lesions as well as patients with (<i>AD</i>) and without (<i>No AD</i>) atopic predisposition. Best antipruritic effects were observed in patients with atopic predisposition and prurigo nodularis. Bar: median response in each group.</p>", "links"=>[], "tags"=>["pruritus", "scored", "analog", "10"], "article_id"=>516742, "categories"=>["Medicine", "Developmental Biology"], "users"=>["Sonja Stander", "Dorothee Siepmann", "Ilka Herrgott", "Cord Sunderkötter", "Thomas A. Luger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0010968.g001", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_values_for_pruritus_intensity_as_scored_on_the_visual_analog_scale_VAS_from_0_to_10_before_pre_and_after_post_aprepitant_/516742", "title"=>"Distribution of values for pruritus intensity as scored on the visual analog scale (VAS) from 0 to 10 before (pre) and after (post) aprepitant.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-21 01:06:15"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"30", "full-text"=>"32", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
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  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
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Relative Metric

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