Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood: A 21-Year Longitudinal Study
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{"title"=>"Brain serotonin synthesis in adult males characterized by physical aggression during childhood: A 21-year longitudinal study", "type"=>"journal", "authors"=>[{"first_name"=>"Linda", "last_name"=>"Booij", "scopus_author_id"=>"9943615100"}, {"first_name"=>"Richard E.", "last_name"=>"Tremblay", "scopus_author_id"=>"7201663558"}, {"first_name"=>"Marco", "last_name"=>"Leyton", "scopus_author_id"=>"7003655724"}, {"first_name"=>"Jean R.", "last_name"=>"Séguin", "scopus_author_id"=>"7103084114"}, {"first_name"=>"Frank", "last_name"=>"Vitaro", "scopus_author_id"=>"56803476500"}, {"first_name"=>"Paul", "last_name"=>"Gravel", "scopus_author_id"=>"12771400500"}, {"first_name"=>"Elisabeth", "last_name"=>"Perreau-Linck", "scopus_author_id"=>"35109666800"}, {"first_name"=>"Mélissa L.", "last_name"=>"Lévesque", "scopus_author_id"=>"7102530712"}, {"first_name"=>"France", "last_name"=>"Durand", "scopus_author_id"=>"26031420000"}, {"first_name"=>"Mirko", "last_name"=>"Diksic", "scopus_author_id"=>"7006711600"}, {"first_name"=>"Gustavo", "last_name"=>"Turecki", "scopus_author_id"=>"7006625367"}, {"first_name"=>"Chawki", "last_name"=>"Benkelfat", "scopus_author_id"=>"35460928800"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-77955286631", "sgr"=>"77955286631", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0011255", "pmid"=>"20582306", "isbn"=>"1932-6203", "pui"=>"359301804"}, "id"=>"4915b753-4591-30a8-ba3f-fe34b5ef4fce", "abstract"=>"BACKGROUND: Adults exhibiting severe impulsive and aggressive behaviors have multiple indices of low serotonin (5-HT) neurotransmission. It remains unclear though whether low 5-HT mediates the behavior or instead reflects a pre-existing vulnerability trait. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, positron emission tomography with the tracer alpha-[(11)C]methyl-L-tryptophan ((11)C-AMT) was used to compare 5-HT synthesis capacity in two groups of adult males from a 21-year longitudinal study (mean age +/- SD: 27.1+/-0.7): individuals with a history of childhood-limited high physical aggression (C-LHPA; N = 8) and individuals with normal (low) patterns of physical aggression (LPA; N = 18). The C-LHPA males had significantly lower trapping of (11)C-AMT bilaterally in the orbitofrontal cortex and self-reported more impulsiveness. Despite this, in adulthood there were no group differences in plasma tryptophan levels, genotyping, aggression, emotional intelligence, working memory, computerized measures of impulsivity, psychosocial functioning/adjustment, and personal and family history of mood and substance abuse disorders. CONCLUSIONS/SIGNIFICANCE: These results force a re-examination of the low 5-HT hypothesis as central in the biology of violence. They suggest that low 5-HT does not mediate current behavior and should be considered a vulnerability factor for impulsive-aggressive behavior that may or may not be expressed depending on other biological factors, experience, and environmental support during development", "link"=>"http://www.mendeley.com/research/brain-serotonin-synthesis-adult-males-characterized-physical-aggression-during-childhood-21year-long", "reader_count"=>75, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>3, "Researcher"=>8, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>11, "Student > Bachelor"=>9, "Lecturer > Senior Lecturer"=>2, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>3, "Researcher"=>8, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>4, "Other"=>4, "Student > Master"=>11, "Student > Bachelor"=>9, "Lecturer > Senior Lecturer"=>2, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>8, "Agricultural and Biological Sciences"=>11, "Chemistry"=>2, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>10, "Neuroscience"=>1, "Sports and Recreations"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>1, "Psychology"=>31, "Social Sciences"=>5, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Social Sciences"=>{"Social Sciences"=>5}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>31}, "Unspecified"=>{"Unspecified"=>8}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Netherlands"=>1, "China"=>1, "Finland"=>1, "Mexico"=>1, "Chile"=>1, "Portugal"=>1, "Switzerland"=>1}, "group_count"=>5}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/420232"], "description"=>"<div><h3>Background</h3><p>Adults exhibiting severe impulsive and aggressive behaviors have multiple indices of low serotonin (5-HT) neurotransmission. It remains unclear though whether low 5-HT mediates the behavior or instead reflects a pre-existing vulnerability trait.</p><h3>Methodology/Principal Findings</h3><p>In the present study, positron emission tomography with the tracer alpha-[<sup>11</sup>C]methyl-L-tryptophan (<sup>11</sup>C-AMT) was used to compare 5-HT synthesis capacity in two groups of adult males from a 21-year longitudinal study (mean age ± SD: 27.1±0.7): individuals with a history of childhood-limited high physical aggression (C-LHPA; <em>N</em> = 8) and individuals with normal (low) patterns of physical aggression (LPA; <em>N</em> = 18). The C-LHPA males had significantly lower trapping of <sup>11</sup>C-AMT bilaterally in the orbitofrontal cortex and self-reported more impulsiveness. Despite this, in adulthood there were no group differences in plasma tryptophan levels, genotyping, aggression, emotional intelligence, working memory, computerized measures of impulsivity, psychosocial functioning/adjustment, and personal and family history of mood and substance abuse disorders.</p><h3>Conclusions/Significance</h3><p>These results force a re-examination of the low 5-HT hypothesis as central in the biology of violence. They suggest that low 5-HT does not mediate current behavior and should be considered a vulnerability factor for impulsive-aggressive behavior that may or may not be expressed depending on other biological factors, experience, and environmental support during development.</p></div>", "links"=>[], "tags"=>["serotonin", "synthesis", "males", "characterized", "21-year", "longitudinal"], "article_id"=>142957, "categories"=>["Neuroscience", "Mental Health"], "users"=>["Linda Booij", "Richard E. Tremblay", "Marco Leyton", "Jean R. Séguin", "Frank Vitaro", "Paul Gravel", "Elisabeth Perreau-Linck", "Mélissa L. Lévesque", "France Durand", "Mirko Diksic", "Gustavo Turecki", "Chawki Benkelfat"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011255", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Brain_Serotonin_Synthesis_in_Adult_Males_Characterized_by_Physical_Aggression_during_Childhood_A_21_Year_Longitudinal_Study/142957", "title"=>"Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood: A 21-Year Longitudinal Study", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-06-22 00:49:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/843975"], "description"=>"<p>Schematic overview of the recruitment process.</p>", "links"=>[], "tags"=>["overview", "recruitment"], "article_id"=>514422, "categories"=>["Neuroscience", "Mental Health"], "users"=>["Linda Booij", "Richard E. Tremblay", "Marco Leyton", "Jean R. Séguin", "Frank Vitaro", "Paul Gravel", "Elisabeth Perreau-Linck", "Mélissa L. Lévesque", "France Durand", "Mirko Diksic", "Gustavo Turecki", "Chawki Benkelfat"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011255.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_overview_of_the_recruitment_process_/514422", "title"=>"Schematic overview of the recruitment process.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-06-22 01:13:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/844077"], "description"=>"<p><b>Note.</b> Table represents the raw (uncorrected) means (s.e.m.) (<i>N</i> = 26). <i>F</i>-values are corrected for probability of trajectory (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011255#s4\" target=\"_blank\">methods</a> section). The Go/NoGo task was missing for one participant in the LPA group.</p><p>LPA =  Normal development of low physical aggression.</p><p>C-LHPA =  Childhood-limited high physical aggression.</p>", "links"=>[], "tags"=>["Mental health", "neuroscience/behavioral neuroscience", "neurological disorders/neuroimaging", "neuroscience/psychology"], "article_id"=>514524, "categories"=>["Neuroscience", "Mental Health"], "users"=>["Linda Booij", "Richard E. Tremblay", "Marco Leyton", "Jean R. Séguin", "Frank Vitaro", "Paul Gravel", "Elisabeth Perreau-Linck", "Mélissa L. Lévesque", "France Durand", "Mirko Diksic", "Gustavo Turecki", "Chawki Benkelfat"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011255.t001", "stats"=>{"downloads"=>4, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_sample_/514524", "title"=>"Characteristics of the sample.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-06-22 01:15:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/843795"], "description"=>"<p>Values represents the mean ± s.e.m. of the high <i>vs</i>. low physical aggression developmental trajectory) (<i>N</i> = 26). *** <i>P</i><0.001; ** <i>P</i><0.01.</p>", "links"=>[], "tags"=>["voi"], "article_id"=>514241, "categories"=>["Neuroscience", "Mental Health"], "users"=>["Linda Booij", "Richard E. Tremblay", "Marco Leyton", "Jean R. Séguin", "Frank Vitaro", "Paul Gravel", "Elisabeth Perreau-Linck", "Mélissa L. Lévesque", "France Durand", "Mirko Diksic", "Gustavo Turecki", "Chawki Benkelfat"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011255.g001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Normalized_K_values_as_a_function_of_VOI_and_group_/514241", "title"=>"Normalized K* values, as a function of VOI and group.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-06-22 01:10:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/843897"], "description"=>"<p>The figure represents a comparison between young adults with a high physical aggression trajectory during elementary school and desisted during adolescence (C-LHPA) <i>vs</i>. those who had a more normal pattern (low) of physical aggression (LPA) (<i>N</i> = 26). The color-coded images indicate a marked decrease in brain serotonin synthesis capacity bilaterally in the OBFC in those subjects with the high physical aggression trajectory.</p>", "links"=>[], "tags"=>["parametric", "plasma-to-brain"], "article_id"=>514341, "categories"=>["Neuroscience", "Mental Health"], "users"=>["Linda Booij", "Richard E. Tremblay", "Marco Leyton", "Jean R. Séguin", "Frank Vitaro", "Paul Gravel", "Elisabeth Perreau-Linck", "Mélissa L. Lévesque", "France Durand", "Mirko Diksic", "Gustavo Turecki", "Chawki Benkelfat"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011255.g002", "stats"=>{"downloads"=>4, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Statistical_Parametric_Mapping_of_11_C_AMT_Plasma_to_Brain_clearance_/514341", "title"=>"Statistical Parametric Mapping of <sup>11</sup>C-AMT Plasma-to-Brain clearance.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-06-22 01:12:21"}

PMC Usage Stats | Further Information

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