Genome-Wide Analysis of Effectors of Peroxisome Biogenesis
Publication Date
August 04, 2010
Journal
PLOS ONE
Authors
Ramsey A. Saleem, Rose Long O'donnell, David J. Dilworth, Abraham M. Armstrong, et al
Volume
5
Issue
8
Pages
e11953
DOI
https://dx.plos.org/10.1371/journal.pone.0011953
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0011953
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/20694151
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915925
Europe PMC
http://europepmc.org/abstract/MED/20694151
Web of Science
000280574300009
Scopus
77957758512
Mendeley
http://www.mendeley.com/research/genomewide-analysis-effectors-peroxisome-biogenesis
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/837289"], "description"=>"<p>Plot of the log<sub>10</sub> fluorescence of candidate deletion strains tested at 6 h and 24 h of oleate incubation. Deletion strains are indicated with open circles, while wild type is indicated by the line. The tables at the right show the flow cytometry analysis of the candidate genes with percentage of Pot1p-GFP fluorescence relative to wild type, the mean of the fluorescence values and the z value or standard score of the fluorescence at 6 h or 24 h respectively. Genes are shown that show decreases of Pot1p-GFP fluorescence that are at least 1SD from the wild type <i>POT1-GFP</i> strain. Genes boxed by blue or red indicate the naturally occurring separation of values shown in the plot at 6 h (blue) and 24 h (red). The remaining flow cytometry results are shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011953#pone.0011953.s004\" target=\"_blank\">Table S1</a>-2. BY4741 is used as a non-fluorescent control strain.</p>", "links"=>[], "tags"=>["cytometry", "deletion"], "article_id"=>507648, "categories"=>["Molecular Biology", "Cell Biology", "Genetics"], "users"=>["Ramsey A. Saleem", "Rose Long-O'Donnell", "David J. Dilworth", "Abraham M. Armstrong", "Arvind P. Jamakhandi", "Yakun Wan", "Theo A. Knijnenburg", "Antti Niemistö", "John Boyle", "Richard A. Rachubinski", "Ilya Shmulevich", "John D. Aitchison"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011953.g001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_cytometry_analysis_of_candidate_deletion_strains_/507648", "title"=>"Flow cytometry analysis of candidate deletion strains.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-08-04 02:07:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/837432"], "description"=>"<p>Bright field images are shown on the left panel and fluorescence images are shown on the right. Known peroxins show mislocalization of the Pot1p-GFP reporter when deleted. Partial mislocalization phenotypes are seen in <i>pex1</i>Δ, <i>pex18</i>Δ, and <i>pex21</i>Δ.</p>", "links"=>[], "tags"=>["peroxisomal"], "article_id"=>507796, "categories"=>["Molecular Biology", "Cell Biology", "Genetics"], "users"=>["Ramsey A. Saleem", "Rose Long-O'Donnell", "David J. Dilworth", "Abraham M. Armstrong", "Arvind P. Jamakhandi", "Yakun Wan", "Theo A. Knijnenburg", "Antti Niemistö", "John Boyle", "Richard A. Rachubinski", "Ilya Shmulevich", "John D. Aitchison"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011953.g002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Identification_of_peroxisomal_mutants_/507796", "title"=>"Identification of peroxisomal mutants.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-08-04 02:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/417178", "https://ndownloader.figshare.com/files/417198", "https://ndownloader.figshare.com/files/417211", "https://ndownloader.figshare.com/files/417227", "https://ndownloader.figshare.com/files/417239"], "description"=>"<div><p>Peroxisomes are intracellular organelles that house a number of diverse metabolic processes, notably those required for β-oxidation of fatty acids. Peroxisomes biogenesis can be induced by the presence of peroxisome proliferators, including fatty acids, which activate complex cellular programs that underlie the induction process. Here, we used multi-parameter quantitative phenotype analyses of an arrayed mutant collection of yeast cells induced to proliferate peroxisomes, to establish a comprehensive inventory of genes required for peroxisome induction and function. The assays employed include growth in the presence of fatty acids, and confocal imaging and flow cytometry through the induction process. In addition to the classical phenotypes associated with loss of peroxisomal functions, these studies identified 169 genes required for robust signaling, transcription, normal peroxisomal development and morphologies, and transmission of peroxisomes to daughter cells. These gene products are localized throughout the cell, and many have indirect connections to peroxisome function. By integration with extant data sets, we present a total of 211 genes linked to peroxisome biogenesis and highlight the complex networks through which information flows during peroxisome biogenesis and function.</p></div>", "links"=>[], "tags"=>["genome-wide", "effectors", "peroxisome", "biogenesis"], "article_id"=>142348, "categories"=>["Molecular Biology", "Cell Biology", "Genetics"], "users"=>["Ramsey A. Saleem", "Rose Long-O'Donnell", "David J. Dilworth", "Abraham M. Armstrong", "Arvind P. Jamakhandi", "Yakun Wan", "Theo A. Knijnenburg", "Antti Niemistö", "John Boyle", "Richard A. Rachubinski", "Ilya Shmulevich", "John D. Aitchison"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0011953.s001", "https://dx.doi.org/10.1371/journal.pone.0011953.s002", "https://dx.doi.org/10.1371/journal.pone.0011953.s003", "https://dx.doi.org/10.1371/journal.pone.0011953.s004", "https://dx.doi.org/10.1371/journal.pone.0011953.s005"], "stats"=>{"downloads"=>10, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Genome_Wide_Analysis_of_Effectors_of_Peroxisome_Biogenesis/142348", "title"=>"Genome-Wide Analysis of Effectors of Peroxisome Biogenesis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-08-04 00:39:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/837672"], "description"=>"<p>Strains deleted for <i>mnn11</i> or the 5′ end of <i>hsl7</i> (<i>hsl7</i>ΔN generated by the <i>ybr134w</i> deletion) were backcrossed against an allelic deletion or a wild type strain (<i>BY4742</i>). An increased number of small peroxisomes are seen in cells deleted for <i>mnn11</i>, while <i>hsl7</i>ΔN lead to an increase in size or tendency for the peroxisomes to cluster. Both phenotypes are complemented by mating to the wild type strain.</p>", "links"=>[], "tags"=>["hsl7p", "regulators", "peroxisome"], "article_id"=>508026, "categories"=>["Molecular Biology", "Cell Biology", "Genetics"], "users"=>["Ramsey A. Saleem", "Rose Long-O'Donnell", "David J. Dilworth", "Abraham M. Armstrong", "Arvind P. Jamakhandi", "Yakun Wan", "Theo A. Knijnenburg", "Antti Niemistö", "John Boyle", "Richard A. Rachubinski", "Ilya Shmulevich", "John D. Aitchison"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011953.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mnn11p_and_Hsl7p_are_regulators_of_peroxisome_morphology_/508026", "title"=>"Mnn11p and Hsl7p are regulators of peroxisome morphology.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-08-04 02:13:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/837562"], "description"=>"<p>A. Strains lacking Inp1p, Vps52p, Pir3p or YKL015Cp accumulate peroxisomes near the bud neck or in daughter cells as indicated by the arrowheads. B. Summary of the effect of (i) deletions, (ii) complementation, and (iii) double deletions of <i>vps52Δ</i>, <i>pir3Δ</i> and <i>ykl015cΔ</i>.</p>", "links"=>[], "tags"=>["pir3p", "ykl015c", "peroxisome", "inheritance"], "article_id"=>507916, "categories"=>["Molecular Biology", "Cell Biology", "Genetics"], "users"=>["Ramsey A. Saleem", "Rose Long-O'Donnell", "David J. Dilworth", "Abraham M. Armstrong", "Arvind P. Jamakhandi", "Yakun Wan", "Theo A. Knijnenburg", "Antti Niemistö", "John Boyle", "Richard A. Rachubinski", "Ilya Shmulevich", "John D. Aitchison"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011953.g003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Vps52p_Pir3p_and_YKL015C_are_novel_peroxisome_inheritance_factors_/507916", "title"=>"Vps52p, Pir3p and YKL015C are novel peroxisome inheritance factors.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-08-04 02:11:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/837807"], "description"=>"<p>The circular nodes represent proteins identified in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011953#pone.0011953.s005\" target=\"_blank\">Table S2</a> and protein-protein interactions from the literature shown by edges between the nodes. For ease of display, protein localized to the vacuole, ER and Golgi are represented by the annotation “Cytosol”. Distinct functional modules within the nucleus, peroxisomal and mitchondrial localizations can be seen as well as the high connectivity of ubiquitin (UBI4).</p>", "links"=>[], "tags"=>["cellular", "regulating", "biogenesis", "peroxisomes", "utilization", "fatty"], "article_id"=>508159, "categories"=>["Molecular Biology", "Cell Biology", "Genetics"], "users"=>["Ramsey A. Saleem", "Rose Long-O'Donnell", "David J. Dilworth", "Abraham M. Armstrong", "Arvind P. Jamakhandi", "Yakun Wan", "Theo A. Knijnenburg", "Antti Niemistö", "John Boyle", "Richard A. Rachubinski", "Ilya Shmulevich", "John D. Aitchison"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0011953.g005", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_cellular_network_regulating_biogenesis_of_peroxisomes_and_the_utilization_of_fatty_acids_/508159", "title"=>"The cellular network regulating biogenesis of peroxisomes and the utilization of fatty acids.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-08-04 02:15:59"}

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Relative Metric

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