Ezrin Is Highly Expressed in Early Thymocytes, but Dispensable for T Cell Development in Mice
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{"title"=>"Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice", "type"=>"journal", "authors"=>[{"first_name"=>"Meredith H.", "last_name"=>"Shaffer", "scopus_author_id"=>"24167128500"}, {"first_name"=>"Yanping", "last_name"=>"Huang", "scopus_author_id"=>"37862621000"}, {"first_name"=>"Evann", "last_name"=>"Corbo", "scopus_author_id"=>"36016212800"}, {"first_name"=>"Gregory F.", "last_name"=>"Wu", "scopus_author_id"=>"7404976255"}, {"first_name"=>"Marielena K.", "last_name"=>"Velez", "scopus_author_id"=>"16426214400"}, {"first_name"=>"John K.", "last_name"=>"Choi", "scopus_author_id"=>"35073745400"}, {"first_name"=>"Ichiko", "last_name"=>"Saotome", "scopus_author_id"=>"6603084320"}, {"first_name"=>"Judy L.", "last_name"=>"Cannon", "scopus_author_id"=>"7201637574"}, {"first_name"=>"Andrea I.", "last_name"=>"Mcclatchey", "scopus_author_id"=>"7004758792"}, {"first_name"=>"Anne I.", "last_name"=>"Sperling", "scopus_author_id"=>"7006236008"}, {"first_name"=>"Jonathan S.", "last_name"=>"Maltzman", "scopus_author_id"=>"6602279615"}, {"first_name"=>"Paula M.", "last_name"=>"Oliver", "scopus_author_id"=>"57189210594"}, {"first_name"=>"Avinash", "last_name"=>"Bhandoola", "scopus_author_id"=>"6603778052"}, {"first_name"=>"Terri M.", "last_name"=>"Laufer", "scopus_author_id"=>"7004003918"}, {"first_name"=>"Janis K.", "last_name"=>"Burkhardt", "scopus_author_id"=>"7102736302"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "sgr"=>"77957914392", "doi"=>"10.1371/journal.pone.0012404", "scopus"=>"2-s2.0-77957914392", "pui"=>"359761776", "pmid"=>"20806059"}, "id"=>"737bfe8c-8b74-34cb-a1da-3a8dd3c5d435", "abstract"=>"BACKGROUND: Ezrin/radixin/moesin (ERM) proteins are highly homologous proteins that function to link cargo molecules to the actin cytoskeleton. Ezrin and moesin are both expressed in mature lymphocytes, where they play overlapping roles in cell signaling and polarity, but their role in lymphoid development has not been explored.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: We characterized ERM protein expression in lymphoid tissues and analyzed the requirement for ezrin expression in lymphoid development. In wildtype mice, we found that most cells in the spleen and thymus express both ezrin and moesin, but little radixin. ERM protein expression in the thymus was differentially regulated, such that ezrin expression was highest in immature thymocytes and diminished during T cell development. In contrast, moesin expression was low in early thymocytes and upregulated during T cell development. Mice bearing a germline deletion of ezrin exhibited profound defects in the size and cellularity of the spleen and thymus, abnormal thymic architecture, diminished hematopoiesis, and increased proportions of granulocytic precursors. Further analysis using fetal liver chimeras and thymic transplants showed that ezrin expression is dispensable in hematopoietic and stromal lineages, and that most of the defects in lymphoid development in ezrin(-/-) mice likely arise as a consequence of nutritional stress.\\n\\nCONCLUSIONS/SIGNIFICANCE: We conclude that despite high expression in lymphoid precursor cells, ezrin is dispensable for lymphoid development, most likely due to redundancy with moesin.", "link"=>"http://www.mendeley.com/research/ezrin-highly-expressed-early-thymocytes-dispensable-t-cell-development-mice", "reader_count"=>12, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>3, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>3, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>9, "Neuroscience"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/833356"], "description"=>"<p>A and B, Fetal liver cells isolated from E14 ezrin<sup>−/−</sup> or wild type controls were injected into lethally irradiated congenic wildtype recipients. Bone marrow, spleen and thymii were harvested at 6 weeks and analyzed by flow cytometry. A, Cellularity of donor cells was assessed. B, Population analysis of CD45.2 donor cells. C, Thymii from one to three day old ezrin<sup>−/−</sup> mice or littermate controls were transplanted into wildtype recipients. After nine weeks, thymii were harvested and analyzed by flow cytometry.</p>", "links"=>[], "tags"=>["proceeds", "fetal", "chimeras", "transplanted"], "article_id"=>503707, "categories"=>["Cell Biology", "Immunology"], "users"=>["Meredith H. Shaffer", "Yanping Huang", "Evann Corbo", "Gregory F. Wu", "Marielena Velez", "John K. Choi", "Ichiko Saotome", "Judy L. Cannon", "Andrea I. McClatchey", "Anne I. Sperling", "Jonathan S. Maltzman", "Paula M. Oliver", "Avinash Bhandoola", "Terri M. Laufer", "Janis K. Burkhardt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0012404.g007", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Development_proceeds_normally_in_fetal_liver_chimeras_and_transplanted_thymii_/503707", "title"=>"Development proceeds normally in fetal liver chimeras and transplanted thymii.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 23:45:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/833494"], "description"=>"<p>Ezrin<sup>−/−</sup> mice and wildtype littermates were sacrificed within 12 hours of birth, and single cell suspensions were made from the spleen, thymus, and bone marrow. Splenocytes (A and B), thymocytes (C), or bone marrow cells (D) were stained using antibodies as shown and analyzed by flow cytometry.</p>", "links"=>[], "tags"=>["mice", "lymphoid"], "article_id"=>503848, "categories"=>["Cell Biology", "Immunology"], "users"=>["Meredith H. Shaffer", "Yanping Huang", "Evann Corbo", "Gregory F. Wu", "Marielena Velez", "John K. Choi", "Ichiko Saotome", "Judy L. Cannon", "Andrea I. McClatchey", "Anne I. Sperling", "Jonathan S. Maltzman", "Paula M. Oliver", "Avinash Bhandoola", "Terri M. Laufer", "Janis K. Burkhardt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0012404.g008", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_At_birth_ezrin_8722_8722_mice_exhibit_normal_lymphoid_populations_/503848", "title"=>"At birth, ezrin<sup>−/−</sup> mice exhibit normal lymphoid populations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 23:46:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/833574"], "description"=>"<p>Blood samples were collected from ezrin<sup>−/−</sup> and wildtype littermates in EDTA-containing tubes. Analysis was done using an automated hematocrit analyzer. Shown are averages and standard deviations of 7 ezrin<sup>−/−</sup> and 14 ezrin<sup>+/+</sup> mice. RBC (Red Blood Cells, M/µL), Hb (Hemoglobin, g/dL), HCT (Hematocrit, %), MCHC (Mean Corpuscular Hemoglobin Concentration, g/dL), RDW (Red Cell Distribution Width), WBC (White Blood Cells, K/µL), Ly (Lymphocytes, K/µL), PLT (Platelets, K/µL), MPV (Mean Platelet Volume, fL).</p>", "links"=>[], "tags"=>["mice", "altered"], "article_id"=>503927, "categories"=>["Cell Biology", "Immunology"], "users"=>["Meredith H. Shaffer", "Yanping Huang", "Evann Corbo", "Gregory F. Wu", "Marielena Velez", "John K. Choi", "Ichiko Saotome", "Judy L. Cannon", "Andrea I. McClatchey", "Anne I. Sperling", "Jonathan S. Maltzman", "Paula M. Oliver", "Avinash Bhandoola", "Terri M. Laufer", "Janis K. Burkhardt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0012404.t001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ezrin_8722_8722_mice_have_altered_blood_cell_counts_/503927", "title"=>"Ezrin<sup>−/−</sup> mice have altered blood cell counts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 23:46:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/832767"], "description"=>"<p>Spleens (A) and Thymii (B) from wildtype mice at 6–8 weeks (Adult) or P3–P5 (Neonate), were fixed, sectioned and stained using antibodies against ezrin or moesin (brown) in combination with hematoxylin staining (blue). Organ structures are labeled as thymic cortex (C), thymic medulla (M), and peri-arteriolar lymphoid sheath (P). Bars = 100uM.</p>", "links"=>[], "tags"=>["moesin", "differentially"], "article_id"=>503124, "categories"=>["Cell Biology", "Immunology"], "users"=>["Meredith H. Shaffer", "Yanping Huang", "Evann Corbo", "Gregory F. Wu", "Marielena Velez", "John K. Choi", "Ichiko Saotome", "Judy L. Cannon", "Andrea I. McClatchey", "Anne I. Sperling", "Jonathan S. Maltzman", "Paula M. Oliver", "Avinash Bhandoola", "Terri M. Laufer", "Janis K. Burkhardt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0012404.g003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ezrin_and_moesin_are_differentially_expressed_within_the_thymus_/503124", "title"=>"Ezrin and moesin are differentially expressed within the thymus.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 23:42:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/833616"], "description"=>"<p>Blood samples were collected from ezrin<sup>−/−</sup> and ezrin<sup>+/+</sup> fetal liver chimeras in EDTA-containing tubes. Analysis was done using an automated hematocrit analyzer. Shown are averages and standard deviations of 4 ezrin<sup>−/−</sup> and 14 ezrin<sup>+/−</sup> or 6 ezrin<sup>+/+</sup> chimeric mice. RBC (Red Blood Cells, M/µL), Hb (Hemoglobin, g/dL), HCT (Hematocrit, %), MCHC (Mean Corpuscular Hemoglobin Concentration, g/dL), RDW (Red Cell Distribution Width), WBC (White Blood Cells, K/µL), Ly (Lymphocytes, K/µL), PLT (Platelets, K/µL), MPV (Mean Platelet Volume, fL).</p>", "links"=>[], "tags"=>["fetal", "chimeras"], "article_id"=>503971, "categories"=>["Cell Biology", "Immunology"], "users"=>["Meredith H. Shaffer", "Yanping Huang", "Evann Corbo", "Gregory F. Wu", "Marielena Velez", "John K. Choi", "Ichiko Saotome", "Judy L. Cannon", "Andrea I. McClatchey", "Anne I. Sperling", "Jonathan S. Maltzman", "Paula M. Oliver", "Avinash Bhandoola", "Terri M. Laufer", "Janis K. Burkhardt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0012404.t002", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ezrin_8722_8722_fetal_liver_chimeras_have_normal_blood_cell_counts_/503971", "title"=>"Ezrin<sup>−/−</sup> fetal liver chimeras have normal blood cell counts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 23:47:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/832542"], "description"=>"<p>Thymii were harvested from wildtype mice and single cell suspensions were separated on a Percoll gradient, and sorted for the populations shown. mRNA was isolated was analyzed by real-time PCR for ezrin (A), radixin (B), and moesin (C) expression, relative to total unsorted thymus. D. Expression profiles of ezrin (blue), radixin (green), and moesin (red), each normalized to its own expression in total thymus, were overlayed to facilitate comparison of relative expression patterns of ezrin and moesin. Samples were run in triplicate and are representative of 2 independent experiments. Data represent means +/− StDev.</p>", "links"=>[], "tags"=>["moesin", "mrnas", "reciprocal", "patterns", "thymocyte"], "article_id"=>502894, "categories"=>["Cell Biology", "Immunology"], "users"=>["Meredith H. Shaffer", "Yanping Huang", "Evann Corbo", "Gregory F. Wu", "Marielena Velez", "John K. Choi", "Ichiko Saotome", "Judy L. Cannon", "Andrea I. McClatchey", "Anne I. Sperling", "Jonathan S. Maltzman", "Paula M. Oliver", "Avinash Bhandoola", "Terri M. Laufer", "Janis K. Burkhardt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0012404.g002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ezrin_and_moesin_mRNAs_show_reciprocal_expression_patterns_during_thymocyte_development_/502894", "title"=>"Ezrin and moesin mRNAs show reciprocal expression patterns during thymocyte development.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 23:41:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/833197"], "description"=>"<p>Thymii were dissected from ezrin<sup>−/−</sup> mice and wildtype littermates at P7 and either fixed with formalin (A) or frozen (B and C). Formalin-fixed samples were analyzed by hematoxylin and eosin staining (A), and frozen samples were stained with K5-specific antibody (B) or UAE (C) in combination with hematoxylin staining. Scale bars indicate magnification. C, cortex; M, medulla. Bars = 100uM.</p>", "links"=>[], "tags"=>["deletion", "ezrin", "altered", "thymic"], "article_id"=>503545, "categories"=>["Cell Biology", "Immunology"], "users"=>["Meredith H. Shaffer", "Yanping Huang", "Evann Corbo", "Gregory F. Wu", "Marielena Velez", "John K. Choi", "Ichiko Saotome", "Judy L. Cannon", "Andrea I. McClatchey", "Anne I. Sperling", "Jonathan S. Maltzman", "Paula M. Oliver", "Avinash Bhandoola", "Terri M. Laufer", "Janis K. Burkhardt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0012404.g006", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Germline_deletion_of_ezrin_results_in_altered_thymic_architecture_/503545", "title"=>"Germline deletion of ezrin results in altered thymic architecture.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 23:44:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/833006"], "description"=>"<p>A. Single cell suspensions were made from the spleen, thymus, and bone marrow of P3–P5 ezrin<sup>−/−</sup> mice and wildtype littermates. Cells were stained with indicated antibodies, and analyzed by flow cytometry. B. Thymii were harvested from ezrin<sup>−/−</sup> and mice and littermate controls, and mRNA was isolated and analyzed by real-time PCR. Expression of each mRNA was normalized to control. Data represent means from 4 mice of each genotype, each run in triplicate, +/− SEM.</p>", "links"=>[], "tags"=>["deletion", "ezrin", "altered", "lymphoid", "populations", "upregulation", "moesin", "radixin"], "article_id"=>503351, "categories"=>["Cell Biology", "Immunology"], "users"=>["Meredith H. Shaffer", "Yanping Huang", "Evann Corbo", "Gregory F. Wu", "Marielena Velez", "John K. Choi", "Ichiko Saotome", "Judy L. Cannon", "Andrea I. McClatchey", "Anne I. Sperling", "Jonathan S. Maltzman", "Paula M. Oliver", "Avinash Bhandoola", "Terri M. Laufer", "Janis K. Burkhardt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0012404.g005", "stats"=>{"downloads"=>3, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Germline_deletion_of_ezrin_results_in_altered_lymphoid_populations_and_upregulation_of_moesin_and_radixin_mRNA_/503351", "title"=>"Germline deletion of ezrin results in altered lymphoid populations and upregulation of moesin and radixin mRNA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 23:43:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/832901"], "description"=>"<p>A. Spleens and thymii from ezrin<sup>−/−</sup> neonatal mice and wildtype littermates were collected and photographed. B. Single cell suspensions were counted for total cellularity. C and D. Absolute immune cell populations from the thymus (C) or spleen (D) were calculated by antibody staining followed by flow cytometry. Data shown are means +/− StDev of at least 3 mice, all at P3–P5. *p≤0.05.</p>", "links"=>[], "tags"=>["deletion", "ezrin", "defects", "lymphoid"], "article_id"=>503256, "categories"=>["Cell Biology", "Immunology"], "users"=>["Meredith H. Shaffer", "Yanping Huang", "Evann Corbo", "Gregory F. Wu", "Marielena Velez", "John K. Choi", "Ichiko Saotome", "Judy L. Cannon", "Andrea I. McClatchey", "Anne I. Sperling", "Jonathan S. Maltzman", "Paula M. Oliver", "Avinash Bhandoola", "Terri M. Laufer", "Janis K. Burkhardt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0012404.g004", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Germline_deletion_of_ezrin_results_in_profound_defects_in_lymphoid_development_/503256", "title"=>"Germline deletion of ezrin results in profound defects in lymphoid development.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 23:43:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/832427"], "description"=>"<p>Mouse organs were lysed in SDS sample buffer and analyzed by western blot with antibodies specific for pERM (A), and ezrin or GAPDH (C). B. Relative abundance of each pERM protein within a tissue was calculated using an Odyssey Imager and normalized to the total pERM expression in that tissue. D. Expression of ezrin among tissues was calculated after normalization to GAPDH.</p>", "links"=>[], "tags"=>["ezrin", "moesin", "lymphoid"], "article_id"=>502771, "categories"=>["Cell Biology", "Immunology"], "users"=>["Meredith H. Shaffer", "Yanping Huang", "Evann Corbo", "Gregory F. Wu", "Marielena Velez", "John K. Choi", "Ichiko Saotome", "Judy L. Cannon", "Andrea I. McClatchey", "Anne I. Sperling", "Jonathan S. Maltzman", "Paula M. Oliver", "Avinash Bhandoola", "Terri M. Laufer", "Janis K. Burkhardt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0012404.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_ezrin_and_moesin_in_lymphoid_organs_/502771", "title"=>"Expression of ezrin and moesin in lymphoid organs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 23:40:48"}

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  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
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  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
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  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
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  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
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  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"1"}
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  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
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  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
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  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
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  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
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  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"5", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
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Relative Metric

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