Differential Genetic Regulation of Canine Hip Dysplasia and Osteoarthritis
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Mendeley | Further Information

{"title"=>"Differential genetic regulation of canine hip dysplasia and osteoarthritis", "type"=>"journal", "authors"=>[{"first_name"=>"Zhengkui", "last_name"=>"Zhou", "scopus_author_id"=>"55579568900"}, {"first_name"=>"Xihui", "last_name"=>"Sheng", "scopus_author_id"=>"35367017000"}, {"first_name"=>"Zhiwu", "last_name"=>"Zhang", "scopus_author_id"=>"9742909300"}, {"first_name"=>"Keyan", "last_name"=>"Zhao", "scopus_author_id"=>"8714320500"}, {"first_name"=>"Lan", "last_name"=>"Zhu", "scopus_author_id"=>"35277583700"}, {"first_name"=>"Gang", "last_name"=>"Guo", "scopus_author_id"=>"37040432300"}, {"first_name"=>"Steve G.", "last_name"=>"Friedenberg", "scopus_author_id"=>"36876098300"}, {"first_name"=>"Linda S.", "last_name"=>"Hunter", "scopus_author_id"=>"7202850388"}, {"first_name"=>"Wendy S.", "last_name"=>"Vandenberg-Foels", "scopus_author_id"=>"15030258100"}, {"first_name"=>"William E.", "last_name"=>"Hornbuckle", "scopus_author_id"=>"6701389854"}, {"first_name"=>"Ursula", "last_name"=>"Krotscheck", "scopus_author_id"=>"8315666200"}, {"first_name"=>"Elizabeth", "last_name"=>"Corey", "scopus_author_id"=>"25958971800"}, {"first_name"=>"Nancy S.", "last_name"=>"Moise", "scopus_author_id"=>"7006510309"}, {"first_name"=>"Nathan L.", "last_name"=>"Dykes", "scopus_author_id"=>"35517760700"}, {"first_name"=>"Junya", "last_name"=>"Li", "scopus_author_id"=>"7410071953"}, {"first_name"=>"Shangzhong", "last_name"=>"Xu", "scopus_author_id"=>"12779380100"}, {"first_name"=>"Lixin", "last_name"=>"Du", "scopus_author_id"=>"7201904882"}, {"first_name"=>"Yachun", "last_name"=>"Wang", "scopus_author_id"=>"14920022000"}, {"first_name"=>"Jody", "last_name"=>"Sandler", "scopus_author_id"=>"7005249167"}, {"first_name"=>"Gregory M.", "last_name"=>"Acland", "scopus_author_id"=>"7005243953"}, {"first_name"=>"George", "last_name"=>"Lust", "scopus_author_id"=>"7005766496"}, {"first_name"=>"Rory J.", "last_name"=>"Todhunter", "scopus_author_id"=>"7005344382"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"78149427066", "doi"=>"10.1371/journal.pone.0013219", "pui"=>"359930913", "pmid"=>"20949002", "scopus"=>"2-s2.0-78149427066", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)"}, "id"=>"760549d8-4f0d-3ae4-b351-f29e22840302", "abstract"=>"BACKGROUND: Canine hip dysplasia (HD) is a common polygenic trait characterized by hip malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human hip which also leads to OA.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: A total of 721 dogs, including both an association and linkage population, were genotyped. The association population included 8 pure breeds (Labrador retriever, Greyhounds, German Shepherd, Newfoundland, Golden retriever, Rottweiler, Border Collie and Bernese Mountain Dog). The linkage population included Labrador retrievers, Greyhounds, and their crosses. Of these, 366 dogs were genotyped at ∼22,000 single nucleotide polymorphism (SNP) loci and a targeted screen across 8 chromosomes with ∼3,300 SNPs was performed on 551 dogs (196 dogs were common to both sets). A mixed linear model approach was used to perform an association study on this combined association and linkage population. The study identified 4 susceptibility SNPs associated with HD and 2 SNPs associated with hip OA.\\n\\nCONCLUSION/SIGNIFICANCE: The identified SNPs included those near known genes (PTPRD, PARD3B, and COL15A1) reported to be associated with, or expressed in, OA in humans. This suggested that the canine model could provide a unique opportunity to identify genes underlying natural HD and hip OA, which are common and debilitating conditions in both dogs and humans.", "link"=>"http://www.mendeley.com/research/differential-genetic-regulation-canine-hip-dysplasia-osteoarthritis", "reader_count"=>66, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>5, "Researcher"=>17, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>4, "Student > Bachelor"=>9, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>5, "Researcher"=>17, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>4, "Student > Bachelor"=>9, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>6, "Environmental Science"=>3, "Biochemistry, Genetics and Molecular Biology"=>3, "Mathematics"=>2, "Agricultural and Biological Sciences"=>35, "Medicine and Dentistry"=>10, "Arts and Humanities"=>1, "Veterinary Science and Veterinary Medicine"=>3, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>35}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>6}, "Environmental Science"=>{"Environmental Science"=>3}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>3}}, "reader_count_by_country"=>{"Belgium"=>1, "United States"=>3, "Norway"=>1, "Ukraine"=>1, "Peru"=>1, "Germany"=>1, "Spain"=>1}, "group_count"=>6}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/826813"], "description"=>"a<p>The SNPs are categorized by traits (hip dysplasia or osteoarthritis). The chromosome (Chr), position in base pair (bp), minor allele frequency (MAF), and distance to the candidate genes are listed for each SNP.</p>", "links"=>[], "tags"=>["snps", "genes", "dysplasia"], "article_id"=>497152, "categories"=>["Genetics"], "users"=>["Zhengkui Zhou", "Xihui Sheng", "Zhiwu Zhang", "Keyan Zhao", "Lan Zhu", "Gang Guo", "Steve G. Friedenberg", "Linda S. Hunter", "Wendy S. Vandenberg-Foels", "William E. Hornbuckle", "Ursula Krotscheck", "Elizabeth Corey", "Nancy S. Moise", "Nathan L. Dykes", "Junya Li", "Shangzhong Xu", "Lixin Du", "Yachun Wang", "Jody Sandler", "Gregory M. Acland", "George Lust", "Rory J. Todhunter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013219.t001", "stats"=>{"downloads"=>17, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_associated_SNPs_and_nearby_candidate_genes_for_hip_dysplasia_and_osteoarthritis_a_/497152", "title"=>"The associated SNPs and nearby candidate genes for hip dysplasia and osteoarthritis<sup>a</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-11 01:59:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/826445"], "description"=>"<p>The plots summarize the genome-wide association results for hip dysplasia (A) and hip osteoarthritis (B). The genome-wide <i>P</i> values (−log<sub>10 </sub><i>P</i>) of the F test for the SNP effect are plotted against position on each chromosome. The inset shows QQ plots of the observed <i>P</i> values versus the expected <i>P</i> values under the null hypothesis that there was no association.</p>", "links"=>[], "tags"=>["quantile-quantile"], "article_id"=>496781, "categories"=>["Genetics"], "users"=>["Zhengkui Zhou", "Xihui Sheng", "Zhiwu Zhang", "Keyan Zhao", "Lan Zhu", "Gang Guo", "Steve G. Friedenberg", "Linda S. Hunter", "Wendy S. Vandenberg-Foels", "William E. Hornbuckle", "Ursula Krotscheck", "Elizabeth Corey", "Nancy S. Moise", "Nathan L. Dykes", "Junya Li", "Shangzhong Xu", "Lixin Du", "Yachun Wang", "Jody Sandler", "Gregory M. Acland", "George Lust", "Rory J. Todhunter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013219.g001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Manhattan_and_Quantile_Quantile_QQ_plots_/496781", "title"=>"Manhattan and Quantile-Quantile (QQ) plots.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-11 01:53:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/411112", "https://ndownloader.figshare.com/files/411141", "https://ndownloader.figshare.com/files/411166", "https://ndownloader.figshare.com/files/411191", "https://ndownloader.figshare.com/files/411217", "https://ndownloader.figshare.com/files/411241", "https://ndownloader.figshare.com/files/411259", "https://ndownloader.figshare.com/files/411281", "https://ndownloader.figshare.com/files/411298"], "description"=>"<div><h3>Background</h3><p>Canine hip dysplasia (HD) is a common polygenic trait characterized by hip malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human hip which also leads to OA.</p><h3>Methodology/Principal Findings</h3><p>A total of 721 dogs, including both an association and linkage population, were genotyped. The association population included 8 pure breeds (Labrador retriever, Greyhounds, German Shepherd, Newfoundland, Golden retriever, Rottweiler, Border Collie and Bernese Mountain Dog). The linkage population included Labrador retrievers, Greyhounds, and their crosses. Of these, 366 dogs were genotyped at ∼22,000 single nucleotide polymorphism (SNP) loci and a targeted screen across 8 chromosomes with ∼3,300 SNPs was performed on 551 dogs (196 dogs were common to both sets). A mixed linear model approach was used to perform an association study on this combined association and linkage population. The study identified 4 susceptibility SNPs associated with HD and 2 SNPs associated with hip OA.</p><h3>Conclusion/Significance</h3><p>The identified SNPs included those near known genes (<em>PTPRD, PARD3B</em>, and <em>COL15A1</em>) reported to be associated with, or expressed in, OA in humans. This suggested that the canine model could provide a unique opportunity to identify genes underlying natural HD and hip OA, which are common and debilitating conditions in both dogs and humans.</p></div>", "links"=>[], "tags"=>["differential", "canine", "dysplasia", "osteoarthritis"], "article_id"=>141206, "categories"=>["Genetics"], "users"=>["Zhengkui Zhou", "Xihui Sheng", "Zhiwu Zhang", "Keyan Zhao", "Lan Zhu", "Gang Guo", "Steve G. Friedenberg", "Linda S. Hunter", "Wendy S. Vandenberg-Foels", "William E. Hornbuckle", "Ursula Krotscheck", "Elizabeth Corey", "Nancy S. Moise", "Nathan L. Dykes", "Junya Li", "Shangzhong Xu", "Lixin Du", "Yachun Wang", "Jody Sandler", "Gregory M. Acland", "George Lust", "Rory J. Todhunter"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0013219.s001", "https://dx.doi.org/10.1371/journal.pone.0013219.s002", "https://dx.doi.org/10.1371/journal.pone.0013219.s003", "https://dx.doi.org/10.1371/journal.pone.0013219.s004", "https://dx.doi.org/10.1371/journal.pone.0013219.s005", "https://dx.doi.org/10.1371/journal.pone.0013219.s006", "https://dx.doi.org/10.1371/journal.pone.0013219.s007", "https://dx.doi.org/10.1371/journal.pone.0013219.s008", "https://dx.doi.org/10.1371/journal.pone.0013219.s009"], "stats"=>{"downloads"=>5, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Differential_Genetic_Regulation_of_Canine_Hip_Dysplasia_and_Osteoarthritis/141206", "title"=>"Differential Genetic Regulation of Canine Hip Dysplasia and Osteoarthritis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-10-11 00:20:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/826615"], "description"=>"<p>A: Unaffected hips. B: Moderate hip dysplasia. The arrow indicates the included angle which is the Norberg angle. C: Severely affected hip dysplasia with luxation. D: Severe secondary osteoarthritis as a result of previous hip dysplasia. E: A CT image of a hip with moderate hip dysplasia illustrating the subluxation and impingement of the femoral head on the lateral acetabular rim when the dog is imaged with its hips in a weight bearing position. F: A CT image of a dog with severe hip dysplasia characterized by complete luxation. G: The gross appearance of a femoral head from a hip joint moderately affected with HD and early secondary OA with articular cartilage fibrillation in the perifoveal area and hypertrophy of the teres ligament. H: A femoral head from a severely affected hip with full thickness articular cartilage erosion and loss of the teres ligament due to mechanical abrasion and enzymatic degradation. These affected hips are painful.</p>", "links"=>[], "tags"=>["computed", "tomography", "images", "canine"], "article_id"=>496951, "categories"=>["Genetics"], "users"=>["Zhengkui Zhou", "Xihui Sheng", "Zhiwu Zhang", "Keyan Zhao", "Lan Zhu", "Gang Guo", "Steve G. Friedenberg", "Linda S. Hunter", "Wendy S. Vandenberg-Foels", "William E. Hornbuckle", "Ursula Krotscheck", "Elizabeth Corey", "Nancy S. Moise", "Nathan L. Dykes", "Junya Li", "Shangzhong Xu", "Lixin Du", "Yachun Wang", "Jody Sandler", "Gregory M. Acland", "George Lust", "Rory J. Todhunter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013219.g002", "stats"=>{"downloads"=>3, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Radiographs_and_computed_tomography_CT_images_of_the_canine_hip_joint_/496951", "title"=>"Radiographs and computed tomography (CT) images of the canine hip joint.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-11 01:55:51"}

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Relative Metric

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