Inhibition of Toxic Shock by Human Monoclonal Antibodies against Staphylococcal Enterotoxin B
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{"title"=>"Inhibition of toxic shock by human monoclonal antibodies against staphylococcal enterotoxin B", "type"=>"journal", "authors"=>[{"first_name"=>"Eileen A.", "last_name"=>"Larkin", "scopus_author_id"=>"35741196300"}, {"first_name"=>"Bradley G.", "last_name"=>"Stiles", "scopus_author_id"=>"7005266263"}, {"first_name"=>"Robert G.", "last_name"=>"Ulrich", "scopus_author_id"=>"7201561808"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-78149455684", "pui"=>"359930911", "doi"=>"10.1371/journal.pone.0013253", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "sgr"=>"78149455684", "pmid"=>"20949003"}, "id"=>"bee804f8-3c8a-3763-96a6-f7fe2bc01bbd", "abstract"=>"BACKGROUND: Staphylococcus aureus is implicated in many opportunistic bacterial infections around the world. Rising antibiotic resistance and few alternative methods of treatment are just two looming problems associated with clinical management of S. aureus. Among numerous virulence factors produced by S. aureus, staphylococcal enterotoxin (SE) B is a secreted protein that binds T-cell receptor and major histocompatibility complex class II, potentially causing toxic shock mediated by pathological activation of T cells. Recombinant monoclonal antibodies that target SEB and block receptor interactions can be of therapeutic value.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: The inhibitory and biophysical properties of ten human monoclonal antibodies, isolated from a recombinant library by panning against SEB vaccine (STEBVax), were examined as bivalent Fabs and native full-length IgG (Mab). The best performing Fabs had binding affinities equal to polyclonal IgG, low nanomolar IC(50)s against SEB in cell culture assays, and protected mice from SEB-induced toxic shock. The orthologous staphylococcal proteins, SEC1 and SEC2, as well as streptococcal pyrogenic exotoxin C were recognized by several Fabs. Four Fabs against SEB, with the lowest IC(50)s, were converted into native full-length Mabs. Although SEB-binding kinetics were identical between each Fab and respective Mab, a 250-fold greater inhibition of SEB-induced T-cell activation was observed with two Mabs.\\n\\nCONCLUSIONS/SIGNIFICANCE: Results suggest that these human monoclonal antibodies possess high affinity, target specificity, and toxin neutralization qualities essential for any therapeutic agent.", "link"=>"http://www.mendeley.com/research/inhibition-toxic-shock-human-monoclonal-antibodies-against-staphylococcal-enterotoxin-b", "reader_count"=>37, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>4, "Researcher"=>7, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>12, "Other"=>2, "Student > Bachelor"=>4, "Unspecified"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>4, "Researcher"=>7, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>12, "Other"=>2, "Student > Bachelor"=>4, "Unspecified"=>3}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>4, "Agricultural and Biological Sciences"=>16, "Medicine and Dentistry"=>12, "Veterinary Science and Veterinary Medicine"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Unspecified"=>{"Unspecified"=>4}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Chile"=>1, "Spain"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/825265"], "description"=>"<p>A 10–20% gradient SDS-PAGE separated crude <i>S. aureus</i> antigen preparations subsequently transferred onto nitrocellulose. Each Fab (1 µg/ml) was used to probe the nitrocellulose for 1 h. Lanes include: A- 50 ng purified SEB; B – 20 µg cell lysate; and C – 20 µg culture supernatant.</p>", "links"=>[], "tags"=>["detection", "seb", "antigen"], "article_id"=>495635, "categories"=>["Microbiology", "Immunology"], "users"=>["Eileen A. Larkin", "Bradley G. Stiles", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013253.g001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antibody_detection_of_SEB_in_a_complex_antigen_mixture_by_Western_blot_/495635", "title"=>"Antibody detection of SEB in a complex antigen mixture by Western blot.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 22:57:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/825335"], "description"=>"<p>Fab or native full-length (FL) Mabs were used at a final concentration of 1000 nM and added at designated times after SEB (0.35 nM). Culture fluids were collected 16 h after SEB addition and IFNγ concentrations ascertained as described in the <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013253#s4\" target=\"_blank\">Materials and Methods</a>. Panels A and C respectively show Fab and FL-Mab results. Antibody controls consisted of a SEA-specific Fab and SEB affinity-purified IgG from human sera (Panel B). Results are representative of two separate experiments.</p>", "links"=>[], "tags"=>["capabilities", "antibodies", "seb", "pbmc"], "article_id"=>495704, "categories"=>["Microbiology", "Immunology"], "users"=>["Eileen A. Larkin", "Bradley G. Stiles", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013253.g002", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Therapeutic_capabilities_of_antibodies_added_after_SEB_in_human_PBMC_cultures_/495704", "title"=>"Therapeutic capabilities of antibodies added after SEB in human PBMC cultures.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 22:58:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/825481"], "description"=>"a<p>Antibody immobilized on a CM5 chip with SEB used as analyte. Polyclonal IgG was SEB affinity-purified IgG from human sera.</p>b<p>Standard deviation.</p>c<p>Not tested.</p>", "links"=>[], "tags"=>["immobilized", "antibody", "interactions", "seb"], "article_id"=>495850, "categories"=>["Microbiology", "Immunology"], "users"=>["Eileen A. Larkin", "Bradley G. Stiles", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013253.t002", "stats"=>{"downloads"=>5, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kinetic_Analysis_of_Immobilized_Human_Antibody_Interactions_with_SEB_in_Solution_/495850", "title"=>"Kinetic Analysis of Immobilized Human Antibody Interactions with SEB in Solution.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 22:59:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/825540"], "description"=>"a<p>Numbered antibodies are monoclonal Fabs. Polyclonal IgG is anti-SEB affinity purified from human sera.</p>b<p>Scoring by ELISA:</p><p>- = <0.5 mean absorbance +/− standard deviation.</p><p>+ = 0.5–1.0.</p><p>++ = 1.0–2.0.</p><p>+++ = 2.0–3.0</p><p>++++ = 3.0–4.0.</p>", "links"=>[], "tags"=>["monoclonal", "fabs", "staphylococcal", "streptococcal"], "article_id"=>495915, "categories"=>["Microbiology", "Immunology"], "users"=>["Eileen A. Larkin", "Bradley G. Stiles", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013253.t001", "stats"=>{"downloads"=>3, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Specificity_of_Human_Monoclonal_Fabs_for_Staphylococcal_and_Streptococcal_Superantigens_/495915", "title"=>"Specificity of Human Monoclonal Fabs for Staphylococcal and Streptococcal Superantigens.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 22:59:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/825515"], "description"=>"a<p>FL  =  full-length native Mab. All data show antibody inhibition of toxin-induced IFNγ release, relative to toxin only-treated PBMCs that act as a control. Data represent the mean of quadruplicate readings resulting from two separate experiments.</p>b<p>Not tested, due to weak cross-reactivity by ELISA.</p>c<p>Percent inhibition given in parentheses at the highest concentration (1500 nM for Fab and 1000 nM for FL Mab) of weak-performing antibodies.</p>d<p>Polyclonal anti-SEB from human sera, affinity-purified against SEB.</p>e<p>Control human Fab against SEA that did not cross-react with SEB by ELISA.</p>", "links"=>[], "tags"=>["inhibition", "t-cell", "responses", "bacterial"], "article_id"=>495884, "categories"=>["Microbiology", "Immunology"], "users"=>["Eileen A. Larkin", "Bradley G. Stiles", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013253.t003", "stats"=>{"downloads"=>7, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antibody_Inhibition_of_Human_T_Cell_Responses_to_Bacterial_Superantigens_/495884", "title"=>"Antibody Inhibition of Human T-Cell Responses to Bacterial Superantigens.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 22:59:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/825447"], "description"=>"a<p>FL  =  full-length native Mab.</p>b<p>n = 12 for Fab 1, SEA Fab, and None. n = 6 for all other groups. Before intraperitoneal injection of each mouse, antibody (10 µg) was premixed with SEB (2.5 µg) for 30 min at 22°C. Survival was recorded over a 72 h period.</p>c<p>Control human Fab against SEA and not cross-reacting with SEB by ELISA.</p>", "links"=>[], "tags"=>["neutralization", "seb"], "article_id"=>495822, "categories"=>["Microbiology", "Immunology"], "users"=>["Eileen A. Larkin", "Bradley G. Stiles", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013253.t004", "stats"=>{"downloads"=>2, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antibody_Neutralization_of_SEB_in_vivo_/495822", "title"=>"Antibody Neutralization of SEB <i>in vivo</i>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 22:58:53"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"22", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
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Relative Metric

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