Reduced Satellite Cell Numbers and Myogenic Capacity in Aging Can Be Alleviated by Endurance Exercise
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{"title"=>"Reduced satellite cell numbers and myogenic capacity in aging can be alleviated by endurance exercise", "type"=>"journal", "authors"=>[{"first_name"=>"Gabi", "last_name"=>"Shefer", "scopus_author_id"=>"6602535316"}, {"first_name"=>"Gat", "last_name"=>"Rauner", "scopus_author_id"=>"23502315000"}, {"first_name"=>"Zipora", "last_name"=>"Yablonka-Reuveni", "scopus_author_id"=>"7003330089"}, {"first_name"=>"Dafna", "last_name"=>"Benayahu", "scopus_author_id"=>"7004641782"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"359930949", "issn"=>"19326203", "pmid"=>"20967266", "sgr"=>"78149443609", "scopus"=>"2-s2.0-78149443609", "isbn"=>"1932-6203 (Electronic)1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0013307"}, "id"=>"444b6b29-bcc2-3a61-9f94-6283b1bd341d", "abstract"=>"BACKGROUND Muscle regeneration depends on satellite cells, myogenic stem cells that reside on the myofiber surface. Reduced numbers and/or decreased myogenic aptitude of these cells may impede proper maintenance and contribute to the age-associated decline in muscle mass and repair capacity. Endurance exercise was shown to improve muscle performance; however, the direct impact on satellite cells in aging was not yet thoroughly determined. Here, we focused on characterizing the effect of moderate-intensity endurance exercise on satellite cell, as possible means to attenuate adverse effects of aging. Young and old rats of both genders underwent 13 weeks of treadmill-running or remained sedentary. METHODOLOGY Gastrocnemius muscles were assessed for the effect of age, gender and exercise on satellite-cell numbers and myogenic capacity. Satellite cells were identified in freshly isolated myofibers based on Pax7 immunostaining (i.e., ex-vivo). The capacity of individual myofiber-associated cells to produce myogenic progeny was determined in clonal assays (in-vitro). We show an age-associated decrease in satellite-cell numbers and in the percent of myogenic clones in old sedentary rats. Upon exercise, there was an increase in myofibers that contain higher numbers of satellite cells in both young and old rats, and an increase in the percent of myogenic clones derived from old rats. Changes at the satellite cell level in old rats were accompanied with positive effects on the lean-to-fat Gast muscle composition and on spontaneous locomotion levels. The significance of these data is that they suggest that the endurance exercise-mediated boost in both satellite numbers and myogenic properties may improve myofiber maintenance in aging.", "link"=>"http://www.mendeley.com/research/reduced-satellite-cell-numbers-myogenic-capacity-aging-alleviated-endurance-exercise", "reader_count"=>118, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>12, "Researcher"=>17, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>26, "Student > Postgraduate"=>4, "Student > Master"=>19, "Other"=>6, "Student > Bachelor"=>16, "Lecturer"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>12, "Researcher"=>17, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>26, "Student > Postgraduate"=>4, "Student > Master"=>19, "Other"=>6, "Student > Bachelor"=>16, "Lecturer"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Agricultural and Biological Sciences"=>49, "Business, Management and Accounting"=>1, "Chemistry"=>1, "Computer Science"=>1, "Earth and Planetary Sciences"=>1, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>16, "Nursing and Health Professions"=>1, "Materials Science"=>1, "Medicine and Dentistry"=>23, "Neuroscience"=>1, "Sports and Recreations"=>15, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>23}, "Sports and Recreations"=>{"Sports and Recreations"=>15}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>5}, "Engineering"=>{"Engineering"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>49}, "Computer Science"=>{"Computer Science"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>16}}, "reader_count_by_country"=>{"United States"=>6, "Japan"=>1, "Brazil"=>3, "Denmark"=>1, "United Kingdom"=>4, "Spain"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/825569"], "description"=>"1<p>Data presented in this table were collected from the same animals detailed in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013307#pone-0013307-t001\" target=\"_blank\">Table 1</a>.</p>", "links"=>[], "tags"=>["myogenic", "nonmyogenic", "clones", "myofiber"], "article_id"=>495936, "categories"=>["Cell Biology", "Physiology", "Medicine"], "users"=>["Gabi Shefer", "Gat Rauner", "Zipora Yablonka-Reuveni", "Dafna Benayahu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013307.t003", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_comparison_of_the_mean_number_of_myogenic_and_nonmyogenic_clones_per_individual_myofiber_between_the_eight_experimental_groups_1_/495936", "title"=>"A comparison of the mean number of myogenic and nonmyogenic clones per individual myofiber between the eight experimental groups.<sup>1</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-12 01:38:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/825538"], "description"=>"1<p>Data presented in this table were collected from the same animals detailed in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013307#pone-0013307-t001\" target=\"_blank\">Table 1</a>.</p>2<p>Myofibers from all 8 groups were pooled together and ranked from low to high according to the number of satellite cells per each myofiber. The obtained rank was then divided to four equal quartiles (each containing one quarter of the ranked data). The ranges of satellite-cell numbers contained within each quartile are: 0–6, 1<sup>st</sup> quartile; 7–11, 2<sup>nd</sup> quartile; 12–20, 3<sup>rd</sup> quartile; 21–40, 4<sup>th</sup> quartile. These ranges are depicted at the top the Table. The total number of myofibers per each group is depicted at the right-hand column (these are same fibers as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013307#pone-0013307-t001\" target=\"_blank\">Table 1</a>).</p>", "links"=>[], "tags"=>["myofibers", "quartiles", "ranges", "satellite-cell", "numbers"], "article_id"=>495902, "categories"=>["Cell Biology", "Physiology", "Medicine"], "users"=>["Gabi Shefer", "Gat Rauner", "Zipora Yablonka-Reuveni", "Dafna Benayahu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013307.t002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_myofibers_into_quartiles_according_to_ranges_of_satellite_cell_numbers_per_myofiber_quartiles_are_determined_based_on_all_myofibers_from_all_experimental_groups_/495902", "title"=>"Distribution of myofibers into quartiles according to ranges of satellite-cell numbers per myofiber; quartiles are determined based on all myofibers from all experimental groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-12 01:38:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/825345"], "description"=>"<p>Each bar depicts the average values of young/old, male/female exercised (open bars) and sedentary (gray bars) rats. Error bars indicate standard error of the mean.</p>", "links"=>[], "tags"=>["percent", "myogenic", "clones", "developed", "cells", "extracted", "gast"], "article_id"=>495714, "categories"=>["Cell Biology", "Physiology", "Medicine"], "users"=>["Gabi Shefer", "Gat Rauner", "Zipora Yablonka-Reuveni", "Dafna Benayahu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013307.g003", "stats"=>{"downloads"=>1, "page_views"=>40, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Average_values_of_the_percent_of_myogenic_clones_that_developed_from_single_cells_extracted_from_Gast_myofibers_/495714", "title"=>"Average values of the percent of myogenic clones that developed from single cells extracted from Gast myofibers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-12 01:35:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/825411"], "description"=>"<p>(A) Myofibers were ranked from low to high according to the total number of clones (myogenic and nonmyogenic) they gave rise-to. The y-axis represents the cumulative percentile of the analyzed myofibers. Each data point (triangle or square) represents the accumulating percent of myofibers (y axis) that contain the number of clones that is presented in the X axis in addition to all the myofibers that gave rise to lower numbers of clones. Gray broken line depicts the median (50%) value of clones per myofiber. (B) Each bar represents the percent of myofibers that gave rise to the number of myogenic clones, indicated in the X axis. Percent values for male and female rats are depicted as follows: open bard for young sedentary, black bars for young exercised, striped bars for old sedentary and gray bars for old exercised.</p>", "links"=>[], "tags"=>["clones", "myogenic", "recovered", "gast", "myofibers", "sedentary", "exercised"], "article_id"=>495772, "categories"=>["Cell Biology", "Physiology", "Medicine"], "users"=>["Gabi Shefer", "Gat Rauner", "Zipora Yablonka-Reuveni", "Dafna Benayahu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013307.g004", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantification_of_clones_total_and_myogenic_only_recovered_from_individual_Gast_myofibers_from_male_female_young_old_sedentary_and_exercised_rats_/495772", "title"=>"Quantification of clones (total and myogenic only) recovered from individual Gast myofibers from male, female, young, old sedentary and exercised rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-12 01:36:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/411051", "https://ndownloader.figshare.com/files/411076", "https://ndownloader.figshare.com/files/411098", "https://ndownloader.figshare.com/files/411117"], "description"=>"<div><h3>Background</h3><p>Muscle regeneration depends on satellite cells, myogenic stem cells that reside on the myofiber surface. Reduced numbers and/or decreased myogenic aptitude of these cells may impede proper maintenance and contribute to the age-associated decline in muscle mass and repair capacity. Endurance exercise was shown to improve muscle performance; however, the direct impact on satellite cells in aging was not yet thoroughly determined. Here, we focused on characterizing the effect of moderate-intensity endurance exercise on satellite cell, as possible means to attenuate adverse effects of aging. Young and old rats of both genders underwent 13 weeks of treadmill-running or remained sedentary.</p><h3>Methodology</h3><p>Gastrocnemius muscles were assessed for the effect of age, gender and exercise on satellite-cell numbers and myogenic capacity. Satellite cells were identified in freshly isolated myofibers based on Pax7 immunostaining (i.e., ex-vivo). The capacity of individual myofiber-associated cells to produce myogenic progeny was determined in clonal assays (in-vitro). We show an age-associated decrease in satellite-cell numbers and in the percent of myogenic clones in old sedentary rats. Upon exercise, there was an increase in myofibers that contain higher numbers of satellite cells in both young and old rats, and an increase in the percent of myogenic clones derived from old rats. Changes at the satellite cell level in old rats were accompanied with positive effects on the lean-to-fat Gast muscle composition and on spontaneous locomotion levels. The <b>significance</b> of these data is that they suggest that the endurance exercise-mediated boost in both satellite numbers and myogenic properties may improve myofiber maintenance in aging.</p></div>", "links"=>[], "tags"=>["reduced", "numbers", "myogenic", "aging", "alleviated", "endurance"], "article_id"=>141202, "categories"=>["Cell Biology", "Physiology", "Medicine"], "users"=>["Gabi Shefer", "Gat Rauner", "Zipora Yablonka-Reuveni", "Dafna Benayahu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0013307.s001", "https://dx.doi.org/10.1371/journal.pone.0013307.s002", "https://dx.doi.org/10.1371/journal.pone.0013307.s003", "https://dx.doi.org/10.1371/journal.pone.0013307.s004"], "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Reduced_Satellite_Cell_Numbers_and_Myogenic_Capacity_in_Aging_Can_Be_Alleviated_by_Endurance_Exercise/141202", "title"=>"Reduced Satellite Cell Numbers and Myogenic Capacity in Aging Can Be Alleviated by Endurance Exercise", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-10-12 00:20:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/825510"], "description"=>"1<p>The age of animals in the different groups at the beginning of the 13 week No-Run/Run experiment were: young male/female groups, 3.5 months; old male groups, 15–17 months; old female groups, 15 months.</p>2<p>a,b,c,d,e,f,g,h denote significant differences, based on Post-hoc comparisons (Fisher LSD), between the eight experimental groups as follows:</p><p><b><sup>a</sup></b>difference from the male young sedentary group,</p><p><b><sup>b</sup></b>difference from the male young exercised group,</p><p><b><sup>c</sup></b>difference from the male sedentary old group,</p><p><b><sup>d</sup></b>difference from the male exercised old group,</p><p><b><sup>e</sup></b>difference indicates difference from the female young sedentary group,</p><p><b><sup>f</sup></b>difference from the female young exercised group,</p><p><b><sup>g</sup></b>difference from the female sedentary old group,</p><p><b><sup>h</sup></b>difference from the female exercised old group.</p>", "links"=>[], "tags"=>["cells", "myofibers", "sedentary", "exercised", "males"], "article_id"=>495877, "categories"=>["Cell Biology", "Physiology", "Medicine"], "users"=>["Gabi Shefer", "Gat Rauner", "Zipora Yablonka-Reuveni", "Dafna Benayahu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013307.t001", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Descriptive_statistics_of_the_number_of_satellite_cells_in_individual_myofibers_in_young_sedentary_and_exercised_males_and_females_1_/495877", "title"=>"Descriptive statistics of the number of satellite cells in individual myofibers in young sedentary and exercised males and females.<sup>1</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-12 01:37:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/825184"], "description"=>"<p>(A) A Gast myofiber from a young exercised male rat depicting two Pax7<sup>+</sup> (red) satellite cells (A′); satellite cell nuclei (arrowhead) and myofiber nuclei counterstained with DAPI (blue; A). (B) Quantification of Pax7<sup>+</sup> satellite cells situated in Gast myofibers isolated from male female young old sedentary (black broken line) and exercised (gray line) rats. The number of myofibers, the minimum and maximum values of satellite cells per myofiber as well as the average number of satellite cells per myofiber for each group are detailed in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013307#pone-0013307-t001\" target=\"_blank\">Table 1</a>. Per each experimental group, myofibers were ranked according to the number of satellite cells they contained from low to high. The y-axis represents the cumulative percentile of the analyzed myofibers. Each data point (black triangle or gray square) displays the accumulating percent of myofibers (Y axis) that contain the specific range of Pax7<sup>+</sup> cells that is presented in the X axis plus all the myofibers with a lower number of satellite cells. Gray broken line depicts the median value of satellite cells per myofiber.</p>", "links"=>[], "tags"=>["localization"], "article_id"=>495553, "categories"=>["Cell Biology", "Physiology", "Medicine"], "users"=>["Gabi Shefer", "Gat Rauner", "Zipora Yablonka-Reuveni", "Dafna Benayahu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013307.g001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Satellite_cell_localization_and_quantification_/495553", "title"=>"Satellite cell localization and quantification.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-12 01:32:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/825268"], "description"=>"<p>The myogenic clones (A, A', B) are composed of round cells and myotubes (A), both of which express MyoD (red, A'), or just myotubes (B). The nonmyogenic clone depicted in panel C is composed of fibroblast-like cells that do not express MyoD (C').</p>", "links"=>[], "tags"=>["morphology", "skeletal", "myod", "myogenic", "nonmyogenic"], "article_id"=>495634, "categories"=>["Cell Biology", "Physiology", "Medicine"], "users"=>["Gabi Shefer", "Gat Rauner", "Zipora Yablonka-Reuveni", "Dafna Benayahu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0013307.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cell_morphology_and_expression_of_the_skeletal_muscle_specific_marker_MyoD_in_myogenic_and_nonmyogenic_clones_/495634", "title"=>"Cell morphology and expression of the skeletal muscle specific marker MyoD in myogenic and nonmyogenic clones.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-12 01:33:54"}

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