Down-Regulation of mir-424 Contributes to the Abnormal Angiogenesis via MEK1 and Cyclin E1 in Senile Hemangioma: Its Implications to Therapy
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: Its implications to therapy", "type"=>"journal", "authors"=>[{"first_name"=>"Taiji", "last_name"=>"Nakashima", "scopus_author_id"=>"37079420200"}, {"first_name"=>"Masatoshi", "last_name"=>"Jinnin", "scopus_author_id"=>"6701798015"}, {"first_name"=>"Tomomi", "last_name"=>"Etoh", "scopus_author_id"=>"37079180000"}, {"first_name"=>"Satoshi", "last_name"=>"Fukushima", "scopus_author_id"=>"7202543185"}, {"first_name"=>"Shinichi", "last_name"=>"Masuguchi", "scopus_author_id"=>"24399467700"}, {"first_name"=>"Keishi", "last_name"=>"Maruo", "scopus_author_id"=>"57190962055"}, {"first_name"=>"Yuji", "last_name"=>"Inoue", "scopus_author_id"=>"16063680200"}, {"first_name"=>"Tsuyoshi", "last_name"=>"Ishihara", "scopus_author_id"=>"55621449800"}, {"first_name"=>"Hironobu", "last_name"=>"Ihn", "scopus_author_id"=>"26642945900"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"361026052", "issn"=>"19326203", "isbn"=>"10.1371/journal.pone.0014334", "doi"=>"10.1371/journal.pone.0014334", "scopus"=>"2-s2.0-78650779471", "pmid"=>"21179471", "sgr"=>"78650779471"}, "id"=>"4d6a338b-7ee0-3f07-b304-5ab2c853f4e0", "abstract"=>"BACKGROUND: Senile hemangioma, so-called cherry angioma, is known as the most common vascular anomalies specifically seen in the aged skin. The pathogenesis of its abnormal angiogenesis is still unclear.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: In this study, we found that senile hemangioma consisted of clusters of proliferated small vascular channels in upper dermis, indicating that this tumor is categorized as a vascular tumor. We then investigated the mechanism of endothelial proliferation in senile hemangioma, focusing on microRNA (miRNA). miRNA PCR array analysis revealed the mir-424 level in senile hemangioma was lower than in other vascular anomalies. Protein expression of MEK1 and cyclin E1, the predicted target genes of mir-424, was increased in senile hemangioma compared to normal skin or other anomalies, but their mRNA levels were not. The inhibition of mir-424 in normal human dermal microvascular ECs (HDMECs) using specific inhibitor in vitro resulted in the increase of protein expression of MEK1 or cyclin E1, while mRNA levels were not affected by the inhibitor. Specific inhibitor of mir-424 also induced the cell proliferation of HDMECs significantly, while the cell number was decreased by the transfection of siRNA for MEK1 or cyclin E1.\\n\\nCONCLUSIONS/SIGNIFICANCE: Taken together, decreased mir-424 expression and increased levels of MEK1 or cyclin E1 in senile hemangioma may cause abnormal cell proliferation in the tumor. Senile hemangioma may be the good model for cutaneous angiogenesis. Investigation of senile hemangioma and the regulatory mechanisms of angiogenesis by miRNA in the aged skin may lead to new treatments using miRNA by the transfection into senile hemangioma.", "link"=>"http://www.mendeley.com/research/downregulation-mir424-contributes-abnormal-angiogenesis-via-mek1-cyclin-e1-senile-hemangioma-implica", "reader_count"=>31, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>9, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>2, "Other"=>2, "Student > Bachelor"=>1, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>9, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>2, "Other"=>2, "Student > Bachelor"=>1, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Materials Science"=>1, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>7, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>6}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Belgium"=>1}, "group_count"=>5}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/78650779471"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/78650779471?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78650779471&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=78650779471&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/78650779471", "dc:identifier"=>"SCOPUS_ID:78650779471", "eid"=>"2-s2.0-78650779471", "dc:title"=>"Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: Its implications to therapy", "dc:creator"=>"Nakashima T.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"5", "prism:issueIdentifier"=>"12", "prism:pageRange"=>nil, "prism:coverDate"=>"2010-12-01", "prism:coverDisplayDate"=>"2010", "prism:doi"=>"10.1371/journal.pone.0014334", "citedby-count"=>"79", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Kumamoto University", "affiliation-city"=>"Kumamoto", "affiliation-country"=>"Japan"}], "pubmed-id"=>"21179471", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e14334", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0014334", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"54", "xml_views"=>"4", "html_views"=>"167"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"62", "xml_views"=>"4", "html_views"=>"102"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"20", "xml_views"=>"4", "html_views"=>"43"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"5", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"30"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"23"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"28"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"24"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"81"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"42"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"28"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"26"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"3", "html_views"=>"6"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"4", "html_views"=>"4"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"8"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"9"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"0"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/812599"], "description"=>"<p>Panel (a) shows clinical pictures of senile hemangioma (SH), vascular malformation (VM), angiosarcoma (AS), venous lake (VL) and infantile hemangioma (IH). Panel (b) (magnification, ×10) and (c) (magnification, ×100) show hematoxylin-eosin staining of each anomalies. SH showed clusters of proliferated small vascular channels in upper dermis and dilated vessels in the deep dermis. AS consisted of diffuse proliferation of atypical ECs accompanied with irregular vessel-like spaces. Diffuse proliferation of tumor cells and dilated vessels were seen in IH. VM and VL were characterized by thin-walled, dilated vessels accompanied with thrombosis throughout the dermis.</p>", "links"=>[], "tags"=>["histological", "findings", "vascular"], "article_id"=>482944, "categories"=>["Developmental Biology", "Medicine"], "users"=>["Taiji Nakashima", "Masatoshi Jinnin", "Tomomi Etoh", "Satoshi Fukushima", "Shinichi Masuguchi", "Keishi Maruo", "Yuji Inoue", "Tsuyoshi Ishihara", "Hironobu Ihn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014334.g001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_presentation_and_histological_findings_of_vascular_anomalies_/482944", "title"=>"Clinical presentation and histological findings of vascular anomalies.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 21:50:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/812835"], "description"=>"<p>Box-and-whisker plots of mir-424 levels in normal skin (normal), senile hemangioma (SH), vascular malformation (VM) and angiosarcoma (AS) by real-time PCR. Boxes represent the interquartile ranges and the lines emanating from each box (the whiskers) extend to the smallest and largest observations in a group. Dotted bars show medians. The median transcript level in samples of normal skin was set at 100. * P<0.05 as compared with the values in normal skin, VM or AS.</p>", "links"=>[], "tags"=>["transcript", "mir-424", "senile"], "article_id"=>483194, "categories"=>["Developmental Biology", "Medicine"], "users"=>["Taiji Nakashima", "Masatoshi Jinnin", "Tomomi Etoh", "Satoshi Fukushima", "Shinichi Masuguchi", "Keishi Maruo", "Yuji Inoue", "Tsuyoshi Ishihara", "Hironobu Ihn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014334.g003", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_transcript_mir_424_level_in_senile_hemangioma_/483194", "title"=>"The transcript mir-424 level in senile hemangioma.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 21:51:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/812952"], "description"=>"<p>In situ detection of mir-424 in paraffin-embedded, formalin-fixed tissues of normal skin (a) and senile hemangioma (SH, b). Nucleus was counterstained with nuclear fast red (magnification, ×200). The immunoreactivity for mir-424 (blue) is indicated by arrows. Results are representative of 3 normal skins and 3 SH.</p>", "links"=>[], "tags"=>["immunoreactivity", "mir-424", "senile"], "article_id"=>483313, "categories"=>["Developmental Biology", "Medicine"], "users"=>["Taiji Nakashima", "Masatoshi Jinnin", "Tomomi Etoh", "Satoshi Fukushima", "Shinichi Masuguchi", "Keishi Maruo", "Yuji Inoue", "Tsuyoshi Ishihara", "Hironobu Ihn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014334.g004", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_immunoreactivity_for_mir_424_in_senile_hemangioma_/483313", "title"=>"The immunoreactivity for mir-424 in senile hemangioma.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 21:52:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/813274"], "description"=>"<p>(a, b) mir-424 inhibitor induces the protein expression of MEK1 and cyclin E1 but not mRNA expression in human dermal microvascular ECs. Cells were transfected with the control inhibitor or mir-424 inhibitor for 48 hours. (a) Relative amounts of transcripts (normalized with GAPDH) determined in total RNA with quantitative PCR. Error bars represent SD of +1. (b) Lysates from cells transfected with control or mir-424 inhibitor were subjected to immunoblotting with antibody for MEK1 or cyclin E1. The same membrane was then stripped and reprobed with anti β-actin antibody as a loading control. (c, d) mir-424/MEK1/cyclin E1 pathway altered the cell proliferation activity. (c) HDMECs at a density of 5×10<sup>3</sup> cells/well in 24-well culture plates were transfected with control inhibitor or inhibitors specific for mir-424 or mir-1. After 48 hours, the number of cells was counted with a Colter® Particle Counter (Beckman Coulter, Fullerton, CA) as described in ‘<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014334#s2\" target=\"_blank\">Materials and Methods</a>’. The value in the cells transfected with control inhibitor were set at 1. The mean and SD from 3 separate experiments are shown. * P<0.05 in comparison to the value in the cells transfected with control inhibitor. (d) HDMECs at a density of 1×10<sup>4</sup> cells/well in 24-well culture plates were transfected with control siRNA or siRNA specific for MEK1 or cyclin E1. After 72 hours, the cell number was counted as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014334#pone-0014334-g007\" target=\"_blank\">Fig. 7c</a>.</p>", "links"=>[], "tags"=>["mir-424", "mek1", "cyclin"], "article_id"=>483631, "categories"=>["Developmental Biology", "Medicine"], "users"=>["Taiji Nakashima", "Masatoshi Jinnin", "Tomomi Etoh", "Satoshi Fukushima", "Shinichi Masuguchi", "Keishi Maruo", "Yuji Inoue", "Tsuyoshi Ishihara", "Hironobu Ihn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014334.g007", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_association_of_mir_424_with_MEK1_or_cyclin_E1_/483631", "title"=>"The association of mir-424 with MEK1 or cyclin E1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 21:54:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/813053"], "description"=>"<p>Mean relative transcript levels of MEK1 (white bars) and cyclin E1 (black bars) in the tissues from normal skin (normal) or vascular anomalies such as senile hemangioma (SH), vascular malformation (VM), angiosarcoma (AS), venous lake (VL) and infantile hemangioma (IH) by real-time quantitative PCR. The transcript levels in normal skin were set at 1.</p>", "links"=>[], "tags"=>["transcript", "levels", "mek1", "cyclin", "e1", "senile"], "article_id"=>483408, "categories"=>["Developmental Biology", "Medicine"], "users"=>["Taiji Nakashima", "Masatoshi Jinnin", "Tomomi Etoh", "Satoshi Fukushima", "Shinichi Masuguchi", "Keishi Maruo", "Yuji Inoue", "Tsuyoshi Ishihara", "Hironobu Ihn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014334.g005", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_transcript_levels_of_MEK1_and_cyclin_E1_in_senile_hemangioma_/483408", "title"=>"The transcript levels of MEK1 and cyclin E1 in senile hemangioma.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 21:53:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/812720"], "description"=>"<p>(a) Mean relative transcript levels of HIF-1α, VEGFR1 or VEGFR2 (normalized to GAPDH) in tissues from 7 normal skin (normal) or vascular anomalies such as 7 senile hemangioma (SH), 3 vascular malformation (VM), 4 angiosarcoma (AS), 4 venous lake (VL) and 3 infantile hemangioma (IH) by real-time quantitative PCR. The transcript levels in samples of normal skin were set at 1. Error bars represent SD of +1. (b) The expression of α-smooth muscle actin (SMA) or type IV collagen (COL4) in the affected vessels of senile hemangioma (SH), vascular malformation (VM) and venous lake (VL). Paraffin sections were subjected to immunohistochemical analysis with antibodies against α-SMA or COL4 as described in ‘<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014334#s2\" target=\"_blank\">Materials and Methods</a>’. Results are representative of several cases.</p>", "links"=>[], "tags"=>["angiogenic", "factors"], "article_id"=>483086, "categories"=>["Developmental Biology", "Medicine"], "users"=>["Taiji Nakashima", "Masatoshi Jinnin", "Tomomi Etoh", "Satoshi Fukushima", "Shinichi Masuguchi", "Keishi Maruo", "Yuji Inoue", "Tsuyoshi Ishihara", "Hironobu Ihn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014334.g002", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_expression_of_angiogenic_factors_or_the_structure_of_vessels_/483086", "title"=>"The expression of angiogenic factors or the structure of vessels.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 21:51:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/813157"], "description"=>"<p>Increased expression of MEK1 (a) or cyclin E1 (b) in ECs of senile hemangioma. Sections of normal skin or vascular anomalies were stained with antibodies against MEK1 or cyclin E1 (green) and CD34 (red). SH; senile hemangioma, VM; vascular malformation.</p>", "links"=>[], "tags"=>["immunoreactivity", "mek1", "cyclin", "e1", "senile"], "article_id"=>483516, "categories"=>["Developmental Biology", "Medicine"], "users"=>["Taiji Nakashima", "Masatoshi Jinnin", "Tomomi Etoh", "Satoshi Fukushima", "Shinichi Masuguchi", "Keishi Maruo", "Yuji Inoue", "Tsuyoshi Ishihara", "Hironobu Ihn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014334.g006", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_immunoreactivity_for_MEK1_and_cyclin_E1_in_senile_hemangioma_/483516", "title"=>"The immunoreactivity for MEK1 and cyclin E1 in senile hemangioma.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 21:53:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/813429"], "description"=>"<p>A mixture of equal amounts of miRNAs from 3 senile hemangioma, 3 venous malformation or 3 angiosarcoma were prepared, and miRNA expression profile in each tumor in vivo was evaluated using RT<sup>2</sup> Profiler PCR Array. The raw threshold cycle (Ct) was normalized using the values of small RNA housekeeping genes. ΔΔCt (the raw Ct of each miRNA – Ct of small RNA housekeeping genes) were shown.</p>", "links"=>[], "tags"=>["profiles", "mirnas", "pcr"], "article_id"=>483786, "categories"=>["Developmental Biology", "Medicine"], "users"=>["Taiji Nakashima", "Masatoshi Jinnin", "Tomomi Etoh", "Satoshi Fukushima", "Shinichi Masuguchi", "Keishi Maruo", "Yuji Inoue", "Tsuyoshi Ishihara", "Hironobu Ihn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014334.t002", "stats"=>{"downloads"=>6, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_expression_profiles_of_miRNAs_as_measured_with_the_PCR_array_/483786", "title"=>"The expression profiles of miRNAs as measured with the PCR array.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 21:55:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/813380"], "description"=>"<p>Sample No.5 and No.6 of senile hemangioma were obtained from same patient.</p>", "links"=>[], "tags"=>["ages", "patients", "resection"], "article_id"=>483740, "categories"=>["Developmental Biology", "Medicine"], "users"=>["Taiji Nakashima", "Masatoshi Jinnin", "Tomomi Etoh", "Satoshi Fukushima", "Shinichi Masuguchi", "Keishi Maruo", "Yuji Inoue", "Tsuyoshi Ishihara", "Hironobu Ihn"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014334.t001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_data_ages_of_patients_at_the_time_of_resection_and_location_of_the_lesions_/483740", "title"=>"Clinical data: ages of patients at the time of resection and location of the lesions.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 21:54:49"}

PMC Usage Stats | Further Information

  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"16", "year"=>"2010", "pdf"=>"21", "unique-ip"=>"20", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"90", "unique-ip"=>"92", "pdf"=>"77", "year"=>"2011", "figure"=>"26", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"44", "year"=>"2011", "pdf"=>"26", "unique-ip"=>"43", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"6", "full-text"=>"48", "unique-ip"=>"47", "pdf"=>"18", "year"=>"2011", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"36", "year"=>"2011", "pdf"=>"19", "unique-ip"=>"36", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"50", "unique-ip"=>"46", "pdf"=>"19", "year"=>"2011", "figure"=>"23", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"17", "year"=>"2011", "pdf"=>"18", "unique-ip"=>"21", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"34", "unique-ip"=>"33", "pdf"=>"26", "year"=>"2011", "figure"=>"16", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"18", "year"=>"2011", "pdf"=>"6", "unique-ip"=>"16", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"33", "unique-ip"=>"35", "pdf"=>"20", "year"=>"2011", "figure"=>"20", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"34", "year"=>"2011", "pdf"=>"15", "unique-ip"=>"31", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"39", "unique-ip"=>"33", "pdf"=>"25", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"18", "year"=>"2011", "pdf"=>"11", "unique-ip"=>"16", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"39", "unique-ip"=>"31", "pdf"=>"18", "year"=>"2012", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"22", "year"=>"2012", "pdf"=>"16", "unique-ip"=>"22", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"41", "unique-ip"=>"38", "pdf"=>"11", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"28", "year"=>"2012", "pdf"=>"11", "unique-ip"=>"25", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"35", "unique-ip"=>"32", "pdf"=>"11", "year"=>"2012", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"21", "year"=>"2012", "pdf"=>"6", "unique-ip"=>"19", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"33", "full-text"=>"41", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"26", "full-text"=>"27", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"24", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"29", "full-text"=>"32", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"29", "full-text"=>"23", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"26", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"25", "full-text"=>"25", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"23", "full-text"=>"27", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"28", "full-text"=>"27", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"25", "full-text"=>"24", "pdf"=>"2", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"133", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"12", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"26", "full-text"=>"23", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"21", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"22", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"28", "full-text"=>"27", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"19", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2010-01-01T00:00:00Z", "end_date"=>"2010-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[276, 544, 702, 826, 936, 1045, 1140, 1222, 1305, 1377, 1453, 1528, 1584, 1661, 1725, 1783, 1848, 1913, 1977, 2038, 2103, 2158, 2223, 2290, 2346, 2406, 2467, 2529, 2588, 2652, 2722, 2779, 2835, 2892, 2943, 2999]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[265, 560, 722, 863, 978, 1083, 1172, 1261, 1345, 1428, 1488, 1559, 1630, 1701, 1764, 1840, 1899, 1965, 2028, 2088, 2150, 2211, 2270, 2348, 2410, 2461, 2531, 2598, 2645, 2719, 2793, 2870, 2923, 2974, 3020, 3080, 3142, 3198, 3259, 3351, 3418, 3471, 3527, 3581, 3637, 3706, 3761, 3817, 3872]}, {"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[286, 573, 735, 872, 989, 1096, 1185, 1277, 1365, 1449, 1520, 1597, 1668, 1729, 1799, 1852, 1917, 1984, 2054, 2108, 2169, 2234, 2303, 2374, 2436, 2501, 2560, 2620, 2683, 2742, 2830, 2909, 2981, 3032, 3089, 3148, 3210, 3266, 3323, 3379, 3448, 3512, 3576, 3635, 3693, 3747, 3827, 3876, 3938]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[275, 545, 699, 818, 931, 1035, 1128, 1212, 1291, 1366, 1439, 1514, 1580, 1649, 1708, 1765, 1826, 1877, 1940, 2009, 2076, 2150, 2215, 2266, 2335, 2395, 2459, 2521, 2596, 2669, 2724, 2787, 2840, 2890, 2961, 3025, 3081, 3142, 3195, 3261, 3314, 3377, 3442, 3491, 3538, 3583, 3649, 3699, 3747]}, {"subject_area"=>"/Earth sciences", "average_usage"=>[353, 610, 749, 873, 979, 1064, 1156, 1243, 1309, 1390, 1466, 1529, 1615, 1684, 1765, 1841, 1915, 1988, 2056, 2112, 2171, 2241, 2314, 2416, 2481, 2545, 2602, 2678, 2767, 2836, 2911, 3003, 3087, 3166, 3239, 3327, 3390, 3486, 3549, 3646, 3712, 3776, 3836, 3917, 4008, 4093, 4204, 4288, 4382]}, {"subject_area"=>"/Ecology and environmental sciences/Aquatic environments", "average_usage"=>[385, 606, 793, 992, 1202, 1299, 1393, 1464, 1546, 1616, 1698, 1787, 1902, 1977, 2063, 2174, 2202, 2258, 2356, 2412, 2455, 2498, 2548, 2612, 2671, 2719, 2795, 2867, 2926, 3027, 3161, 3271, 3360, 3469, 3597, 3723, 3863, 3990, 4049, 4102, 4159, 4247, 4344, 4406, 4476, 4558, 4605, 4674, 4760]}, {"subject_area"=>"/Ecology and environmental sciences/Ecological environments", "average_usage"=>[338, 603, 721, 822, 923, 1012, 1074, 1152, 1248, 1331, 1386, 1454, 1515, 1577, 1627, 1674, 1733, 1787, 1868, 1974, 2063, 2137, 2196, 2238, 2289, 2355, 2455, 2504, 2603, 2685, 2745, 2800, 2898, 2955, 3047, 3125, 3188]}, {"subject_area"=>"/Medicine and health sciences/Oncology", "average_usage"=>[266, 580, 762, 935, 1085, 1218, 1336, 1459, 1581, 1680, 1759, 1835, 1914, 1994, 2067, 2144, 2213, 2278, 2341, 2423, 2496, 2581, 2672, 2768, 2836, 2898, 2978, 3068, 3137, 3218, 3284, 3351, 3420, 3465, 3549, 3629, 3696, 3756, 3819, 3875, 3938, 3985, 4038, 4103, 4177, 4246, 4321, 4382, 4449]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[279, 551, 699, 817, 930, 1027, 1124, 1209, 1287, 1362, 1438, 1512, 1582, 1650, 1717, 1772, 1831, 1888, 1948, 2002, 2070, 2138, 2203, 2267, 2331, 2395, 2467, 2523, 2592, 2656, 2718, 2785, 2839, 2892, 2960, 3034, 3087, 3144, 3194, 3254, 3313, 3373, 3446, 3496, 3551, 3607, 3660, 3712, 3773]}]}
Loading … Spinner
There are currently no alerts