Grifonin-1: A Small HIV-1 Entry Inhibitor Derived from the Algal Lectin, Griffithsin
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{"title"=>"Grifonin-1: A small HIV-1 entry inhibitor derived from the algal lectin, griffithsin", "type"=>"journal", "authors"=>[{"first_name"=>"Ewa D.", "last_name"=>"Micewicz", "scopus_author_id"=>"23989255600"}, {"first_name"=>"Amy L.", "last_name"=>"Cole", "scopus_author_id"=>"9632539200"}, {"first_name"=>"Chun Ling", "last_name"=>"Jung", "scopus_author_id"=>"24068981700"}, {"first_name"=>"Hai", "last_name"=>"Luong", "scopus_author_id"=>"35074498800"}, {"first_name"=>"Martin L.", "last_name"=>"Phillips", "scopus_author_id"=>"7402770386"}, {"first_name"=>"Pratikhya", "last_name"=>"Pratikhya", "scopus_author_id"=>"36814389600"}, {"first_name"=>"Shantanu", "last_name"=>"Sharma", "scopus_author_id"=>"24779074100"}, {"first_name"=>"Alan J.", "last_name"=>"Waring", "scopus_author_id"=>"35499797400"}, {"first_name"=>"Alexander M.", "last_name"=>"Cole", "scopus_author_id"=>"7201573811"}, {"first_name"=>"Piotr", "last_name"=>"Ruchala", "scopus_author_id"=>"6603056503"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"21179548", "sgr"=>"78650733043", "doi"=>"10.1371/journal.pone.0014360", "scopus"=>"2-s2.0-78650733043", "pui"=>"361019974", "issn"=>"19326203"}, "id"=>"99ea95aa-fa10-3f71-8e06-5764bc0e2c54", "abstract"=>"Griffithsin, a 121-residue protein isolated from a red algal Griffithsia sp., binds high mannose N-linked glycans of virus surface glycoproteins with extremely high affinity, a property that allows it to prevent the entry of primary isolates and laboratory strains of T- and M-tropic HIV-1. We used the sequence of a portion of griffithsin's sequence as a design template to create smaller peptides with antiviral and carbohydrate-binding properties.", "link"=>"http://www.mendeley.com/research/grifonin1-small-hiv1-entry-inhibitor-derived-algal-lectin-griffithsin", "reader_count"=>17, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Agricultural and Biological Sciences"=>11, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>2}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Unspecified"=>{"Unspecified"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"India"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/812012"], "description"=>"<p>Binding to: (A) gp120<sub>LAV</sub>, (B) gp120<sub>BAL</sub>, (C) gp41 and (D) GRFN-1 (self-association). K<sub>D</sub>±SEM values were calculated as an average from at least 5 independent experiments.</p>", "links"=>[], "tags"=>["grfn-1", "viral"], "article_id"=>482369, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.g005", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Binding_of_GRFN_1_to_viral_glycoproteins_/482369", "title"=>"Binding of GRFN-1 to viral glycoproteins.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-16 00:39:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/812655"], "description"=>"<p>All depicted carbohydrates were used in SPR competition studies. Critical hydroxymethyl moiety is in red and methyl group in position 5 of fucose is in blue.</p>", "links"=>[], "tags"=>["components", "n-linked"], "article_id"=>483018, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.g013", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Monomeric_components_of_N_linked_glycans_/483018", "title"=>"Monomeric components of N-linked glycans.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-16 00:50:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/812722"], "description"=>"<p>Cysteins forming intra-molecular disulfide bonds are bolded. <i>Cha-(L)-Cyclohexyl-alanine, Chg-(L)-Cyclohexyl-glycine, (D)Cys-(D)-Cysteine.</i></p>", "links"=>[], "tags"=>["grifonins"], "article_id"=>483085, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.t001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sequences_of_Grifonins_GRFNs_/483085", "title"=>"Sequences of Grifonins (GRFNs).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-16 00:51:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/405048"], "description"=>"<div><h3>Background</h3><p>Griffithsin, a 121-residue protein isolated from a red algal <em>Griffithsia sp.</em>, binds high mannose N-linked glycans of virus surface glycoproteins with extremely high affinity, a property that allows it to prevent the entry of primary isolates and laboratory strains of T- and M-tropic HIV-1. We used the sequence of a portion of griffithsin's sequence as a design template to create smaller peptides with antiviral and carbohydrate-binding properties.</p><h3>Methodology/Results</h3><p>The new peptides derived from a trio of homologous β-sheet repeats that comprise the motifs responsible for its biological activity. Our most active antiviral peptide, grifonin-1 (GRFN-1), had an EC<sub>50</sub> of 190.8±11.0 nM in <em>in vitro</em> TZM-bl assays and an EC<sub>50</sub> of 546.6±66.1 nM in <em>p24<sup>gag</sup></em> antigen release assays. GRFN-1 showed considerable structural plasticity, assuming different conformations in solvents that differed in polarity and hydrophobicity. Higher concentrations of GRFN-1 formed oligomers, based on intermolecular β-sheet interactions. Like its parent protein, GRFN-1 bound viral glycoproteins gp41 and gp120 <em>via</em> the N-linked glycans on their surface.</p><h3>Conclusion</h3><p>Its substantial antiviral activity and low toxicity <em>in vitro</em> suggest that GRFN-1 and/or its derivatives may have therapeutic potential as topical and/or systemic agents directed against HIV-1.</p></div>", "links"=>[], "tags"=>["hiv-1", "inhibitor", "derived", "algal", "griffithsin"], "article_id"=>140046, "categories"=>["Biochemistry", "Medicine", "Cancer", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Grifonin_1_A_Small_HIV_1_Entry_Inhibitor_Derived_from_the_Algal_Lectin_Griffithsin/140046", "title"=>"Grifonin-1: A Small HIV-1 Entry Inhibitor Derived from the Algal Lectin, Griffithsin", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-16 00:00:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/812799"], "description"=>"<p>Hemolytic effect of GRFN-1 on human red blood cells (hRBCs).</p>", "links"=>[], "tags"=>["grfn-1", "cells"], "article_id"=>483160, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.t003", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hemolytic_effect_of_GRFN_1_on_human_red_blood_cells_hRBCs_/483160", "title"=>"Hemolytic effect of GRFN-1 on human red blood cells (hRBCs).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-16 00:52:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/811641"], "description"=>"<p>Position of the unknown amino acid X<sup>31</sup> (shaded) is occupied by Ala in the expressed variant of the protein.</p>", "links"=>[], "tags"=>["griffithsin", "repeats"], "article_id"=>482002, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sequence_of_the_griffithsin_and_comparison_of_the_functional_repeats_boxed_in_its_structure_/482002", "title"=>"Sequence of the griffithsin and comparison of the functional repeats (boxed) in its structure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-16 00:33:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/812610"], "description"=>"<p>(A) residues 18–35 of griffithsin in blue (PDB 2GTY), (B) structure of GRFN-1 in red and their overlay (C). Structure of GRFN-1 was obtained from molecular dynamics simulation in water for 50 ns.</p>", "links"=>[], "tags"=>["grfn-1", "corresponding", "griffithsin"], "article_id"=>482968, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.g012", "stats"=>{"downloads"=>2, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_GRFN_1_and_corresponding_griffithsin_fragment_structures_/482968", "title"=>"Comparison of GRFN-1 and corresponding griffithsin fragment structures.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-16 00:49:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/811722"], "description"=>"<p>Panel A: Dimer of griffithsin (PDB entry code 2GTY, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014360#pone.0014360-Ziolkowska1\" target=\"_blank\">[23]</a>). Fragments corresponding to GRFN-1/2 and GRFN-3 are in red and in blue respectively. Remaining homological domain necessary to form core of the griffithsin's monomer is in green. Panel B: Core of griffithsin. Residues Tyr<sup>28</sup>, Tyr<sup>68</sup> and Tyr<sup>110</sup>, which are components of monosaccharides' binding domain, are in magenta.</p>", "links"=>[], "tags"=>["chemical biology/small molecule chemistry", "chemistry/organic chemistry", "virology/antivirals, including modes of action and resistance", "virology/new therapies, including antivirals and immunotherapy", "infectious diseases/hiv infection and aids"], "article_id"=>482073, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_structure_of_griffithsin_/482073", "title"=>"The structure of griffithsin.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-16 00:34:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/811912"], "description"=>"<p>Panel A: Comparison of dose response experiments of GRFNs in TZM-bl assay. Panel B: Comparison of dose response experiments of GRFN-1 in TZM-bl assay (EC<sub>50</sub> = 190.8±11.0 nM) and <i>p24<sup>gag</sup></i> antigen release assay (EC<sub>50</sub> = 546.6±66.1 nM) with RC-101 in TZM-bl assay (EC<sub>50</sub> = 3404.0±91 nM). RC-101 is a θ-defensin which is currently being developed as topical microbicide. Panel C: Antiviral activity of griffithsin (GRFT) in TZM-bl assay (EC<sub>50</sub> = 19.6±1.9 pM). Panel D: Comparison of antiviral activity of GRFT and GRFN-1 in <i>p24<sup>gag</sup></i> antigen release assay using PBMCs and CXCR4 (HIV-1<sub>IIIB</sub>) and CCR5 (HIV-1<sub>BAL</sub>) strains.</p>", "links"=>[], "tags"=>["chemical biology/small molecule chemistry", "chemistry/organic chemistry", "virology/antivirals, including modes of action and resistance", "virology/new therapies, including antivirals and immunotherapy", "infectious diseases/hiv infection and aids"], "article_id"=>482268, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.g004", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antiviral_activity_of_GRFNs_/482268", "title"=>"Antiviral activity of GRFNs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-16 00:37:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/812907"], "description"=>"<p>*peptides in 10 mM phosphate buffer pH = 6.5, TFE:10 mM phosphate buffer pH = 6.5 (4∶6, v∶v) or HFIP:10 mM phosphate buffer pH = 6.5 (4∶6, v∶v) were analyzed for secondary conformation based on secondary structural analysis using Selcon (Methods).</p>", "links"=>[], "tags"=>["elements", "grfn-1", "peptide", "aqueous", "tfe-buffer", "hfip-buffer", "circular", "dichroic", "spectroscopic"], "article_id"=>483258, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.t005", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Proportions_of_different_elements_of_secondary_structure_for_GRFN_1_peptide_in_aqueous_buffer_TFE_buffer_and_HFIP_buffer_based_on_Circular_Dichroic_spectroscopic_analysis_/483258", "title"=>"Proportions of different elements of secondary structure for GRFN-1 peptide in aqueous buffer, TFE-buffer and HFIP-buffer based on Circular Dichroic spectroscopic analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-16 00:54:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/812173"], "description"=>"<p>(A)- galactose, (B) Man<sub>3</sub>GlcNAc<sub>2</sub> (“core pentasaccharide”).</p>", "links"=>[], "tags"=>["spr", "experiments", "grfn-1"], "article_id"=>482527, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.g006", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Examples_of_SPR_competition_experiments_of_GRFN_1_with_saccharide_s_using_gp120_LAV_chip_/482527", "title"=>"Examples of SPR competition experiments of GRFN-1 with saccharide(s) using gp120<sub>LAV</sub> chip.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-16 00:42:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/812755"], "description"=>"<p>R<sub>T</sub>- retention time.</p>", "links"=>[], "tags"=>["grfn"], "article_id"=>483115, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.t002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analytical_data_of_GRFN_peptides_/483115", "title"=>"Analytical data of GRFN peptides.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-16 00:51:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/812946"], "description"=>"<p>Analytical ultracentrifugation results.</p>", "links"=>[], "tags"=>["ultracentrifugation"], "article_id"=>483309, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.t006", "stats"=>{"downloads"=>3, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analytical_ultracentrifugation_results_/483309", "title"=>"Analytical ultracentrifugation results.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-16 00:55:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/812251"], "description"=>"<p>Stability of human RBCs in the presence of various concentrations of GRFN-1.</p>", "links"=>[], "tags"=>["rbcs", "concentrations"], "article_id"=>482606, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.g007", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Stability_of_human_RBCs_in_the_presence_of_various_concentrations_of_GRFN_1_/482606", "title"=>"Stability of human RBCs in the presence of various concentrations of GRFN-1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-16 00:43:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/812391"], "description"=>"<p>Inhibition of cell metabolism by various concentrations of GRFN-1 (MTT assay) determined in primary vaginal epithelial cells (VEC), human peripheral blood mononuclear cells (PBMC) and PM1 cells (continuously CD4+ T-cell line, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014360#pone.0014360-Lusso1\" target=\"_blank\">[<b>52</b>]</a>).</p>", "links"=>[], "tags"=>["metabolism", "concentrations", "grfn-1", "vaginal", "epithelial", "cells", "peripheral", "mononuclear", "pm1", "t-cell"], "article_id"=>482737, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.g009", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Inhibition_of_cell_metabolism_by_various_concentrations_of_GRFN_1_MTT_assay_determined_in_primary_vaginal_epithelial_cells_VEC_human_peripheral_blood_mononuclear_cells_PBMC_and_PM1_cells_continuously_CD4_T_cell_line_52_/482737", "title"=>"Inhibition of cell metabolism by various concentrations of GRFN-1 (MTT assay) determined in primary vaginal epithelial cells (VEC), human peripheral blood mononuclear cells (PBMC) and PM1 cells (continuously CD4+ T-cell line, [<b>52</b>]).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-16 00:45:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/812319"], "description"=>"<p>Viability (blue) and % of cell metabolism inhibition (red) of TZM-bl cells in the presence of various concentrations of GRFN-1.</p>", "links"=>[], "tags"=>["metabolism", "inhibition", "tzm-bl", "cells", "concentrations"], "article_id"=>482674, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.g008", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Viability_blue_and_of_cell_metabolism_inhibition_red_of_TZM_bl_cells_in_the_presence_of_various_concentrations_of_GRFN_1_/482674", "title"=>"Viability (blue) and % of cell metabolism inhibition (red) of TZM-bl cells in the presence of various concentrations of GRFN-1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-16 00:44:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/812447"], "description"=>"<p>(A) FTIR spectra; (B) CD spectra in in 10 mM phosphate buffer, pH = 6.5 ((---) 0.25 mM; (─) 0.5 mM); (C) CD spectra in TFE:10 mM phosphate buffer pH = 6.5 (4∶6, v∶v) and HFIP (---); 10 mM phosphate buffer pH = 6.5 (4∶6, v∶v) (─).</p>", "links"=>[], "tags"=>["grfn-1"], "article_id"=>482810, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.g010", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analysis_of_GRFN_1_structure_/482810", "title"=>"Analysis of GRFN-1 structure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-16 00:46:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/811816"], "description"=>"<p>(A) analytical HPLC profile and (B) MS spectra.</p>", "links"=>[], "tags"=>["chemical biology/small molecule chemistry", "chemistry/organic chemistry", "virology/antivirals, including modes of action and resistance", "virology/new therapies, including antivirals and immunotherapy", "infectious diseases/hiv infection and aids"], "article_id"=>482173, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analytical_data_for_GRFN_1_/482173", "title"=>"Analytical data for GRFN-1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-16 00:36:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/812525"], "description"=>"<p>Evolution of GRFN-1 secondary structure as a function of simulation time in aqueous periodic solvent box.</p>", "links"=>[], "tags"=>["grfn-1", "simulation", "aqueous", "periodic", "solvent"], "article_id"=>482879, "categories"=>["Biochemistry", "Medicine", "Virology", "Chemistry"], "users"=>["Ewa D. Micewicz", "Amy L. Cole", "Chun-Ling Jung", "Hai Luong", "Martin L. Phillips", "Pratikhya Pratikhya", "Shantanu Sharma", "Alan J. Waring", "Alexander M. Cole", "Piotr Ruchala"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014360.g011", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Evolution_of_GRFN_1_secondary_structure_as_a_function_of_simulation_time_in_aqueous_periodic_solvent_box_/482879", "title"=>"Evolution of GRFN-1 secondary structure as a function of simulation time in aqueous periodic solvent box.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-16 00:47:59"}

PMC Usage Stats | Further Information

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  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"32", "unique-ip"=>"42", "pdf"=>"38", "year"=>"2011", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"18", "year"=>"2011", "pdf"=>"15", "unique-ip"=>"21", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"12", "unique-ip"=>"18", "pdf"=>"6", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"14", "year"=>"2011", "pdf"=>"28", "unique-ip"=>"16", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"8", "pdf"=>"25", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"9", "year"=>"2011", "pdf"=>"7", "unique-ip"=>"13", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "unique-ip"=>"8", "pdf"=>"6", "year"=>"2011", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2011", "pdf"=>"4", "unique-ip"=>"10", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"5", "pdf"=>"4", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2011", "pdf"=>"5", "unique-ip"=>"7", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "unique-ip"=>"9", "pdf"=>"1", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"8", "year"=>"2011", "pdf"=>"8", "unique-ip"=>"11", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "unique-ip"=>"15", "pdf"=>"10", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"9", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"14", "unique-ip"=>"15", "pdf"=>"7", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2012", "pdf"=>"6", "unique-ip"=>"8", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"5", "unique-ip"=>"7", "pdf"=>"6", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"2", "year"=>"2012", "pdf"=>"0", "unique-ip"=>"3", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"27", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"17", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"22", "full-text"=>"61", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
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Relative Metric

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