The NOD2 Single Nucleotide Polymorphisms rs2066843 and rs2076756 Are Novel and Common Crohn's Disease Susceptibility Gene Variants
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common crohn's disease susceptibility gene variants", "type"=>"journal", "authors"=>[{"first_name"=>"Jürgen", "last_name"=>"Glas", "scopus_author_id"=>"7004217999"}, {"first_name"=>"Julia", "last_name"=>"Seiderer", "scopus_author_id"=>"8267365800"}, {"first_name"=>"Cornelia", "last_name"=>"Tillack", "scopus_author_id"=>"12775838900"}, {"first_name"=>"Simone", "last_name"=>"Pfennig", "scopus_author_id"=>"12774861800"}, {"first_name"=>"Florian", "last_name"=>"Beigel", "scopus_author_id"=>"8930101600"}, {"first_name"=>"Matthias", "last_name"=>"Jürgens", "scopus_author_id"=>"23111087200"}, {"first_name"=>"Torsten", "last_name"=>"Olszak", "scopus_author_id"=>"8635944600"}, {"first_name"=>"Rüdiger P.", "last_name"=>"Laubender", "scopus_author_id"=>"31767520800"}, {"first_name"=>"Maria", "last_name"=>"Weidinger", "scopus_author_id"=>"6701856611"}, {"first_name"=>"Bertram", "last_name"=>"Müller-Myhsok", "scopus_author_id"=>"56234961000"}, {"first_name"=>"Burkhard", "last_name"=>"Göke", "scopus_author_id"=>"35417480400"}, {"first_name"=>"Thomas", "last_name"=>"Ochsenkühn", "scopus_author_id"=>"6701539995"}, {"first_name"=>"Peter", "last_name"=>"Lohse", "scopus_author_id"=>"7006050789"}, {"first_name"=>"Julia", "last_name"=>"Diegelmann", "scopus_author_id"=>"23570525100"}, {"first_name"=>"Darina", "last_name"=>"Czamara", "scopus_author_id"=>"36625216100"}, {"first_name"=>"Stephan", "last_name"=>"Brand", "scopus_author_id"=>"7102840140"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-78651239059", "pmid"=>"21209938", "doi"=>"10.1371/journal.pone.0014466", "pui"=>"361077774", "isbn"=>"1932-6203", "sgr"=>"78651239059"}, "id"=>"cc251678-5848-3f53-b179-e03b60131877", "abstract"=>"BACKGROUND: The aims were to analyze two novel NOD2 variants (rs2066843 and rs2076756) in a large cohort of patients with inflammatory bowel disease and to elucidate phenotypic consequences.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: Genomic DNA from 2700 Caucasians including 812 patients with Crohn's disease (CD), 442 patients with ulcerative colitis (UC), and 1446 healthy controls was analyzed for the NOD2 SNPs rs2066843 and rs2076756 and the three main CD-associated NOD2 variants p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847). Haplotype and genotype-phenotype analyses were performed. The SNPs rs2066843 (p = 3.01×10(-5), OR 1.48, [95% CI 1.23-1.78]) and rs2076756 (p = 4.01×10(-6); OR 1.54, [95% CI 1.28-1.86]) were significantly associated with CD but not with UC susceptibility. Haplotype analysis revealed a number of significant associations with CD susceptibility with omnibus p values <10(-10). The SNPs rs2066843 and rs2076756 were in linkage disequilibrium with each other and with the three main CD-associated NOD2 mutations (D'>0.9). However, in CD, SNPs rs2066843 and rs2076756 were more frequently observed than the other three common NOD2 mutations (minor allele frequencies for rs2066843 and rs2076756: 0.390 and 0.380, respectively). In CD patients homozygous for these novel NOD2 variants, genotype-phenotype analysis revealed higher rates of a penetrating phenotype (rs2076756: p = 0.015) and fistulas (rs2076756: p = 0.015) and significant associations with CD-related surgery (rs2076756: p = 0.003; rs2066843: p = 0.015). However, in multivariate analysis only disease localization (p<2×10(-16)) and behaviour (p = 0.02) were significantly associated with the need for surgery.\\n\\nCONCLUSION/SIGNIFICANCE: The NOD2 variants rs2066843 and rs2076756 are novel and common CD susceptibility gene variants.", "link"=>"http://www.mendeley.com/research/nod2-single-nucleotide-polymorphisms-rs2066843-rs2076756-novel-common-crohns-disease-susceptibility", "reader_count"=>24, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>9, "Chemistry"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Chemistry"=>{"Chemistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>2}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/78651239059"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/78651239059?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78651239059&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=78651239059&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/78651239059", "dc:identifier"=>"SCOPUS_ID:78651239059", "eid"=>"2-s2.0-78651239059", "dc:title"=>"The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common crohn's disease susceptibility gene variants", "dc:creator"=>"Glas J.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"5", "prism:issueIdentifier"=>"12", "prism:pageRange"=>nil, "prism:coverDate"=>"2010-12-01", "prism:coverDisplayDate"=>"2010", "prism:doi"=>"10.1371/journal.pone.0014466", "citedby-count"=>"24", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Ludwig-Maximilians-Universität München", "affiliation-city"=>"Munich", "affiliation-country"=>"Germany"}, {"@_fa"=>"true", "affilname"=>"Rheinisch-Westfälische Technische Hochschule Aachen", "affiliation-city"=>"Aachen", "affiliation-country"=>"Germany"}], "pubmed-id"=>"21209938", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e14466", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0014466", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"61", "xml_views"=>"8", "html_views"=>"176"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"4", "html_views"=>"32"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"15"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"5", "html_views"=>"15"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"43"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"30"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"48"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"52"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"19"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"45"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"6"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/808610"], "description"=>"2<p>Immunosuppressive agents included azathioprine, 6-mercaptopurine, 6-thioguanine, methotrexate, and/or infliximab.</p>3<p>Only surgery related to CD-specific problems (e.g. fistulectomy, colectomy, ileostomy) was included. For each variable, the number of patients included is given.</p>", "links"=>[], "tags"=>["rs2066843", "genotype", "cd"], "article_id"=>478956, "categories"=>["Immunology", "Genetics", "Chemistry", "Medicine"], "users"=>["Jürgen Glas", "Julia Seiderer", "Cornelia Tillack", "Simone Pfennig", "Florian Beigel", "Matthias Jürgens", "Torsten Olszak", "Rüdiger P. Laubender", "Maria Weidinger", "Bertram Müller-Myhsok", "Burkhard Göke", "Thomas Ochsenkühn", "Peter Lohse", "Julia Diegelmann", "Darina Czamara", "Stephan Brand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014466.t005", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_rs2066843_genotype_and_CD_disease_characteristics_/478956", "title"=>"Association between rs2066843 genotype and CD disease characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:29:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/808789"], "description"=>"<p>Minor allele frequencies (MAF), allelic test <i>P</i>-values, and odds ratios (OR, shown for the minor allele) with 95% confidence intervals (CI) are depicted for both the CD and UC case-control cohorts.</p>", "links"=>[], "tags"=>["frequencies", "snps", "rs2066843", "rs2076756", "patients", "ulcerative", "colitis"], "article_id"=>479130, "categories"=>["Immunology", "Genetics", "Chemistry", "Medicine"], "users"=>["Jürgen Glas", "Julia Seiderer", "Cornelia Tillack", "Simone Pfennig", "Florian Beigel", "Matthias Jürgens", "Torsten Olszak", "Rüdiger P. Laubender", "Maria Weidinger", "Bertram Müller-Myhsok", "Burkhard Göke", "Thomas Ochsenkühn", "Peter Lohse", "Julia Diegelmann", "Darina Czamara", "Stephan Brand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014466.t002", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Allele_frequencies_of_the_SNPs_rs2066843_and_rs2076756_in_patients_with_Crohn_s_disease_ulcerative_colitis_and_controls_/479130", "title"=>"Allele frequencies of the SNPs rs2066843 and rs2076756 in patients with Crohn's disease, ulcerative colitis and controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:32:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/808551"], "description"=>"<p>Association between rs2076756 genotype and CD disease characteristics based on the Montreal classification <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014466#pone.0014466-Silverberg1\" target=\"_blank\">[28]</a>.</p>", "links"=>[], "tags"=>["rs2076756", "genotype", "cd", "characteristics", "montreal", "classification"], "article_id"=>478888, "categories"=>["Immunology", "Genetics", "Chemistry", "Medicine"], "users"=>["Jürgen Glas", "Julia Seiderer", "Cornelia Tillack", "Simone Pfennig", "Florian Beigel", "Matthias Jürgens", "Torsten Olszak", "Rüdiger P. Laubender", "Maria Weidinger", "Bertram Müller-Myhsok", "Burkhard Göke", "Thomas Ochsenkühn", "Peter Lohse", "Julia Diegelmann", "Darina Czamara", "Stephan Brand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014466.t006", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_rs2076756_genotype_and_CD_disease_characteristics_based_on_the_Montreal_classification_28_/478888", "title"=>"Association between rs2076756 genotype and CD disease characteristics based on the Montreal classification [28].", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:28:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/808493"], "description"=>"<p>For each variable, the number of patients included is given. Footnotes: see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014466#pone-0014466-t004\" target=\"_blank\">Table 4</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014466#pone-0014466-t005\" target=\"_blank\">5</a> for details.</p>", "links"=>[], "tags"=>["rs2076756", "genotype", "cd"], "article_id"=>478837, "categories"=>["Immunology", "Genetics", "Chemistry", "Medicine"], "users"=>["Jürgen Glas", "Julia Seiderer", "Cornelia Tillack", "Simone Pfennig", "Florian Beigel", "Matthias Jürgens", "Torsten Olszak", "Rüdiger P. Laubender", "Maria Weidinger", "Bertram Müller-Myhsok", "Burkhard Göke", "Thomas Ochsenkühn", "Peter Lohse", "Julia Diegelmann", "Darina Czamara", "Stephan Brand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014466.t007", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_rs2076756_genotype_and_CD_disease_characteristics_/478837", "title"=>"Association between rs2076756 genotype and CD disease characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:27:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/808677"], "description"=>"1<p>Disease behaviour was defined according to the Montreal classification <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014466#pone.0014466-Silverberg1\" target=\"_blank\">[28]</a>. Stricturing disease phenotype was defined as presence of stenosis without penetrating disease. The diagnosis of stenosis was made surgically, endoscopically, or radiologically (using MR enteroclysis). For each variable, the number of patients included is given.</p>", "links"=>[], "tags"=>["rs2066843", "genotype", "cd", "characteristics", "montreal", "classification"], "article_id"=>479011, "categories"=>["Immunology", "Genetics", "Chemistry", "Medicine"], "users"=>["Jürgen Glas", "Julia Seiderer", "Cornelia Tillack", "Simone Pfennig", "Florian Beigel", "Matthias Jürgens", "Torsten Olszak", "Rüdiger P. Laubender", "Maria Weidinger", "Bertram Müller-Myhsok", "Burkhard Göke", "Thomas Ochsenkühn", "Peter Lohse", "Julia Diegelmann", "Darina Czamara", "Stephan Brand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014466.t004", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_rs2066843_genotype_and_CD_disease_characteristics_based_on_the_Montreal_classification_28_/479011", "title"=>"Association between rs2066843 genotype and CD disease characteristics based on the Montreal classification [28].", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:30:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/808845"], "description"=>"<p>Demographic characteristics of the IBD study population.</p>", "links"=>[], "tags"=>["characteristics", "ibd"], "article_id"=>479188, "categories"=>["Immunology", "Genetics", "Chemistry", "Medicine"], "users"=>["Jürgen Glas", "Julia Seiderer", "Cornelia Tillack", "Simone Pfennig", "Florian Beigel", "Matthias Jürgens", "Torsten Olszak", "Rüdiger P. Laubender", "Maria Weidinger", "Bertram Müller-Myhsok", "Burkhard Göke", "Thomas Ochsenkühn", "Peter Lohse", "Julia Diegelmann", "Darina Czamara", "Stephan Brand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014466.t001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_characteristics_of_the_IBD_study_population_/479188", "title"=>"Demographic characteristics of the IBD study population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:33:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/403711", "https://ndownloader.figshare.com/files/403742", "https://ndownloader.figshare.com/files/403766", "https://ndownloader.figshare.com/files/403789", "https://ndownloader.figshare.com/files/403816", "https://ndownloader.figshare.com/files/403836", "https://ndownloader.figshare.com/files/403884", "https://ndownloader.figshare.com/files/403926", "https://ndownloader.figshare.com/files/403949"], "description"=>"<div><h3>Background</h3><p>The aims were to analyze two novel <em>NOD2</em> variants (rs2066843 and rs2076756) in a large cohort of patients with inflammatory bowel disease and to elucidate phenotypic consequences.</p> <h3>Methodology/Principal Findings</h3><p>Genomic DNA from 2700 Caucasians including 812 patients with Crohn's disease (CD), 442 patients with ulcerative colitis (UC), and 1446 healthy controls was analyzed for the <em>NOD2</em> SNPs rs2066843 and rs2076756 and the three main CD-associated <em>NOD2</em> variants p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847). Haplotype and genotype-phenotype analyses were performed. The SNPs rs2066843 (p = 3.01×10<sup>−5</sup>, OR 1.48, [95% CI 1.23-1.78]) and rs2076756 (p = 4.01×10<sup>−6</sup>; OR 1.54, [95% CI 1.28-1.86]) were significantly associated with CD but not with UC susceptibility. Haplotype analysis revealed a number of significant associations with CD susceptibility with omnibus p values <10<sup>−10</sup>. The SNPs rs2066843 and rs2076756 were in linkage disequilibrium with each other and with the three main CD-associated <em>NOD2</em> mutations (D'>0.9). However, in CD, SNPs rs2066843 and rs2076756 were more frequently observed than the other three common <em>NOD2</em> mutations (minor allele frequencies for rs2066843 and rs2076756: 0.390 and 0.380, respectively). In CD patients homozygous for these novel <em>NOD2</em> variants, genotype-phenotype analysis revealed higher rates of a penetrating phenotype (rs2076756: p = 0.015) and fistulas (rs2076756: p = 0.015) and significant associations with CD-related surgery (rs2076756: p = 0.003; rs2066843: p = 0.015). However, in multivariate analysis only disease localization (p<2×10<sup>−16</sup>) and behaviour (p = 0.02) were significantly associated with the need for surgery.</p> <h3>Conclusion/Significance</h3><p>The <em>NOD2</em> variants rs2066843 and rs2076756 are novel and common CD susceptibility gene variants.</p> </div>", "links"=>[], "tags"=>["nucleotide", "polymorphisms", "rs2066843", "rs2076756", "are", "susceptibility", "variants"], "article_id"=>139760, "categories"=>["Immunology", "Genetics", "Chemistry", "Medicine"], "users"=>["Jürgen Glas", "Julia Seiderer", "Cornelia Tillack", "Simone Pfennig", "Florian Beigel", "Matthias Jürgens", "Torsten Olszak", "Rüdiger P. Laubender", "Maria Weidinger", "Bertram Müller-Myhsok", "Burkhard Göke", "Thomas Ochsenkühn", "Peter Lohse", "Julia Diegelmann", "Darina Czamara", "Stephan Brand"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0014466.s001", "https://dx.doi.org/10.1371/journal.pone.0014466.s002", "https://dx.doi.org/10.1371/journal.pone.0014466.s003", "https://dx.doi.org/10.1371/journal.pone.0014466.s004", "https://dx.doi.org/10.1371/journal.pone.0014466.s005", "https://dx.doi.org/10.1371/journal.pone.0014466.s006", "https://dx.doi.org/10.1371/journal.pone.0014466.s007", "https://dx.doi.org/10.1371/journal.pone.0014466.s008", "https://dx.doi.org/10.1371/journal.pone.0014466.s009"], "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_NOD2_Single_Nucleotide_Polymorphisms_rs2066843_and_rs2076756_Are_Novel_and_Common_Crohn_s_Disease_Susceptibility_Gene_Variants/139760", "title"=>"The <em>NOD2</em> Single Nucleotide Polymorphisms rs2066843 and rs2076756 Are Novel and Common Crohn's Disease Susceptibility Gene Variants", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-12-30 02:42:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/808918"], "description"=>"<p>Significant CD phenotype associations of rs2066843 and rs2076756 as shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014466#pone-0014466-t005\" target=\"_blank\">Tables 5</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014466#pone-0014466-t006\" target=\"_blank\">6</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014466#pone-0014466-t007\" target=\"_blank\">7</a> stratified for the presence (<i>NOD2+</i>) or absence (<i>NOD2-</i>) of the three CD-associated <i>NOD2</i> mutations p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847).</p>", "links"=>[], "tags"=>["cd", "phenotype", "associations", "rs2066843", "rs2076756", "shown", "stratified", "cd-associated", "mutations"], "article_id"=>479246, "categories"=>["Immunology", "Genetics", "Chemistry", "Medicine"], "users"=>["Jürgen Glas", "Julia Seiderer", "Cornelia Tillack", "Simone Pfennig", "Florian Beigel", "Matthias Jürgens", "Torsten Olszak", "Rüdiger P. Laubender", "Maria Weidinger", "Bertram Müller-Myhsok", "Burkhard Göke", "Thomas Ochsenkühn", "Peter Lohse", "Julia Diegelmann", "Darina Czamara", "Stephan Brand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014466.t008", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Significant_CD_phenotype_associations_of_rs2066843_and_rs2076756_as_shown_in_Tables_5_6_and_7_stratified_for_the_presence_NOD2_or_absence_NOD2_of_the_three_CD_associated_NOD2_mutations_p_Arg702Trp_rs2066844_p_Gly908Arg_rs2066847_and_p_Leu1007fsX1008_rs20/479246", "title"=>"Significant CD phenotype associations of rs2066843 and rs2076756 as shown in Tables 5, 6 and 7 stratified for the presence (<i>NOD2+</i>) or absence (<i>NOD2-</i>) of the three CD-associated <i>NOD2</i> mutations p.Arg702Trp (rs2066844), p.Gly908Arg (rs2066847), and p.Leu1007fsX1008 (rs2066847).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:34:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/808730"], "description"=>"<p>Omnibus as well as individual p-values are presented.</p>", "links"=>[], "tags"=>["snps", "cd"], "article_id"=>479076, "categories"=>["Immunology", "Genetics", "Chemistry", "Medicine"], "users"=>["Jürgen Glas", "Julia Seiderer", "Cornelia Tillack", "Simone Pfennig", "Florian Beigel", "Matthias Jürgens", "Torsten Olszak", "Rüdiger P. Laubender", "Maria Weidinger", "Bertram Müller-Myhsok", "Burkhard Göke", "Thomas Ochsenkühn", "Peter Lohse", "Julia Diegelmann", "Darina Czamara", "Stephan Brand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014466.t003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Haplotype_analysis_for_NOD2_SNPs_in_the_CD_patient_cohort_/479076", "title"=>"Haplotype analysis for <i>NOD2</i> SNPs in the CD patient cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:31:16"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"42", "unique-ip"=>"37", "pdf"=>"25", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"22", "year"=>"2011", "pdf"=>"15", "unique-ip"=>"19", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"24", "unique-ip"=>"22", "pdf"=>"16", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"24", "year"=>"2011", "pdf"=>"15", "unique-ip"=>"20", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"9"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"11", "unique-ip"=>"13", "pdf"=>"6", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"8", "year"=>"2011", "pdf"=>"8", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "unique-ip"=>"13", "pdf"=>"8", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"26", "year"=>"2011", "pdf"=>"6", "unique-ip"=>"21", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "unique-ip"=>"14", "pdf"=>"8", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"26", "year"=>"2011", "pdf"=>"9", "unique-ip"=>"22", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"7"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "unique-ip"=>"14", "pdf"=>"7", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"7", "pdf"=>"5", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"8", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"14", "unique-ip"=>"15", "pdf"=>"7", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"11", "year"=>"2012", "pdf"=>"5", "unique-ip"=>"11", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"13", "unique-ip"=>"13", "pdf"=>"9", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"6", "year"=>"2012", "pdf"=>"1", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"4", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"17", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"17", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"25", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"12", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"24", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"20", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"41", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"26", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"22", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"24", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"19", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}

Relative Metric

{"start_date"=>"2010-01-01T00:00:00Z", "end_date"=>"2010-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[288, 576, 733, 867, 984, 1087, 1182, 1267, 1346, 1424, 1501, 1577, 1646, 1711, 1778, 1841, 1908, 1970, 2034, 2102, 2162, 2227, 2296, 2359, 2422, 2482, 2550, 2610, 2679, 2747, 2820, 2887, 2955, 3009, 3067, 3130, 3200, 3257, 3322, 3379, 3443, 3507, 3571, 3632, 3683, 3753, 3822, 3877]}, {"subject_area"=>"/Biology and life sciences/Evolutionary biology", "average_usage"=>[342, 639, 812, 953, 1062, 1178, 1282, 1358, 1452, 1515, 1604, 1668, 1734, 1819, 1896, 1947, 2009, 2062, 2128, 2213, 2269, 2350, 2422, 2490, 2565, 2629, 2699, 2768, 2834, 2909, 2962, 3034, 3097, 3167, 3232, 3321, 3372, 3439, 3496, 3534, 3598, 3659, 3715, 3780, 3845, 3903, 3992, 4051, 4123]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[306, 610, 768, 915, 1043, 1164, 1255, 1349, 1432, 1511, 1592, 1674, 1744, 1817, 1889, 1950, 2028, 2087, 2153, 2217, 2274, 2349, 2418, 2488, 2558, 2616, 2686, 2745, 2809, 2869, 2938, 3008, 3071, 3131, 3189, 3258, 3320, 3389, 3446, 3503, 3552, 3613, 3677, 3744, 3788, 3842, 3907, 3966, 4015]}, {"subject_area"=>"/Biology and life sciences/Microbiology", "average_usage"=>[306, 616, 785, 930, 1062, 1178, 1267, 1361, 1440, 1545, 1627, 1690, 1764, 1825, 1903, 1965, 2043, 2099, 2172, 2232, 2313, 2376, 2451, 2524, 2595, 2661, 2729, 2781, 2848, 2911, 2974, 3059, 3138, 3196, 3272, 3342, 3408, 3471, 3530, 3601, 3661, 3734, 3803, 3862, 3922, 3966, 4035, 4092, 4165]}, {"subject_area"=>"/Biology and life sciences/Population biology", "average_usage"=>[336, 599, 748, 884, 971, 1067, 1170, 1240, 1328, 1415, 1474, 1553, 1615, 1677, 1758, 1821, 1885, 1938, 2007, 2079, 2139, 2216, 2302, 2408, 2462, 2535, 2577, 2636, 2711, 2793, 2863, 2916, 2984, 3040, 3093, 3144, 3209, 3281, 3345, 3417, 3465, 3516, 3565, 3646, 3710, 3753, 3813, 3850, 3906]}, {"subject_area"=>"/Medicine and health sciences/Diagnostic medicine", "average_usage"=>[259, 533, 687, 800, 923, 1038, 1137, 1218, 1295, 1363, 1442, 1514, 1588, 1650, 1714, 1776, 1846, 1926, 2001, 2065, 2128, 2176, 2232, 2280, 2340, 2406, 2466, 2539, 2632, 2685, 2750, 2803, 2873, 2919, 2974, 3040, 3094, 3137, 3178, 3228, 3299, 3348, 3409, 3452, 3502, 3544, 3596, 3649, 3700]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[274, 546, 703, 837, 951, 1058, 1152, 1234, 1323, 1387, 1453, 1538, 1606, 1694, 1753, 1814, 1873, 1941, 2011, 2079, 2137, 2193, 2260, 2325, 2386, 2459, 2528, 2598, 2651, 2728, 2788, 2859, 2931, 2999, 3068, 3131, 3209, 3258, 3321, 3372, 3426, 3500, 3561, 3613, 3685, 3743, 3805, 3839]}]}
Loading … Spinner
There are currently no alerts