MicroRNA Expression Profiling of the Porcine Developing Brain
Publication Date
January 06, 2011
Journal
PLOS ONE
Authors
Agnieszka Podolska, Bogumil Kaczkowski, Peter Kamp Busk, Rolf Søkilde, et al
Volume
6
Issue
1
Pages
e14494
DOI
https://dx.plos.org/10.1371/journal.pone.0014494
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0014494
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/21253018
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017054
Europe PMC
http://europepmc.org/abstract/MED/21253018
Web of Science
000286511900003
Scopus
79251577674
Mendeley
http://www.mendeley.com/research/microrna-expression-profiling-porcine-developing
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Mendeley | Further Information

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CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/403285", "https://ndownloader.figshare.com/files/403304", "https://ndownloader.figshare.com/files/403310"], "description"=>"<div><h3>Background</h3><p>MicroRNAs are small, non-coding RNA molecules that regulate gene expression at the post-transcriptional level and play an important role in the control of developmental and physiological processes. In particular, the developing brain contains an impressive diversity of microRNAs. Most microRNA expression profiling studies have been performed in human or rodents and relatively limited knowledge exists in other mammalian species. The domestic pig is considered to be an excellent, alternate, large mammal model for human-related neurological studies, due to its similarity in both brain development and the growth curve when compared to humans. Considering these similarities, studies examining microRNA expression during porcine brain development could potentially be used to predict the expression profile and role of microRNAs in the human brain.</p><h3>Methodology/Principal Findings</h3><p>MicroRNA expression profiling by use of microRNA microarrays and qPCR was performed on the porcine developing brain. Our results show that microRNA expression is regulated in a developmentally stage-specific, as well as a tissue-specific manner. Numerous developmental stage or tissue-specific microRNAs including, miR-17, miR-18a, miR-29c, miR-106a, miR-135a and b, miR-221 and miR-222 were found by microarray analysis. Expression profiles of selected candidates were confirmed by qPCR.</p><h3>Conclusions/Significance</h3><p>The differential expression of specific microRNAs in fetal versus postnatal samples suggests that they likely play an important role in the regulation of developmental and physiological processes during brain development. The data presented here supports the notion that microRNAs act as post-transcriptional switches which may regulate gene expression when required.</p></div>", "links"=>[], "tags"=>["microrna", "profiling", "porcine"], "article_id"=>139680, "categories"=>["Molecular Biology", "Biotechnology", "Cell Biology", "Genetics"], "users"=>["Agnieszka Podolska", "Bogumil Kaczkowski", "Peter Kamp Busk", "Rolf Søkilde", "Thomas Litman", "Merete Fredholm", "Susanna Cirera"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0014494.s001", "https://dx.doi.org/10.1371/journal.pone.0014494.s002", "https://dx.doi.org/10.1371/journal.pone.0014494.s003"], "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/MicroRNA_Expression_Profiling_of_the_Porcine_Developing_Brain/139680", "title"=>"MicroRNA Expression Profiling of the Porcine Developing Brain", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-01-06 02:41:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/807984"], "description"=>"<p>Clustering of the samples is determined by the microRNA (miRNA) expression influenced by the developmental stage and tissue. Statistically significant miRNAs (p-value <9.95E<sup>−06</sup>) are presented. Three replicates from each stage and tissue cluster together. The blue color denotes downregulated expression and the red color denotes upregulated expression level from the mean. Columns and rows represent samples and particular miRNAs, respectively. F50 and F100 stand for fetus gestation day 50 and fetus gestation day 100, respectively.</p>", "links"=>[], "tags"=>["microrna", "profiles", "porcine"], "article_id"=>478349, "categories"=>["Molecular Biology", "Biotechnology", "Cell Biology", "Genetics"], "users"=>["Agnieszka Podolska", "Bogumil Kaczkowski", "Peter Kamp Busk", "Rolf Søkilde", "Thomas Litman", "Merete Fredholm", "Susanna Cirera"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014494.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heatmap_of_microRNA_expression_profiles_in_the_developing_porcine_brain_with_developmental_stage_as_well_as_the_tissue_being_the_source_of_variation_/478349", "title"=>"Heatmap of microRNA expression profiles in the developing porcine brain, with developmental stage as well as the tissue being the source of variation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-06 02:19:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/808067"], "description"=>"<p>MicroRNA specific qPCR expression profiles. Expression rates between various samples are presented by fold changes in relation to the lowest, normalized expressed value. The error bars of qPCR represent a standard deviation of the mean of 16 replicates.</p>", "links"=>[], "tags"=>["pcr", "profiles"], "article_id"=>478432, "categories"=>["Molecular Biology", "Biotechnology", "Cell Biology", "Genetics"], "users"=>["Agnieszka Podolska", "Bogumil Kaczkowski", "Peter Kamp Busk", "Rolf Søkilde", "Thomas Litman", "Merete Fredholm", "Susanna Cirera"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014494.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantitative_PCR_expression_profiles_of_selected_microRNAs_/478432", "title"=>"Quantitative PCR expression profiles of selected microRNAs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-06 02:20:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/807748"], "description"=>"<p>Clustering of the samples according to their origin is shown. In each case, three replicates from each particular developmental stage and tissue cluster together. F50 and F100 stand for fetus gestation day 50 and fetus gestation day 100, respectively.</p>", "links"=>[], "tags"=>["microarray"], "article_id"=>478113, "categories"=>["Molecular Biology", "Biotechnology", "Cell Biology", "Genetics"], "users"=>["Agnieszka Podolska", "Bogumil Kaczkowski", "Peter Kamp Busk", "Rolf Søkilde", "Thomas Litman", "Merete Fredholm", "Susanna Cirera"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014494.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Principal_Component_Analysis_PCA_plot_of_microarray_data_/478113", "title"=>"Principal Component Analysis (PCA) plot of microarray data.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-06 02:15:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/807876"], "description"=>"<p>Developmental stage-dependent microRNA (miRNA) expression determines the clustering. Statistically significant miRNAs (p-value <9.39E<sup>−05</sup>, selected by ANOVA test) are presented. Three replicates from each stage and tissue cluster together. The blue color denotes downregulated expression and the red color denotes upregulated expression level from the mean. Columns and rows represent samples and particular miRNAs, respectively. F50 and F100 stand for fetus gestation day 50 and fetus gestation day 100, respectively.</p>", "links"=>[], "tags"=>["microrna", "profiles", "porcine"], "article_id"=>478241, "categories"=>["Molecular Biology", "Biotechnology", "Cell Biology", "Genetics"], "users"=>["Agnieszka Podolska", "Bogumil Kaczkowski", "Peter Kamp Busk", "Rolf Søkilde", "Thomas Litman", "Merete Fredholm", "Susanna Cirera"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014494.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heatmap_of_microRNA_expression_profiles_in_the_developing_porcine_brain_with_developmental_stage_being_the_main_source_of_variation_/478241", "title"=>"Heatmap of microRNA expression profiles in the developing porcine brain, with developmental stage being the main source of variation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-06 02:17:21"}

PMC Usage Stats | Further Information

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Relative Metric

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