Pyronaridine-Artesunate versus Chloroquine in Patients with Acute Plasmodium vivax Malaria: A Randomized, Double-Blind, Non-Inferiority Trial
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{"title"=>"Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax Malaria: A randomized, double-blind, non-inferiority trial", "type"=>"journal", "authors"=>[{"first_name"=>"Yi", "last_name"=>"Poravuth", "scopus_author_id"=>"6507660774"}, {"first_name"=>"Duong", "last_name"=>"Socheat", "scopus_author_id"=>"6603089282"}, {"first_name"=>"Ronnatrai", "last_name"=>"Rueangweerayut", "scopus_author_id"=>"36873231700"}, {"first_name"=>"Chirapong", "last_name"=>"Uthaisin", "scopus_author_id"=>"36873373800"}, {"first_name"=>"Aung Pyae", "last_name"=>"Phyo", "scopus_author_id"=>"57192366468"}, {"first_name"=>"Neena", "last_name"=>"Valecha", "scopus_author_id"=>"7004555676"}, {"first_name"=>"B. H.", "last_name"=>"Krishnamoorthy Rao", "scopus_author_id"=>"36872595600"}, {"first_name"=>"Emiliana", "last_name"=>"Tjitra", "scopus_author_id"=>"6701682211"}, {"first_name"=>"Asep", "last_name"=>"Purnama", "scopus_author_id"=>"37461782200"}, {"first_name"=>"Isabelle", "last_name"=>"Borghini-Fuhrer", "scopus_author_id"=>"36089729600"}, {"first_name"=>"Stephan", "last_name"=>"Duparc", "scopus_author_id"=>"26641860800"}, {"first_name"=>"Chang Sik", "last_name"=>"Shin", "scopus_author_id"=>"36090344900"}, {"first_name"=>"Lawrence", "last_name"=>"Fleckenstein", "scopus_author_id"=>"7004766536"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-79251569264", "sgr"=>"79251569264", "pui"=>"361185823", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"21267072", "doi"=>"10.1371/journal.pone.0014501"}, "id"=>"bc128482-cd24-3bfb-abd1-b15dff008e2c", "abstract"=>"BACKGROUND: New antimalarials are needed for P. vivax and P. falciparum malaria. This study compared the efficacy and safety of pyronaridine-artesunate with that of chloroquine for the treatment of uncomplicated P. vivax malaria. METHODS AND FINDINGS: This phase III randomized, double-blind, non-inferiority trial included five centers across Cambodia, Thailand, India, and Indonesia. In a double-dummy design, patients (aged >3-</= 60 years) with microscopically confirmed P. vivax mono-infection were randomized (1:1) to receive pyronaridine-artesunate (target dose 7.2:2.4 mg/kg to 13.8:4.6 mg/kg) or chloroquine (standard dose) once daily for three days. Each treatment group included 228 randomized patients. Outcomes for the primary endpoint, Day-14 cure rate in the per-protocol population, were 99.5%, (217/218; 95%CI 97.5, 100) with pyronaridine-artesunate and 100% (209/209; 95%CI 98.3, 100) with chloroquine. Pyronaridine was non-inferior to chloroquine: treatment difference -0.5% (95%CI -2.6, 1.4), i.e., the lower limit of the 2-sided 95%CI for the treatment difference was greater than -10%. Pyronaridine-artesunate cure rates were non-inferior to chloroquine for Days 21, 28, 35 and 42. Parasite clearance time was shorter with pyronaridine-artesunate (median 23.0 h) versus chloroquine (32.0 h; p<0.0001), as was fever clearance time (median 15.9 h and 23.8 h, respectively; p = 0.0017). Kaplan-Meier estimates of post-baseline P. falciparum infection incidence until Day 42 were 2.5% with pyronaridine-artesunate, 6.1% with chloroquine (p = 0.048, log-rank test). Post-baseline P. vivax or P. falciparum infection incidence until Day 42 was 6.8% and 12.4%, respectively (p = 0.022, log rank test). There were no deaths. Adverse events occurred in 92/228 (40.4%) patients with pyronaridine-artesunate and 72/228 (31.6%) with chloroquine. Mild and transient increases in hepatic enzymes were observed for pyronaridine-artesunate. CONCLUSION: Pyronaridine-artesunate efficacy in acute uncomplicated P. vivax malaria was at least that of chloroquine. As pyronaridine-artesunate is also efficacious against P. falciparum malaria, this combination has potential utility as a global antimalarial drug. TRIAL REGISTRATION: Clinicaltrials.gov NCT00440999.", "link"=>"http://www.mendeley.com/research/pyronaridineartesunate-versus-chloroquine-patients-acute-plasmodium-vivax-malaria-randomized-doubleb", "reader_count"=>49, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>10, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>4, "Other"=>8, "Student > Master"=>10, "Student > Bachelor"=>3, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>10, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>4, "Other"=>8, "Student > Master"=>10, "Student > Bachelor"=>3, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Nursing and Health Professions"=>4, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>17, "Medicine and Dentistry"=>17, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>1, "Computer Science"=>2, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>17}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>17}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "Pakistan"=>1, "United Kingdom"=>1, "Thailand"=>1, "Indonesia"=>2}, "group_count"=>8}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/805191"], "description"=>"<p>Trial flow and subject disposition.</p>", "links"=>[], "tags"=>["Infectious diseases", "infectious diseases/antimicrobials and drug resistance", "infectious diseases/neglected tropical diseases", "infectious diseases/tropical and travel-associated diseases"], "article_id"=>475545, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Yi Poravuth", "Duong Socheat", "Ronnatrai Rueangweerayut", "Chirapong Uthaisin", "Aung Pyae Phyo", "Neena Valecha", "B. H. Krishnamoorthy Rao", "Emiliana Tjitra", "Asep Purnama", "Isabelle Borghini-Fuhrer", "Stephan Duparc", "Chang-Sik Shin", "Lawrence Fleckenstein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014501.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Trial_flow_and_subject_disposition_/475545", "title"=>"Trial flow and subject disposition.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-18 01:32:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/805368"], "description"=>"<p>Kaplan-Meier estimates of <i>P. vivax</i> parasite clearance time (h) (intent-to-treat population).</p>", "links"=>[], "tags"=>["estimates", "parasite", "clearance"], "article_id"=>475724, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Yi Poravuth", "Duong Socheat", "Ronnatrai Rueangweerayut", "Chirapong Uthaisin", "Aung Pyae Phyo", "Neena Valecha", "B. H. Krishnamoorthy Rao", "Emiliana Tjitra", "Asep Purnama", "Isabelle Borghini-Fuhrer", "Stephan Duparc", "Chang-Sik Shin", "Lawrence Fleckenstein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014501.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kaplan_Meier_estimates_of_P_vivax_parasite_clearance_time_h_intent_to_treat_population_/475724", "title"=>"Kaplan-Meier estimates of <i>P. vivax</i> parasite clearance time (h) (intent-to-treat population).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-18 01:35:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/805794"], "description"=>"<p>All patients were of Asian/Oriental ethnicity.</p>", "links"=>[], "tags"=>["randomized"], "article_id"=>476153, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Yi Poravuth", "Duong Socheat", "Ronnatrai Rueangweerayut", "Chirapong Uthaisin", "Aung Pyae Phyo", "Neena Valecha", "B. H. Krishnamoorthy Rao", "Emiliana Tjitra", "Asep Purnama", "Isabelle Borghini-Fuhrer", "Stephan Duparc", "Chang-Sik Shin", "Lawrence Fleckenstein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014501.t001", "stats"=>{"downloads"=>4, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_demographic_and_clinical_data_of_the_randomized_intent_to_treat_population_/476153", "title"=>"Baseline demographic and clinical data of the randomized (intent-to-treat) population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-01-18 01:42:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/805848"], "description"=>"<p>Data are mean (SD) [range] or number (%).</p><p>*No Grade 4 toxicities. Hb, hemoglobin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; TBIL, total bilirubin. Grade 3 toxicity: Hb (65–79 g/L); ALT/AST/ALP (5.1–10×ULN); TBIL (2.6–5×ULN). Grade 4 toxicity: ALT/AST (>10×ULN). ULN, upper limit of normal.</p>", "links"=>[], "tags"=>["baseline", "days", "28", "measures", "incidence", "post-baseline", "toxicity"], "article_id"=>476193, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Yi Poravuth", "Duong Socheat", "Ronnatrai Rueangweerayut", "Chirapong Uthaisin", "Aung Pyae Phyo", "Neena Valecha", "B. H. Krishnamoorthy Rao", "Emiliana Tjitra", "Asep Purnama", "Isabelle Borghini-Fuhrer", "Stephan Duparc", "Chang-Sik Shin", "Lawrence Fleckenstein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014501.t004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_values_and_change_from_baseline_at_Days_3_7_and_28_for_key_laboratory_measures_and_incidence_of_post_baseline_Grade_3_or_4_toxicity_values_/476193", "title"=>"Baseline values and change from baseline at Days 3, 7 and 28 for key laboratory measures and incidence of post-baseline Grade 3 or 4 toxicity values.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-01-18 01:43:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/402392", "https://ndownloader.figshare.com/files/402423"], "description"=>"<div><h3>Background</h3><p>New antimalarials are needed for <em>P. vivax</em> and <em>P. falciparum</em> malaria. This study compared the efficacy and safety of pyronaridine-artesunate with that of chloroquine for the treatment of uncomplicated <em>P. vivax</em> malaria.</p><h3>Methods and Findings</h3><p>This phase III randomized, double-blind, non-inferiority trial included five centers across Cambodia, Thailand, India, and Indonesia. In a double-dummy design, patients (aged >3–≤60 years) with microscopically confirmed <em>P. vivax</em> mono-infection were randomized (1∶1) to receive pyronaridine-artesunate (target dose 7.2∶2.4 mg/kg to 13.8∶4.6 mg/kg) or chloroquine (standard dose) once daily for three days. Each treatment group included 228 randomized patients. Outcomes for the primary endpoint, Day-14 cure rate in the per-protocol population, were 99.5%, (217/218; 95%CI 97.5, 100) with pyronaridine-artesunate and 100% (209/209; 95%CI 98.3, 100) with chloroquine. Pyronaridine was non-inferior to chloroquine: treatment difference −0.5% (95%CI −2.6, 1.4), i.e., the lower limit of the 2-sided 95%CI for the treatment difference was greater than −10%. Pyronaridine-artesunate cure rates were non-inferior to chloroquine for Days 21, 28, 35 and 42. Parasite clearance time was shorter with pyronaridine-artesunate (median 23.0 h) versus chloroquine (32.0 h; p<0.0001), as was fever clearance time (median 15.9 h and 23.8 h, respectively; p = 0.0017). Kaplan-Meier estimates of post-baseline <em>P. falciparum</em> infection incidence until Day 42 were 2.5% with pyronaridine-artesunate, 6.1% with chloroquine (p = 0.048, log-rank test). Post-baseline <em>P. vivax</em> or <em>P. falciparum</em> infection incidence until Day 42 was 6.8% and 12.4%, respectively (p = 0.022, log rank test). There were no deaths. Adverse events occurred in 92/228 (40.4%) patients with pyronaridine-artesunate and 72/228 (31.6%) with chloroquine. Mild and transient increases in hepatic enzymes were observed for pyronaridine-artesunate.</p><h3>Conclusion</h3><p>Pyronaridine-artesunate efficacy in acute uncomplicated <em>P. vivax</em> malaria was at least that of chloroquine. As pyronaridine-artesunate is also efficacious against <em>P. falciparum</em> malaria, this combination has potential utility as a global antimalarial drug.</p><h3>Trial registration</h3><p>Clinicaltrials.gov <a href=\"http://clinicaltrials.gov/ct2/show/NCT00440999\">NCT00440999</a></p></div>", "links"=>[], "tags"=>["pyronaridine-artesunate", "chloroquine", "patients", "acute", "non-inferiority"], "article_id"=>139513, "categories"=>["Cancer", "Medicine"], "users"=>["Yi Poravuth", "Duong Socheat", "Ronnatrai Rueangweerayut", "Chirapong Uthaisin", "Aung Pyae Phyo", "Neena Valecha", "B. H. Krishnamoorthy Rao", "Emiliana Tjitra", "Asep Purnama", "Isabelle Borghini-Fuhrer", "Stephan Duparc", "Chang-Sik Shin", "Lawrence Fleckenstein"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0014501.s001", "https://dx.doi.org/10.1371/journal.pone.0014501.s002"], "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Pyronaridine_Artesunate_versus_Chloroquine_in_Patients_with_Acute_Plasmodium_vivax_Malaria_A_Randomized_Double_Blind_Non_Inferiority_Trial/139513", "title"=>"Pyronaridine-Artesunate versus Chloroquine in Patients with Acute <em>Plasmodium vivax</em> Malaria: A Randomized, Double-Blind, Non-Inferiority Trial", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-01-18 02:38:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/805542"], "description"=>"<p>Kaplan-Meier estimates of time (h) to <i>P. falciparum</i> infection in patients treated for an initial <i>P. vivax</i> malaria (intent-to-treat population).</p>", "links"=>[], "tags"=>["estimates", "patients", "treated", "malaria"], "article_id"=>475896, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Yi Poravuth", "Duong Socheat", "Ronnatrai Rueangweerayut", "Chirapong Uthaisin", "Aung Pyae Phyo", "Neena Valecha", "B. H. Krishnamoorthy Rao", "Emiliana Tjitra", "Asep Purnama", "Isabelle Borghini-Fuhrer", "Stephan Duparc", "Chang-Sik Shin", "Lawrence Fleckenstein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014501.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kaplan_Meier_estimates_of_time_h_to_P_falciparum_infection_in_patients_treated_for_an_initial_P_vivax_malaria_intent_to_treat_population_/475896", "title"=>"Kaplan-Meier estimates of time (h) to <i>P. falciparum</i> infection in patients treated for an initial <i>P. vivax</i> malaria (intent-to-treat population).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-18 01:38:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/805458"], "description"=>"<p>Kaplan-Meier estimates of fever clearance time (h) in patients with <i>P. vivax</i> malaria (intent-to-treat population).</p>", "links"=>[], "tags"=>["estimates", "clearance", "patients", "malaria"], "article_id"=>475813, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Yi Poravuth", "Duong Socheat", "Ronnatrai Rueangweerayut", "Chirapong Uthaisin", "Aung Pyae Phyo", "Neena Valecha", "B. H. Krishnamoorthy Rao", "Emiliana Tjitra", "Asep Purnama", "Isabelle Borghini-Fuhrer", "Stephan Duparc", "Chang-Sik Shin", "Lawrence Fleckenstein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014501.g004", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kaplan_Meier_estimates_of_fever_clearance_time_h_in_patients_with_P_vivax_malaria_intent_to_treat_population_/475813", "title"=>"Kaplan-Meier estimates of fever clearance time (h) in patients with <i>P. vivax</i> malaria (intent-to-treat population).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-18 01:36:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/805696"], "description"=>"<p>Data are number (%) unless otherwise indicated. CPK, creatine phosphokinase.</p><p>*Adverse events that occurred in ≥2% of patients in either treatment group.</p><p>†Drug-related adverse events that occurred in ≥1% of patients in either treatment group.</p>", "links"=>[], "tags"=>["adverse", "events"], "article_id"=>476054, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Yi Poravuth", "Duong Socheat", "Ronnatrai Rueangweerayut", "Chirapong Uthaisin", "Aung Pyae Phyo", "Neena Valecha", "B. H. Krishnamoorthy Rao", "Emiliana Tjitra", "Asep Purnama", "Isabelle Borghini-Fuhrer", "Stephan Duparc", "Chang-Sik Shin", "Lawrence Fleckenstein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014501.t003", "stats"=>{"downloads"=>4, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Treatment_emergent_adverse_events_in_the_safety_intent_to_treat_population_/476054", "title"=>"Treatment-emergent adverse events in the safety (intent-to-treat) population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-01-18 01:40:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/805295"], "description"=>"<p>Non-inferiority of pyronaridine-artesunate to chloroquine was concluded for all assessments.</p>", "links"=>[], "tags"=>["malaria", "days", "42", "per-protocol"], "article_id"=>475652, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Yi Poravuth", "Duong Socheat", "Ronnatrai Rueangweerayut", "Chirapong Uthaisin", "Aung Pyae Phyo", "Neena Valecha", "B. H. Krishnamoorthy Rao", "Emiliana Tjitra", "Asep Purnama", "Isabelle Borghini-Fuhrer", "Stephan Duparc", "Chang-Sik Shin", "Lawrence Fleckenstein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014501.g002", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cure_rate_for_P_vivax_malaria_on_Days_14_21_28_35_and_42_in_the_per_protocol_population_/475652", "title"=>"Cure rate for <i>P. vivax</i> malaria on Days 14, 21, 28, 35, and 42 in the per-protocol population.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-18 01:34:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/805618"], "description"=>"<p>Kaplan-Meier estimates of time (h) to <i>P. vivax</i> or <i>P. falciparum</i> infection in patients treated for an initial <i>P. vivax</i> malaria (intent-to-treat population).</p>", "links"=>[], "tags"=>["estimates", "patients", "treated", "malaria"], "article_id"=>475969, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Yi Poravuth", "Duong Socheat", "Ronnatrai Rueangweerayut", "Chirapong Uthaisin", "Aung Pyae Phyo", "Neena Valecha", "B. H. Krishnamoorthy Rao", "Emiliana Tjitra", "Asep Purnama", "Isabelle Borghini-Fuhrer", "Stephan Duparc", "Chang-Sik Shin", "Lawrence Fleckenstein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014501.g006", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kaplan_Meier_estimates_of_time_h_to_P_vivax_or_P_falciparum_infection_in_patients_treated_for_an_initial_P_vivax_malaria_intent_to_treat_population_/475969", "title"=>"Kaplan-Meier estimates of time (h) to <i>P. vivax</i> or <i>P. falciparum</i> infection in patients treated for an initial <i>P. vivax</i> malaria (intent-to-treat population).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-18 01:39:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/805740"], "description"=>"<p>Data are median time to parasite clearance (95%CI) [range]. Units are hours.</p><p>Ranges do not include censored times.</p><p>*Log-rank test.</p>", "links"=>[], "tags"=>["parasite", "clearance"], "article_id"=>476095, "categories"=>["Virology", "Infectious Diseases", "Medicine"], "users"=>["Yi Poravuth", "Duong Socheat", "Ronnatrai Rueangweerayut", "Chirapong Uthaisin", "Aung Pyae Phyo", "Neena Valecha", "B. H. Krishnamoorthy Rao", "Emiliana Tjitra", "Asep Purnama", "Isabelle Borghini-Fuhrer", "Stephan Duparc", "Chang-Sik Shin", "Lawrence Fleckenstein"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014501.t002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Median_parasite_clearance_time_for_P_vivax_intent_to_treat_population_/476095", "title"=>"Median parasite clearance time for <i>P. vivax</i> (intent-to-treat population).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-01-18 01:41:35"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
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  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
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  • {"unique-ip"=>"15", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
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  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
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  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
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  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
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  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
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Relative Metric

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