Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism", "type"=>"journal", "authors"=>[{"first_name"=>"Sarah", "last_name"=>"Garrido-Urbani", "scopus_author_id"=>"6508126456"}, {"first_name"=>"Stephane", "last_name"=>"Jemelin", "scopus_author_id"=>"6506861492"}, {"first_name"=>"Christine", "last_name"=>"Deffert", "scopus_author_id"=>"11339192600"}, {"first_name"=>"Stéphanie", "last_name"=>"Carnesecchi", "scopus_author_id"=>"6603253410"}, {"first_name"=>"Olivier", "last_name"=>"Basset", "scopus_author_id"=>"36901539100"}, {"first_name"=>"Cédric", "last_name"=>"Szyndralewiez", "scopus_author_id"=>"8504287600"}, {"first_name"=>"Freddy", "last_name"=>"Heitz", "scopus_author_id"=>"56589601100"}, {"first_name"=>"Patrick", "last_name"=>"Page", "scopus_author_id"=>"57127685700"}, {"first_name"=>"Xavier", "last_name"=>"Montet", "scopus_author_id"=>"6602995025"}, {"first_name"=>"Liliane", "last_name"=>"Michalik", "scopus_author_id"=>"6603864275"}, {"first_name"=>"Jack", "last_name"=>"Arbiser", "scopus_author_id"=>"7006749438"}, {"first_name"=>"Curzio", "last_name"=>"Rüegg", "scopus_author_id"=>"7006047339"}, {"first_name"=>"Karl Heinz", "last_name"=>"Krause", "scopus_author_id"=>"7202103787"}, {"first_name"=>"Beat", "last_name"=>"Imhof", "scopus_author_id"=>"7006787605"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)", "pui"=>"361258498", "sgr"=>"79951539813", "doi"=>"10.1371/journal.pone.0014665", "scopus"=>"2-s2.0-79951539813", "pmid"=>"21326871"}, "id"=>"70b55b36-2833-36bf-a70b-3bd7554eae34", "abstract"=>"Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and survival, events critically involved in angiogenesis. Different isoforms of ROS-generating NOX enzymes are expressed in the vasculature and provide distinct signaling cues through differential localization and activation. We show that mice deficient in NOX1, but not NOX2 or NOX4, have impaired angiogenesis. NOX1 expression and activity is increased in primary mouse and human endothelial cells upon angiogenic stimulation. NOX1 silencing decreases endothelial cell migration and tube-like structure formation, through the inhibition of PPARα, a regulator of NF-κB. Administration of a novel NOX-specific inhibitor reduced angiogenesis and tumor growth in vivo in a PPARα dependent manner. In conclusion, vascular NOX1 is a critical mediator of angiogenesis and an attractive target for anti-angiogenic therapies.", "link"=>"http://www.mendeley.com/research/targeting-vascular-nadph-oxidase-1-blocks-tumor-angiogenesis-through-ppar%CE%B1-mediated-mechanism", "reader_count"=>28, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>15, "Medicine and Dentistry"=>6, "Sports and Recreations"=>1, "Psychology"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"United States"=>2, "Germany"=>2, "Russia"=>1, "India"=>1}, "group_count"=>0}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79951539813"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79951539813?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79951539813&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=79951539813&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/79951539813", "dc:identifier"=>"SCOPUS_ID:79951539813", "eid"=>"2-s2.0-79951539813", "dc:title"=>"Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism", "dc:creator"=>"Garrido-Urbani S.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"6", "prism:issueIdentifier"=>"2", "prism:pageRange"=>nil, "prism:coverDate"=>"2011-02-17", "prism:coverDisplayDate"=>"2011", "prism:doi"=>"10.1371/journal.pone.0014665", "citedby-count"=>"103", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Université de Genève Faculté de Médecine", "affiliation-city"=>"Geneva", "affiliation-country"=>"Switzerland"}], "pubmed-id"=>"21326871", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e14665", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0014665", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"122", "xml_views"=>"9", "html_views"=>"399"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"68", "xml_views"=>"3", "html_views"=>"333"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"44", "xml_views"=>"4", "html_views"=>"229"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"178"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"26", "xml_views"=>"2", "html_views"=>"151"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"152"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"25", "xml_views"=>"2", "html_views"=>"173"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"210"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"460"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"35", "xml_views"=>"4", "html_views"=>"573"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"37", "xml_views"=>"2", "html_views"=>"660"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"38", "xml_views"=>"1", "html_views"=>"456"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"43", "xml_views"=>"1", "html_views"=>"108"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"138"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"25", "xml_views"=>"3", "html_views"=>"238"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"39", "xml_views"=>"7", "html_views"=>"230"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"242"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"26", "xml_views"=>"2", "html_views"=>"259"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"40", "xml_views"=>"7", "html_views"=>"373"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"244"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"284"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"316"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"127"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"89"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"90"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"102"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"129"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"115"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"94"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"114"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"108"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"125"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"110"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"4", "html_views"=>"80"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"29"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"37"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"42"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"3", "html_views"=>"23"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"5"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"8"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"11"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"0"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/800750"], "description"=>"<p>In vitro migration was analyzed by wound-healing assay on mouse primary endothelial cells (a), human primary endothelial cells (b) and endothelioma cell lines (c). Tubular structure formation was measured by 3D culture of mouse primary endothelial cells (d), human primary endothelial cells (e) or endothelioma cell lines (f). Results are expressed in % of control ± s.e.m, n = 3. *p<0.05, **p<0.01, ***<0.001 using Student's t-test. GKT136901 was used at 10 µM.</p>", "links"=>[], "tags"=>["inhibition", "blocks", "endothelial", "tube-like"], "article_id"=>471104, "categories"=>["Cancer", "Cell Biology", "Medicine"], "users"=>["Sarah Garrido-Urbani", "Stephane Jemelin", "Christine Deffert", "Stéphanie Carnesecchi", "Olivier Basset", "Cédric Szyndralewiez", "Freddy Heitz", "Patrick Page", "Xavier Montet", "Liliane Michalik", "Jack Arbiser", "Curzio Ruegg", "Karl Heinz Krause", "Beat Imhof"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014665.g004", "stats"=>{"downloads"=>8, "page_views"=>30, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NOX1_inhibition_blocks_endothelial_cell_migration_and_tube_like_structure_formation_/471104", "title"=>"NOX1 inhibition blocks endothelial cell migration and tube-like structure formation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-02-07 00:18:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/800501"], "description"=>"<p>NOX1 expression was measured by quantitative real-time PCR in mouse primary lung endothelial cells (MLEC, a), HUVEC (b), mouse endothelioma cell line (c) after stimulation with VEGF or b-FGF at 20 ng/ml for 3 hours. The quantity of NOX1 mRNA was normalized to the quantity of a housekeeping gene, tubulin for mouse cells and β2-microglobulin for human cells, ± s.e.m, n = 3. Activity of NOX1 was evaluated by ROS measurement using DHE substrate on MLEC (d,g), HUVEC (e, h) and mouse endothelioma (f, i). ROS production is up-regulated by VEGF and b-FGF stimulation in a NOX1-dependent manner. g, h, i. Graphs show quantification of ROS level in endothelial cells stimulated in presence or absence of VEGF or b-FGF. g. MLEC WT (black bar), MLEC WT + GKT136901 (grey bar), MLEC NOX1KO (white bar). h. HUVEC untreated (black bar) or treated with GKT136901 at 10 µM (grey bar). i. Mouse endothelioma cell line untreated (black bar), treated with GKT136901 at 10 µM (grey bar), treated with NOX1 siRNA (white bar). Results are expressed in fold increase ± s.e.m, n = 3. *p<0.05, ***<0.001 using Student's t-test.</p>", "links"=>[], "tags"=>["up-regulated", "angiogenic"], "article_id"=>470850, "categories"=>["Cancer", "Cell Biology", "Medicine"], "users"=>["Sarah Garrido-Urbani", "Stephane Jemelin", "Christine Deffert", "Stéphanie Carnesecchi", "Olivier Basset", "Cédric Szyndralewiez", "Freddy Heitz", "Patrick Page", "Xavier Montet", "Liliane Michalik", "Jack Arbiser", "Curzio Ruegg", "Karl Heinz Krause", "Beat Imhof"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014665.g002", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NOX1_expression_and_activity_is_up_regulated_by_angiogenic_stimuli_/470850", "title"=>"NOX1 expression and activity is up-regulated by angiogenic stimuli.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-02-07 00:14:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/800637"], "description"=>"<p>(a) Concentration-response curve of GKT136901 (◊) and DPI (x) on membranes prepared from NOX1 over-expressing cells. Results represent one out of four experiments performed in triplicate. Values are presented as means ± s.e.m. (b) Affinities of GKT136901 and DPI on NOX1, NOX2, NOX4 and Xanthine Oxidase. GKT136901 is a NADPH-oxidase specific inhibitor, with selectivity on NOX1 and NOX4 over NOX2, whereas DPI inhibits all the NADPH oxidases tested with the same potency.</p>", "links"=>[], "tags"=>["nox1-dependent", "ros"], "article_id"=>470986, "categories"=>["Cancer", "Cell Biology", "Medicine"], "users"=>["Sarah Garrido-Urbani", "Stephane Jemelin", "Christine Deffert", "Stéphanie Carnesecchi", "Olivier Basset", "Cédric Szyndralewiez", "Freddy Heitz", "Patrick Page", "Xavier Montet", "Liliane Michalik", "Jack Arbiser", "Curzio Ruegg", "Karl Heinz Krause", "Beat Imhof"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014665.g003", "stats"=>{"downloads"=>2, "page_views"=>40, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Inhibition_of_NOX1_dependent_ROS_production_by_GKT136901_/470986", "title"=>"Inhibition of NOX1-dependent ROS production by GKT136901.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-02-07 00:16:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/400272", "https://ndownloader.figshare.com/files/400274", "https://ndownloader.figshare.com/files/400280", "https://ndownloader.figshare.com/files/400283", "https://ndownloader.figshare.com/files/400288", "https://ndownloader.figshare.com/files/400291", "https://ndownloader.figshare.com/files/400294", "https://ndownloader.figshare.com/files/400305", "https://ndownloader.figshare.com/files/400313", "https://ndownloader.figshare.com/files/400321"], "description"=>"<div><p>Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and survival, events critically involved in angiogenesis. Different isoforms of ROS-generating NOX enzymes are expressed in the vasculature and provide distinct signaling cues through differential localization and activation. We show that mice deficient in NOX1, but not NOX2 or NOX4, have impaired angiogenesis. NOX1 expression and activity is increased in primary mouse and human endothelial cells upon angiogenic stimulation. NOX1 silencing decreases endothelial cell migration and tube-like structure formation, through the inhibition of PPARα, a regulator of NF-κB. Administration of a novel NOX-specific inhibitor reduced angiogenesis and tumor growth in vivo in a PPARα dependent manner. In conclusion, vascular NOX1 is a critical mediator of angiogenesis and an attractive target for anti-angiogenic therapies.</p></div>", "links"=>[], "tags"=>["targeting", "vascular", "nadph", "oxidase", "blocks", "angiogenesis", "mediated"], "article_id"=>139053, "categories"=>["Cancer", "Cell Biology", "Medicine"], "users"=>["Sarah Garrido-Urbani", "Stephane Jemelin", "Christine Deffert", "Stéphanie Carnesecchi", "Olivier Basset", "Cédric Szyndralewiez", "Freddy Heitz", "Patrick Page", "Xavier Montet", "Liliane Michalik", "Jack Arbiser", "Curzio Ruegg", "Karl Heinz Krause", "Beat Imhof"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0014665.s001", "https://dx.doi.org/10.1371/journal.pone.0014665.s002", "https://dx.doi.org/10.1371/journal.pone.0014665.s003", "https://dx.doi.org/10.1371/journal.pone.0014665.s004", "https://dx.doi.org/10.1371/journal.pone.0014665.s005", "https://dx.doi.org/10.1371/journal.pone.0014665.s006", "https://dx.doi.org/10.1371/journal.pone.0014665.s007", "https://dx.doi.org/10.1371/journal.pone.0014665.s008", "https://dx.doi.org/10.1371/journal.pone.0014665.s009", "https://dx.doi.org/10.1371/journal.pone.0014665.s010"], "stats"=>{"downloads"=>12, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Targeting_Vascular_NADPH_Oxidase_1_Blocks_Tumor_Angiogenesis_through_a_PPAR_Mediated_Mechanism/139053", "title"=>"Targeting Vascular NADPH Oxidase 1 Blocks Tumor Angiogenesis through a PPARα Mediated Mechanism", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-02-07 02:30:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/801153"], "description"=>"<p>(a) Tumor cells and tumor-infiltrating leukocytes during tumor development produce proangiogenic factors such as VEGF and bFGF. These factors activate the preexisting vessels to form neovessels by sprouting, migration and proliferation. (b) Endothelial cells receive the angiogenic stimulus by fixation of the angiogenic factor to the surface receptor. This interaction initiates a signaling cascade, which leads to NOX1 activation through Rac1. NOX1 dependent ROS inhibits the nuclear hormone receptor PPAR<b>α</b> by post-translational modification and transcriptional regulation. This inhibition leads to NF-κB activation and transcription of angiogenic factors such as MMPs, growth factors or promigratory molecules.</p>", "links"=>[], "tags"=>["nox1"], "article_id"=>471507, "categories"=>["Cancer", "Cell Biology", "Medicine"], "users"=>["Sarah Garrido-Urbani", "Stephane Jemelin", "Christine Deffert", "Stéphanie Carnesecchi", "Olivier Basset", "Cédric Szyndralewiez", "Freddy Heitz", "Patrick Page", "Xavier Montet", "Liliane Michalik", "Jack Arbiser", "Curzio Ruegg", "Karl Heinz Krause", "Beat Imhof"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014665.g007", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_representation_of_the_role_of_NOX1_in_tumor_angiogenesis_/471507", "title"=>"Schematic representation of the role of NOX1 in tumor angiogenesis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-02-07 00:25:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/801058"], "description"=>"<p>B16F0 (a) or LLC1 (b) tumor cells were injected subcutaneously into WT or NOX1 KO mice. Tumors were allowed to develop for 10 days and the density of tumor vasculature was identified using PECAM-1 staining by measuring the positive (vascular) and total (tumor) area ± s.e.m expressed as percentage. n = 8; WT mice injected with LLC1 tumor cells were then treated with the NOX inhibitor GKT136901 at 40 mg/kg/day by oral administration for 8 days; (c). Graph represents tumor weight in mg ± s.e.m n = 8 per group. (d). Tumor vessel density in tumors from the experiment in (c). Graph shows tumor vascularization expressed in percentage of PECAM-1 positive area ± s.e.m.; (e). Changes in tumor volume in mm<sup>3</sup> after therapeutic treatment starting 8 days post tumor cell injection with GKT136901 (black arrows) or anti-VEGFR2 (DC101) (pointed arrows). Tumor volume is measured using a caliper and the formula V = 4/3π(L/2*l/2*w/2). n = 8; (f). Blood vessel density in tumors from the experiment in (e). at day 12. Graph shows tumor vascularization expressed in percentage of PECAM-1 positive area ± s.e.m. WT or PPAR<b>α</b> KO mice injected with B16F0 (g) or LLC1 (h) were then treated with the NOX inhibitor GKT136901 at 40 mg/kg/day by oral administration for 8 days. Graph shows tumor vascularization expressed in percentage of PECAM-1 positive area ± s.e.m. n = 6. * p<0.05, ** p<0.01 (Student's t-test).</p>", "links"=>[], "tags"=>["inhibition"], "article_id"=>471411, "categories"=>["Cancer", "Cell Biology", "Medicine"], "users"=>["Sarah Garrido-Urbani", "Stephane Jemelin", "Christine Deffert", "Stéphanie Carnesecchi", "Olivier Basset", "Cédric Szyndralewiez", "Freddy Heitz", "Patrick Page", "Xavier Montet", "Liliane Michalik", "Jack Arbiser", "Curzio Ruegg", "Karl Heinz Krause", "Beat Imhof"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014665.g006", "stats"=>{"downloads"=>6, "page_views"=>61, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NOX1_inhibition_reduces_tumor_growth_and_angiogenesis_/471411", "title"=>"NOX1 inhibition reduces tumor growth and angiogenesis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-02-07 00:23:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/800893"], "description"=>"<p>NOX1 deficiency induces an up-regulation of PPAR<b>α</b> expression and inhibition of pro-angiogenic signaling in endothelial cells. (a). Expression level of PPAR<b>α</b> in MLEC and endothelioma cell lines by quantitative real-time PCR, normalized to the tubulin expression. (b–c) PPAR<b>α</b> antagonist, GW6471 compensated NOX1 deficiency in MLEC. (b). Migration of NOX1-deficient MLEC in presence or absence of PPAR<b>α</b> antagonist (10 µM). (c). Tube-like structure formation of NOX1-deficient MLEC in presence or absence of PPAR<b>α</b> antagonist (10 µM). VEGF and b-FGF induced-NFκB nuclear translocation is inhibited in absence of NOX1 and is dependent on PPAR<b>α</b> activity. (d). Western blot analysis of p65 NFκB in nuclear and cytoplasmic fractions of WT and NOX1-deficient cells stimulated 30 min with VEGF and bFGF (20 ng/ml). (e). Western blot analysis of p65 NFkB in nuclear and cytoplasmic fractions of NOX1-silenced cells treated or not with 10 µM of GW6471 before stimulation with VEGF and bFGF. The graphs show the abundance of nuclear p65 NF-κB relative to cytoplasmic p65 NF-κB ± s.e.m as determined by densitometry. n = 3. * p<0.05, ** p<0.01 (Student's t-test).</p>", "links"=>[], "tags"=>["negatively", "regulates"], "article_id"=>471256, "categories"=>["Cancer", "Cell Biology", "Medicine"], "users"=>["Sarah Garrido-Urbani", "Stephane Jemelin", "Christine Deffert", "Stéphanie Carnesecchi", "Olivier Basset", "Cédric Szyndralewiez", "Freddy Heitz", "Patrick Page", "Xavier Montet", "Liliane Michalik", "Jack Arbiser", "Curzio Ruegg", "Karl Heinz Krause", "Beat Imhof"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014665.g005", "stats"=>{"downloads"=>4, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NOX1_negatively_regulates_PPAR_945_expression_and_activity_/471256", "title"=>"NOX1 negatively regulates PPARα expression and activity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-02-07 00:20:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/800392"], "description"=>"<p>Matrigel was loaded with 500 ng/ml bFGF and implanted subcutaneously into NOX deficient mice. After one week, iodinated liposomes were injected i.v. and the plugs analyzed by X-ray tomography. (a) Quantification of matrigel plug vascularization. Graph shows mean of grey density ± s.e.m. For WT, NOX1 KO and NOX1/2 KO n = 8 and for NOX2 KO and NOX4 KO n = 6. (b) Photographs of excised plugs, scale bars represent 1 cm. c. Blood vessel density in plugs from the experiment in (a). Graph shows percentage of PECAM-1 positive area ± s.e.m. (d). Photographs of PECAM-1 immunostaining, PECAM-1 in green, nuclei in blue, scale bars represent 20 µm. Images were acquired with a 20x/0.5 numeric aperture lens and analyzed using LSM510 Meta confocal microscope (Carl Zeiss). e. Vessel size analysis; vessel with lumen under 20 µm are considered as small (black), from 20 to 50 medium (dark grey) and over 50 µm as large (light grey) ± s.e.m. Anova p<0.01; * p<0.05, ** p<0.01, *** p<0.001.</p>", "links"=>[], "tags"=>["deficient", "mice", "reduced", "angiogenic"], "article_id"=>470748, "categories"=>["Cancer", "Cell Biology", "Medicine"], "users"=>["Sarah Garrido-Urbani", "Stephane Jemelin", "Christine Deffert", "Stéphanie Carnesecchi", "Olivier Basset", "Cédric Szyndralewiez", "Freddy Heitz", "Patrick Page", "Xavier Montet", "Liliane Michalik", "Jack Arbiser", "Curzio Ruegg", "Karl Heinz Krause", "Beat Imhof"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014665.g001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NOX1_deficient_mice_exhibit_reduced_angiogenic_capacity_/470748", "title"=>"NOX1 deficient mice exhibit reduced angiogenic capacity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-02-07 00:12:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/801259"], "description"=>"<p>Level of expression of target genes in NOX1 deficient primary endothelial cells (MLEC), or silenced cells endothelial cell lines compared to control cells, analyzed by quantitative real-time PCR. Results are expressed in fold increase or decrease ± s.e.m. n = 3.</p>", "links"=>[], "tags"=>["genes", "regulated", "nox1"], "article_id"=>471615, "categories"=>["Cancer", "Cell Biology", "Medicine"], "users"=>["Sarah Garrido-Urbani", "Stephane Jemelin", "Christine Deffert", "Stéphanie Carnesecchi", "Olivier Basset", "Cédric Szyndralewiez", "Freddy Heitz", "Patrick Page", "Xavier Montet", "Liliane Michalik", "Jack Arbiser", "Curzio Ruegg", "Karl Heinz Krause", "Beat Imhof"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014665.t001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_genes_regulated_by_NOX1_deficiency_/471615", "title"=>"Expression of genes regulated by NOX1 deficiency.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-02-07 00:26:55"}

PMC Usage Stats | Further Information

  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"22", "year"=>"2011", "pdf"=>"20", "unique-ip"=>"29", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"14", "full-text"=>"91", "unique-ip"=>"96", "pdf"=>"57", "year"=>"2011", "figure"=>"39", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"13", "full-text"=>"49", "year"=>"2011", "pdf"=>"25", "unique-ip"=>"55", "figure"=>"20", "scanned-summary"=>"0", "supp-data"=>"18"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"41", "unique-ip"=>"42", "pdf"=>"19", "year"=>"2011", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"13"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"24", "year"=>"2011", "pdf"=>"14", "unique-ip"=>"25", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"30", "unique-ip"=>"27", "pdf"=>"19", "year"=>"2011", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"41", "year"=>"2011", "pdf"=>"12", "unique-ip"=>"36", "figure"=>"20", "scanned-summary"=>"0", "supp-data"=>"29"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"54", "unique-ip"=>"52", "pdf"=>"23", "year"=>"2011", "figure"=>"21", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"32", "year"=>"2011", "pdf"=>"16", "unique-ip"=>"36", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"44", "unique-ip"=>"35", "pdf"=>"30", "year"=>"2011", "figure"=>"15", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"33", "year"=>"2011", "pdf"=>"17", "unique-ip"=>"32", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"29", "unique-ip"=>"29", "pdf"=>"14", "year"=>"2012", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"30", "year"=>"2012", "pdf"=>"21", "unique-ip"=>"28", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"38", "unique-ip"=>"33", "pdf"=>"10", "year"=>"2012", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "year"=>"2012", "pdf"=>"14", "unique-ip"=>"20", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "unique-ip"=>"21", "pdf"=>"13", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"24", "year"=>"2012", "pdf"=>"11", "unique-ip"=>"19", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"30", "full-text"=>"29", "pdf"=>"13", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"11", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"28", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"26", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"8", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"1", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"11", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"26", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"19", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[301, 558, 690, 806, 916, 1018, 1112, 1197, 1275, 1349, 1421, 1495, 1561, 1631, 1697, 1762, 1835, 1895, 1954, 2020, 2078, 2142, 2197, 2258, 2313, 2376, 2437, 2494, 2557, 2618, 2682, 2744, 2818, 2880, 2940, 3000, 3056]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[298, 559, 690, 805, 916, 1018, 1115, 1201, 1283, 1356, 1425, 1498, 1565, 1635, 1703, 1767, 1835, 1902, 1962, 2027, 2089, 2150, 2210, 2265]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[290, 559, 698, 813, 927, 1028, 1121, 1206, 1289, 1360, 1433, 1501, 1569, 1637, 1707, 1774, 1841, 1911, 1974, 2038, 2103, 2161, 2219, 2280, 2345, 2406, 2466, 2529, 2592, 2654, 2713, 2772, 2835, 2893, 2954, 3020, 3071]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[289, 559, 699, 817, 931, 1031, 1127, 1214, 1297, 1370, 1444, 1515, 1584, 1656, 1726, 1797, 1862, 1930, 1996, 2061, 2125, 2190, 2250, 2311, 2373, 2435, 2496, 2563, 2630, 2692, 2760, 2824, 2898, 2960, 3019, 3089, 3143]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[301, 573, 717, 840, 956, 1063, 1159, 1248, 1327, 1406, 1478, 1557, 1626, 1700, 1772, 1843, 1910, 1980, 2052, 2124, 2192, 2263, 2328, 2391, 2443, 2496, 2564, 2629, 2698, 2771, 2834, 2897, 2959, 3021, 3077, 3144, 3193]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[296, 554, 686, 802, 910, 1014, 1104, 1195, 1277, 1349, 1419, 1483, 1551, 1620, 1690, 1757, 1820, 1888, 1957, 2017, 2081, 2140, 2202, 2259]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[291, 540, 674, 787, 893, 986, 1087, 1172, 1249, 1319, 1394, 1465, 1526, 1588, 1645, 1713, 1774, 1837, 1903, 1959, 2027, 2085, 2152, 2205, 2259, 2318, 2377, 2436, 2486, 2539, 2603, 2664, 2719, 2779, 2835, 2888, 2944]}]}
Loading … Spinner
There are currently no alerts