Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)
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{"title"=>"Molecular characterization of acquired tolerance of tumor cells to picropodophyllin (PPP)", "type"=>"journal", "authors"=>[{"first_name"=>"Jamileh", "last_name"=>"Hashemi", "scopus_author_id"=>"7004601775"}, {"first_name"=>"Claire", "last_name"=>"Worrall", "scopus_author_id"=>"37076279300"}, {"first_name"=>"Daiana", "last_name"=>"Vasilcanu", "scopus_author_id"=>"9036693000"}, {"first_name"=>"Mårten", "last_name"=>"Fryknäs", "scopus_author_id"=>"12807567100"}, {"first_name"=>"Luqman", "last_name"=>"Sulaiman", "scopus_author_id"=>"37075818300"}, {"first_name"=>"Mohsen", "last_name"=>"Karimi", "scopus_author_id"=>"35746637600"}, {"first_name"=>"Wen Hui", "last_name"=>"Weng", "scopus_author_id"=>"7102625513"}, {"first_name"=>"Weng Onn", "last_name"=>"Lui", "scopus_author_id"=>"7101851159"}, {"first_name"=>"Christina", "last_name"=>"Rudduck", "scopus_author_id"=>"6603049849"}, {"first_name"=>"Magnus", "last_name"=>"Axelson", "scopus_author_id"=>"7005878959"}, {"first_name"=>"Helena", "last_name"=>"Jernberg-Wiklund", "scopus_author_id"=>"6602312043"}, {"first_name"=>"Leonard", "last_name"=>"Girnita", "scopus_author_id"=>"6603297841"}, {"first_name"=>"Olle", "last_name"=>"Larsson", "scopus_author_id"=>"57197776109"}, {"first_name"=>"Catharina", "last_name"=>"Larsson", "scopus_author_id"=>"7201834826"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"21423728", "doi"=>"10.1371/journal.pone.0014757", "pui"=>"361447021", "issn"=>"19326203", "sgr"=>"79952685382", "scopus"=>"2-s2.0-79952685382"}, "id"=>"6b4a5c76-9df6-369e-abd0-9abf20b158d7", "abstract"=>"BACKGROUND: Picropodophyllin (PPP) is a promising novel anti-neoplastic agent that efficiently kills tumor cells in vitro and causes tumor regression and increased survival in vivo. We have previously reported that PPP treatment induced moderate tolerance in two out of 10 cell lines only, and here report the acquired genomic and expression alterations associated with PPP selection over 1.5 years of treatment. METHODOLOGY/PRINCIPAL FINDINGS: Copy number alterations monitored using metaphase and array-based comparative genomic hybridization analyses revealed largely overlapping alterations in parental and maximally tolerant cells. Gain/amplification of the MYC and PVT1 loci in 8q24.21 were verified on the chromosome level. Abnormalities observed in connection to PPP treatment included regular gains and losses, as well as homozygous losses in 10q24.1-q24.2 and 12p12.3-p13.2 in one of the lines and amplification at 5q11.2 in the other. Abnormalities observed in both tolerant derivatives include amplification/gain of 5q11.2, gain of 11q12.1-q14.3 and gain of 13q33.3-qter. Using Nexus software analysis we combined the array-CGH data with data from gene expression profilings and identified genes that were altered in both inputs. A subset of genes identified as downregulated (ALDH1A3, ANXA1, TLR4 and RAB5A) or upregulated (COX6A1, NFIX, ME1, MAPK and TAP2) were validated by siRNA in the tolerant or parental cells to alter sensitivity to PPP and confirmed to alter sensitivity to PPP in further cell lines. CONCLUSIONS: Long-term PPP selection lead to altered gene expression in PPP tolerant cells with increase as well as decrease of genes involved in cell death such as PTEN and BCL2. In addition, acquired genomic copy number alterations were observed that were often reflected by altered mRNA expression levels for genes in the same regions.", "link"=>"http://www.mendeley.com/research/molecular-characterization-acquired-tolerance-tumor-cells-picropodophyllin-ppp", "reader_count"=>15, "reader_count_by_academic_status"=>{"Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>7, "Business, Management and Accounting"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "group_count"=>1}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/791922"], "description"=>"<p>*indicates genes validated by siRNA.</p>", "links"=>[], "tags"=>["dysregulated", "ppp", "tolerant", "line2-t500", "line3-t200", "cells", "0008219"], "article_id"=>462273, "categories"=>["Cancer", "Genetics", "Pharmacology", "Biochemistry"], "users"=>["Jamileh Hashemi", "Claire Worrall", "Daiana Vasilcanu", "Mårten Fryknäs", "Luqman Sulaiman", "Mohsen Karimi", "Wen-Hui Weng", "Weng-Onn Lui", "Christina Rudduck", "Magnus Axelson", "Helena Jernberg-Wiklund", "Leonard Girnita", "Olle Larsson", "Catharina Larsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014757.t003", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genes_dysregulated_in_PPP_tolerant_Line2_T500_and_Line3_T200_cells_in_GO_category_0008219_cell_death_from_gene_list_U_/462273", "title"=>"Genes dysregulated in PPP tolerant Line2-T500 and Line3-T200 cells in GO category 0008219 cell death (from gene list U).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-03-14 00:37:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/791861"], "description"=>"<p>Commonly dysregulated genes in regions of relative copy number alterations in PPP tolerant Line2-T500 and Line3-T200 cells (data by Nexus analyses).</p>", "links"=>[], "tags"=>["dysregulated", "genes", "regions", "alterations", "ppp", "tolerant", "line2-t500", "line3-t200", "cells", "nexus"], "article_id"=>462211, "categories"=>["Cancer", "Genetics", "Pharmacology", "Biochemistry"], "users"=>["Jamileh Hashemi", "Claire Worrall", "Daiana Vasilcanu", "Mårten Fryknäs", "Luqman Sulaiman", "Mohsen Karimi", "Wen-Hui Weng", "Weng-Onn Lui", "Christina Rudduck", "Magnus Axelson", "Helena Jernberg-Wiklund", "Leonard Girnita", "Olle Larsson", "Catharina Larsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014757.t002", "stats"=>{"downloads"=>5, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Commonly_dysregulated_genes_in_regions_of_relative_copy_number_alterations_in_PPP_tolerant_Line2_T500_and_Line3_T200_cells_data_by_Nexus_analyses_/462211", "title"=>"Commonly dysregulated genes in regions of relative copy number alterations in PPP tolerant Line2-T500 and Line3-T200 cells (data by Nexus analyses).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-03-14 00:36:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/791342"], "description"=>"<p>Comparison of relative copy number imbalances between tolerant and parental cells detected in Line2-T500 (top), Line3-T200 (middle), and commonly for Line2-T500 and Line3-T200 (bottom), with corresponding gene expression levels by Affymetrix. Each vertical line represents one abnormality in one sample. In each panel the upper plots for array-CGH data show relative copy number gains (green) and losses (red) from 1pter to Yqter. The lower plots show genes with increased (blue) or decreased (purple) expression at loci with altered gene dose in Line2 and Line3.</p>", "links"=>[], "tags"=>["imbalances", "corresponding"], "article_id"=>461701, "categories"=>["Cancer", "Genetics", "Pharmacology", "Biochemistry"], "users"=>["Jamileh Hashemi", "Claire Worrall", "Daiana Vasilcanu", "Mårten Fryknäs", "Luqman Sulaiman", "Mohsen Karimi", "Wen-Hui Weng", "Weng-Onn Lui", "Christina Rudduck", "Magnus Axelson", "Helena Jernberg-Wiklund", "Leonard Girnita", "Olle Larsson", "Catharina Larsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014757.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_copy_number_imbalances_with_corresponding_gene_expression_levels_/461701", "title"=>"Comparison of copy number imbalances with corresponding gene expression levels.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-14 00:28:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/792025"], "description"=>"<p>The PPP sensitivity ratio was calculated as fluorescence from wells treated with PPP to those treated without PPP.</p><p>Statistical significance was calculated using the T test compared to the wells treated with negative control siRNA.</p><p>↓  =  Trend in decreased tolerance to PPP, p<0.1; ↓*  =  Significant decreased tolerance to PPP, p<0.05.</p><p>↑  =  Trend in increased tolerance to PPP, p<0.1; ↑*  =  Significant increased tolerance to PPP, p<0.05.</p><p>NS  =  No statistically significant change.</p>", "links"=>[], "tags"=>["genes", "sirna"], "article_id"=>462374, "categories"=>["Cancer", "Genetics", "Pharmacology", "Biochemistry"], "users"=>["Jamileh Hashemi", "Claire Worrall", "Daiana Vasilcanu", "Mårten Fryknäs", "Luqman Sulaiman", "Mohsen Karimi", "Wen-Hui Weng", "Weng-Onn Lui", "Christina Rudduck", "Magnus Axelson", "Helena Jernberg-Wiklund", "Leonard Girnita", "Olle Larsson", "Catharina Larsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Validation_of_identified_genes_by_siRNA_treatment_/462374", "title"=>"Validation of identified genes by siRNA treatment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-03-14 00:39:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/791098"], "description"=>"<p>(<b>A</b>) FISH analysis using a Spectrum Orange labelled BAC clone covering the <i>MYC</i> locus. Line2 cells in metaphase show red signals on 4 individual chromosomes as well as 4 signals in interphase. In interphase nuclei of Line3-T200 cells single individual red spots are observed together with clusters of more than 10 signals suggesting a homogeneously staining region. (<b>B</b>) Array-CGH profiles for chromosome 8 in parental and PPP tolerant cells. Parental and PPP tolerant cells show gain of 8q24.13-qter in Line2, narrow amplification of 8q24.21 in Line3. (<b>C</b>) The heatmap illustrates the common regions of gain/amplification including the <i>MYC</i> and <i>PVT1</i> loci, with gain indicated in light blue and amplifications marked in dark blue. The first column is the name of clones in the BAC array.</p>", "links"=>[], "tags"=>["amplifications", "involving", "verification", "array-cgh"], "article_id"=>461451, "categories"=>["Cancer", "Genetics", "Pharmacology", "Biochemistry"], "users"=>["Jamileh Hashemi", "Claire Worrall", "Daiana Vasilcanu", "Mårten Fryknäs", "Luqman Sulaiman", "Mohsen Karimi", "Wen-Hui Weng", "Weng-Onn Lui", "Christina Rudduck", "Magnus Axelson", "Helena Jernberg-Wiklund", "Leonard Girnita", "Olle Larsson", "Catharina Larsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014757.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gains_and_amplifications_involving_8q24_21_and_verification_of_array_CGH_results_by_FISH_for_the_MYC_locus_/461451", "title"=>"Gains and amplifications involving 8q24.21 and verification of array-CGH results by FISH for the <i>MYC</i> locus.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-14 00:24:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/396033", "https://ndownloader.figshare.com/files/396056", "https://ndownloader.figshare.com/files/396087", "https://ndownloader.figshare.com/files/396121", "https://ndownloader.figshare.com/files/396158", "https://ndownloader.figshare.com/files/396183", "https://ndownloader.figshare.com/files/396309", "https://ndownloader.figshare.com/files/396370", "https://ndownloader.figshare.com/files/396421"], "description"=>"<div><h3>Background</h3><p>Picropodophyllin (PPP) is a promising novel anti-neoplastic agent that efficiently kills tumor cells <em>in vitro</em> and causes tumor regression and increased survival <em>in vivo</em>. We have previously reported that PPP treatment induced moderate tolerance in two out of 10 cell lines only, and here report the acquired genomic and expression alterations associated with PPP selection over 1.5 years of treatment.</p><h3>Methodology/Principal Findings</h3><p>Copy number alterations monitored using metaphase and array-based comparative genomic hybridization analyses revealed largely overlapping alterations in parental and maximally tolerant cells. Gain/ amplification of the <em>MYC</em> and <em>PVT1</em> loci in 8q24.21 were verified on the chromosome level. Abnormalities observed in connection to PPP treatment included regular gains and losses, as well as homozygous losses in 10q24.1-q24.2 and 12p12.3-p13.2 in one of the lines and amplification at 5q11.2 in the other. Abnormalities observed in both tolerant derivatives include amplification/gain of 5q11.2, gain of 11q12.1-q14.3 and gain of 13q33.3-qter. Using Nexus software analysis we combined the array-CGH data with data from gene expression profilings and identified genes that were altered in both inputs. A subset of genes identified as downregulated (<em>ALDH1A3</em>, <em>ANXA1</em>, <em>TLR4</em> and <em>RAB5A</em>) or upregulated (<em>COX6A1</em>, <em>NFIX</em>, <em>ME1</em>, <em>MAPK</em> and <em>TAP2</em>) were validated by siRNA in the tolerant or parental cells to alter sensitivity to PPP and confirmed to alter sensitivity to PPP in further cell lines.</p><h3>Conclusions</h3><p>Long-term PPP selection lead to altered gene expression in PPP tolerant cells with increase as well as decrease of genes involved in cell death such as <em>PTEN</em> and <em>BCL2</em>. In addition, acquired genomic copy number alterations were observed that were often reflected by altered mRNA expression levels for genes in the same regions.</p></div>", "links"=>[], "tags"=>["molecular", "characterization", "acquired", "cells", "picropodophyllin"], "article_id"=>138228, "categories"=>["Cancer", "Genetics", "Pharmacology", "Biochemistry"], "users"=>["Jamileh Hashemi", "Claire Worrall", "Daiana Vasilcanu", "Mårten Fryknäs", "Luqman Sulaiman", "Mohsen Karimi", "Wen-Hui Weng", "Weng-Onn Lui", "Christina Rudduck", "Magnus Axelson", "Helena Jernberg-Wiklund", "Leonard Girnita", "Olle Larsson", "Catharina Larsson"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0014757.s001", "https://dx.doi.org/10.1371/journal.pone.0014757.s002", "https://dx.doi.org/10.1371/journal.pone.0014757.s003", "https://dx.doi.org/10.1371/journal.pone.0014757.s004", "https://dx.doi.org/10.1371/journal.pone.0014757.s005", "https://dx.doi.org/10.1371/journal.pone.0014757.s006", "https://dx.doi.org/10.1371/journal.pone.0014757.s007", "https://dx.doi.org/10.1371/journal.pone.0014757.s008", "https://dx.doi.org/10.1371/journal.pone.0014757.s009"], "stats"=>{"downloads"=>52, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Molecular_Characterization_of_Acquired_Tolerance_of_Tumor_Cells_to_Picropodophyllin_PPP_/138228", "title"=>"Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-03-14 02:17:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/791972"], "description"=>"<p>Bold indicates amplification; Homozygous deletions hz are marked in bold and italic.</p><p>Borderline alterations are given within paranthesis; \"Pr\" indicates Pronounced gain.</p>", "links"=>[], "tags"=>["abnormalities", "observed", "array-cgh", "ppp", "tolerant", "lines"], "article_id"=>462328, "categories"=>["Cancer", "Genetics", "Pharmacology", "Biochemistry"], "users"=>["Jamileh Hashemi", "Claire Worrall", "Daiana Vasilcanu", "Mårten Fryknäs", "Luqman Sulaiman", "Mohsen Karimi", "Wen-Hui Weng", "Weng-Onn Lui", "Christina Rudduck", "Magnus Axelson", "Helena Jernberg-Wiklund", "Leonard Girnita", "Olle Larsson", "Catharina Larsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014757.t001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Copy_number_abnormalities_observed_by_array_CGH_in_PPP_tolerant_cell_lines_only_/462328", "title"=>"Copy number abnormalities observed by array-CGH in PPP tolerant cell lines only.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-03-14 00:38:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/791771"], "description"=>"<p>Methylation at CCGG sites measured by LUMA in PPP sensitive Line2 and tolerantLine2-T500 cell<b>s</b>. The Y-axis shows the <i>Hpa</i>II/<i>Msp</i>I ratio, which correlates inversely to DNA methylation levels. Line2 cells cultured in PPP free media were short-term treated for 24 h with or without 500 nM PPP. Line2-T500 cells cultured in 500 nM PPP were similarly treated for 24 h by adding 500 nM PPP (total concentration 1000 nM). Peak heights were plotted with error bars ± SD. P-values were calculated using the t-test, n.s.  =  not statistically significant.</p>", "links"=>[], "tags"=>["hypomethylation", "ppp", "line2"], "article_id"=>462123, "categories"=>["Cancer", "Genetics", "Pharmacology", "Biochemistry"], "users"=>["Jamileh Hashemi", "Claire Worrall", "Daiana Vasilcanu", "Mårten Fryknäs", "Luqman Sulaiman", "Mohsen Karimi", "Wen-Hui Weng", "Weng-Onn Lui", "Christina Rudduck", "Magnus Axelson", "Helena Jernberg-Wiklund", "Leonard Girnita", "Olle Larsson", "Catharina Larsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014757.g006", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Global_hypomethylation_after_PPP_treatment_of_Line2_cells_/462123", "title"=>"Global hypomethylation after PPP treatment of Line2 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-14 00:35:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/791494"], "description"=>"<p>The heat maps show (A) upregulated and (B) downregulated genes in PPP tolerant (Line2-T500 and Line3-T200) cells as compared to parental Line2 and Line3 cells. Relative expression levels are indicated according to the colour scale and further gene information is given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014757#pone.0014757.s007\" target=\"_blank\">Table S5</a>.</p>", "links"=>[], "tags"=>["maps", "hierarchical", "clustering", "genes"], "article_id"=>461850, "categories"=>["Cancer", "Genetics", "Pharmacology", "Biochemistry"], "users"=>["Jamileh Hashemi", "Claire Worrall", "Daiana Vasilcanu", "Mårten Fryknäs", "Luqman Sulaiman", "Mohsen Karimi", "Wen-Hui Weng", "Weng-Onn Lui", "Christina Rudduck", "Magnus Axelson", "Helena Jernberg-Wiklund", "Leonard Girnita", "Olle Larsson", "Catharina Larsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014757.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heat_maps_and_hierarchical_clustering_of_genes_in_gene_list_H_/461850", "title"=>"Heat maps and hierarchical clustering of genes in gene list H.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-14 00:30:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/791206"], "description"=>"<p>Amplification of 5q11.2 in Line3-T200 cells (top) and chromosome 11 copy number alterations in all lines (bottom). Gain of 11q12.1-q14.3 is identified as a common alteration in Line2-T500 and Line3-T200 cells as compared to Line2 and Line3 cells. For Line2 and Line2-T500 the threshold +0.2 is used to illustrate the border-line gain of 11p11.2-q14.3. Copy number loss of distal 11q is present in Line3-T200 and in Line2 and Line2-T500. Candidate genes with common over-expression in the region of gain are shown below the plots. The array-CGH plots of chromosome 5 show alterations outside the thresholds of +0.25 for gain and +1.0 for amplification, as well as borderline alterations at the +0.25 threshold. The alterations were scored as borderline gain of 5pter-q15 in Line3, and in Line 3-T200 as gain of 5p15.1-pter and p13.3-q11.2 with borderline gain of p13.3-p15.1 and amplification of q11.2.</p>", "links"=>[], "tags"=>["profiles"], "article_id"=>461564, "categories"=>["Cancer", "Genetics", "Pharmacology", "Biochemistry"], "users"=>["Jamileh Hashemi", "Claire Worrall", "Daiana Vasilcanu", "Mårten Fryknäs", "Luqman Sulaiman", "Mohsen Karimi", "Wen-Hui Weng", "Weng-Onn Lui", "Christina Rudduck", "Magnus Axelson", "Helena Jernberg-Wiklund", "Leonard Girnita", "Olle Larsson", "Catharina Larsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014757.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Array_CGH_profiles_of_copy_number_alterations_/461564", "title"=>"Array-CGH profiles of copy number alterations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-14 00:26:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/791590"], "description"=>"<p>(<b>A</b>) Line2 cells were treated with siRNA for the downregulated genes <i>ALDH1A3</i> or <i>ANXA1</i>, and (<b>B</b>) PPP tolerant Line2-T500 cells were treated with siRNA for the upregulated genes <i>COX6A1</i> or <i>NFIX</i>. Cell lines transfected with siRNA were incubated with 0, 0.05, 0.5, 1 and 2.5 µM PPP for 48 hours and cell viability assessed using alamarBlue as described in the materials and methods. Cell numbers were interpolated from a standard curve and plotted relative to untreated cells. Statistical significance, p≤0.05, as calculated using a two tailed T test is indicated by *.</p>", "links"=>[], "tags"=>["curves", "sirna"], "article_id"=>461951, "categories"=>["Cancer", "Genetics", "Pharmacology", "Biochemistry"], "users"=>["Jamileh Hashemi", "Claire Worrall", "Daiana Vasilcanu", "Mårten Fryknäs", "Luqman Sulaiman", "Mohsen Karimi", "Wen-Hui Weng", "Weng-Onn Lui", "Christina Rudduck", "Magnus Axelson", "Helena Jernberg-Wiklund", "Leonard Girnita", "Olle Larsson", "Catharina Larsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0014757.g005", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PPP_sensitivity_curves_following_siRNA_treatment_/461951", "title"=>"PPP sensitivity curves following siRNA treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-14 00:32:31"}

PMC Usage Stats | Further Information

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Relative Metric

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