Liposome-Coupled Peptides Induce Long-Lived Memory CD8+ T Cells Without CD4+ T Cells
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{"title"=>"Liposome-Coupled Peptides Induce Long-Lived Memory CD8+ T Cells Without CD4+ T Cells", "type"=>"journal", "authors"=>[{"first_name"=>"Maiko", "last_name"=>"Taneichi", "scopus_author_id"=>"6602000632"}, {"first_name"=>"Yuriko", "last_name"=>"Tanaka", "scopus_author_id"=>"16158815700"}, {"first_name"=>"Terutaka", "last_name"=>"Kakiuchi", "scopus_author_id"=>"24580028900"}, {"first_name"=>"Tetsuya", "last_name"=>"Uchida", "scopus_author_id"=>"34574105500"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"368587285", "doi"=>"10.1371/journal.pone.0015091", "sgr"=>"79955649866", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "pmid"=>"21264321", "scopus"=>"2-s2.0-79955649866"}, "id"=>"f7613edb-8035-395c-8ca8-77e3e7964e7f", "abstract"=>"CD8(+) T cells provide broad immunity to viruses, because they are able to recognize all types of viral proteins. Therefore, the development of vaccines capable of inducing long-lived memory CD8(+) T cells is desired to prevent diseases, especially those for which no vaccines currently exist. However, in designing CD8(+) T cell vaccines, the role of CD4(+) T cells in the induction and maintenance of memory CD8(+) T cells remains uncertain. In the present study, the necessity or not of CD4(+) T cells in the induction and maintenance of memory CD8(+) T cells was investigated in mice immunized with liposome-coupled CTL epitope peptides. When OVA-derived CTL epitope peptides were chemically coupled to the surfaces of liposomes and inoculated into mice, both primary and secondary CTL responses were successfully induced. The results were further confirmed in CD4(+) T cell-eliminated mice, suggesting that CD4(+) T cells were not required for the generation of memory CD8(+) T cells in the case of immunization with liposome-coupled peptides. Thus, surface-linked liposomal antigens, capable of inducing long-lived memory CD8(+) T cells without the contribution of CD4(+) T cells, might be applicable for the development of vaccines to prevent viral infection, especially for those viruses that evade humoral immunity by varying their surface proteins, such as influenza viruses, HIV, HCV, SARS coronaviruses, and Ebola viruses.", "link"=>"http://www.mendeley.com/research/liposomecoupled-peptides-induce-longlived-memory-cd8-t-cells-without-cd4-t-cells", "reader_count"=>30, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>5, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>5, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>17, "Medicine and Dentistry"=>7, "Veterinary Science and Veterinary Medicine"=>1, "Physics and Astronomy"=>1, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>17}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Netherlands"=>1, "Japan"=>1, "Denmark"=>1, "United Kingdom"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/815767"], "description"=>"<p>Mice with (closed box) or without (open box) CD4<sup>+</sup> T-cell elimination were immunized with 50 µl of OVA<sub>257-264</sub>-liposome solution in the presence of 5 µg CpG, and CTL induction was monitored. <b>A</b>, CTL response 1 week after immunization. <b>B</b>, CTL response 20 weeks after immunization with or without booster injection. <i>In vivo</i> CTL assay was performed 3 days after the booster injection. Data represent mean percent killing and SE of three mice per group. ND, not detected. *, significant difference (p>0.01).</p>", "links"=>[], "tags"=>["elimination", "cells", "induction", "ctl", "responses"], "article_id"=>486136, "categories"=>["Biochemistry", "Infectious Diseases", "Immunology"], "users"=>["Maiko Taneichi", "Yuriko Tanaka", "Terutaka Kakiuchi", "Tetsuya Uchida"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015091.g005", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_in_vivo_elimination_of_CD4_T_cells_on_the_induction_of_primary_and_secondary_CTL_responses_by_OVA_257_264_liposomes_/486136", "title"=>"Effect of <i>in vivo</i> elimination of CD4<sup>+</sup> T cells on the induction of primary and secondary CTL responses by OVA<sub>257-264</sub>-liposomes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 22:07:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/815673"], "description"=>"<p>Mice were immunized with OVA<sub>257-264</sub>-liposome and 1 week or 20 weeks later, CD8<sup>+</sup> T cells of the immunized mice were cultured in the presence (closed box) or absence (open box) of OVA as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015091#s4\" target=\"_blank\">Materials and Methods</a>. Data represents mean <sup>3</sup>H- thymidine incorporation and SE of triplicate cultures. *, significant difference (p>0.01).</p>", "links"=>[], "tags"=>["t-cell", "proliferation"], "article_id"=>486047, "categories"=>["Biochemistry", "Infectious Diseases", "Immunology"], "users"=>["Maiko Taneichi", "Yuriko Tanaka", "Terutaka Kakiuchi", "Tetsuya Uchida"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015091.g004", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antigen_specific_CD8_T_cell_proliferation_assay_/486047", "title"=>"Antigen-specific CD8<sup>+</sup> T-cell proliferation assay.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 22:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/815579"], "description"=>"<p>Mice were immunized with 50 µl of OVA<sub>257-264</sub>-liposome in the presence of 5 µg CpG, and 2, 4, 8, 16, and 20 weeks later, they received a booster ip injection with 200 µl of 1 mg/ml OVA in PBS (closed box) or no booster injection (open box). Three days after the booster injection, <i>in vivo</i> CTL assay was performed. Data represent mean percentages of cells killed and SEs of three mice per group. ND, not detected. *, significant difference (p>0.01).</p>", "links"=>[], "tags"=>["ctl", "mice", "immunized"], "article_id"=>485950, "categories"=>["Biochemistry", "Infectious Diseases", "Immunology"], "users"=>["Maiko Taneichi", "Yuriko Tanaka", "Terutaka Kakiuchi", "Tetsuya Uchida"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015091.g003", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Secondary_CTL_response_in_mice_immunized_with_OVA_257_264_liposome_/485950", "title"=>"Secondary CTL response in mice immunized with OVA<sub>257-264</sub>-liposome.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 22:06:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/815329"], "description"=>"<p>Mice were immunized with 50 µl of OVA<sub>257-264</sub>-liposome in the presence of 5 µg CpG; one to 5 days later, an <i>in vivo</i> CTL assay was performed as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015091#s4\" target=\"_blank\">Materials and Methods</a>. The numbers for each time period indicate percentages of target cells killed. Data are representative of three individual mice in each group for which similar results were obtained.</p>", "links"=>[], "tags"=>["ctl", "induced"], "article_id"=>485702, "categories"=>["Biochemistry", "Infectious Diseases", "Immunology"], "users"=>["Maiko Taneichi", "Yuriko Tanaka", "Terutaka Kakiuchi", "Tetsuya Uchida"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015091.g001", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kinetics_of_primary_CTL_response_induced_by_OVA_257_264_liposome_conjugates_/485702", "title"=>"Kinetics of primary CTL response induced by OVA<sub>257-264</sub>-liposome conjugates.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 22:05:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/815489"], "description"=>"<p>A serial two-fold dilution of OVA<sub>257-264</sub>-liposome (open box) and OVA<sub>257-264</sub> solution (closed box) were made in PBS, and mice were immunized with the diluents in the presence of 5 µg CpG. OVA<sub>257-264</sub> solution containing equal amounts of peptides as those in OVA<sub>257-264</sub>-liposome. One week after the immunization, IFN-γ production by CD8<sup>+</sup> T cells (<b>A</b>) and the CTL response (<b>B</b>) were monitored as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015091#s4\" target=\"_blank\">Materials and Methods</a>. Data represent means and SE of three mice per group. *, significant difference (p>0.01).</p>", "links"=>[], "tags"=>["cytokine", "ctl", "induction", "mice", "immunized"], "article_id"=>485855, "categories"=>["Biochemistry", "Infectious Diseases", "Immunology"], "users"=>["Maiko Taneichi", "Yuriko Tanaka", "Terutaka Kakiuchi", "Tetsuya Uchida"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015091.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dose_response_of_cytokine_production_by_CD8_T_cell_and_CTL_induction_in_mice_immunized_with_OVA_257_264_liposome_or_with_OVA_257_264_solution_/485855", "title"=>"Dose-response of cytokine production by CD8<sup>+</sup> T cell and CTL induction in mice immunized with OVA<sub>257-264</sub>-liposome or with OVA<sub>257-264</sub> solution.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 22:06:03"}

PMC Usage Stats | Further Information

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Relative Metric

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