Proteomic Basis of the Antibody Response to Monkeypox Virus Infection Examined in Cynomolgus Macaques and a Comparison to Human Smallpox Vaccination
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{"title"=>"Proteomic basis of the antibody response to monkeypox virus infection examined in cynomolgus macaques and a comparison to human smallpox vaccination", "type"=>"journal", "authors"=>[{"first_name"=>"Sarah", "last_name"=>"Keasey", "scopus_author_id"=>"26650022400"}, {"first_name"=>"Christine", "last_name"=>"Pugh", "scopus_author_id"=>"37097800000"}, {"first_name"=>"Alexander", "last_name"=>"Tikhonov", "scopus_author_id"=>"57198073712"}, {"first_name"=>"Gengxin", "last_name"=>"Chen", "scopus_author_id"=>"56169286000"}, {"first_name"=>"Barry", "last_name"=>"Schweitzer", "scopus_author_id"=>"7006045637"}, {"first_name"=>"Aysegul", "last_name"=>"Nalca", "scopus_author_id"=>"6602348152"}, {"first_name"=>"Robert G.", "last_name"=>"Ulrich", "scopus_author_id"=>"7201561808"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0015547", "pui"=>"361077793", "sgr"=>"78651225669", "pmid"=>"21209900", "scopus"=>"2-s2.0-78651225669"}, "id"=>"201fc1dd-fd68-3b46-b12d-e42e2cefc0a1", "abstract"=>"Monkeypox is a zoonotic viral disease that occurs primarily in Central and West Africa. A recent outbreak in the United States heightened public health concerns for susceptible human populations. Vaccinating with vaccinia virus to prevent smallpox is also effective for monkeypox due to a high degree of sequence conservation. Yet, the identity of antigens within the monkeypox virus proteome contributing to immune responses has not been described in detail. We compared antibody responses to monkeypox virus infection and human smallpox vaccination by using a protein microarray covering 92-95% (166-192 proteins) of representative proteomes from monkeypox viral clades of Central and West Africa, including 92% coverage (250 proteins) of the vaccinia virus proteome as a reference orthopox vaccine. All viral gene clones were verified by sequencing and purified recombinant proteins were used to construct the microarray. Serum IgG of cynomolgus macaques that recovered from monkeypox recognized at least 23 separate proteins within the orthopox proteome, while only 14 of these proteins were recognized by IgG from vaccinated humans. There were 12 of 14 antigens detected by sera of human vaccinees that were also recognized by IgG from convalescent macaques. The greatest level of IgG binding for macaques occurred with the structural proteins F13L and A33R, and the membrane scaffold protein D13L. Significant IgM responses directed towards A44R, F13L and A33R of monkeypox virus were detected before onset of clinical symptoms in macaques. Thus, antibodies from vaccination recognized a small number of proteins shared with pathogenic virus strains, while recovery from infection also involved humoral responses to antigens uniquely recognized within the monkeypox virus proteome.", "link"=>"http://www.mendeley.com/research/proteomic-basis-antibody-response-monkeypox-virus-infection-examined-cynomolgus-macaques-comparison", "reader_count"=>14, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>1, "Business, Management and Accounting"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>2}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/809033"], "description"=>"a<p>Proteins exhibiting more than a fivefold average signal increase. Average signals from sera collected at day 6 normalized to average signal at day -1.</p>b<p>NA, not present in genome,</p>c<p>NP, not present on array.</p>d<p>100% identity between WRAIR and ZAIRE proteins.</p>", "links"=>[], "tags"=>["proteome", "recognized", "igm", "acute"], "article_id"=>479394, "categories"=>["Virology", "Biochemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Sarah Keasey", "Christine Pugh", "Alexander Tikhonov", "Gengxin Chen", "Barry Schweitzer", "Aysegul Nalca", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015547.t002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Orthopoxvirus_proteome_recognized_by_IgM_during_acute_infection_/479394", "title"=>"Orthopoxvirus proteome recognized by IgM during acute infection.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:36:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/808930"], "description"=>"<p>Relative levels of antibody binding were plotted against the most abundant proteins of vaccinia IMV [refs 17–20], using convalescent macaque and vaccinated human sera.</p>", "links"=>[], "tags"=>["antibody", "responses", "abundance", "imv"], "article_id"=>479286, "categories"=>["Virology", "Biochemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Sarah Keasey", "Christine Pugh", "Alexander Tikhonov", "Gengxin Chen", "Barry Schweitzer", "Aysegul Nalca", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015547.g003", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relationship_between_antibody_responses_and_abundance_of_IMV_proteins_/479286", "title"=>"Relationship between antibody responses and abundance of IMV proteins.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-30 02:34:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/808812"], "description"=>"<p>(A) Antibody binding at days -1 and 28 relative to viral challenge in four macaques (1–4). Mean RFUs of 2–4 protein spots (SD<15%). (B) Correlation between IgG binding to IMV and serum neutralizing activity. Total antibody binding level to the IMV surface was estimated as the sum of fluorescent intensities for A26L, A27L, D8L, and H3L and analyzed for association with PRNT80 using linear regression.</p>", "links"=>[], "tags"=>["responses", "zaire", "imv", "proteins"], "article_id"=>479177, "categories"=>["Virology", "Biochemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Sarah Keasey", "Christine Pugh", "Alexander Tikhonov", "Gengxin Chen", "Barry Schweitzer", "Aysegul Nalca", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015547.g002", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_IgG_responses_to_ZAIRE_IMV_envelope_proteins_contribute_to_virus_neutralization_/479177", "title"=>"IgG responses to ZAIRE IMV envelope proteins contribute to virus neutralization.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-30 02:32:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/809073"], "description"=>"a<p>Average signals from sera collected at day 28 normalized to average signal at day -1.</p>b<p>100% identity between WRAIR and ZAIRE proteins.</p>c<p>NA, not present in genome.</p>d<p>NP, not present on array.</p>e<p>VACCOP proteins orthologous to fragments of a monkeypox protein.</p>", "links"=>[], "tags"=>["proteome", "recognized", "igg", "convalescent"], "article_id"=>479435, "categories"=>["Virology", "Biochemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Sarah Keasey", "Christine Pugh", "Alexander Tikhonov", "Gengxin Chen", "Barry Schweitzer", "Aysegul Nalca", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015547.t003", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Orthopoxvirus_proteome_recognized_by_IgG_in_convalescent_serum_/479435", "title"=>"Orthopoxvirus proteome recognized by IgG in convalescent serum.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:37:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/809206"], "description"=>"<p>Protein A44R of monkeypox and vaccinia viruses.</p>", "links"=>[], "tags"=>["a44r", "monkeypox", "vaccinia"], "article_id"=>479567, "categories"=>["Virology", "Biochemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Sarah Keasey", "Christine Pugh", "Alexander Tikhonov", "Gengxin Chen", "Barry Schweitzer", "Aysegul Nalca", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015547.t006", "stats"=>{"downloads"=>4, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Protein_A44R_of_monkeypox_and_vaccinia_viruses_/479567", "title"=>"Protein A44R of monkeypox and vaccinia viruses.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:39:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/808724"], "description"=>"<p>Interactions of arrayed orthopox virus proteins with antibody from serum collected from four macaques (1–4) before (−1) and 6 days after infection with monkeypox virus. Data are presented as mean fluorescent intensity signal (mean RFUs of 2–4 protein spots). SD<15%.</p>", "links"=>[], "tags"=>["igm", "binding", "zaire"], "article_id"=>479089, "categories"=>["Virology", "Biochemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Sarah Keasey", "Christine Pugh", "Alexander Tikhonov", "Gengxin Chen", "Barry Schweitzer", "Aysegul Nalca", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015547.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Acute_phase_IgM_binding_to_ZAIRE_proteins_/479089", "title"=>"Acute phase IgM binding to ZAIRE proteins.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-30 02:31:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/403717"], "description"=>"<div><p>Monkeypox is a zoonotic viral disease that occurs primarily in Central and West Africa. A recent outbreak in the United States heightened public health concerns for susceptible human populations. Vaccinating with vaccinia virus to prevent smallpox is also effective for monkeypox due to a high degree of sequence conservation. Yet, the identity of antigens within the monkeypox virus proteome contributing to immune responses has not been described in detail. We compared antibody responses to monkeypox virus infection and human smallpox vaccination by using a protein microarray covering 92–95% (166–192 proteins) of representative proteomes from monkeypox viral clades of Central and West Africa, including 92% coverage (250 proteins) of the vaccinia virus proteome as a reference orthopox vaccine. All viral gene clones were verified by sequencing and purified recombinant proteins were used to construct the microarray. Serum IgG of cynomolgus macaques that recovered from monkeypox recognized at least 23 separate proteins within the orthopox proteome, while only 14 of these proteins were recognized by IgG from vaccinated humans. There were 12 of 14 antigens detected by sera of human vaccinees that were also recognized by IgG from convalescent macaques. The greatest level of IgG binding for macaques occurred with the structural proteins F13L and A33R, and the membrane scaffold protein D13L. Significant IgM responses directed towards A44R, F13L and A33R of monkeypox virus were detected before onset of clinical symptoms in macaques. Thus, antibodies from vaccination recognized a small number of proteins shared with pathogenic virus strains, while recovery from infection also involved humoral responses to antigens uniquely recognized within the monkeypox virus proteome.</p> </div>", "links"=>[], "tags"=>["proteomic", "antibody", "monkeypox", "examined", "cynomolgus", "macaques", "smallpox", "vaccination"], "article_id"=>139762, "categories"=>["Cancer", "Biochemistry", "Genetics", "Immunology"], "users"=>["Sarah Keasey", "Christine Pugh", "Alexander Tikhonov", "Gengxin Chen", "Barry Schweitzer", "Aysegul Nalca", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015547", "stats"=>{"downloads"=>3, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Proteomic_Basis_of_the_Antibody_Response_to_Monkeypox_Virus_Infection_Examined_in_Cynomolgus_Macaques_and_a_Comparison_to_Human_Smallpox_Vaccination/139762", "title"=>"Proteomic Basis of the Antibody Response to Monkeypox Virus Infection Examined in Cynomolgus Macaques and a Comparison to Human Smallpox Vaccination", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:42:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/809113"], "description"=>"a<p>Average signals in sera of vaccinated normalized to signals in normal sera.</p>b<p>100% identity between WRAIR and ZAIRE proteins.</p>c<p>NA, not present in genome.</p>d<p>NP, not present on array.</p>e<p>VACCOP proteins orthologous to fragments of a monkeypox protein.</p>", "links"=>[], "tags"=>["proteome", "recognized", "igg", "vaccinated"], "article_id"=>479478, "categories"=>["Virology", "Biochemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Sarah Keasey", "Christine Pugh", "Alexander Tikhonov", "Gengxin Chen", "Barry Schweitzer", "Aysegul Nalca", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015547.t004", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Monkeypox_virus_proteome_recognized_by_IgG_from_vaccinated_humans_/479478", "title"=>"Monkeypox virus proteome recognized by IgG from vaccinated humans.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:37:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/808989"], "description"=>"<p><b>*Protein numbers and identity based on the poxvirus database annotations (</b><a href=\"http://www.poxvirus.org\" target=\"_blank\">www.poxvirus.org</a><b>)</b>.</p>", "links"=>[], "tags"=>["microarray", "proteome"], "article_id"=>479355, "categories"=>["Virology", "Biochemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Sarah Keasey", "Christine Pugh", "Alexander Tikhonov", "Gengxin Chen", "Barry Schweitzer", "Aysegul Nalca", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015547.t001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Orthopoxvirus_microarray_proteome_coverage_/479355", "title"=>"Orthopoxvirus microarray proteome coverage.<sup>*</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:35:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/809163"], "description"=>"1<p>Bolded orthopox proteins: identified by mass spectometry as one of 15 most abundant proteins, based on mole percent <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015547#pone.0015547-Chung1\" target=\"_blank\">[17]</a>.</p>2<p>Antibody-binding protein, no abundance data available (−). Antibody-binding protein previously measured <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015547#pone.0015547-Chung1\" target=\"_blank\">[17]</a>–<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015547#pone.0015547-Yoder1\" target=\"_blank\">[20]</a> by mass spectrometry (+).</p>3<p>Vaccinia virus protein similar to protein of monkeypox virus.</p>", "links"=>[], "tags"=>["responses", "convalescent", "macaque", "vaccinated", "compared", "abundance", "viral"], "article_id"=>479518, "categories"=>["Virology", "Biochemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Sarah Keasey", "Christine Pugh", "Alexander Tikhonov", "Gengxin Chen", "Barry Schweitzer", "Aysegul Nalca", "Robert G. Ulrich"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015547.t005", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antibody_IgG_responses_of_convalescent_macaque_and_vaccinated_human_compared_to_relative_abundance_of_viral_protein_/479518", "title"=>"Antibody (IgG) responses of convalescent macaque and vaccinated human compared to relative abundance of viral protein.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-30 02:38:38"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"8", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
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  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
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  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
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  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
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  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"20", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
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  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
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  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"1", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
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Relative Metric

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