Viral Epidemics in a Cell Culture: Novel High Resolution Data and Their Interpretation by a Percolation Theory Based Model
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Viral epidemics in a cell culture: Novel high resolution data and their interpretation by a percolation theory based model", "type"=>"journal", "authors"=>[{"first_name"=>"Balázs", "last_name"=>"Gönci", "scopus_author_id"=>"15750461900"}, {"first_name"=>"Valéria", "last_name"=>"Németh", "scopus_author_id"=>"36722013200"}, {"first_name"=>"Emeric", "last_name"=>"Balogh", "scopus_author_id"=>"7006411639"}, {"first_name"=>"Bálint", "last_name"=>"Szabó", "scopus_author_id"=>"35585585200"}, {"first_name"=>"Ádám", "last_name"=>"Dénes", "scopus_author_id"=>"23004034300"}, {"first_name"=>"Zsuzsanna", "last_name"=>"Környei", "scopus_author_id"=>"55905293700"}, {"first_name"=>"Tamás", "last_name"=>"Vicsek", "scopus_author_id"=>"7005178584"}], "year"=>2010, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-78650897867", "doi"=>"10.1371/journal.pone.0015571", "sgr"=>"78650897867", "pmid"=>"21187920", "issn"=>"19326203", "pui"=>"361048310"}, "id"=>"66ba05a1-86a2-3c64-bc2a-4bc0ccf5d3cc", "abstract"=>"Because of its relevance to everyday life, the spreading of viral infections has been of central interest in a variety of scientific communities involved in fighting, preventing and theoretically interpreting epidemic processes. Recent large scale observations have resulted in major discoveries concerning the overall features of the spreading process in systems with highly mobile susceptible units, but virtually no data are available about observations of infection spreading for a very large number of immobile units. Here we present the first detailed quantitative documentation of percolation-type viral epidemics in a highly reproducible in vitro system consisting of tens of thousands of virtually motionless cells. We use a confluent astroglial monolayer in a Petri dish and induce productive infection in a limited number of cells with a genetically modified herpesvirus strain. This approach allows extreme high resolution tracking of the spatio-temporal development of the epidemic. We show that a simple model is capable of reproducing the basic features of our observations, i.e., the observed behaviour is likely to be applicable to many different kinds of systems. Statistical physics inspired approaches to our data, such as fractal dimension of the infected clusters as well as their size distribution, seem to fit into a percolation theory based interpretation. We suggest that our observations may be used to model epidemics in more complex systems, which are difficult to study in isolation.", "link"=>"http://www.mendeley.com/research/viral-epidemics-cell-culture-novel-high-resolution-data-interpretation-percolation-theory-based-mode", "reader_count"=>15, "reader_count_by_academic_status"=>{"Researcher"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Researcher"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>1, "Neuroscience"=>1, "Physics and Astronomy"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "reader_count_by_country"=>{"Japan"=>1, "Germany"=>1}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/78650897867"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/78650897867?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78650897867&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=78650897867&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/78650897867", "dc:identifier"=>"SCOPUS_ID:78650897867", "eid"=>"2-s2.0-78650897867", "dc:title"=>"Viral epidemics in a cell culture: Novel high resolution data and their interpretation by a percolation theory based model", "dc:creator"=>"Gönci B.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"5", "prism:issueIdentifier"=>"12", "prism:pageRange"=>nil, "prism:coverDate"=>"2010-12-01", "prism:coverDisplayDate"=>"2010", "prism:doi"=>"10.1371/journal.pone.0015571", "citedby-count"=>"7", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Eötvös Loránd University", "affiliation-city"=>"Budapest", "affiliation-country"=>"Hungary"}], "pubmed-id"=>"21187920", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e15571", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0015571", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Wikipedia | Further Information

Counter

  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"46", "xml_views"=>"12", "html_views"=>"150"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"64"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"4", "html_views"=>"31"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"5", "html_views"=>"57"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"63"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"43"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"32"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"3", "html_views"=>"32"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"146"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"48"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"6", "html_views"=>"42"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"12"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"4", "html_views"=>"1"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"5"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"4", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"3"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/405160", "https://ndownloader.figshare.com/files/405182", "https://ndownloader.figshare.com/files/405196", "https://ndownloader.figshare.com/files/405230", "https://ndownloader.figshare.com/files/405270", "https://ndownloader.figshare.com/files/405296", "https://ndownloader.figshare.com/files/405320", "https://ndownloader.figshare.com/files/405346", "https://ndownloader.figshare.com/files/405381", "https://ndownloader.figshare.com/files/405404", "https://ndownloader.figshare.com/files/405442", "https://ndownloader.figshare.com/files/405467", "https://ndownloader.figshare.com/files/405537", "https://ndownloader.figshare.com/files/405570"], "description"=>"<div><p>Because of its relevance to everyday life, the spreading of viral infections has been of central interest in a variety of scientific communities involved in fighting, preventing and theoretically interpreting epidemic processes. Recent large scale observations have resulted in major discoveries concerning the overall features of the spreading process in systems with highly mobile susceptible units, but virtually no data are available about observations of infection spreading for a very large number of immobile units. Here we present the first detailed quantitative documentation of percolation-type viral epidemics in a highly reproducible <em>in vitro</em> system consisting of tens of thousands of virtually motionless cells. We use a confluent astroglial monolayer in a Petri dish and induce productive infection in a limited number of cells with a genetically modified herpesvirus strain. This approach allows extreme high resolution tracking of the spatio-temporal development of the epidemic. We show that a simple model is capable of reproducing the basic features of our observations, i.e., the observed behaviour is likely to be applicable to many different kinds of systems. Statistical physics inspired approaches to our data, such as fractal dimension of the infected clusters as well as their size distribution, seem to fit into a percolation theory based interpretation. We suggest that our observations may be used to model epidemics in more complex systems, which are difficult to study in isolation.</p> </div>", "links"=>[], "tags"=>["viral", "epidemics", "percolation", "based"], "article_id"=>140067, "categories"=>["Cancer", "Microbiology", "Biophysics", "Mathematics", "Biotechnology", "Biological Sciences"], "users"=>["Balázs Gönci", "Valéria Németh", "Emeric Balogh", "Bálint Szabó", "Ádám Dénes", "Zsuzsanna Környei", "Tamás Vicsek"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0015571.s001", "https://dx.doi.org/10.1371/journal.pone.0015571.s002", "https://dx.doi.org/10.1371/journal.pone.0015571.s003", "https://dx.doi.org/10.1371/journal.pone.0015571.s004", "https://dx.doi.org/10.1371/journal.pone.0015571.s005", "https://dx.doi.org/10.1371/journal.pone.0015571.s006", "https://dx.doi.org/10.1371/journal.pone.0015571.s007", "https://dx.doi.org/10.1371/journal.pone.0015571.s008", "https://dx.doi.org/10.1371/journal.pone.0015571.s009", "https://dx.doi.org/10.1371/journal.pone.0015571.s010", "https://dx.doi.org/10.1371/journal.pone.0015571.s011", "https://dx.doi.org/10.1371/journal.pone.0015571.s012", "https://dx.doi.org/10.1371/journal.pone.0015571.s013", "https://dx.doi.org/10.1371/journal.pone.0015571.s014"], "stats"=>{"downloads"=>6, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Viral_Epidemics_in_a_Cell_Culture_Novel_High_Resolution_Data_and_Their_Interpretation_by_a_Percolation_Theory_Based_Model/140067", "title"=>"Viral Epidemics in a Cell Culture: Novel High Resolution Data and Their Interpretation by a Percolation Theory Based Model", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-12-20 00:01:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/811832"], "description"=>"<p>Panels <b>A</b>, <b>C</b> and <b>E</b> show the cluster size distribution after 18, 30 and 42 hours, respectively, as determined from a series of pictures analogous to <b><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015571#pone.0015571.s001\" target=\"_blank\">Fig. S1</a></b>. Corresponding cluster size distribution of the model is presented in panels <b>B</b>, <b>D</b> and <b>F</b>. Experimental graphs are consistent with the predictions of our percolation based simple spreading model: both the experimental scaling behaviour at 42 hours and the spreading of the infection before that are well characterized by the model. A scaling (power law) distribution is built up in time, i.e., the number of infected clusters <i>vs</i> cluster size follows a power function instead of an exponential drop. Model time was scaled to fit to the infection spreading rate of high titer experiments.</p>", "links"=>[], "tags"=>["Virology", "public health and epidemiology", "Infectious diseases", "microbiology", "Computational biology", "biophysics", "mathematics"], "article_id"=>482183, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Biophysics", "Mathematics", "Biotechnology", "Biological Sciences"], "users"=>["Balázs Gönci", "Valéria Németh", "Emeric Balogh", "Bálint Szabó", "Ádám Dénes", "Zsuzsanna Környei", "Tamás Vicsek"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015571.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_distribution_of_cluster_sizes_/482183", "title"=>"The distribution of cluster sizes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-20 00:36:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/811635"], "description"=>"<p>100 (10×10) microscopic field images were taken from fixed cultures with GFP expressing infected cells and stitched together to obtain a high resolution single picture (approximately having 13,000×9,000 pixels). Then, the originally black and white image was analysed by finding clusters of cells (connected regions of larger than 1000 pixels: which number was associated with the average cell size). Next, each separate cluster was coloured by choosing a colour from a random set of 8 possible ones. The obtained clusters and their perimeters display a highly complex spatial structure reminiscent of mathematical fractals and possessing some level of self-similarity illustrated by sequential magnification of parts of the structure. Scale bar: 100 µm. (See original image in <b><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015571#pone.0015571.s001\" target=\"_blank\">Fig. S1</a></b>.)</p>", "links"=>[], "tags"=>["processed", "infected", "monolayer"], "article_id"=>481994, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Biophysics", "Mathematics", "Biotechnology", "Biological Sciences"], "users"=>["Balázs Gönci", "Valéria Németh", "Emeric Balogh", "Bálint Szabó", "Ádám Dénes", "Zsuzsanna Környei", "Tamás Vicsek"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015571.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_An_image_processed_representation_of_a_large_infected_region_of_the_monolayer_of_astrocytes_/481994", "title"=>"An image processed representation of a large infected region of the monolayer of astrocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-20 00:33:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/811344"], "description"=>"<p>All steps are discussed in details throughout the text as well as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015571#s4\" target=\"_blank\">Materials and Methods</a>.</p>", "links"=>[], "tags"=>["diagram"], "article_id"=>481707, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Biophysics", "Mathematics", "Biotechnology", "Biological Sciences"], "users"=>["Balázs Gönci", "Valéria Németh", "Emeric Balogh", "Bálint Szabó", "Ádám Dénes", "Zsuzsanna Környei", "Tamás Vicsek"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015571.g001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_diagram_of_the_experimental_design_/481707", "title"=>"Flow diagram of the experimental design.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-20 00:28:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/812465"], "description"=>"<p>Best fit means that the parameter was optimized to give best overall agreement with the experimental results.</p>", "links"=>[], "tags"=>["parameters"], "article_id"=>482828, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Biophysics", "Mathematics", "Biotechnology", "Biological Sciences"], "users"=>["Balázs Gönci", "Valéria Németh", "Emeric Balogh", "Bálint Szabó", "Ádám Dénes", "Zsuzsanna Környei", "Tamás Vicsek"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015571.t001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_main_parameters_of_the_simulation_/482828", "title"=>"The main parameters of the simulation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-12-20 00:47:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/811440"], "description"=>"<p>The cultures were fixed 18 h (<b>A</b>), 30 h (<b>B</b>) and 42 hours (<b>C</b>) after infection with the BDG-PRV virus. In the bottom row (<b>D</b>) higher magnification images can be seen taken 36 hours after infection. The last image shows accurate overlap between immunostained PRV virus particles (red) and GFP (green) expession by infected cells. Scale bars are 300 µm and 25 µm, respectively. High resolution file can be downloaded from: <a href=\"http://amur.elte.hu/BDGVirus/\" target=\"_blank\">http://amur.elte.hu/BDGVirus/</a>.</p>", "links"=>[], "tags"=>["images", "astrocytic"], "article_id"=>481808, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Biophysics", "Mathematics", "Biotechnology", "Biological Sciences"], "users"=>["Balázs Gönci", "Valéria Németh", "Emeric Balogh", "Bálint Szabó", "Ádám Dénes", "Zsuzsanna Környei", "Tamás Vicsek"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015571.g002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mosaic_images_of_astrocytic_cultures_/481808", "title"=>"Mosaic images of astrocytic cultures.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-20 00:30:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/812387"], "description"=>"<p>The upper picture (<b>A</b>) demonstrates the progression of the infection around a single infected cell (see <b><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015571#pone.0015571.s011\" target=\"_blank\">Videos S4</a></b>, <b><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015571#pone.0015571.s012\" target=\"_blank\">S5</a></b>, <b><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015571#pone.0015571.s013\" target=\"_blank\">S6</a>.</b>). The colour coding is such that lighter colours correspond to later times and the movie frames (also image processed here) were taken at time 15, 18, 21, 24 hours after the initial exposure to the virus. The bottom plot (<b>B</b>) shows the probability distribution function for a single isolated cell (playing the role of a seed for the infection spreading) to become infected. Fitted is a log-normal function giving a significantly better agreement than a Gaussian. Scale bar: 50 µm.</p>", "links"=>[], "tags"=>["spreading", "infected"], "article_id"=>482750, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Biophysics", "Mathematics", "Biotechnology", "Biological Sciences"], "users"=>["Balázs Gönci", "Valéria Németh", "Emeric Balogh", "Bálint Szabó", "Ádám Dénes", "Zsuzsanna Környei", "Tamás Vicsek"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015571.g008", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Visualization_of_the_spreading_of_the_infection_around_a_single_infected_seed_/482750", "title"=>"Visualization of the spreading of the infection around a single infected seed.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-20 00:45:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/812126"], "description"=>"<p>A representative set of clusters (bottom 20% of the original picture has been omitted to save space) is displayed (top, <b>A</b>) for the following parameters: size 500×500 lattice units, 500 starting seed particles with a “switching on” time distribution following a lognormal fitted to the experimentally observed parameters (mean = 7.5 h, standard deviation = 2.5 h) plus 2000 further seeds with a constantly increasing rate in time between 20 h and 42 h (corresponding to the observed second wave of infection, see <b><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015571#pone.0015571.s004\" target=\"_blank\">Fig. S4</a></b>). The implemented values of the two model parameters were ρ = 0.0182 and α = 3. The bottom left (<b>B</b>) figure is a schematic demonstration of the model where the coloured circles correspond to the experiment as follows: black dots → not susceptible or missing cells; red dots → primarily infected cells; brown dots → cells infected by one of their neighbours; yellow dots → cells potentially infected in the next time step; green hollow: a cluster of infected cells. The bottom right (<b>C</b>) plot demonstrates that the cluster size distribution in the model also displays a scaling behaviour for the parameters corresponding to the experimental conditions (the same as for the picture in the top).</p>", "links"=>[], "tags"=>["simulations"], "article_id"=>482487, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Biophysics", "Mathematics", "Biotechnology", "Biological Sciences"], "users"=>["Balázs Gönci", "Valéria Németh", "Emeric Balogh", "Bálint Szabó", "Ádám Dénes", "Zsuzsanna Környei", "Tamás Vicsek"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015571.g006", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_from_the_simulations_of_our_model_/482487", "title"=>"Results from the simulations of our model.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-20 00:41:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/812262"], "description"=>"<p>Screenshots (<b>A–D</b>) and graphical representations (<b>E</b>,<b>F</b>) of videos on virus propagation within astroglial cultures treated with BDG-PRV virus. Supplementary <b><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015571#pone.0015571.s008\" target=\"_blank\">Videos S1</a></b>, <b><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015571#pone.0015571.s009\" target=\"_blank\">S2</a></b> and <b><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015571#pone.0015571.s010\" target=\"_blank\">S3</a></b> were recorded using cultures infected with different titers showing virus spread on large scale. Titers in these experiments were <b>A</b>) 2,5×10<sup>4</sup> PFU/ml (“low” titer) <b>B</b>) 2.5×10<sup>5</sup> PFU/ml (“high” titer) <b>C</b>) 1,25×10<sup>6</sup> PFU/ml (“highest” titer). Image series <b>D</b>) and <b>E</b>) and supplementary <b><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015571#pone.0015571.s011\" target=\"_blank\">Videos S4</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015571#pone.0015571.s012\" target=\"_blank\">S5</a></b> show the appearance of GFP in “low titer” infected cells over time within a representative microscopic field. Formation of cell clusters with more advanced infection can be seen in image series <b>F</b>) and <b>Video 6,</b> representing 9 stiched microscopic fields. Red cells indicate the foci of the developing clusters. High resolution videos and images can be downloaded from: <a href=\"http://amur.elte.hu/BDGVirus/\" target=\"_blank\">http://amur.elte.hu/BDGVirus/</a>.</p>", "links"=>[], "tags"=>["demonstrating", "spreading"], "article_id"=>482621, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Biophysics", "Mathematics", "Biotechnology", "Biological Sciences"], "users"=>["Balázs Gönci", "Valéria Németh", "Emeric Balogh", "Bálint Szabó", "Ádám Dénes", "Zsuzsanna Környei", "Tamás Vicsek"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015571.g007", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Images_demonstrating_the_spreading_of_the_infection_/482621", "title"=>"Images demonstrating the spreading of the infection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-20 00:43:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/812038"], "description"=>"<p>This figure (squares) shows the number of cells in the largest clusters of infected cells as a function of the linear size (L) of the regions in which they were counted. The fitted line indicates that the geometry of the largest infected regions is analogous to those of fractals with a dimension of about 1.78. Remarkably, the simulation data (crosses) are almost indistinguishable from those obtained from the observations.</p>", "links"=>[], "tags"=>["fractal", "largest"], "article_id"=>482398, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Biophysics", "Mathematics", "Biotechnology", "Biological Sciences"], "users"=>["Balázs Gönci", "Valéria Németh", "Emeric Balogh", "Bálint Szabó", "Ádám Dénes", "Zsuzsanna Környei", "Tamás Vicsek"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015571.g005", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Determination_of_the_fractal_dimension_of_the_largest_clusters_/482398", "title"=>"Determination of the fractal dimension of the largest clusters.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-12-20 00:39:58"}

PMC Usage Stats | Further Information

  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"0", "year"=>"2010", "pdf"=>"1", "unique-ip"=>"1", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"9", "unique-ip"=>"14", "pdf"=>"9", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"25", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"24", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"9", "unique-ip"=>"13", "pdf"=>"5", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"10", "year"=>"2011", "pdf"=>"1", "unique-ip"=>"9", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"3", "pdf"=>"3", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"0", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"3", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "unique-ip"=>"4", "pdf"=>"0", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"18", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"7", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "unique-ip"=>"9", "pdf"=>"1", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"4", "year"=>"2011", "pdf"=>"1", "unique-ip"=>"6", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"5", "pdf"=>"2", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2012", "pdf"=>"2", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"6", "pdf"=>"1", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2012", "pdf"=>"0", "unique-ip"=>"4", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"2", "pdf"=>"0", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"0", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"2", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"27", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"2", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"21", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"30", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"28", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"4", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"6", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"1", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2010-01-01T00:00:00Z", "end_date"=>"2010-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[288, 576, 733, 867, 984, 1087, 1182, 1267, 1346, 1424, 1501, 1577, 1646, 1711, 1778, 1841, 1908, 1970, 2034, 2102, 2162, 2227, 2296, 2359, 2422, 2482, 2550, 2610, 2679, 2747, 2820, 2887, 2955, 3009, 3067, 3130, 3200, 3257, 3322, 3379, 3443, 3507, 3571, 3632, 3683, 3753, 3822, 3877]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[280, 562, 725, 863, 974, 1083, 1177, 1268, 1347, 1421, 1489, 1570, 1638, 1706, 1763, 1823, 1890, 1951, 2016, 2076, 2134, 2192, 2257, 2319, 2378, 2438, 2501, 2572, 2634, 2700, 2759, 2825, 2887, 2936, 3007, 3070, 3121, 3184, 3237, 3304, 3363, 3425, 3484, 3531, 3612, 3663, 3718, 3771]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[290, 557, 702, 824, 930, 1032, 1119, 1197, 1276, 1347, 1410, 1477, 1539, 1603, 1678, 1741, 1801, 1866, 1930, 1988, 2060, 2117, 2185, 2239, 2300, 2358, 2429, 2486, 2548, 2613, 2693, 2758, 2824, 2891, 2950, 3019, 3093, 3163, 3224, 3284, 3355, 3421, 3486, 3552, 3622, 3684, 3749, 3799, 3859]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[286, 543, 687, 806, 915, 1004, 1092, 1169, 1234, 1309, 1372, 1435, 1502, 1563, 1627, 1685, 1747, 1796, 1859, 1921, 1977, 2032, 2093, 2157, 2210, 2278, 2333, 2406, 2463, 2535, 2590, 2642, 2692, 2753, 2813, 2872, 2941, 2989, 3040, 3080, 3151, 3218, 3269, 3323, 3375, 3437, 3500, 3550, 3604]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[314, 590, 728, 851, 953, 1050, 1127, 1206, 1276, 1336, 1390, 1451, 1504, 1569, 1619, 1674, 1732, 1792, 1851, 1900, 1959, 2004, 2076, 2126, 2182, 2239, 2292, 2353, 2427, 2522, 2595, 2676, 2735, 2785, 2836, 2893, 2943, 2993, 3041, 3097, 3160, 3214, 3251, 3299, 3357, 3428, 3482, 3515, 3555]}]}
Loading … Spinner
There are currently no alerts