Influences of the Common FTO rs9939609 Variant on Inflammatory Markers Throughout a Broad Range of Body Mass Index
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{"title"=>"Influences of the common FTO rs9939609 variant on inflammatory markers throughout a broad range of body mass index", "type"=>"journal", "authors"=>[{"first_name"=>"Esther", "last_name"=>"Zimmermann", "scopus_author_id"=>"7101967729"}, {"first_name"=>"Kristin", "last_name"=>"Skogstrand", "scopus_author_id"=>"8842753000"}, {"first_name"=>"David M.", "last_name"=>"Hougaard", "scopus_author_id"=>"7003632207"}, {"first_name"=>"Arne", "last_name"=>"Astrup", "scopus_author_id"=>"7103121619"}, {"first_name"=>"Torben", "last_name"=>"Hansen", "scopus_author_id"=>"7401667966"}, {"first_name"=>"Oluf", "last_name"=>"Pedersen", "scopus_author_id"=>"35373396900"}, {"first_name"=>"Thorkild I.A.", "last_name"=>"Sørensen", "scopus_author_id"=>"36043939900"}, {"first_name"=>"Tine", "last_name"=>"Jess", "scopus_author_id"=>"26643354600"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"79251575560", "pmid"=>"21246032", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"361180147", "issn"=>"19326203", "scopus"=>"2-s2.0-79251575560", "doi"=>"10.1371/journal.pone.0015958"}, "id"=>"099f2071-af7d-3ec6-aba6-8a4b3704cffa", "abstract"=>"BACKGROUND: A recent study reported that the fatness associated A-allele of FTO rs9939609 increased plasma high sensitivity C-reactive protein (hs-CRP) levels independent of fatness. We aimed to investigate if this gene variant had fatness-independent effects on plasma hs-CRP and 10 additional circulating obesity-related adipokines throughout a broad range of body mass index (BMI) among Danish men.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: In a population of 362,200 young men, examined for military service between 1943 and 1977, two groups were identified: 1) a random 1% sample and 2) all obese men (BMI = 31.0 kg/m(2), all of whom were above the 99(th) percentile of this population). At an average age of 49 years (range: 39 through 65 years), 551 men, hereof 231 of the obese, were re-examined, including genotyping and measurement of the fasting circulating inflammatory markers hs-CRP, IL-1β, IL-6, IL-10, IL-18, mip1α, mip1β, sTNFα-R1, TGF-β, TNF-α and leptin. Men with known disease were excluded from the examination. All the inflammatory markers were log-transformed to approximate a normal distribution. Genotype-phenotype relationships were studied using linear regression analyses with the inflammatory markers as the response variable. Significant positive associations between hs-CRP, leptin and a broad range of BMI were observed, but the associations did not significantly differ across FTO rs9939609 genotype. There were no significant associations between the other inflammatory markers, FTO rs9939609 genotype or BMI, respectively.\\n\\nCONCLUSION: No fatness-independent effects of the FTO rs9939609 A-allele on a series of inflammatory markers were observed in this cohort of healthy middle-aged men representing a broad range of fatness.", "link"=>"http://www.mendeley.com/research/influences-common-fto-rs9939609-variant-inflammatory-markers-throughout-broad-range-body-mass-index", "reader_count"=>30, "reader_count_by_academic_status"=>{"Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>9, "Student > Ph. D. Student"=>7, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>3, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>4}, "reader_count_by_user_role"=>{"Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>9, "Student > Ph. D. Student"=>7, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>3, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>4}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>5, "Medicine and Dentistry"=>15, "Agricultural and Biological Sciences"=>8, "Psychology"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>15}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}}, "reader_count_by_country"=>{"New Zealand"=>1, "United States"=>2, "Russia"=>1, "Indonesia"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/807789"], "description"=>"<p><i>FTO</i> rs9939609 genotype had no main effect on hs-CRP neither in the crude analysis nor when BMI was taken into account (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015958#pone-0015958-t003\" target=\"_blank\">Table 3</a>); further, this figure shows there was no interaction between BMI and <i>FTO</i> rs9939609 genotype in relation to IL-6 (p = 0.82).</p>", "links"=>[], "tags"=>["bmi", "il-6", "rs9939609"], "article_id"=>478152, "categories"=>["Genetics", "Biotechnology"], "users"=>["Esther Zimmermann", "Kristin Skogstrand", "David M. Hougaard", "Arne Astrup", "Torben Hansen", "Oluf Pedersen", "Thorkild I. A. Sørensen", "Tine Jess"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015958.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_association_between_BMI_and_IL_6_according_to_FTO_rs9939609_genotype_/478152", "title"=>"The association between BMI and IL-6 according to <i>FTO</i> rs9939609 genotype.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-05 02:15:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/807962"], "description"=>"<p><i>FTO</i> rs9939609 genotype had no main effect on leptin when BMI was taken into account (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015958#pone-0015958-t003\" target=\"_blank\">Table 3</a>); further, this figure shows there was no interaction between BMI and <i>FTO</i> rs9939609 genotype in relation to leptin (p = 0.31).</p>", "links"=>[], "tags"=>["bmi", "leptin", "rs9939609"], "article_id"=>478325, "categories"=>["Genetics", "Biotechnology"], "users"=>["Esther Zimmermann", "Kristin Skogstrand", "David M. Hougaard", "Arne Astrup", "Torben Hansen", "Oluf Pedersen", "Thorkild I. A. Sørensen", "Tine Jess"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015958.g003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_association_between_BMI_and_Leptin_according_to_FTO_rs9939609_genotype_/478325", "title"=>"The association between BMI and Leptin according to <i>FTO</i> rs9939609 genotype.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-05 02:18:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/403338", "https://ndownloader.figshare.com/files/403374"], "description"=>"<div><h3>Background</h3><p>A recent study reported that the fatness associated A-allele of <em>FTO</em> rs9939609 increased plasma high sensitivity C-reactive protein (hs-CRP) levels independent of fatness. We aimed to investigate if this gene variant had fatness-independent effects on plasma hs-CRP and 10 additional circulating obesity-related adipokines throughout a broad range of body mass index (BMI) among Danish men.</p> <h3>Methodology/Principal Findings</h3><p>In a population of 362,200 young men, examined for military service between 1943 and 1977, two groups were identified: 1) a random 1% sample and 2) all obese men (BMI = 31.0 kg/m<sup>2</sup>, all of whom were above the 99<sup>th</sup> percentile of this population). At an average age of 49 years (range: 39 through 65 years), 551 men, hereof 231 of the obese, were re-examined, including genotyping and measurement of the fasting circulating inflammatory markers hs-CRP, IL-1β, IL-6, IL-10, IL-18, mip1α, mip1β, sTNFα-R1, TGF-β, TNF-α and leptin. Men with known disease were excluded from the examination. All the inflammatory markers were log-transformed to approximate a normal distribution. Genotype-phenotype relationships were studied using linear regression analyses with the inflammatory markers as the response variable. Significant positive associations between hs-CRP, leptin and a broad range of BMI were observed, but the associations did not significantly differ across <em>FTO</em> rs9939609 genotype. There were no significant associations between the other inflammatory markers, <em>FTO</em> rs9939609 genotype or BMI, respectively.</p> <h3>Conclusion</h3><p>No fatness-independent effects of the <em>FTO</em> rs9939609 A-allele on a series of inflammatory markers were observed in this cohort of healthy middle-aged men representing a broad range of fatness.</p> </div>", "links"=>[], "tags"=>["influences", "rs9939609", "variant", "inflammatory", "markers"], "article_id"=>139695, "categories"=>["Genetics", "Biotechnology"], "users"=>["Esther Zimmermann", "Kristin Skogstrand", "David M. Hougaard", "Arne Astrup", "Torben Hansen", "Oluf Pedersen", "Thorkild I. A. Sørensen", "Tine Jess"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0015958.s001", "https://dx.doi.org/10.1371/journal.pone.0015958.s002"], "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Influences_of_the_Common_FTO_rs9939609_Variant_on_Inflammatory_Markers_Throughout_a_Broad_Range_of_Body_Mass_Index/139695", "title"=>"Influences of the Common <em>FTO</em> rs9939609 Variant on Inflammatory Markers Throughout a Broad Range of Body Mass Index", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-01-05 02:41:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/808181"], "description"=>"<p>Abbreviations: BMI: Body mass index. WHR: Waist-to-hip ratio.</p><p>All models were adjusted for age (per year).</p><p>*Factor of the change in the inflammatory marker relative to the measurement unit in the predicting covariate (e.g. an estimate of 1.17 for <i>FTO</i> genotype in relation to hs-CRP is to be interpreted as a 17% higher hs-CRP-level per additional A-allele).</p>", "links"=>[], "tags"=>["cis", "regression", "analyses", "inflammatory", "markers"], "article_id"=>478544, "categories"=>["Genetics", "Biotechnology"], "users"=>["Esther Zimmermann", "Kristin Skogstrand", "David M. Hougaard", "Arne Astrup", "Torben Hansen", "Oluf Pedersen", "Thorkild I. A. Sørensen", "Tine Jess"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015958.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_estimates_with_95_CIs_based_on_regression_analyses_of_the_inflammatory_markers_per_the_unit_of_the_covariates_/478544", "title"=>"Effect estimates<sup>*</sup> with 95% CIs based on regression analyses of the inflammatory markers per the unit of the covariates.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-01-05 02:22:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/808100"], "description"=>"<p>Abbreviations: BMI: Body mass index.</p><p>*Test for trend.</p>†<p>Chi<sup>2</sup>-test of the obese vs. randomly sampled according to genotype distribution of <i>FTO</i> rs9939609.</p>", "links"=>[], "tags"=>["rs9939609", "cohorts", "danish", "draftees", "obese"], "article_id"=>478461, "categories"=>["Genetics", "Biotechnology"], "users"=>["Esther Zimmermann", "Kristin Skogstrand", "David M. Hougaard", "Arne Astrup", "Torben Hansen", "Oluf Pedersen", "Thorkild I. A. Sørensen", "Tine Jess"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015958.t001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_according_to_FTO_rs9939609_given_as_mean_S_D_of_the_two_study_cohorts_representing_respectively_a_random_sample_of_Danish_male_draftees_and_all_obese_male_draftees_/478461", "title"=>"Characteristics according to <i>FTO</i> rs9939609 given as mean (S.D.) of the two study cohorts representing, respectively, a random sample of Danish male draftees and all obese male draftees.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-01-05 02:21:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/808139"], "description"=>"<p>*Test for trend.</p><p>The geometric means of the inflammatory markers according to <i>FTO</i> genotype are presented for the two cohorts separately in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015958#pone.0015958.s001\" target=\"_blank\">Table S1</a>.</p>", "links"=>[], "tags"=>["inflammatory", "markers", "rs9939609", "genotype", "cohorts"], "article_id"=>478501, "categories"=>["Genetics", "Biotechnology"], "users"=>["Esther Zimmermann", "Kristin Skogstrand", "David M. Hougaard", "Arne Astrup", "Torben Hansen", "Oluf Pedersen", "Thorkild I. A. Sørensen", "Tine Jess"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015958.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Geometric_mean_95_confidence_intervals_of_the_inflammatory_markers_according_to_FTO_rs9939609_genotype_for_the_two_cohorts_combined_/478501", "title"=>"Geometric mean (95% confidence intervals) of the inflammatory markers according to <i>FTO</i> rs9939609 genotype for the two cohorts combined.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-01-05 02:21:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/807671"], "description"=>"<p><i>FTO</i> rs9939609 genotype had no main effect on hs-CRP when BMI was taken into account (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015958#pone-0015958-t003\" target=\"_blank\">Table 3</a>); further, this figure shows there was no interaction between BMI and <i>FTO</i> rs9939609 genotype in relation to hs-CRP (p = 0.62).</p>", "links"=>[], "tags"=>["bmi", "hs-crp", "rs9939609"], "article_id"=>478038, "categories"=>["Genetics", "Biotechnology"], "users"=>["Esther Zimmermann", "Kristin Skogstrand", "David M. Hougaard", "Arne Astrup", "Torben Hansen", "Oluf Pedersen", "Thorkild I. A. Sørensen", "Tine Jess"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0015958.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_association_between_BMI_and_hs_CRP_according_to_FTO_rs9939609_genotype_/478038", "title"=>"The association between BMI and hs-CRP according to <i>FTO</i> rs9939609 genotype.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-05 02:13:58"}

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Relative Metric

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