Microbial Dysbiosis in Colorectal Cancer (CRC) Patients
Publication Date
January 27, 2011
Journal
PLOS ONE
Authors
Iradj Sobhani, Julien Tap, Françoise Roudot Thoraval, Jean P. Roperch, et al
Volume
6
Issue
1
Pages
e16393
DOI
https://dx.plos.org/10.1371/journal.pone.0016393
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0016393
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/21297998
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029306
Europe PMC
http://europepmc.org/abstract/MED/21297998
Web of Science
000286663900045
Scopus
79551571717
Mendeley
http://www.mendeley.com/research/microbial-dysbiosis-colorectal-cancer-crc-patients
Events
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Mendeley | Further Information

{"title"=>"Microbial dysbiosis in colorectal cancer (CRC) patients", "type"=>"journal", "authors"=>[{"first_name"=>"Iradj", "last_name"=>"Sobhani", "scopus_author_id"=>"16742231800"}, {"first_name"=>"Julien", "last_name"=>"Tap", "scopus_author_id"=>"26536756600"}, {"first_name"=>"Françoise", "last_name"=>"Roudot-Thoraval", "scopus_author_id"=>"55406322600"}, {"first_name"=>"Jean P.", "last_name"=>"Roperch", "scopus_author_id"=>"57193800795"}, {"first_name"=>"Sophie", "last_name"=>"Letulle", "scopus_author_id"=>"35069780800"}, {"first_name"=>"Philippe", "last_name"=>"Langella", "scopus_author_id"=>"7003598187"}, {"first_name"=>"Corthier", "last_name"=>"Gérard", "scopus_author_id"=>"37661215100"}, {"first_name"=>"Jeanne Tran", "last_name"=>"van Nhieu", "scopus_author_id"=>"6603589207"}, {"first_name"=>"Jean P.", "last_name"=>"Furet", "scopus_author_id"=>"6603284121"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"361204510", "sgr"=>"79551571717", "issn"=>"19326203", "pmid"=>"21297998", "scopus"=>"2-s2.0-79551571717", "doi"=>"10.1371/journal.pone.0016393", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"7249ded2-9663-367c-a7c1-7d110f2fbe2f", "abstract"=>"The composition of the human intestinal microbiota is linked to health status. The aim was to analyze the microbiota of normal and colon cancer patients in order to establish cancer-related dysbiosis. PATIENTS AND METHODS: Stool bacterial DNA was extracted prior to colonoscopy from 179 patients: 60 with colorectal cancer, and 119 with normal colonoscopy. Bacterial genes obtained by pyrosequencing of 12 stool samples (6 Normal and 6 Cancer) were subjected to a validated Principal Component Analysis (PCA) test. The dominant and subdominant bacterial population (C. leptum, C. coccoides, Bacteroides/Prevotella, Lactobacillus/Leuconostoc/Pediococcus groups, Bifidobacterium genus, and E. coli, and Faecalibacterium prausnitzii species) were quantified in all individuals using qPCR and specific IL17 producer cells in the intestinal mucosa were characterized using immunohistochemistry. FINDINGS: Pyrosequencing (Minimal sequence 200 nucleotide reads) revealed 80% of all sequences could be assigned to a total of 819 taxa based on default parameter of Classifier software. The phylogenetic core in Cancer individuals was different from that in Normal individuals according to the PCA analysis, with trends towards differences in the dominant and subdominant families of bacteria. Consequently, All-bacteria [log(10) (bacteria/g of stool)] in Normal, and Cancer individuals were similar [11.88+/-0.35, and 11.80+/-0.56, respectively, (P = 0.16)], according to qPCR values whereas among all dominant and subdominant species only those of Bacteroides/Prevotella were higher (All bacteria-specific bacterium; P = 0.009) in Cancer (-1.04+/-0.55) than in Normal (-1.40+/-0.83) individuals. IL17 immunoreactive cells were significantly expressed more in the normal mucosa of cancer patients than in those with normal colonoscopy. CONCLUSION: This is the first large series to demonstrate a composition change in the microbiota of colon cancer patients with possible impact on mucosal immune response. These data open new filed for mass screening and pathophysiology investigations.", "link"=>"http://www.mendeley.com/research/microbial-dysbiosis-colorectal-cancer-crc-patients", "reader_count"=>311, "reader_count_by_academic_status"=>{"Unspecified"=>8, "Professor > Associate Professor"=>15, "Librarian"=>2, "Researcher"=>89, "Student > Doctoral Student"=>23, "Student > Ph. D. Student"=>57, "Student > Postgraduate"=>9, "Student > Master"=>43, "Other"=>16, "Student > Bachelor"=>37, "Lecturer"=>5, "Lecturer > Senior Lecturer"=>2, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>8, "Professor > Associate Professor"=>15, "Librarian"=>2, "Researcher"=>89, "Student > Doctoral Student"=>23, "Student > Ph. D. Student"=>57, "Student > Postgraduate"=>9, "Student > Master"=>43, "Other"=>16, "Student > Bachelor"=>37, "Lecturer"=>5, "Lecturer > Senior Lecturer"=>2, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>20, "Agricultural and Biological Sciences"=>152, "Philosophy"=>1, "Business, Management and Accounting"=>2, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>4, "Computer Science"=>1, "Engineering"=>4, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>40, "Nursing and Health Professions"=>3, "Materials Science"=>2, "Medicine and Dentistry"=>63, "Immunology and Microbiology"=>16}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>63}, "Unspecified"=>{"Unspecified"=>20}, "Environmental Science"=>{"Environmental Science"=>2}, "Engineering"=>{"Engineering"=>4}, "Chemistry"=>{"Chemistry"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>16}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>152}, "Computer Science"=>{"Computer Science"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>40}, "Philosophy"=>{"Philosophy"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>6, "Japan"=>1, "United Kingdom"=>4, "Malaysia"=>2, "Switzerland"=>2, "Spain"=>1, "Russia"=>1, "Canada"=>2, "Netherlands"=>2, "Belgium"=>1, "Norway"=>1, "Denmark"=>2, "France"=>6, "Chile"=>1, "Germany"=>4, "Croatia"=>2}, "group_count"=>20}

CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/803399"], "description"=>"1<p>- includes invasive cancers (n = 53), advanced adenomas (n = 2) and large villous tumours of at least 3 cm in diameter (n = 5);</p>2<p>- includes those individuals who are under any particular regimen (diabetes, vegetarian, hyper proteic, hyper vitaminic etc…);</p>3<p>- No antibiotics.</p>", "links"=>[], "tags"=>["individuals", "included"], "article_id"=>473760, "categories"=>["Cancer", "Chemistry"], "users"=>["Iradj Sobhani", "Julien Tap", "Françoise Roudot-Thoraval", "Jean P. Roperch", "Sophie Letulle", "Philippe Langella", "Gérard Corthier", "Jeanne Tran Van Nhieu", "Jean P. Furet"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0016393.t001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_individuals_included_in_the_current_study_N_8202_8202_179_/473760", "title"=>"Characteristics of the individuals included in the current study N = 179.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-01-27 01:02:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/803441"], "description"=>"<p>n: represents the numbers of studied samples.</p><p>*All-bacteria results obtained by qPCR were expressed as mean of the log10 value ± SD.</p>†<p>Results were expressed as mean of normalized values ± SD,</p><p>calculated as the log number of targeted bacteria minus the log number of all-bacteria.</p>‡<p><i>Faecalibacterium prausnitzii</i> is the major component of the <i>Clostridium leptum</i> group.</p>", "links"=>[], "tags"=>["microbiota", "sub", "groups", "colonoscopy", "pathology"], "article_id"=>473801, "categories"=>["Cancer", "Chemistry"], "users"=>["Iradj Sobhani", "Julien Tap", "Françoise Roudot-Thoraval", "Jean P. Roperch", "Sophie Letulle", "Philippe Langella", "Gérard Corthier", "Jeanne Tran Van Nhieu", "Jean P. Furet"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0016393.t002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Composition_of_microbiota_regarding_dominant_and_sub_dominant_bacteria_groups_according_to_the_colonoscopy_and_pathology_results_/473801", "title"=>"Composition of microbiota regarding dominant and sub dominant bacteria groups according to the colonoscopy and pathology results.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-01-27 01:03:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/401075"], "description"=>"<div><p>The composition of the human intestinal microbiota is linked to health status. The aim was to analyze the microbiota of normal and colon cancer patients in order to establish cancer-related dysbiosis.</p> <h3>Patients and Methods</h3><p>Stool bacterial DNA was extracted prior to colonoscopy from 179 patients: 60 with colorectal cancer, and 119 with normal colonoscopy. Bacterial genes obtained by pyrosequencing of 12 stool samples (6 Normal and 6 Cancer) were subjected to a validated Principal Component Analysis (PCA) test. The dominant and subdominant bacterial population (<em>C. leptum</em>, <em>C. coccoides</em>, <em>Bacteroides/Prevotella</em>, <em>Lactobacillus/Leuconostoc/Pediococcus groups</em>, <em>Bifidobacterium genus</em>, and <em>E. coli,</em> and <em>Faecalibacterium prausnitzii</em> species) were quantified in all individuals using qPCR and specific IL17 producer cells in the intestinal mucosa were characterized using immunohistochemistry.</p> <h3>Findings</h3><p>Pyrosequencing (Minimal sequence 200 nucleotide reads) revealed 80% of all sequences could be assigned to a total of 819 taxa based on default parameter of Classifier software. The phylogenetic core in Cancer individuals was different from that in Normal individuals according to the PCA analysis, with trends towards differences in the dominant and subdominant families of bacteria. Consequently, All-bacteria [log<sub>10</sub> (bacteria/g of stool)] in Normal, and Cancer individuals were similar [11.88±0.35, and 11.80±0.56, respectively, (P = 0.16)], according to qPCR values whereas among all dominant and subdominant species only those of <em>Bacteroides/Prevotella</em> were higher (All bacteria-specific bacterium; P = 0.009) in Cancer (-1.04±0.55) than in Normal (-1.40±0.83) individuals. IL17 immunoreactive cells were significantly expressed more in the normal mucosa of cancer patients than in those with normal colonoscopy.</p> <h3>Conclusion</h3><p>This is the first large series to demonstrate a composition change in the microbiota of colon cancer patients with possible impact on mucosal immune response. These data open new filed for mass screening and pathophysiology investigations.</p> </div>", "links"=>[], "tags"=>["microbial", "dysbiosis", "colorectal", "cancer", "patients"], "article_id"=>139243, "categories"=>["Cancer", "Chemistry"], "users"=>["Iradj Sobhani", "Julien Tap", "Françoise Roudot-Thoraval", "Jean P. Roperch", "Sophie Letulle", "Philippe Langella", "Gérard Corthier", "Jeanne Tran Van Nhieu", "Jean P. Furet"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0016393", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Microbial_Dysbiosis_in_Colorectal_Cancer_CRC_Patients/139243", "title"=>"Microbial Dysbiosis in Colorectal Cancer (CRC) Patients", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-01-27 02:34:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/803263"], "description"=>"<p>In the normal individual's tissue (A) gel migration system shows <i>Bacteroides</i>/Albumin ratios close to 1 whereas they appeared higher in homologous normal (N) or tumour (Ca) mucosa in the colon cancer patient's tissues (B). Note that <i>Bacteroides</i> gene amplification product in stool is dramatically higher than that detected from mucosal DNA; amplification is referred to the human Albumin gene.</p>", "links"=>[], "tags"=>["pcr", "products", "corresponding", "appeared", "albumin", "elevated", "stool"], "article_id"=>473623, "categories"=>["Cancer", "Chemistry"], "users"=>["Iradj Sobhani", "Julien Tap", "Françoise Roudot-Thoraval", "Jean P. Roperch", "Sophie Letulle", "Philippe Langella", "Gérard Corthier", "Jeanne Tran Van Nhieu", "Jean P. Furet"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0016393.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_PCR_products_corresponding_to_Bacteroides_108_pb_appeared_to_be_similar_to_those_of_human_Albumin_77_pb_in_the_tissue_but_highly_elevated_in_stool_samples_/473623", "title"=>"The PCR products corresponding to <i>Bacteroides</i> (108 pb) appeared to be similar to those of human Albumin (77 pb) in the tissue but highly elevated in stool samples.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-27 01:00:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/803157"], "description"=>"<p>Samples from the same individuals and colonic sites were submitted to DNA extraction and PCR. Interleukin 17 (IL17)-immunoreactive cells in colonic tissues were mainly located in the <i>lamina propria</i> in the normal tissues [A: colonic normal mucosa from a normal individual (high magnification x40 at the bottom), B: colonic normal mucosa from a patient with colon cancer (high magnification x40 at the bottom)] and infiltrated the tumour tissue in a the same individual than in B [C: IL17 imlmunoreactive cells infiltrating the tumour with high magnification x40 at the bottom & D: In this double staining IL17 and CD3, the goat anti-human IL-17 antibody was added first before staining with Naphthol/Fast (red) followed by the rabbit anti-human CD3 antibody that was revealed with DAB substrate (brown); this showed that CD3 was not the only cell producing IL-17.</p>", "links"=>[], "tags"=>["samples", "immunostained", "antihuman", "il17", "antibody", "revealed", "dab", "counterstained", "haematoxylin", "magnifications"], "article_id"=>473505, "categories"=>["Cancer", "Chemistry"], "users"=>["Iradj Sobhani", "Julien Tap", "Françoise Roudot-Thoraval", "Jean P. Roperch", "Sophie Letulle", "Philippe Langella", "Gérard Corthier", "Jeanne Tran Van Nhieu", "Jean P. Furet"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0016393.g002", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tissue_samples_are_immunostained_by_using_specific_antihuman_IL17_goat_antibody_1_8758_40_concentration_at_room_temperature_for_1_h_and_revealed_by_DAB_system_and_counterstained_with_haematoxylin_with_high_magnifications_in_the_windows_/473505", "title"=>"Tissue samples are immunostained by using specific antihuman IL17 goat antibody (1∶40 concentration at room temperature for 1 h) and revealed by DAB system and counterstained with haematoxylin with high magnifications in the windows.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-27 00:58:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/802977"], "description"=>"<p>Principal component analysis, based on the 16S rRNA gene sequence abundance of 7 discriminates genera which represented at least 1% of microbiota abundance, was carried out with 6 healthy individuals (N) and 6 cancer* patients (Ca) with two replicates (noted as mid1 and mid2). Two first components (PC1 and PC2) were plotted and represented 70.83% of whole inertia. Individuals (represented by their sample id) were clustered and centre of gravity computed for each class. * They all have been selected from stage I-II of TNM classification (see also Tables S2 and S3 and Figures S2&S3 in the supplementary <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0016393#pone.0016393.s001\" target=\"_blank\">File S1</a>).</p>", "links"=>[], "tags"=>["genera", "abundance", "differentiates", "cancer", "patients", "colonoscopy"], "article_id"=>473330, "categories"=>["Cancer", "Chemistry"], "users"=>["Iradj Sobhani", "Julien Tap", "Françoise Roudot-Thoraval", "Jean P. Roperch", "Sophie Letulle", "Philippe Langella", "Gérard Corthier", "Jeanne Tran Van Nhieu", "Jean P. Furet"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0016393.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bacterial_genera_abundance_differentiates_cancer_patients_and_normal_colonoscopy_individuals_/473330", "title"=>"Bacterial genera abundance differentiates cancer patients and normal colonoscopy individuals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-01-27 00:55:30"}

PMC Usage Stats | Further Information

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