Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Distinct cerebrospinal fluid proteomes differentiate post-treatment Lyme disease from Chronic fatigue syndrome", "type"=>"journal", "authors"=>[{"first_name"=>"Steven E.", "last_name"=>"Schutzer", "scopus_author_id"=>"7003390617"}, {"first_name"=>"Thomas E.", "last_name"=>"Angel", "scopus_author_id"=>"13409996600"}, {"first_name"=>"Tao", "last_name"=>"Liu", "scopus_author_id"=>"56147215500"}, {"first_name"=>"Athena A.", "last_name"=>"Schepmoes", "scopus_author_id"=>"14827175600"}, {"first_name"=>"Therese R.", "last_name"=>"Clauss", "scopus_author_id"=>"10141101200"}, {"first_name"=>"Joshua N.", "last_name"=>"Adkins", "scopus_author_id"=>"7005564601"}, {"first_name"=>"David G.", "last_name"=>"Camp", "scopus_author_id"=>"7005585783"}, {"first_name"=>"Bart K.", "last_name"=>"Holland", "scopus_author_id"=>"7102232176"}, {"first_name"=>"Jonas", "last_name"=>"Bergquist", "scopus_author_id"=>"7004571643"}, {"first_name"=>"Patricia K.", "last_name"=>"Coyle", "scopus_author_id"=>"23157884200"}, {"first_name"=>"Richard D.", "last_name"=>"Smith", "scopus_author_id"=>"55542871600"}, {"first_name"=>"Brian A.", "last_name"=>"Fallon", "scopus_author_id"=>"7005931082"}, {"first_name"=>"Benjamin H.", "last_name"=>"Natelson", "scopus_author_id"=>"7102447974"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"79952023217", "doi"=>"10.1371/journal.pone.0017287", "issn"=>"19326203", "pui"=>"361332450", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "pmid"=>"21383843", "scopus"=>"2-s2.0-79952023217"}, "id"=>"f7d808e7-4413-3bf7-81f0-adc03cfb8fa5", "abstract"=>"Neurologic Post Treatment Lyme disease (nPTLS) and Chronic Fatigue (CFS) are syndromes of unknown etiology. They share features of fatigue and cognitive dysfunction, making it difficult to differentiate them. Unresolved is whether nPTLS is a subset of CFS.", "link"=>"http://www.mendeley.com/research/distinct-cerebrospinal-fluid-proteomes-differentiate-posttreatment-lyme-disease-chronic-fatigue-synd", "reader_count"=>85, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>7, "Librarian"=>3, "Researcher"=>28, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>3, "Student > Master"=>4, "Other"=>11, "Student > Bachelor"=>6, "Lecturer"=>2, "Professor"=>7}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>7, "Librarian"=>3, "Researcher"=>28, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>3, "Student > Master"=>4, "Other"=>11, "Student > Bachelor"=>6, "Lecturer"=>2, "Professor"=>7}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>22, "Arts and Humanities"=>1, "Philosophy"=>1, "Business, Management and Accounting"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>4, "Computer Science"=>3, "Engineering"=>2, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>6, "Nursing and Health Professions"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>29, "Neuroscience"=>3, "Physics and Astronomy"=>2, "Psychology"=>2, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>29}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Psychology"=>{"Psychology"=>2}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>2}, "Chemistry"=>{"Chemistry"=>4}, "Neuroscience"=>{"Neuroscience"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>22}, "Computer Science"=>{"Computer Science"=>3}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Philosophy"=>{"Philosophy"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "Austria"=>1, "Norway"=>1, "United States"=>3, "Finland"=>1, "Australia"=>1, "Spain"=>1}, "group_count"=>8}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79952023217"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79952023217?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952023217&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=79952023217&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/79952023217", "dc:identifier"=>"SCOPUS_ID:79952023217", "eid"=>"2-s2.0-79952023217", "dc:title"=>"Distinct cerebrospinal fluid proteomes differentiate post-treatment Lyme disease from Chronic fatigue syndrome", "dc:creator"=>"Schutzer S.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"6", "prism:issueIdentifier"=>"2", "prism:pageRange"=>nil, "prism:coverDate"=>"2011-03-02", "prism:coverDisplayDate"=>"2011", "prism:doi"=>"10.1371/journal.pone.0017287", "citedby-count"=>"62", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Rutgers New Jersey Medical School", "affiliation-city"=>"Newark", "affiliation-country"=>"United States"}], "pubmed-id"=>"21383843", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e17287", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0017287", "share_count"=>3, "like_count"=>2, "comment_count"=>4, "click_count"=>0, "total_count"=>9}

Journal Comments | Further Information

Twitter

Counter

  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"508", "xml_views"=>"11", "html_views"=>"3579"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"425", "xml_views"=>"8", "html_views"=>"3076"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"119", "xml_views"=>"1", "html_views"=>"889"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"55", "xml_views"=>"1", "html_views"=>"383"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"28", "xml_views"=>"3", "html_views"=>"282"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"256"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"387"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"37", "xml_views"=>"1", "html_views"=>"404"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"462"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"50", "xml_views"=>"5", "html_views"=>"293"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"56", "xml_views"=>"0", "html_views"=>"623"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"71", "xml_views"=>"3", "html_views"=>"1067"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"36", "xml_views"=>"1", "html_views"=>"437"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"61", "xml_views"=>"2", "html_views"=>"499"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"40", "xml_views"=>"2", "html_views"=>"835"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"41", "xml_views"=>"3", "html_views"=>"826"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"386"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"330"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"33", "xml_views"=>"5", "html_views"=>"400"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"434"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"401"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"495"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"381"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"396"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"300"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"318"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"383"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"252"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"189"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"204"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"285"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"263"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"248"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"295"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"206"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"181"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"176"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"199"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"206"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"218"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"296"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"175"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"209"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"209"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"180"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"253"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"5", "html_views"=>"352"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"289"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"417"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"249"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"236"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"212"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"257"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"233"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"231"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"336"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"249"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"285"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"244"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"280"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"177"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"206"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"170"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"177"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"144"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"144"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"145"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"328"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"572"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"473"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"537"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"629"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"563"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"595"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"518"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"446"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"392"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"352"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"399"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"486"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"5", "html_views"=>"367"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"301"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"4", "html_views"=>"312"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"196"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"75"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"79"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"212"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"3", "html_views"=>"71"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"46"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"61"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"4", "html_views"=>"22"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"4", "html_views"=>"41"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"40"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"32", "xml_views"=>"2", "html_views"=>"51"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"81", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"7"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/398376", "https://ndownloader.figshare.com/files/398437", "https://ndownloader.figshare.com/files/398487", "https://ndownloader.figshare.com/files/398614", "https://ndownloader.figshare.com/files/398729", "https://ndownloader.figshare.com/files/398779", "https://ndownloader.figshare.com/files/398829", "https://ndownloader.figshare.com/files/398870"], "description"=>"<div><h3>Background</h3><p>Neurologic Post Treatment Lyme disease (<em>nPTLS</em>) and Chronic Fatigue (<em>CFS</em>) are syndromes of unknown etiology. They share features of fatigue and cognitive dysfunction, making it difficult to differentiate them. Unresolved is whether <em>nPTLS</em> is a subset of <em>CFS</em>.</p> <h3>Methods and Principal Findings</h3><p>Pooled cerebrospinal fluid (CSF) samples from <em>nPTLS patients</em>, <em>CFS</em> patients, and healthy volunteers were comprehensively analyzed using high-resolution mass spectrometry (MS), coupled with immunoaffinity depletion methods to reduce protein-masking by abundant proteins. Individual patient and healthy control CSF samples were analyzed directly employing a MS-based label-free quantitative proteomics approach. We found that both groups, and individuals within the groups, could be distinguished from each other and normals based on their specific CSF proteins (p<0.01). <em>CFS</em> (n = 43) had 2,783 non-redundant proteins, <em>nPTLS</em> (n = 25) contained 2,768 proteins, and healthy normals had 2,630 proteins. Preliminary pathway analysis demonstrated that the data could be useful for hypothesis generation on the pathogenetic mechanisms underlying these two related syndromes.</p> <h3>Conclusions</h3><p><em>nPTLS</em> and <em>CFS</em> have distinguishing CSF protein complements. Each condition has a number of CSF proteins that can be useful in providing candidates for future validation studies and insights on the respective mechanisms of pathogenesis. Distinguishing <em>nPTLS</em> and <em>CFS</em> permits more focused study of each condition, and can lead to novel diagnostics and therapeutic interventions.</p> </div>", "links"=>[], "tags"=>["cerebrospinal", "proteomes", "differentiate", "post-treatment", "lyme"], "article_id"=>138688, "categories"=>["Cancer", "Neuroscience", "Biochemistry", "Immunology", "Physiology"], "users"=>["Steven E. Schutzer", "Thomas E. Angel", "Tao Liu", "Athena A. Schepmoes", "Therese R. Clauss", "Joshua N. Adkins", "David G. Camp II", "Bart K. Holland", "Jonas Bergquist", "Patricia K. Coyle", "Richard D. Smith", "Brian A. Fallon", "Benjamin H. Natelson"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0017287.s001", "https://dx.doi.org/10.1371/journal.pone.0017287.s002", "https://dx.doi.org/10.1371/journal.pone.0017287.s003", "https://dx.doi.org/10.1371/journal.pone.0017287.s004", "https://dx.doi.org/10.1371/journal.pone.0017287.s005", "https://dx.doi.org/10.1371/journal.pone.0017287.s006", "https://dx.doi.org/10.1371/journal.pone.0017287.s007", "https://dx.doi.org/10.1371/journal.pone.0017287.s008"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Distinct_Cerebrospinal_Fluid_Proteomes_Differentiate_Post_Treatment_Lyme_Disease_from_Chronic_Fatigue_Syndrome/138688", "title"=>"Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-02-23 02:24:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/796543"], "description"=>"<p><b>A</b>) Venn diagram of the qualitative distribution of proteins identified in the pooled, immunodepleted, and fractionated cerebrospinal fluid (CSF) from normal healthy control subjects, Chronic Fatigue Syndrome (<i>CFS</i>), and Neurologic Post Treatment Lyme Syndrome (<i>nPTLS</i>). The numbers of proteins for each of these three categories separately is shown outside the circles below the category (2,630 for true normal controls, 2,783 for <i>CFS</i>, and 2,768 for <i>nPTLS</i>). The subsets of intersections between these categories are shown within the circles. There were 1) 738 proteins that were identified in <i>CFS,</i> but not in either healthy normal controls or <i>nPTLS</i>; 2) 1,582 proteins that were not identified in <i>CFS,</i> but were in either <i>nPTLS</i> disease or healthy normal controls; 3) 692 proteins that were identified in the <i>nPTLS</i> patients, but not in healthy normal controls or <i>CFS</i>; and 4) 1,597 proteins that were not identified in <i>nPTLS,</i> but were identified in either healthy normal controls or <i>CFS</i>. This figure also shows that the <i>nPTLS</i> and <i>CFS</i> groups shared significantly more proteins (n = 305) than each disease group shared with controls (n's = 135 and 166). The specific lists of these subsets are presented in additional <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017287#pone.0017287.s003\" target=\"_blank\">Table S1</a>.</p>", "links"=>[], "tags"=>["proteome", "pooled", "csf"], "article_id"=>466902, "categories"=>["Neuroscience", "Biochemistry", "Infectious Diseases", "Immunology", "Physiology"], "users"=>["Steven E. Schutzer", "Thomas E. Angel", "Tao Liu", "Athena A. Schepmoes", "Therese R. Clauss", "Joshua N. Adkins", "David G. Camp II", "Bart K. Holland", "Jonas Bergquist", "Patricia K. Coyle", "Richard D. Smith", "Brian A. Fallon", "Benjamin H. Natelson"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0017287.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characterization_of_the_proteome_from_pooled_and_individual_CSF_samples_/466902", "title"=>"Characterization of the proteome from pooled and individual CSF samples.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-02-23 01:55:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/796687"], "description"=>"<p><b>A</b>) Unsupervised hierarchical clustering of 59 proteins (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017287#pone.0017287.s005\" target=\"_blank\">Table S3</a>) that are differentially abundant as determined by ANOVA (p<0.01) clearly separates these two disease states with the exception of one <i>nPTLS</i> sample clustering with <i>CFS</i> patient samples. <b>B</b>) Principal Component Analysis (PCA) of <i>CFS</i> and <i>nPTLS</i> samples demonstrates that the CSF proteomes, and by extension of the CNS status, differ between <i>CFS</i> and <i>nPTLS</i>.</p>", "links"=>[], "tags"=>["csf"], "article_id"=>467050, "categories"=>["Neuroscience", "Biochemistry", "Infectious Diseases", "Immunology", "Physiology"], "users"=>["Steven E. Schutzer", "Thomas E. Angel", "Tao Liu", "Athena A. Schepmoes", "Therese R. Clauss", "Joshua N. Adkins", "David G. Camp II", "Bart K. Holland", "Jonas Bergquist", "Patricia K. Coyle", "Richard D. Smith", "Brian A. Fallon", "Benjamin H. Natelson"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0017287.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparative_analysis_of_individual_CFS_and_nPTLS_CSF_proteomes_/467050", "title"=>"Comparative analysis of individual <i>CFS</i> and <i>nPTLS</i> CSF proteomes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-02-23 01:57:30"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"139", "unique-ip"=>"132", "pdf"=>"47", "year"=>"2011", "figure"=>"40", "scanned-summary"=>"0", "supp-data"=>"37"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"8", "full-text"=>"89", "year"=>"2011", "pdf"=>"46", "unique-ip"=>"94", "figure"=>"32", "scanned-summary"=>"0", "supp-data"=>"9"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"60", "unique-ip"=>"53", "pdf"=>"32", "year"=>"2011", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"60", "year"=>"2011", "pdf"=>"24", "unique-ip"=>"53", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"29"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"46", "unique-ip"=>"44", "pdf"=>"26", "year"=>"2011", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"54", "year"=>"2011", "pdf"=>"17", "unique-ip"=>"48", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"21"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"82", "unique-ip"=>"63", "pdf"=>"14", "year"=>"2011", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"26"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"88", "year"=>"2011", "pdf"=>"21", "unique-ip"=>"69", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"45", "unique-ip"=>"42", "pdf"=>"15", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"47", "year"=>"2011", "pdf"=>"15", "unique-ip"=>"43", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"96", "unique-ip"=>"85", "pdf"=>"19", "year"=>"2012", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"9"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"39", "year"=>"2012", "pdf"=>"19", "unique-ip"=>"38", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"18"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"27", "unique-ip"=>"30", "pdf"=>"10", "year"=>"2012", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"44", "year"=>"2012", "pdf"=>"15", "unique-ip"=>"40", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"8"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"34", "unique-ip"=>"32", "pdf"=>"14", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"21", "year"=>"2012", "pdf"=>"11", "unique-ip"=>"24", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"unique-ip"=>"40", "full-text"=>"33", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"21", "cited-by"=>"1", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"34", "full-text"=>"41", "pdf"=>"19", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"24", "full-text"=>"19", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"27", "full-text"=>"29", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"32", "full-text"=>"42", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"34", "full-text"=>"36", "pdf"=>"16", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"31", "full-text"=>"35", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"32", "full-text"=>"43", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"23", "full-text"=>"32", "pdf"=>"6", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"35", "full-text"=>"53", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"21", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"45", "full-text"=>"53", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"25", "full-text"=>"30", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"19", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"4", "cited-by"=>"3", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"23", "full-text"=>"27", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"6", "cited-by"=>"1", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"27", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"21", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"38", "full-text"=>"39", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"24", "full-text"=>"39", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"22", "full-text"=>"27", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"23", "full-text"=>"45", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"22", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"24", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"40", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"36", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"24", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"27", "full-text"=>"44", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"19", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"33", "full-text"=>"42", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"54", "full-text"=>"62", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"14", "cited-by"=>"1", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"26", "full-text"=>"47", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"35", "full-text"=>"49", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"24", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"7", "cited-by"=>"1", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"22", "full-text"=>"27", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"12", "cited-by"=>"2", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"49", "full-text"=>"50", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"36", "full-text"=>"39", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"13", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"20", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"25", "full-text"=>"41", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"29", "full-text"=>"31", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"26", "full-text"=>"25", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"21", "full-text"=>"26", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"43", "full-text"=>"49", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"9", "cited-by"=>"3", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"11", "cited-by"=>"1", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"78", "full-text"=>"93", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"15", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"22", "full-text"=>"25", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"31", "full-text"=>"31", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"22", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"30", "full-text"=>"44", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"19", "cited-by"=>"2", "year"=>"2020", "month"=>"6"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[304, 568, 702, 818, 927, 1027, 1118, 1206, 1285, 1357, 1427, 1500, 1564, 1636, 1705, 1773, 1840, 1909, 1974, 2039, 2106, 2170, 2234, 2296, 2358, 2423, 2484, 2546, 2606, 2673, 2734, 2795, 2857, 2921, 2984, 3046, 3100]}, {"subject_area"=>"/Engineering and technology/Industrial engineering", "average_usage"=>[310, 536, 668, 780, 896, 944, 1037, 1103, 1176, 1250, 1302, 1367, 1462, 1566, 1626, 1692, 1749, 1820, 1918, 1975, 2029, 2070, 2140, 2223, 2305, 2391, 2451, 2538, 2623, 2674, 2751, 2835, 2875, 2909, 2930, 2980, 3069]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[301, 559, 686, 796, 908, 1013, 1103, 1196, 1281, 1355, 1431, 1507, 1579, 1648, 1711, 1778, 1841, 1910, 1967, 2034, 2087, 2141, 2202, 2261, 2320, 2386, 2444, 2502, 2566, 2632, 2691, 2755, 2812, 2873, 2929, 2997, 3047]}, {"subject_area"=>"/Medicine and health sciences/Diagnostic medicine", "average_usage"=>[327, 595, 718, 842, 949, 1065, 1147, 1225, 1316, 1399, 1468, 1541, 1618, 1690, 1756, 1814, 1872, 1924, 1987, 2054, 2118, 2189, 2244, 2300, 2364, 2422, 2480, 2543, 2597, 2665, 2727, 2777, 2821, 2877, 2940, 2996, 3052]}, {"subject_area"=>"/Medicine and health sciences/Neurology", "average_usage"=>[306, 594, 747, 886, 1029, 1141, 1243, 1346, 1446, 1520, 1606, 1689, 1766, 1845, 1921, 1996, 2076, 2136, 2224, 2295, 2367, 2436, 2519, 2589, 2662, 2731, 2806, 2865, 2924, 2980, 3064, 3112, 3167, 3225, 3298, 3364, 3438]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[291, 540, 674, 787, 893, 986, 1087, 1172, 1249, 1319, 1394, 1465, 1526, 1588, 1645, 1713, 1774, 1837, 1903, 1959, 2027, 2085, 2152, 2205, 2259, 2318, 2377, 2436, 2486, 2539, 2603, 2664, 2719, 2779, 2835, 2888, 2944]}]}
Loading … Spinner
There are currently no alerts