Moderate Caloric Restriction during Gestation in Rats Alters Adipose Tissue Sympathetic Innervation and Later Adiposity in Offspring
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{"title"=>"Moderate caloric restriction during gestation in rats alters adipose tissue sympathetic innervation and later adiposity in offspring", "type"=>"journal", "authors"=>[{"first_name"=>"Ana Paula", "last_name"=>"García", "scopus_author_id"=>"55452178200"}, {"first_name"=>"Mariona", "last_name"=>"Palou", "scopus_author_id"=>"23477995700"}, {"first_name"=>"Juana", "last_name"=>"Sánchez", "scopus_author_id"=>"7403998617"}, {"first_name"=>"Teresa", "last_name"=>"Priego", "scopus_author_id"=>"6603485620"}, {"first_name"=>"Andreu", "last_name"=>"Palou", "scopus_author_id"=>"7005715770"}, {"first_name"=>"Catalina", "last_name"=>"Picó", "scopus_author_id"=>"35472867200"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"79951965635", "doi"=>"10.1371/journal.pone.0017313", "pui"=>"361327602", "pmid"=>"21364997", "scopus"=>"2-s2.0-79951965635", "issn"=>"19326203", "isbn"=>"1467-7881"}, "id"=>"27e3b04b-d2e8-3ce2-b85a-1899e14e7960", "abstract"=>"Maternal prenatal undernutrition predisposes offspring to higher adiposity in adulthood. Mechanisms involved in these programming effects, apart from those described in central nervous system development, have not been established. Here we aimed to evaluate whether moderate caloric restriction during early pregnancy in rats affects white adipose tissue (WAT) sympathetic innervation in the offspring, and its relationship with adiposity development. For this purpose, inguinal and retroperitoneal WAT (iWAT and rpWAT, respectively) were analyzed in male and female offspring of control and 20% caloric-restricted (from 1-12 d of pregnancy) (CR) dams. Body weight (BW), the weight, DNA-content, morphological features and the immunoreactive tyrosine hydroxylase and Neuropeptide Y area (TH+ and NPY+ respectively, performed by immunohistochemistry) of both fat depots, were studied at 25 d and 6 m of age, the latter after 2 m exposure to high fat diet. At 6 m of life, CR males but not females, exhibited greater BW, and greater weight and total DNA-content in iWAT, without changes in adipocytes size, suggesting the development of hyperplasia in this depot. However, in rpWAT, CR males but not females, showed larger adipocyte diameter, with no changes in DNA-content, suggesting the development of hypertrophy. These parameters were not different between control and CR animals at the age of 25 d. In iWAT, both at 25 d and 6 m, CR males but not females, showed lower TH(+) and NPY(+), suggesting lower sympathetic innervation in CR males compared to control males. In rpWAT, at 6 m but not at 25 d, CR males but not females, showed lower TH(+) and NPY(+). Thus, the effects of caloric restriction during gestation on later adiposity and on the differences in the adult phenotype between internal and subcutaneous fat depots in the male offspring may be associated in part with specific alterations in sympathetic innervation, which may impact on WAT architecture.", "link"=>"http://www.mendeley.com/research/moderate-caloric-restriction-during-gestation-rats-alters-adipose-tissue-sympathetic-innervation-lat", "reader_count"=>46, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>10, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Student > Master"=>8, "Other"=>3, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>10, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Student > Master"=>8, "Other"=>3, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>9, "Nursing and Health Professions"=>2, "Agricultural and Biological Sciences"=>18, "Medicine and Dentistry"=>7, "Neuroscience"=>2, "Design"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>3}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>2}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>18}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>9}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/797791"], "description"=>"<p>mRNA expression levels of β3 and α2 adrenergic receptor (β3-AR and α2-AR) in inguinal and retroperitoneal white adipose tissue depots (iWAT and rpWAT respectively), in 25 d and 6 m old male and female offspring of controls (C) and 20% caloric restricted dams during gestation (CR). mRNA expression levels in male and female controls are set to 100% and values of CR animals expressed relative to their controls. Each group is made up of animals from at least four different litters. Data are mean ± s.e.m.</p><p>*Different from their respective C group (p<0.05; Student's t -test).</p>", "links"=>[], "tags"=>["levels", "wat", "25"], "article_id"=>468156, "categories"=>["Physiology", "Biochemistry", "Developmental Biology"], "users"=>["Ana Paula García", "Mariona Palou", "Juana Sánchez", "Teresa Priego", "Andreu Palou", "Catalina Picó"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0017313.t003", "stats"=>{"downloads"=>3, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_mRNA_expression_levels_of_946_3_AR_and_945_2AR_in_WAT_in_25_d_and_6_m_old_animals_/468156", "title"=>"mRNA expression levels of β3-AR and α-2AR in WAT in 25 d and 6 m old animals.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 20:30:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/797583"], "description"=>"<p>Immunoreactive NPY area (NPY<sup>+</sup>) - expressed as µm/mm<sup>2</sup> (left axis) and as µm/adipocyte (right axis) - in retroperitoneal white adipose tissue (rpWAT) of 25 d (A and B) and 6 m (C and D), male (A and C) and female (B and D) offspring of controls (C) and 20% caloric restricted dams during gestation (CR) and their corresponding representative immunostained sections (C on the left and CR on the right). Scale bar: 20 µm and 50 µm for 25 d old and 6 m old animals respectively. Data are mean ± s.e.m. (n = 5–6, coming from at least four different litters). For each animal, 16–20 measurements were performed in different random fields coming from two non consecutive sections of the tissue (7–10 fields per section).* Different from their respective C group (p<0.05; Student's t -test).</p>", "links"=>[], "tags"=>["npy", "rpwat"], "article_id"=>467953, "categories"=>["Physiology", "Biochemistry", "Developmental Biology"], "users"=>["Ana Paula García", "Mariona Palou", "Juana Sánchez", "Teresa Priego", "Andreu Palou", "Catalina Picó"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0017313.g004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemical_analysis_of_NPY_in_rpWAT_depot_/467953", "title"=>"Immunohistochemical analysis of NPY in rpWAT depot.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 20:29:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/796987"], "description"=>"<p>Immunoreactive TH area (TH<sup>+</sup>) - expressed as µm/mm<sup>2</sup> (left axis) and as µm/adipocyte (right axis) - in inguinal white adipose tissue (iWAT) of 25 d (A and B) and 6 m (C and D), male (A and C) and female (B and D) offspring of controls (C) and 20% caloric restricted dams during gestation (CR) and their corresponding representative immunostained sections (C on the left and CR on the right). Scale bar: 20 µm and 50 µm for 25 d old and 6 m old animals respectively. Data are mean ± s.e.m. (n = 5–6, coming from at least four different litters). For each animal, 16–20 measurements were performed in different random fields coming from two non consecutive sections of the tissue (7–10 fields per section).* Different from their respective C group (p<0.05; Student's t -test).</p>", "links"=>[], "tags"=>["th", "iwat"], "article_id"=>467350, "categories"=>["Physiology", "Biochemistry", "Developmental Biology"], "users"=>["Ana Paula García", "Mariona Palou", "Juana Sánchez", "Teresa Priego", "Andreu Palou", "Catalina Picó"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0017313.g001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemical_analysis_of_TH_in_iWAT_depot_/467350", "title"=>"Immunohistochemical analysis of TH in iWAT depot.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 20:26:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/797398"], "description"=>"<p>Immunoreactive NPY area (NPY<sup>+</sup>) - expressed as µm/mm<sup>2</sup> (left axis) and as µm/adipocyte (right axis) - in inguinal white adipose tissue (iWAT) of 25 d (A and B) and 6 m (C and D), male (A and C) and female (B and D) offspring of controls (C) and 20% caloric restricted dams during gestation (CR) and their corresponding representative immunostained sections (C on the left and CR on the right). Scale bar: 20 µm and 50 µm for 25 d old and 6 m old animals respectively. Data are mean ± s.e.m. (n = 5–6, coming from at least four different litters). For each animal, 16–20 measurements were performed in different random fields coming from two non consecutive sections of the tissue (7–10 fields per section).* Different from their respective C group (p<0.05; Student's t -test).</p>", "links"=>[], "tags"=>["npy", "iwat"], "article_id"=>467767, "categories"=>["Physiology", "Biochemistry", "Developmental Biology"], "users"=>["Ana Paula García", "Mariona Palou", "Juana Sánchez", "Teresa Priego", "Andreu Palou", "Catalina Picó"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0017313.g003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemical_analysis_of_NPY_in_iWAT_depot_/467767", "title"=>"Immunohistochemical analysis of NPY in iWAT depot.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 20:28:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/797720"], "description"=>"<p>mRNA expression levels of Leptin in inguinal and retroperitoneal white adipose tissue depots (iWAT and rpWAT respectively), in 25 d and 6 m old male and female offspring of controls (C) and 20% caloric restricted dams during gestation (CR). mRNA expression levels in male and female controls are set to 100% and values of CR animals expressed relative to their controls. Each group is made up of animals from at least four different litters. Data are mean ± s.e.m.</p><p>*Different from their respective C group (p<0.05; Student's t -test).</p>", "links"=>[], "tags"=>["levels", "leptin", "wat", "25"], "article_id"=>468089, "categories"=>["Physiology", "Biochemistry", "Developmental Biology"], "users"=>["Ana Paula García", "Mariona Palou", "Juana Sánchez", "Teresa Priego", "Andreu Palou", "Catalina Picó"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0017313.t004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_mRNA_expression_levels_of_Leptin_in_WAT_in_25_d_and_6_m_old_animals_/468089", "title"=>"mRNA expression levels of Leptin in WAT in 25 d and 6 m old animals.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 20:29:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/797752"], "description"=>"<p>Nucleotide sequences of primers and amplicon size.</p>", "links"=>[], "tags"=>["sequences", "primers", "amplicon"], "article_id"=>468122, "categories"=>["Physiology", "Biochemistry", "Developmental Biology"], "users"=>["Ana Paula García", "Mariona Palou", "Juana Sánchez", "Teresa Priego", "Andreu Palou", "Catalina Picó"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0017313.t001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nucleotide_sequences_of_primers_and_amplicon_size_/468122", "title"=>"Nucleotide sequences of primers and amplicon size.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 20:30:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/797215"], "description"=>"<p>Immunoreactive TH area (TH<sup>+</sup>) - expressed as µm/mm<sup>2</sup> (left axis) and as µm/adipocyte (right axis) - in retroperitoneal white adipose (rpWAT) tissue of 25 d (A and B) and 6 m (C and D), male (A and C) and female (B and D) offspring of controls (C) and 20% caloric restricted dams during gestation (CR) and their corresponding representative immunostained sections (C on the left and CR on the right). Scale bar: 20 µm and 50 µm for 25 d old and 6 m old animals respectively. Data are mean ± s.e.m. (n = 5–6, coming from at least four different litters). For each animal, 16–20 measurements were performed in different random fields coming from two non consecutive sections of the tissue (7–10 fields per section).* Different from their respective C group (p<0.05; Student's t -test).</p>", "links"=>[], "tags"=>["th", "rpwat"], "article_id"=>467580, "categories"=>["Physiology", "Biochemistry", "Developmental Biology"], "users"=>["Ana Paula García", "Mariona Palou", "Juana Sánchez", "Teresa Priego", "Andreu Palou", "Catalina Picó"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0017313.g002", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemical_analysis_of_TH_in_rpWAT_depot_/467580", "title"=>"Immunohistochemical analysis of TH in rpWAT depot.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 20:27:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/797819"], "description"=>"<p>Body weight and weight, adipocyte diameter, DNA expressed per gram of wet tissue and total DNA content of inguinal and retroperitoneal white adipose tissue depots (iWAT and rpWAT respectively), in 25 d and 6 m old male and female offspring of controls (C) and 20% caloric restricted dams during gestation (CR). Each group is made up of animals from at least four different litters. Data are mean ± s.e.m.</p><p>*Different from their respective C group (p<0.05; Student's t -test).</p>", "links"=>[], "tags"=>["morphological", "wat", "25"], "article_id"=>468186, "categories"=>["Physiology", "Biochemistry", "Developmental Biology"], "users"=>["Ana Paula García", "Mariona Palou", "Juana Sánchez", "Teresa Priego", "Andreu Palou", "Catalina Picó"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0017313.t002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Weight_and_morphological_features_of_WAT_in_25_d_and_6_m_old_animals_/468186", "title"=>"Weight and morphological features of WAT in 25 d and 6 m old animals.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 20:30:33"}

PMC Usage Stats | Further Information

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Relative Metric

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