Purified Mesenchymal Stem Cells Are an Efficient Source for iPS Cell Induction
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Purified mesenchymal stem cells are an efficient source for iPS cell induction", "type"=>"journal", "authors"=>[{"first_name"=>"Kunimichi", "last_name"=>"Niibe", "scopus_author_id"=>"25960299300"}, {"first_name"=>"Yoshimi", "last_name"=>"Kawamura", "scopus_author_id"=>"8315768900"}, {"first_name"=>"Daisuke", "last_name"=>"Araki", "scopus_author_id"=>"56346452000"}, {"first_name"=>"Satoru", "last_name"=>"Morikawa", "scopus_author_id"=>"7102226416"}, {"first_name"=>"Kyoko", "last_name"=>"Miura", "scopus_author_id"=>"55581309200"}, {"first_name"=>"Sadafumi", "last_name"=>"Suzuki", "scopus_author_id"=>"7405350348"}, {"first_name"=>"Shigeto", "last_name"=>"Shimmura", "scopus_author_id"=>"7004451634"}, {"first_name"=>"Takehiko", "last_name"=>"Sunabori", "scopus_author_id"=>"14034676400"}, {"first_name"=>"Yo", "last_name"=>"Mabuchi", "scopus_author_id"=>"23989018100"}, {"first_name"=>"Yasuo", "last_name"=>"Nagai", "scopus_author_id"=>"55238202700"}, {"first_name"=>"Taneaki", "last_name"=>"Nakagawa", "scopus_author_id"=>"7404044513"}, {"first_name"=>"Hideyuki", "last_name"=>"Okano", "scopus_author_id"=>"7201660094"}, {"first_name"=>"Yumi", "last_name"=>"Matsuzaki", "scopus_author_id"=>"7201743234"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-79952585969", "sgr"=>"79952585969", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0017610", "pmid"=>"21412425", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"361433584"}, "id"=>"7a3f3192-7874-3ec9-90f9-e08f187afd90", "abstract"=>"Induced pluripotent stem (iPS) cells are generated from mouse and human somatic cells by the forced expression of defined transcription factors. Although most somatic cells are capable of acquiring pluripotency with minimal gene transduction, the poor efficiency of cell reprogramming and the uneven quality of iPS cells are still important problems. In particular, the choice of cell type most suitable for inducing high-quality iPS cells remains unclear.", "link"=>"http://www.mendeley.com/research/purified-mesenchymal-stem-cells-efficient-source-ips-cell-induction-2", "reader_count"=>79, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>25, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>4, "Student > Master"=>7, "Other"=>3, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>25, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>4, "Student > Master"=>7, "Other"=>3, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Biochemistry, Genetics and Molecular Biology"=>8, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>47, "Arts and Humanities"=>1, "Neuroscience"=>2, "Sports and Recreations"=>1, "Psychology"=>1, "Economics, Econometrics and Finance"=>1, "Computer Science"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Neuroscience"=>{"Neuroscience"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>47}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Unspecified"=>{"Unspecified"=>6}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Iran"=>1, "United States"=>2, "Japan"=>2, "Brazil"=>3, "Poland"=>1, "United Kingdom"=>1, "France"=>2, "Germany"=>1, "Spain"=>1}, "group_count"=>4}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79952585969"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79952585969?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952585969&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=79952585969&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/79952585969", "dc:identifier"=>"SCOPUS_ID:79952585969", "eid"=>"2-s2.0-79952585969", "dc:title"=>"Purified mesenchymal stem cells are an efficient source for iPS cell induction", "dc:creator"=>"Niibe K.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"6", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2011-03-18", "prism:coverDisplayDate"=>"2011", "prism:doi"=>"10.1371/journal.pone.0017610", "citedby-count"=>"39", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Keio University School of Medicine", "affiliation-city"=>"Tokyo", "affiliation-country"=>"Japan"}], "pubmed-id"=>"21412425", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e17610", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0017610", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"260", "xml_views"=>"12", "html_views"=>"697"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"100", "xml_views"=>"3", "html_views"=>"222"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"129"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"29", "xml_views"=>"2", "html_views"=>"84"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"45", "xml_views"=>"1", "html_views"=>"78"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"110"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"56", "xml_views"=>"4", "html_views"=>"109"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"84"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"112"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"3", "html_views"=>"91"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"151"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"119"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"93"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"100"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"22", "xml_views"=>"5", "html_views"=>"82"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"117"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"145"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"100"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"107"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"67"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"60"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"102"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"2", "html_views"=>"111"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"91"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"3", "html_views"=>"87"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"91"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"46", "xml_views"=>"2", "html_views"=>"63"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"80"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"85"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"74"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"117"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"14"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"3", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"2", "html_views"=>"11"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"7"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"8"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/790952"], "description"=>"<p>RT-PCR of 4F-iPS cells (<b>A</b>) and 3F-iPS cells (<b>B</b>) for ES-cell marker genes, including Eras, Rex1, Dax1, Gdf3, Esg1, Nanog, Oct3/4, and Sox2 and to detect silencing of the transgenes. <b>C</b>, Number of ES-cell marker genes expressed using 4F induction. <b>D</b>, Number of ES-cell marker genes expressed using 3F induction. <b>E</b>, Transgenes silenced in 4F induction. <b>F,</b> Transgenes silenced in 3F induction. <b>G</b>, Teratomas from iPS cells, transplanted subcutaneously into nude mice. After 4-6 weeks, the teratomas were analyzed histologically with haematoxylin and eosin staining. TTF-iPS 4F1 did not differentiate mesoderm. <b>H</b>, Undifferentiated cells from 4F OP-iPS #3.</p>", "links"=>[], "tags"=>["vivo", "differentiation", "ips"], "article_id"=>461305, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Kunimichi Niibe", "Yoshimi Kawamura", "Daisuke Araki", "Satoru Morikawa", "Kyoko Miura", "Sadafumi Suzuki", "Shigeto Shimmura", "Takehiko Sunabori", "Yo Mabuchi", "Yasuo Nagai", "Taneaki Nakagawa", "Hideyuki Okano", "Yumi Matsuzaki"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0017610.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gene_expression_and_in_vivo_differentiation_of_iPS_cells_/461305", "title"=>"Gene expression and in vivo differentiation of iPS cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-11 00:21:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/791244"], "description"=>"<p><b>A</b>, Chimeric and F1 mice from 4F-PαS-iPS and 3F-PαS-iPS cells. 3F-PαS-iPS could observe nine over 50% chimerism chimeras. <b>B</b>, Germline-competent chimeric mice and F1 mice. Seven chimeras (>50% coloured coat colour) from 3F-PαS-iPS #1 and two from 3F-PαS-iPS #2 were bred with ICR females, and three of seven chimeas from 3F-PαS-iPS #1 and one of two chimera from 3F-PαS-iPS #2 produced iPS derived F1 mice. The ratio of pigmented F1 mice was observed. Numbers below each panel give the percentage of pigmented F1 mice. <b>C</b>, PCR analysis showing the presence of the GFP cassette in F1 mice obtained from the intercross between a chimeric male and an ICR female. <b>D</b>, Scatter plots compared the Gtl2 and Rian gene expression between 4F/3F PαS-iPS and ES cells. <b>E</b>, Hierarchical clustering comparing the global gene expression between ES and iPS cells determined by DNA microarray. <b>F</b>, Scatter plots comparing the global gene expression between ES cells and source cells including PαS cells, OP cells, and TTF cells determined by DNA microarray.</p>", "links"=>[], "tags"=>["chimeras", "offspring"], "article_id"=>461603, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Kunimichi Niibe", "Yoshimi Kawamura", "Daisuke Araki", "Satoru Morikawa", "Kyoko Miura", "Sadafumi Suzuki", "Shigeto Shimmura", "Takehiko Sunabori", "Yo Mabuchi", "Yasuo Nagai", "Taneaki Nakagawa", "Hideyuki Okano", "Yumi Matsuzaki"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0017610.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Germline_chimeras_and_offspring_from_P_945_S_iPS_cells_/461603", "title"=>"Germline chimeras and offspring from PαS-iPS cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-11 00:26:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/790800"], "description"=>"<p><b>A</b>, FACS profile and differentiation capacity of PαS cells and OP cells. PαS cells positive for PDGFRα and Sca-1 after gating on CD45<sup>−</sup> and Ter119<sup>−</sup>. OP cells negative for PDGFRα and Sca-1 after gating on CD45<sup>−</sup> and Ter119<sup>−</sup>. Phase-contrast is a micrograph of CFU-Fs from PαS cells. Osteogenesis was indicated by alkaline phosphatase staining on day 14, adipogenesis by neutral lipid vacuoles stained with oil red O on day 14, and chondrogenesis by toluidine blue staining on day 21 and by morphological changes of PαS (top) and OP (bottom) cells. <b>B</b>, Number of total colonies (counted EGFP<sup>+</sup> and EGFP<sup>−</sup> cells) obtained from 4Factor-transfection of PαS cells, OP cells, TTFs, and MEFs. Colonies were counted 28 days after retroviral transduction and 1×10<sup>4</sup> cells were replated. <b>C</b>, Phase and fluorescence images of PαS iPS GFP<sup>+</sup>/DsRed<sup>−</sup> colony. <b>D</b>, Phase and fluorescence images of PαS iPS GFP<sup>+</sup>/DsRed<sup>+</sup> colony. <b>E</b>, Number of GFP<sup>+</sup>/DsRed<sup>−</sup> colonies from 4-factor induction. *P<0.05 (n = 3). <b>F</b>, Number of total colonies (counted EGFP<sup>+</sup> and EGFP<sup>−</sup> cells) from 3-factor induction. Colonies were counted 35 days after retroviral transduction and 1×10<sup>4</sup> cells were replated. *P<0.05 (n = 3). <b>G</b>, Number of GFP<sup>+</sup>/DsRed<sup>−</sup> colonies from 3-factor induction. **P<0.01 (n = 3). Bar, 200 µm.</p>", "links"=>[], "tags"=>["ips", "cells", "sources", "transgenic"], "article_id"=>461156, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Kunimichi Niibe", "Yoshimi Kawamura", "Daisuke Araki", "Satoru Morikawa", "Kyoko Miura", "Sadafumi Suzuki", "Shigeto Shimmura", "Takehiko Sunabori", "Yo Mabuchi", "Yasuo Nagai", "Taneaki Nakagawa", "Hideyuki Okano", "Yumi Matsuzaki"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0017610.g001", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Generation_of_iPS_cells_from_three_cell_sources_obtained_from_Nanog_GFP_Puro_r_transgenic_mice_/461156", "title"=>"Generation of iPS cells from three cell sources obtained from Nanog-GFP-Puro<sup>r</sup> transgenic mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-11 00:19:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/396233", "https://ndownloader.figshare.com/files/396261", "https://ndownloader.figshare.com/files/396299", "https://ndownloader.figshare.com/files/396349", "https://ndownloader.figshare.com/files/396376", "https://ndownloader.figshare.com/files/396394"], "description"=>"<div><h3>Background</h3><p>Induced pluripotent stem (iPS) cells are generated from mouse and human somatic cells by the forced expression of defined transcription factors. Although most somatic cells are capable of acquiring pluripotency with minimal gene transduction, the poor efficiency of cell reprogramming and the uneven quality of iPS cells are still important problems. In particular, the choice of cell type most suitable for inducing high-quality iPS cells remains unclear.</p> <h3>Methodology/Principal Findings</h3><p>Here, we generated iPS cells from PDGFRα<sup>+</sup> Sca-1<sup>+</sup> (PαS) adult mouse mesenchymal stem cells (MSCs) and PDGFRα<sup>−</sup> Sca-1<sup>−</sup> osteo-progenitors (OP cells), and compared the induction efficiency and quality of individual iPS clones. MSCs had a higher reprogramming efficiency compared with OP cells and Tail Tip Fibroblasts (TTFs). The iPS cells induced from MSCs by Oct3/4, Sox2, and Klf4 appeared to be the closest equivalent to ES cells by DNA microarray gene profile and germline-transmission efficiency.</p> <h3>Conclusions/Significance</h3><p>Our findings suggest that a purified source of undifferentiated cells from adult tissue can produce high-quality iPS cells. In this context, prospectively enriched MSCs are a promising candidate for the efficient generation of high-quality iPS cells.</p> </div>", "links"=>[], "tags"=>["purified", "mesenchymal", "cells", "are", "ips", "induction"], "article_id"=>138261, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Kunimichi Niibe", "Yoshimi Kawamura", "Daisuke Araki", "Satoru Morikawa", "Kyoko Miura", "Sadafumi Suzuki", "Shigeto Shimmura", "Takehiko Sunabori", "Yo Mabuchi", "Yasuo Nagai", "Taneaki Nakagawa", "Hideyuki Okano", "Yumi Matsuzaki"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0017610.s001", "https://dx.doi.org/10.1371/journal.pone.0017610.s002", "https://dx.doi.org/10.1371/journal.pone.0017610.s003", "https://dx.doi.org/10.1371/journal.pone.0017610.s004", "https://dx.doi.org/10.1371/journal.pone.0017610.s005", "https://dx.doi.org/10.1371/journal.pone.0017610.s006"], "stats"=>{"downloads"=>6, "page_views"=>30, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Purified_Mesenchymal_Stem_Cells_Are_an_Efficient_Source_for_iPS_Cell_Induction/138261", "title"=>"Purified Mesenchymal Stem Cells Are an Efficient Source for iPS Cell Induction", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-03-11 02:17:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/791087"], "description"=>"<p><b>A</b>, DNA methylation of the promoter region of the Nanog gene. White circles indicate unmethylated CpG dinucleotides; black circles indicate methylated CpG dinucleotides. <b>B</b>, Scatter plots showing the comparison of global gene expression between ES cells and PαS-iPS, OP-iPS, and TTF-iPS cells determined by DNA microarray. Red number; R<sup>2</sup> values over 0.92 compared with ES cells as positive. <b>C</b>, Microarray Scatter Plots were especially showing klf4, Sox2, Pou5f1 (Oct3/4), Nanog, c-Myc, Tbx3, and GM397 (Zscan4) gene.</p>", "links"=>[], "tags"=>["ips", "cells"], "article_id"=>461446, "categories"=>["Cell Biology", "Developmental Biology"], "users"=>["Kunimichi Niibe", "Yoshimi Kawamura", "Daisuke Araki", "Satoru Morikawa", "Kyoko Miura", "Sadafumi Suzuki", "Shigeto Shimmura", "Takehiko Sunabori", "Yo Mabuchi", "Yasuo Nagai", "Taneaki Nakagawa", "Hideyuki Okano", "Yumi Matsuzaki"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0017610.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characterization_of_iPS_cells_and_P_945_S_cells_/461446", "title"=>"Characterization of iPS cells and PαS cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-11 00:24:06"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"11", "full-text"=>"153", "unique-ip"=>"141", "pdf"=>"142", "year"=>"2011", "figure"=>"22", "scanned-summary"=>"0", "supp-data"=>"9"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"7", "full-text"=>"160", "year"=>"2011", "pdf"=>"117", "unique-ip"=>"154", "figure"=>"66", "scanned-summary"=>"0", "supp-data"=>"14"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"107", "unique-ip"=>"88", "pdf"=>"79", "year"=>"2011", "figure"=>"30", "scanned-summary"=>"0", "supp-data"=>"30"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"57", "year"=>"2011", "pdf"=>"37", "unique-ip"=>"55", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"69", "unique-ip"=>"60", "pdf"=>"62", "year"=>"2011", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"36", "year"=>"2011", "pdf"=>"38", "unique-ip"=>"36", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"66", "unique-ip"=>"63", "pdf"=>"57", "year"=>"2011", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"65", "year"=>"2011", "pdf"=>"53", "unique-ip"=>"56", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"42", "unique-ip"=>"42", "pdf"=>"22", "year"=>"2011", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"33", "year"=>"2011", "pdf"=>"12", "unique-ip"=>"32", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "unique-ip"=>"24", "pdf"=>"9", "year"=>"2012", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"42", "year"=>"2012", "pdf"=>"35", "unique-ip"=>"47", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"45", "unique-ip"=>"44", "pdf"=>"15", "year"=>"2012", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"35", "year"=>"2012", "pdf"=>"14", "unique-ip"=>"31", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"25", "unique-ip"=>"22", "pdf"=>"14", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"29", "year"=>"2012", "pdf"=>"13", "unique-ip"=>"28", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"15", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"16", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"4", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"19", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"21", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"13", "cited-by"=>"1", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"7", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"4", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"13", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"106", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"6", "pdf"=>"163", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"20", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[298, 559, 690, 805, 916, 1018, 1115, 1201, 1283, 1356, 1425, 1498, 1565, 1635, 1703, 1767, 1835, 1902, 1962, 2027, 2089, 2150, 2210, 2265]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[296, 554, 686, 802, 910, 1014, 1104, 1195, 1277, 1349, 1419, 1483, 1551, 1620, 1690, 1757, 1820, 1888, 1957, 2017, 2081, 2140, 2202, 2259]}, {"subject_area"=>"/Medicine and health sciences/Oncology", "average_usage"=>[301, 605, 771, 919, 1050, 1160, 1277, 1380, 1481, 1574, 1669, 1766, 1848, 1924, 1996, 2075, 2157, 2238, 2309, 2375, 2458, 2527, 2586, 2676, 2747, 2806, 2865, 2932, 2994, 3059, 3134, 3194, 3256, 3310, 3388, 3467, 3523]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[344, 630, 756, 876, 981, 1083, 1179, 1272, 1346, 1421, 1508, 1583, 1659, 1744, 1809, 1891, 1954, 2030, 2105, 2174, 2247, 2324, 2386, 2441, 2502, 2557, 2621, 2685, 2753, 2825, 2882, 2935, 2989, 3052, 3117, 3181, 3242]}]}
Loading … Spinner
There are currently no alerts