A Melanoma Molecular Disease Model
Publication Date
March 30, 2011
Journal
PLOS ONE
Authors
Smruti J. Vidwans, Keith T. Flaherty, David E. Fisher, Jay M. Tenenbaum, et al
Volume
6
Issue
3
Pages
e18257
DOI
https://dx.plos.org/10.1371/journal.pone.0018257
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0018257
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/21479172
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068163
Europe PMC
http://europepmc.org/abstract/MED/21479172
Web of Science
000289055700041
Scopus
79953305486
Mendeley
http://www.mendeley.com/research/melanoma-molecular-disease-model
Events
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Mendeley | Further Information

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CrossRef

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/787434"], "description"=>"<p>There is a lot of cross-talk between these pathways and their downstream effectors, which we have classified into 8 pathways for simplicity to account for differences in treatment modalities (e.g. signaling through NRAS could affect both MAPK and AKT/PI3K pathways). The additional 6 pathways are: c-KIT (pink), CDK (blue), GNAQ/GNA11 (brown), MITF (orange), NRAS (yellow), and P53/BCL (purple). The complex relationship among BRAF, ARF/INK4A (via dashed line), p16, and p14ARF connotes an alternative splicing relationship.</p>", "links"=>[], "tags"=>["signaling", "pathways", "implicated", "melanoma", "mapk", "pathway", "proliferation"], "article_id"=>457799, "categories"=>["Information And Computing Sciences", "Cell Biology", "Developmental Biology", "Cancer", "Genetics"], "users"=>["Smruti J. Vidwans", "Keith T. Flaherty", "David E. Fisher", "Jay M. Tenenbaum", "Michael D. Travers", "Jeff Shrager"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0018257.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_two_major_signaling_pathways_implicated_in_melanoma_are_the_MAPK_pathway_red_and_the_AKT_PI3K_green_pathway_which_regulate_cell_growth_proliferation_and_cell_death_/457799", "title"=>"The two major signaling pathways implicated in melanoma are the MAPK pathway (red) and the AKT/PI3K (green) pathway which regulate cell growth, proliferation and cell death.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-30 02:09:59"}

PMC Usage Stats | Further Information

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Relative Metric

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