Comparison of Three Targeted Enrichment Strategies on the SOLiD Sequencing Platform
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{"title"=>"Comparison of three targeted enrichment strategies on the Solid sequencing platform", "type"=>"journal", "authors"=>[{"first_name"=>"Dale J.", "last_name"=>"Hedges", "scopus_author_id"=>"7003363735"}, {"first_name"=>"Toumy", "last_name"=>"Guettouche", "scopus_author_id"=>"6507532637"}, {"first_name"=>"Shan", "last_name"=>"Yang", "scopus_author_id"=>"57199267520"}, {"first_name"=>"Guney", "last_name"=>"Bademci", "scopus_author_id"=>"36155122500"}, {"first_name"=>"Ashley", "last_name"=>"Diaz", "scopus_author_id"=>"52063242200"}, {"first_name"=>"Ashley", "last_name"=>"Andersen", "scopus_author_id"=>"26533970900"}, {"first_name"=>"William F.", "last_name"=>"Hulme", "scopus_author_id"=>"26659005500"}, {"first_name"=>"Sara", "last_name"=>"Linker", "scopus_author_id"=>"52063505300"}, {"first_name"=>"Arpit", "last_name"=>"Mehta", "scopus_author_id"=>"16039939100"}, {"first_name"=>"Yvonne J.K.", "last_name"=>"Edwards", "scopus_author_id"=>"7005034373"}, {"first_name"=>"Gary W.", "last_name"=>"Beecham", "scopus_author_id"=>"25928274300"}, {"first_name"=>"Eden R.", "last_name"=>"Martin", "scopus_author_id"=>"7404092528"}, {"first_name"=>"Margaret A.", "last_name"=>"Pericak-Vance", "scopus_author_id"=>"7102304343"}, {"first_name"=>"Stephan", "last_name"=>"Zuchner", "scopus_author_id"=>"6602168993"}, {"first_name"=>"Jeffery M.", "last_name"=>"Vance", "scopus_author_id"=>"7201366505"}, {"first_name"=>"John R.", "last_name"=>"Gilbert", "scopus_author_id"=>"7401451965"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-79955708249", "sgr"=>"79955708249", "pui"=>"361724269", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"21559511", "doi"=>"10.1371/journal.pone.0018595"}, "id"=>"7d38f3d5-b5fe-3539-abfa-30641d52b6fa", "abstract"=>"Despite the ever-increasing throughput and steadily decreasing cost of next generation sequencing (NGS), whole genome sequencing of humans is still not a viable option for the majority of genetics laboratories. This is particularly true in the case of complex disease studies, where large sample sets are often required to achieve adequate statistical power. To fully leverage the potential of NGS technology on large sample sets, several methods have been developed to selectively enrich for regions of interest. Enrichment reduces both monetary and computational costs compared to whole genome sequencing, while allowing researchers to take advantage of NGS throughput. Several targeted enrichment approaches are currently available, including molecular inversion probe ligation sequencing (MIPS), oligonucleotide hybridization based approaches, and PCR-based strategies. To assess how these methods performed when used in conjunction with the ABI SOLID3+, we investigated three enrichment techniques: Nimblegen oligonucleotide hybridization array-based capture; Agilent SureSelect oligonucleotide hybridization solution-based capture; and Raindance Technologies' multiplexed PCR-based approach. Target regions were selected from exons and evolutionarily conserved areas throughout the human genome. Probe and primer pair design was carried out for all three methods using their respective informatics pipelines. In all, approximately 0.8 Mb of target space was identical for all 3 methods. SOLiD sequencing results were analyzed for several metrics, including consistency of coverage depth across samples, on-target versus off-target efficiency, allelic bias, and genotype concordance with array-based genotyping data. Agilent SureSelect exhibited superior on-target efficiency and correlation of read depths across samples. Nimblegen performance was similar at read depths at 20× and below. Both Raindance and Nimblegen SeqCap exhibited tighter distributions of read depth around the mean, but both suffered from lower on-target efficiency in our experiments. Raindance demonstrated the highest versatility in assay design.", "link"=>"http://www.mendeley.com/research/comparison-three-targeted-enrichment-strategies-solid-sequencing-platform", "reader_count"=>169, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>6, "Librarian"=>1, "Researcher"=>68, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>41, "Student > Postgraduate"=>5, "Other"=>8, "Student > Master"=>10, "Student > Bachelor"=>10, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>12}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>6, "Librarian"=>1, "Researcher"=>68, "Student > Doctoral Student"=>4, "Student > Ph. D. 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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/4434004"], "description"=>"<p>Depicts kernel density function for the three enrichment platforms\n studied. The set of coverage depth values at each target position were\n pooled across all individuals from the matched sample set and the\n frequency of values at each depth were used to calculate the density\n function.</p>", "links"=>[], "tags"=>["Targeted Enrichment Strategies", "genome sequencing", "SOLiD Sequencing Platform", "Agilent", "Raindance", "hybridization", "sample sets", "NGS", "approach", "method", "efficiency", "oligonucleotide", "SOLiD sequencing results", "throughput", "SureSelect", "primer pair design", "Nimblegen", "SOLID", "region", "MIPS", "ABI", "inversion probe ligation sequencing", "depth", "enrichment"], "article_id"=>448451, "categories"=>["Biochemistry", "Microbiology", "Genetics", "Molecular Biology", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy"], "users"=>["Dale J. Hedges", "Toumy Guettouche", "Shan Yang", "Guney Bademci", "Ashley Diaz", "Ashley Andersen", "William F. Hulme", "Sara Linker", "Arpit Mehta", "Yvonne J. K. Edwards", "Gary W. Beecham", "Eden R. Martin", "Margaret A. Pericak-Vance", "Stephan Zuchner", "Jeffery M. Vance", "John R. Gilbert"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018595.g003"], "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kernel_density_of_coverage_depth_/448451", "title"=>"Kernel density of coverage depth.", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-29 14:31:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/4433953"], "description"=>"<p>Percent of on-target bases (y-axis) covered at a given sequence depth\n (x-axis). On target percentage calculated as the fraction of nucleotide\n bases falling on targeted regions divided by the total number of\n nucleotides mapping anywhere in the genome. Thick lines represent\n average coverage for each platform (Agilent\n Surelect = blue circles; Nimblegen\n SeqCap = green triangles; Raindance parallel\n PCR = red diamonds). Dashed lines represent two\n standard deviations above and below the average for each platform.</p>", "links"=>[], "tags"=>["Targeted Enrichment Strategies", "genome sequencing", "SOLiD Sequencing Platform", "Agilent", "Raindance", "hybridization", "sample sets", "NGS", "approach", "method", "efficiency", "oligonucleotide", "SOLiD sequencing results", "throughput", "SureSelect", "primer pair design", "Nimblegen", "SOLID", "region", "MIPS", "ABI", "inversion probe ligation sequencing", "depth", "enrichment"], "article_id"=>448164, "categories"=>["Biochemistry", "Microbiology", "Genetics", "Molecular Biology", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy"], "users"=>["Dale J. Hedges", "Toumy Guettouche", "Shan Yang", "Guney Bademci", "Ashley Diaz", "Ashley Andersen", "William F. Hulme", "Sara Linker", "Arpit Mehta", "Yvonne J. K. Edwards", "Gary W. Beecham", "Eden R. Martin", "Margaret A. Pericak-Vance", "Stephan Zuchner", "Jeffery M. Vance", "John R. Gilbert"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018595.g001"], "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Depth_of_sequencing_coverage_of_matched_sample_set____N_8202_8202_6_unique_samples_/448164", "title"=>"Depth of sequencing coverage of matched sample set\n (N = 6 unique samples).", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-29 14:31:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/4434100"], "description"=>"<p>Genotype concordance.</p>", "links"=>[], "tags"=>["Targeted Enrichment Strategies", "genome sequencing", "SOLiD Sequencing Platform", "Agilent", "Raindance", "hybridization", "sample sets", "NGS", "approach", "method", "efficiency", "oligonucleotide", "SOLiD sequencing results", "throughput", "SureSelect", "primer pair design", "Nimblegen", "SOLID", "region", "MIPS", "ABI", "inversion probe ligation sequencing", "depth", "enrichment"], "article_id"=>448806, "categories"=>["Biochemistry", "Microbiology", "Genetics", "Molecular Biology", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy"], "users"=>["Dale J. Hedges", "Toumy Guettouche", "Shan Yang", "Guney Bademci", "Ashley Diaz", "Ashley Andersen", "William F. Hulme", "Sara Linker", "Arpit Mehta", "Yvonne J. K. Edwards", "Gary W. Beecham", "Eden R. Martin", "Margaret A. Pericak-Vance", "Stephan Zuchner", "Jeffery M. Vance", "John R. Gilbert"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018595.t005"], "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genotype_concordance_/448806", "title"=>"Genotype concordance.", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-29 14:31:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/4434013"], "description"=>"<p>Pearson correlation matrix depicting sample to sample comparisons for\n each independent platform. Only matched samples (i.e. individual samples\n that were separately enriched on across all three platforms) were used\n for this analysis. Cells with higher correlation values appear in darker\n shades.</p>", "links"=>[], "tags"=>["Targeted Enrichment Strategies", "genome sequencing", "SOLiD Sequencing Platform", "Agilent", "Raindance", "hybridization", "sample sets", "NGS", "approach", "method", "efficiency", "oligonucleotide", "SOLiD sequencing results", "throughput", "SureSelect", "primer pair design", "Nimblegen", "SOLID", "region", "MIPS", "ABI", "inversion probe ligation sequencing", "depth", "enrichment"], "article_id"=>448617, "categories"=>["Biochemistry", "Microbiology", "Genetics", "Molecular Biology", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy"], "users"=>["Dale J. Hedges", "Toumy Guettouche", "Shan Yang", "Guney Bademci", "Ashley Diaz", "Ashley Andersen", "William F. Hulme", "Sara Linker", "Arpit Mehta", "Yvonne J. K. Edwards", "Gary W. Beecham", "Eden R. Martin", "Margaret A. Pericak-Vance", "Stephan Zuchner", "Jeffery M. Vance", "John R. Gilbert"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018595.g004"], "stats"=>{"downloads"=>4, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pearson_correlation_matrix_for_coverage_depth_/448617", "title"=>"Pearson correlation matrix for coverage depth.", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-29 14:31:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/4434070"], "description"=>"<p>Percent on-target, matched sample sets\n (N = 6).</p>", "links"=>[], "tags"=>["Targeted Enrichment Strategies", "genome sequencing", "SOLiD Sequencing Platform", "Agilent", "Raindance", "hybridization", "sample sets", "NGS", "approach", "method", "efficiency", "oligonucleotide", "SOLiD sequencing results", "throughput", "SureSelect", "primer pair design", "Nimblegen", "SOLID", "region", "MIPS", "ABI", "inversion probe ligation sequencing", "depth", "enrichment"], "article_id"=>448906, "categories"=>["Biochemistry", "Microbiology", "Genetics", "Molecular Biology", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy"], "users"=>["Dale J. Hedges", "Toumy Guettouche", "Shan Yang", "Guney Bademci", "Ashley Diaz", "Ashley Andersen", "William F. Hulme", "Sara Linker", "Arpit Mehta", "Yvonne J. K. Edwards", "Gary W. Beecham", "Eden R. Martin", "Margaret A. Pericak-Vance", "Stephan Zuchner", "Jeffery M. Vance", "John R. Gilbert"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018595.t003"], "stats"=>{"downloads"=>4, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percent_on_target_matched_sample_sets____N_8202_8202_6_/448906", "title"=>"Percent on-target, matched sample sets\n (N = 6).", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-29 14:31:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/4433893", "https://ndownloader.figshare.com/files/4433899", "https://ndownloader.figshare.com/files/4433905", "https://ndownloader.figshare.com/files/4433911", "https://ndownloader.figshare.com/files/4433929", "https://ndownloader.figshare.com/files/4433932", "https://ndownloader.figshare.com/files/4433938"], "description"=>"<div><p>Despite the ever-increasing throughput and steadily decreasing cost of next\n generation sequencing (NGS), whole genome sequencing of humans is still not a\n viable option for the majority of genetics laboratories. This is particularly\n true in the case of complex disease studies, where large sample sets are often\n required to achieve adequate statistical power. To fully leverage the potential\n of NGS technology on large sample sets, several methods have been developed to\n selectively enrich for regions of interest. Enrichment reduces both monetary and\n computational costs compared to whole genome sequencing, while allowing\n researchers to take advantage of NGS throughput. Several targeted enrichment\n approaches are currently available, including molecular inversion probe ligation\n sequencing (MIPS), oligonucleotide hybridization based approaches, and PCR-based\n strategies. To assess how these methods performed when used in conjunction with\n the ABI SOLID3+, we investigated three enrichment techniques: Nimblegen\n oligonucleotide hybridization array-based capture; Agilent SureSelect\n oligonucleotide hybridization solution-based capture; and Raindance\n Technologies' multiplexed PCR-based approach. Target regions were selected\n from exons and evolutionarily conserved areas throughout the human genome. Probe\n and primer pair design was carried out for all three methods using their\n respective informatics pipelines. In all, approximately 0.8 Mb of target space\n was identical for all 3 methods. SOLiD sequencing results were analyzed for\n several metrics, including consistency of coverage depth across samples,\n on-target versus off-target efficiency, allelic bias, and genotype concordance\n with array-based genotyping data. Agilent SureSelect exhibited superior\n on-target efficiency and correlation of read depths across samples. Nimblegen\n performance was similar at read depths at 20× and below. Both Raindance\n and Nimblegen SeqCap exhibited tighter distributions of read depth around the\n mean, but both suffered from lower on-target efficiency in our experiments.\n Raindance demonstrated the highest versatility in assay design.</p></div>", "links"=>[], "tags"=>["Targeted Enrichment Strategies", "genome sequencing", "SOLiD Sequencing Platform", "Agilent", "Raindance", "hybridization", "sample sets", "NGS", "approach", "method", "efficiency", "oligonucleotide", "SOLiD sequencing results", "throughput", "SureSelect", "primer pair design", "Nimblegen", "SOLID", "region", "MIPS", "ABI", "inversion probe ligation sequencing", "depth", "enrichment"], "article_id"=>1083629, "categories"=>["Biochemistry", "Microbiology", "Genetics", "Molecular Biology", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy"], "users"=>["Dale J. Hedges", "Toumy Guettouche", "Shan Yang", "Guney Bademci", "Ashley Diaz", "Ashley Andersen", "William F. Hulme", "Sara Linker", "Arpit Mehta", "Yvonne J. K. Edwards", "Gary W. Beecham", "Eden R. Martin", "Margaret A. Pericak-Vance", "Stephan Zuchner", "Jeffery M. Vance", "John R. Gilbert"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018595.s001", "https://dx.doi.org/10.1371/journal.pone.0018595.s002", "https://dx.doi.org/10.1371/journal.pone.0018595.s003", "https://dx.doi.org/10.1371/journal.pone.0018595.s004", "https://dx.doi.org/10.1371/journal.pone.0018595.s005", "https://dx.doi.org/10.1371/journal.pone.0018595.s006", "https://dx.doi.org/10.1371/journal.pone.0018595.s007"], "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_Three_Targeted_Enrichment_Strategies_on_the_SOLiD___Sequencing_Platform_/1083629", "title"=>"Comparison of Three Targeted Enrichment Strategies on the SOLiD\n Sequencing Platform", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-29 14:31:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/4434040"], "description"=>"<p>Oligonucleotide sequences used, in conjunction with the Universal\n Probe Library # 149 (Roche), for qPCR of the SOLiD sequencing\n library.</p>", "links"=>[], "tags"=>["Targeted Enrichment Strategies", "genome sequencing", "SOLiD Sequencing Platform", "Agilent", "Raindance", "hybridization", "sample sets", "NGS", "approach", "method", "efficiency", "oligonucleotide", "SOLiD sequencing results", "throughput", "SureSelect", "primer pair design", "Nimblegen", "SOLID", "region", "MIPS", "ABI", "inversion probe ligation sequencing", "depth", "enrichment"], "article_id"=>448851, "categories"=>["Biochemistry", "Microbiology", "Genetics", "Molecular Biology", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy"], "users"=>["Dale J. Hedges", "Toumy Guettouche", "Shan Yang", "Guney Bademci", "Ashley Diaz", "Ashley Andersen", "William F. Hulme", "Sara Linker", "Arpit Mehta", "Yvonne J. K. Edwards", "Gary W. Beecham", "Eden R. Martin", "Margaret A. Pericak-Vance", "Stephan Zuchner", "Jeffery M. Vance", "John R. Gilbert"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018595.t002"], "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Oligonucleotide_sequences_used_in_conjunction_with_the_Universal____Probe_Library_149_Roche_for_qPCR_of_the_SOLiD_sequencing____library_/448851", "title"=>"Oligonucleotide sequences used, in conjunction with the Universal\n Probe Library # 149 (Roche), for qPCR of the SOLiD sequencing\n library.", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-29 14:31:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/4433986"], "description"=>"<p>Percent of on-target bases (y-axis) covered at a given sequence depth\n (x-axis). On target percentage calculated as the fraction of nucleotide\n bases falling on targeted regions divided by the total number of\n nucleotides mapping anywhere in the genome. Thick lines represent\n average coverage for each platform (Agilent\n Surelect = blue circles; Nimblegen\n SeqCap = green triangles; Raindance parallel\n PCR = red diamonds). Dashed lines represent two\n standard deviations above and below the average for each platform.</p>", "links"=>[], "tags"=>["Targeted Enrichment Strategies", "genome sequencing", "SOLiD Sequencing Platform", "Agilent", "Raindance", "hybridization", "sample sets", "NGS", "approach", "method", "efficiency", "oligonucleotide", "SOLiD sequencing results", "throughput", "SureSelect", "primer pair design", "Nimblegen", "SOLID", "region", "MIPS", "ABI", "inversion probe ligation sequencing", "depth", "enrichment"], "article_id"=>448280, "categories"=>["Biochemistry", "Microbiology", "Genetics", "Molecular Biology", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy"], "users"=>["Dale J. Hedges", "Toumy Guettouche", "Shan Yang", "Guney Bademci", "Ashley Diaz", "Ashley Andersen", "William F. Hulme", "Sara Linker", "Arpit Mehta", "Yvonne J. K. Edwards", "Gary W. Beecham", "Eden R. Martin", "Margaret A. Pericak-Vance", "Stephan Zuchner", "Jeffery M. Vance", "John R. Gilbert"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018595.g002"], "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Depth_of_sequencing_coverage_of_matched_sample_set____N_8202_8202_6_samples_per_method_/448280", "title"=>"Depth of sequencing coverage of matched sample set\n (N = 6 samples (per method)).", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-29 14:31:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/4434091"], "description"=>"<p>Percent on-target, unmatched sample sets\n (N = 6).</p>", "links"=>[], "tags"=>["Targeted Enrichment Strategies", "genome sequencing", "SOLiD Sequencing Platform", "Agilent", "Raindance", "hybridization", "sample sets", "NGS", "approach", "method", "efficiency", "oligonucleotide", "SOLiD sequencing results", "throughput", "SureSelect", "primer pair design", "Nimblegen", "SOLID", "region", "MIPS", "ABI", "inversion probe ligation sequencing", "depth", "enrichment"], "article_id"=>448761, "categories"=>["Biochemistry", "Microbiology", "Genetics", "Molecular Biology", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy"], "users"=>["Dale J. Hedges", "Toumy Guettouche", "Shan Yang", "Guney Bademci", "Ashley Diaz", "Ashley Andersen", "William F. Hulme", "Sara Linker", "Arpit Mehta", "Yvonne J. K. Edwards", "Gary W. Beecham", "Eden R. Martin", "Margaret A. Pericak-Vance", "Stephan Zuchner", "Jeffery M. Vance", "John R. Gilbert"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018595.t004"], "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percent_on_target_unmatched_sample_sets____N_8202_8202_6_/448761", "title"=>"Percent on-target, unmatched sample sets\n (N = 6).", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-29 14:31:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/4434025"], "description"=>"<p>Enrichment methods performed for each sample.</p>", "links"=>[], "tags"=>["Targeted Enrichment Strategies", "genome sequencing", "SOLiD Sequencing Platform", "Agilent", "Raindance", "hybridization", "sample sets", "NGS", "approach", "method", "efficiency", "oligonucleotide", "SOLiD sequencing results", "throughput", "SureSelect", "primer pair design", "Nimblegen", "SOLID", "region", "MIPS", "ABI", "inversion probe ligation sequencing", "depth", "enrichment"], "article_id"=>448958, "categories"=>["Biochemistry", "Microbiology", "Genetics", "Molecular Biology", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy"], "users"=>["Dale J. Hedges", "Toumy Guettouche", "Shan Yang", "Guney Bademci", "Ashley Diaz", "Ashley Andersen", "William F. Hulme", "Sara Linker", "Arpit Mehta", "Yvonne J. K. Edwards", "Gary W. Beecham", "Eden R. Martin", "Margaret A. Pericak-Vance", "Stephan Zuchner", "Jeffery M. Vance", "John R. Gilbert"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018595.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Enrichment_methods_performed_for_each_sample_/448958", "title"=>"Enrichment methods performed for each sample.", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-29 14:31:39"}

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  • {"unique-ip"=>"15", "full-text"=>"22", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
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  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"17", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
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  • {"unique-ip"=>"10", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
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  • {"unique-ip"=>"10", "full-text"=>"22", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"24", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"53", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"19", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}

Relative Metric

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