Tensor Decomposition Reveals Concurrent Evolutionary Convergences and Divergences and Correlations with Structural Motifs in Ribosomal RNA
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Tensor decomposition reveals concurrent evolutionary convergences and divergences and correlations with structural motifs in ribosomal RNA", "type"=>"journal", "authors"=>[{"first_name"=>"Chaitanya", "last_name"=>"Muralidhara", "scopus_author_id"=>"38663225600"}, {"first_name"=>"Andrew M.", "last_name"=>"Gross", "scopus_author_id"=>"38662418700"}, {"first_name"=>"Robin R.", "last_name"=>"Gutell", "scopus_author_id"=>"7006693029"}, {"first_name"=>"Orly", "last_name"=>"Alter", "scopus_author_id"=>"6602496494"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"21625625", "doi"=>"10.1371/journal.pone.0018768", "pui"=>"361724260", "issn"=>"19326203", "sgr"=>"79955747168", "scopus"=>"2-s2.0-79955747168"}, "id"=>"a3de7b34-c39f-358a-9c26-93d7ab8a32d7", "abstract"=>"Evolutionary relationships among organisms are commonly described by using a hierarchy derived from comparisons of ribosomal RNA (rRNA) sequences. We propose that even on the level of a single rRNA molecule, an organism's evolution is composed of multiple pathways due to concurrent forces that act independently upon different rRNA degrees of freedom. Relationships among organisms are then compositions of coexisting pathway-dependent similarities and dissimilarities, which cannot be described by a single hierarchy. We computationally test this hypothesis in comparative analyses of 16S and 23S rRNA sequence alignments by using a tensor decomposition, i.e., a framework for modeling composite data. Each alignment is encoded in a cuboid, i.e., a third-order tensor, where nucleotides, positions and organisms, each represent a degree of freedom. A tensor mode-1 higher-order singular value decomposition (HOSVD) is formulated such that it separates each cuboid into combinations of patterns of nucleotide frequency variation across organisms and positions, i.e., \"eigenpositions\" and corresponding nucleotide-specific segments of \"eigenorganisms,\" respectively, independent of a-priori knowledge of the taxonomic groups or rRNA structures. We find, in support of our hypothesis that, first, the significant eigenpositions reveal multiple similarities and dissimilarities among the taxonomic groups. Second, the corresponding eigenorganisms identify insertions or deletions of nucleotides exclusively conserved within the corresponding groups, that map out entire substructures and are enriched in adenosines, unpaired in the rRNA secondary structure, that participate in tertiary structure interactions. This demonstrates that structural motifs involved in rRNA folding and function are evolutionary degrees of freedom. Third, two previously unknown coexisting subgenic relationships between Microsporidia and Archaea are revealed in both the 16S and 23S rRNA alignments, a convergence and a divergence, conferred by insertions and deletions of these motifs, which cannot be described by a single hierarchy. This shows that mode-1 HOSVD modeling of rRNA alignments might be used to computationally predict evolutionary mechanisms.", "link"=>"http://www.mendeley.com/research/tensor-decomposition-reveals-concurrent-evolutionary-convergences-divergences-correlations-structura", "reader_count"=>15, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>1, "Student > Bachelor"=>1, "Lecturer"=>2, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>1, "Student > Bachelor"=>1, "Lecturer"=>2, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Mathematics"=>2, "Agricultural and Biological Sciences"=>9, "Chemistry"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Computer Science"=>{"Computer Science"=>1}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Belgium"=>1, "United States"=>1, "France"=>1}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79955747168"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79955747168?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79955747168&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=79955747168&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/79955747168", "dc:identifier"=>"SCOPUS_ID:79955747168", "eid"=>"2-s2.0-79955747168", "dc:title"=>"Tensor decomposition reveals concurrent evolutionary convergences and divergences and correlations with structural motifs in ribosomal RNA", "dc:creator"=>"Muralidhara C.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"6", "prism:issueIdentifier"=>"4", "prism:pageRange"=>nil, "prism:coverDate"=>"2011-05-12", "prism:coverDisplayDate"=>"2011", "prism:doi"=>"10.1371/journal.pone.0018768", "citedby-count"=>"7", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"The University of Texas at Austin", "affiliation-city"=>"Austin", "affiliation-country"=>"United States"}], "pubmed-id"=>"21625625", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e18768", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0018768", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"98"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"46", "xml_views"=>"7", "html_views"=>"311"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"88"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"42"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"67"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"4", "html_views"=>"47"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"87"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"162"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"174"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"187"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"5", "html_views"=>"109"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"66"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"6", "html_views"=>"44"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"24", "xml_views"=>"47", "html_views"=>"19"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"68"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"32"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"66"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"40"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"3"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"0"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"0"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"7"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"11", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"1"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/778050"], "description"=>"<p>Organisms, positions and sequence elements, each represent a degree of freedom in\n the alignment encoded in a cuboid (Equation 1). Mode-1 HOSVD (Equation 2)\n separates the alignment into combinations of “eigenpositions” and\n nulceotide-specific segments of “eigenorganisms,” i.e., patterns of\n nucleotide frequency variation across the organisms and positions, with increase\n (red), no change (black) and decrease in the nucleotide frequency (green) relative\n to the average frequency across the organisms and positions. It was shown that SVD\n provides a framework for modeling DNA microarray data <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768-Alter2\" target=\"_blank\">[32]</a>: The mathematical variables,\n significant patterns uncovered in the data, correlate with activities of cellular\n elements, such as regulators or transcription factors. The mathematical operations\n simulate experimental observation of the correlations and possibly causal\n coordination of these activities. Recent experimental results <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768-Omberg2\" target=\"_blank\">[16]</a> demonstrate\n that SVD modeling of DNA microarray data can be used to correctly predict\n previously unknown cellular mechanisms <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768-Omberg1\" target=\"_blank\">[15]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768-Alter3\" target=\"_blank\">[36]</a>. We now show that mode-1 HOSVD,\n which is computed by using SVD (Equation 3), provides a framework for modeling\n rRNA sequence alignments: The mathematical variables, significant patterns of\n nucleotide frequency variation, represent multiple subgenic evolutionary\n relationships of convergence and divergence among the organisms, some known and\n some previously unknown, and correlations with structural motifs. Our mode-1 HOSVD\n analyses of 16S and 23 rRNA alignments support the hypothesis that even on the\n level of a single rRNA molecule, an organism's evolution is composed of\n multiple pathways due to concurrent forces that act independently upon different\n rRNA degrees of freedom. These analyses demonstrate that entire rRNA substructures\n and unpaired adenosines, i.e., rRNA structural motifs which are involved in rRNA\n folding and function, are evolutionary degrees of freedom. These analyses also\n show that mode-1 HOSVD modeling of rRNA alignments might be used to\n computationally predict evolutionary mechanisms, i.e., evolutionary pathways and\n the underlying structural changes that these pathways are correlated, possibly\n even coordinated with.</p>", "links"=>[], "tags"=>["hosvd", "16s", "rrna"], "article_id"=>448418, "categories"=>["Mathematics", "Molecular Biology", "Microbiology", "Evolutionary Biology"], "users"=>["Chaitanya Muralidhara", "Andrew M. Gross", "Robin R. Gutell", "Orly Alter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0018768.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mode_1_HOSVD_of_the_16S_rRNA_sequence_alignment_/448418", "title"=>"Mode-1 HOSVD of the 16S rRNA sequence alignment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-29 02:20:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/778630"], "description"=>"<p>Probabilistic significance of the enrichment of the\n <i>m</i> = 100 positions with largest frequency\n increase or decrease in each of the nulceotide-specific segments of the\n significant eigenorganisms (except for the gap segment of the second\n eigenorganism, where the largest nucleotide frequency increase is shared by\n  = 124 positions) in sequence and\n structure motifs exclusively conserved in the corresponding taxonomic groups.\n The <i>P</i>-value of each enrichment is calculated assuming, for\n each nucleotide, hypergeometric probability distribution of the\n <i>N</i> conserved motifs among the\n <i>M</i> = 3249 positions, and of the subset of\n motifs among the subset of <i>m</i> positions.\n Exclusive sequence gap conservation is defined as conservation of gaps within\n at least 80% of the organisms of the corresponding taxonomic group but\n in less than 20% of the remaining organisms. Exclusive unpaired A\n nucleotide conservation is defined as conservation of an adenosine within at\n least 80% of the organisms of the group but in less than 20% of\n the remaining organisms, together with greater frequency of unpaired\n nucleotides within the group rather than among the remaining organisms. Helix\n conservation is defined as conservation of base-paired nucleotides within at\n least 60% of the organisms of the group.</p>", "links"=>[], "tags"=>["16s", "eigenorganisms", "motifs", "conserved", "taxonomic"], "article_id"=>448996, "categories"=>["Mathematics", "Molecular Biology", "Microbiology", "Evolutionary Biology"], "users"=>["Chaitanya Muralidhara", "Andrew M. Gross", "Robin R. Gutell", "Orly Alter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0018768.t003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Enrichment_of_the_significant_16S_eigenorganisms_sequence_and_structure_motifs___exclusively_conserved_in_taxonomic_groups_/448996", "title"=>"Enrichment of the significant 16S eigenorganisms sequence and structure motifs\n exclusively conserved in taxonomic groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-04-29 02:29:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/778399"], "description"=>"<p>The 100 positions identified in the A nucleotide segment of the second 16S\n eigenorganism with the largest decrease in relative nucleotide frequency include\n all 50 positions (red) in the alignment with unpaired A nucleotides exclusively\n conserved in the Bacteria. Of these 50 positions, 28 (yellow) map to known\n tertiary interactions in the crystal structure of the bacterium <i>T.\n thermophilus</i><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768-Schluenzen1\" target=\"_blank\">[8]</a>, plotted\n on the secondary structure model of the bacterium <i>E. coli</i><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768-Cannone1\" target=\"_blank\">[14]</a>. These\n include 22 base-base interactions (blue) and eight base-backbone interactions\n (green). Of the 50 positions of unpaired A nucleotides exclusively conserved in\n the Bacteria, 13 correspond to gaps exclusively conserved in the Eukarya excluding\n the Microsporidia. These 13 positions map to the entire 16S rRNA substructures\n that are deleted in the Eukarya with respect to the Bacteria (gray), identified by\n the gap segment of the second eigenorganism (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone-0018768-g003\" target=\"_blank\">Figure 3</a>). These 100 positions identified in the\n A nucleotide segment of the second 16S eigenorganism are displayed in the inset\n raster, ordered by their significance, with the most significant position at the\n top. The nucleotides are color-coded A (red), C (green), G (blue), U (yellow),\n unknown (gray) and gap (black). The color bars highlight the taxonomic groups that\n are differentiated by the second eigenposition and eigenorganism, i.e., the\n Eukarya excluding the Microsporidia and the Bacteria.</p>", "links"=>[], "tags"=>["adenosines", "16s"], "article_id"=>448773, "categories"=>["Mathematics", "Molecular Biology", "Microbiology", "Evolutionary Biology"], "users"=>["Chaitanya Muralidhara", "Andrew M. Gross", "Robin R. Gutell", "Orly Alter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0018768.g004", "stats"=>{"downloads"=>4, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Unpaired_adenosines_exclusive_to_Bacteria_16S_rRNAs_/448773", "title"=>"Unpaired adenosines exclusive to Bacteria 16S rRNAs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-29 02:26:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/778663"], "description"=>"<p>Probabilistic significance of the enrichment of the\n <i>m</i> = 200 positions with largest frequency\n increase or decrease in each of the nulceotide-specific segments of the\n significant eigenorganisms (except for the gap segments of the second, third\n and fifth eigenorganisms, where the largest nucleotide frequency decrease is\n shared by  = 91, 100 and 199 positions,\n respectively) in sequence and structure motifs exclusively conserved in the\n corresponding taxonomic groups. The <i>P</i>-value of each enrichment\n is calculated assuming, for each nucleotide, hypergeometric probability\n distribution of the <i>N</i> conserved motifs among the\n <i>M</i> = 6636 positions, and of the subset\n of motifs among the subset of <i>m</i> positions.\n Exclusive sequence gap conservation is defined as conservation of gaps within\n at least 80% of the organisms of the corresponding taxonomic group but\n in less than 20% of the remaining organisms. Exclusive unpaired A\n nucleotide conservation is defined as conservation of an adenosine within at\n least 80% of the organisms of the group but in less than 20% of\n the remaining organisms, together with greater frequency of unpaired\n nucleotides within the group rather than among the remaining organisms.</p>", "links"=>[], "tags"=>["23s", "eigenorganisms", "structure", "motifs", "conserved", "taxonomic"], "article_id"=>449029, "categories"=>["Mathematics", "Molecular Biology", "Microbiology", "Evolutionary Biology"], "users"=>["Chaitanya Muralidhara", "Andrew M. Gross", "Robin R. Gutell", "Orly Alter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0018768.t004", "stats"=>{"downloads"=>3, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Enrichment_of_the_significant_23S_eigenorganisms_in_sequence_and_structure___motifs_exclusively_conserved_in_taxonomic_groups_/449029", "title"=>"Enrichment of the significant 23S eigenorganisms in sequence and structure\n motifs exclusively conserved in taxonomic groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-04-29 02:30:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/391708", "https://ndownloader.figshare.com/files/391858", "https://ndownloader.figshare.com/files/391940", "https://ndownloader.figshare.com/files/392068", "https://ndownloader.figshare.com/files/392092", "https://ndownloader.figshare.com/files/392237", "https://ndownloader.figshare.com/files/392256", "https://ndownloader.figshare.com/files/392289", "https://ndownloader.figshare.com/files/392323", "https://ndownloader.figshare.com/files/392340", "https://ndownloader.figshare.com/files/392364", "https://ndownloader.figshare.com/files/392384"], "description"=>"<div><p>Evolutionary relationships among organisms are commonly described by using a hierarchy derived from comparisons of ribosomal RNA (rRNA) sequences. We propose that even on the level of a single rRNA molecule, an organism's evolution is composed of multiple pathways due to concurrent forces that act independently upon different rRNA degrees of freedom. Relationships among organisms are then compositions of coexisting pathway-dependent similarities and dissimilarities, which cannot be described by a single hierarchy. We computationally test this hypothesis in comparative analyses of 16S and 23S rRNA sequence alignments by using a tensor decomposition, i.e., a framework for modeling composite data. Each alignment is encoded in a cuboid, i.e., a third-order tensor, where nucleotides, positions and organisms, each represent a degree of freedom. A tensor mode-1 higher-order singular value decomposition (HOSVD) is formulated such that it separates each cuboid into combinations of patterns of nucleotide frequency variation across organisms and positions, i.e., “eigenpositions” and corresponding nucleotide-specific segments of “eigenorganisms,” respectively, independent of a-priori knowledge of the taxonomic groups or rRNA structures. We find, in support of our hypothesis that, first, the significant eigenpositions reveal multiple similarities and dissimilarities among the taxonomic groups. Second, the corresponding eigenorganisms identify insertions or deletions of nucleotides exclusively conserved within the corresponding groups, that map out entire substructures and are enriched in adenosines, unpaired in the rRNA secondary structure, that participate in tertiary structure interactions. This demonstrates that structural motifs involved in rRNA folding and function are evolutionary degrees of freedom. Third, two previously unknown coexisting subgenic relationships between Microsporidia and Archaea are revealed in both the 16S and 23S rRNA alignments, a convergence and a divergence, conferred by insertions and deletions of these motifs, which cannot be described by a single hierarchy. This shows that mode-1 HOSVD modeling of rRNA alignments might be used to computationally predict evolutionary mechanisms.</p> </div>", "links"=>[], "tags"=>["tensor", "decomposition", "reveals", "concurrent", "evolutionary", "convergences", "and", "divergences", "correlations", "motifs", "ribosomal", "rna"], "article_id"=>137357, "categories"=>["Mathematics", "Molecular Biology", "Microbiology", "Evolutionary Biology"], "users"=>["Chaitanya Muralidhara", "Andrew M. Gross", "Robin R. Gutell", "Orly Alter"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0018768.s001", "https://dx.doi.org/10.1371/journal.pone.0018768.s002", "https://dx.doi.org/10.1371/journal.pone.0018768.s003", "https://dx.doi.org/10.1371/journal.pone.0018768.s004", "https://dx.doi.org/10.1371/journal.pone.0018768.s005", "https://dx.doi.org/10.1371/journal.pone.0018768.s006", "https://dx.doi.org/10.1371/journal.pone.0018768.s007", "https://dx.doi.org/10.1371/journal.pone.0018768.s008", "https://dx.doi.org/10.1371/journal.pone.0018768.s009", "https://dx.doi.org/10.1371/journal.pone.0018768.s010", "https://dx.doi.org/10.1371/journal.pone.0018768.s011", "https://dx.doi.org/10.1371/journal.pone.0018768.s012"], "stats"=>{"downloads"=>23, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Tensor_Decomposition_Reveals_Concurrent_Evolutionary_Convergences_and__Divergences_and_Correlations_with_Structural_Motifs_in_Ribosomal_RNA/137357", "title"=>"Tensor Decomposition Reveals Concurrent Evolutionary Convergences and\n Divergences and Correlations with Structural Motifs in Ribosomal RNA", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-04-29 02:02:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/778162"], "description"=>"<p>Line-joined graphs of the second through seventh 16S eigenpositions, i.e.,\n patterns of nucleotide frequency across the organisms, and their correlation with\n the taxonomic groups in the 16S alignment, classified according to the top six\n hierarchical levels of the NCBI Taxonomy Browser <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768-Sayers1\" target=\"_blank\">[19]</a> (Figure S1 in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768.s001\" target=\"_blank\">Appendix S1</a>).\n (<i>a</i>) The second most significant eigenposition (red)\n differentiates the Eukarya excluding the Microsporidia from the Bacteria, as\n indicated by the color bar (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone-0018768-t001\" target=\"_blank\">Table\n 1</a>). The fourth (blue) distinguishes between the Gamma Proteobacteria and\n the Actinobacteria and Archaea. (<i>b</i>) The third (red) and fifth\n (blue) eigenpositions describe similarities and dissimilarities among the Archaea\n and Microsporidia, respectively. (<i>c</i>) The sixth (red) and seventh\n (blue) eigenpositions differentiate the Fungi/Metazoa excluding the Microsporidia\n from the Rhodophyta and the Alveolata, respectively.</p>", "links"=>[], "tags"=>["16s"], "article_id"=>448537, "categories"=>["Mathematics", "Molecular Biology", "Microbiology", "Evolutionary Biology"], "users"=>["Chaitanya Muralidhara", "Andrew M. Gross", "Robin R. Gutell", "Orly Alter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0018768.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Significant_16S_eigenpositions_/448537", "title"=>"Significant 16S eigenpositions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-29 02:22:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/778488"], "description"=>"<p>The 100 positions identified in the gap segment of the third 16S eigenorganism\n with the largest decrease in relative nucleotide frequency map out entire\n substructures in the Bacteria 16S rRNAs that are convergently lost in the Archaea\n and the Microsporidia. (<i>a</i>) The 100 gaps conserved in both the\n Archaea and Microsporidia map to the entire substructures I–III in the\n secondary structure model of the bacterium <i>E. coli</i><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768-Cannone1\" target=\"_blank\">[14]</a>.\n (<i>b</i>) Raster display of the 100 positions of conserved gaps in\n both the Archaea and Microsporidia across the alignment. (<i>c</i>)\n Raster display of the same 100 positions across an alignment of 858 mitochondrial\n 16S rRNA sequences show gaps conserved in most Metazoa. The other groups of\n Eukarya represented in the mitochondrial alignment are Alveolata (1), Euglenozoa\n (2), Fungi (3) and Rhodophyta and Viridiplantae (4). The nucleotides are\n color-coded A (red), C (green), G (blue), U (yellow), unknown (gray) and gap\n (black). The color bars highlight the taxonomic groups.</p>", "links"=>[], "tags"=>["gaps", "archaea", "microsporidia", "16s"], "article_id"=>448856, "categories"=>["Mathematics", "Molecular Biology", "Microbiology", "Evolutionary Biology"], "users"=>["Chaitanya Muralidhara", "Andrew M. Gross", "Robin R. Gutell", "Orly Alter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0018768.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sequence_gaps_exclusive_to_both_Archaea_and_Microsporidia_16S_rRNAs_/448856", "title"=>"Sequence gaps exclusive to both Archaea and Microsporidia 16S rRNAs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-29 02:27:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/778294"], "description"=>"<p>The second most significant 16S eigenorganism identifies gaps exclusively\n conserved in either the Eukarya excluding the Microsporidia or the Bacteria (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone-0018768-t003\" target=\"_blank\">Table 3</a>) that map out known as\n well as previously unrecognized, entire substructures deleted or inserted,\n respectively, in the Eukarya relative to the Bacteria. (<i>a</i>) The\n 124 positions with largest increase in relative nucleotide frequency in the gap\n segment of the second eigenorganism, i.e., the 124 positions of gap variation\n across the organisms most correlated with the second eigenposition, map out the\n exclusively conserved known substructures <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768-Winker1\" target=\"_blank\">[31]</a> I and II and the previously\n unrecognized substructures III and IV in the secondary structure model of the\n bacterium <i>E. coli</i><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768-Cannone1\" target=\"_blank\">[14]</a>. These 124\n positions are also displayed in the inset raster, ordered by their significance,\n with the most significant position at the top. The nucleotides are color-coded A\n (red), C (green), G (blue), U (yellow), unknown (gray) and gap (black). The color\n bars highlight the taxonomic groups that are differentiated by the second 16S\n eigenposition and eigenorganism, i.e., the Eukarya excluding the Microsporidia and\n the Bacteria. (<i>b</i>) Of the 100 positions of gap variation across\n the organisms most anticorrelated with the second eigenposition, 99 map out the\n substructures V and VI in the secondary structure model of the eukaryote\n <i>S. cerevisiae</i>. The 100th position is an unknown nucleotide at\n the 3′-end of the molecule, which is not displayed. These 100 positions are\n also displayed in the inset raster.</p>", "links"=>[], "tags"=>["gaps", "eukarya", "16s"], "article_id"=>448665, "categories"=>["Mathematics", "Molecular Biology", "Microbiology", "Evolutionary Biology"], "users"=>["Chaitanya Muralidhara", "Andrew M. Gross", "Robin R. Gutell", "Orly Alter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0018768.g003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sequence_gaps_exclusive_to_Eukarya_or_Bacteria_16S_rRNAs_/448665", "title"=>"Sequence gaps exclusive to Eukarya or Bacteria 16S rRNAs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-04-29 02:24:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/778553"], "description"=>"<p>Probabilistic significance of the enrichment of the\n <i>k</i> = 75 organisms, with largest relative\n nucleotide frequency increase or decrease in each of the significant\n eigenpositions, in the respective taxonomic groups. The\n <i>P</i>-value of each enrichment is calculated as described <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768-Tavazoie1\" target=\"_blank\">[35]</a>, assuming\n hypergeometric probability distribution of the <i>J</i> annotations\n among the <i>K</i> = 339 organisms, and of the\n subset of annotations among the subset of\n <i>k</i> = 75 organisms.</p>", "links"=>[], "tags"=>["16s", "eigenpositions", "taxonomic"], "article_id"=>448922, "categories"=>["Mathematics", "Molecular Biology", "Microbiology", "Evolutionary Biology"], "users"=>["Chaitanya Muralidhara", "Andrew M. Gross", "Robin R. Gutell", "Orly Alter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0018768.t001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Enrichment_of_the_significant_16S_eigenpositions_in_taxonomic_groups_/448922", "title"=>"Enrichment of the significant 16S eigenpositions in taxonomic groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-04-29 02:28:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/778590"], "description"=>"<p>Probabilistic significance of the enrichment of the\n <i>k</i> = 15 organisms, with largest relative\n nucleotide frequency increase or decrease in each of the significant\n eigenpositions, in the respective taxonomic groups. The\n <i>P</i>-value of each enrichment is calculated as described <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018768#pone.0018768-Tavazoie1\" target=\"_blank\">[35]</a>, assuming\n hypergeometric probability distribution of the <i>J</i> annotations\n among the <i>K</i> = 75 organisms, and of the\n subset of annotations among the subset of\n <i>k</i> = 15 organisms.</p>", "links"=>[], "tags"=>["23s", "eigenpositions", "taxonomic"], "article_id"=>448965, "categories"=>["Mathematics", "Molecular Biology", "Microbiology", "Evolutionary Biology"], "users"=>["Chaitanya Muralidhara", "Andrew M. Gross", "Robin R. Gutell", "Orly Alter"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0018768.t002", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Enrichment_of_the_significant_23S_eigenpositions_in_taxonomic_groups_/448965", "title"=>"Enrichment of the significant 23S eigenpositions in taxonomic groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-04-29 02:29:25"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"1", "pdf"=>"1", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2011", "pdf"=>"3", "unique-ip"=>"8", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "unique-ip"=>"9", "pdf"=>"5", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2011", "pdf"=>"0", "unique-ip"=>"5", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "unique-ip"=>"3", "pdf"=>"1", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2011", "pdf"=>"0", "unique-ip"=>"8", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"5", "pdf"=>"0", "year"=>"2011", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2011", "pdf"=>"0", "unique-ip"=>"1", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "unique-ip"=>"3", "pdf"=>"4", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"6", "pdf"=>"1", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "year"=>"2012", "pdf"=>"6", "unique-ip"=>"10", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"11", "unique-ip"=>"14", "pdf"=>"7", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"10", "year"=>"2012", "pdf"=>"5", "unique-ip"=>"9", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"7", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"1", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"0", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"0", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"41", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"27", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"2", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[304, 568, 702, 818, 927, 1027, 1118, 1206, 1285, 1357, 1427, 1500, 1564, 1636, 1705, 1773, 1840, 1909, 1974, 2039, 2106, 2170, 2234, 2296, 2358, 2423, 2484, 2546, 2606, 2673, 2734, 2795, 2857, 2921, 2984, 3046, 3100]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[290, 559, 698, 813, 927, 1028, 1121, 1206, 1289, 1360, 1433, 1501, 1569, 1637, 1707, 1774, 1841, 1911, 1974, 2038, 2103, 2161, 2219, 2280, 2345, 2406, 2466, 2529, 2592, 2654, 2713, 2772, 2835, 2893, 2954, 3020, 3071]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[289, 559, 699, 817, 931, 1031, 1127, 1214, 1297, 1370, 1444, 1515, 1584, 1656, 1726, 1797, 1862, 1930, 1996, 2061, 2125, 2190, 2250, 2311, 2373, 2435, 2496, 2563, 2630, 2692, 2760, 2824, 2898, 2960, 3019, 3089, 3143]}, {"subject_area"=>"/Biology and life sciences/Mycology", "average_usage"=>[330, 564, 723, 851, 962, 1064, 1145, 1232, 1331, 1386, 1446, 1540, 1589, 1706, 1779, 1864, 1945, 2015, 2066, 2138, 2184, 2251, 2303, 2352, 2438, 2485, 2576, 2685, 2798, 2848, 2905, 2960, 3040, 3125, 3181, 3258, 3319]}]}
Loading … Spinner
There are currently no alerts