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• {"link"=>{"url"=>"http://www.citeulike.org/user/olaxton/article/13411588"}, "post_time"=>"2014-10-28 23:34:38", "tag"=>"no-tag", "linkout"=>[{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pone.0019113"}, {"type"=>"Pubmed Central", "url"=>"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098237/"}, {"type"=>"Pubmed", "url"=>"http://view.ncbi.nlm.nih.gov/pubmed/21625533"}, {"type"=>"Hubmed", "url"=>"http://www.hubmed.org/display.cgi?uids=21625533"}], "username"=>"olaxton", "article_id"=>"13411588"}

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{"title"=>"The SOS pilot study: A RCT of routine Oxygen supplementation early after acute stroke-effect on recovery of neurological function at one week", "type"=>"journal", "authors"=>[{"first_name"=>"Christine", "last_name"=>"Roffe", "scopus_author_id"=>"6603757999"}, {"first_name"=>"Khalid", "last_name"=>"Ali", "scopus_author_id"=>"8556913000"}, {"first_name"=>"Anushka", "last_name"=>"Warusevitane", "scopus_author_id"=>"37862465000"}, {"first_name"=>"Sheila", "last_name"=>"Sills", "scopus_author_id"=>"22948731600"}, {"first_name"=>"Sarah", "last_name"=>"Pountain", "scopus_author_id"=>"36806899900"}, {"first_name"=>"Martin", "last_name"=>"Allen", "scopus_author_id"=>"7404105628"}, {"first_name"=>"John", "last_name"=>"Hodsoll", "scopus_author_id"=>"56998605800"}, {"first_name"=>"Frank", "last_name"=>"Lally", "scopus_author_id"=>"9241963800"}, {"first_name"=>"Peter", "last_name"=>"Jones", "scopus_author_id"=>"36080069100"}, {"first_name"=>"Peter", "last_name"=>"Crome", "scopus_author_id"=>"7005014355"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"79956327274", "doi"=>"10.1371/journal.pone.0019113", "pui"=>"361797481", "pmid"=>"16388191", "scopus"=>"2-s2.0-79956327274", "issn"=>"19326203", "isbn"=>"1015-9770 (Print)\\r1015-9770 (Linking)"}, "id"=>"5adc632d-cfbb-3ff0-bf43-033b2f2e6ed4", "abstract"=>"Oxygen is frequently administered to patients with suspected stroke. However, the role of oxygen therapy in ischemic stroke remains controversial in light of the failure of three clinical trials of hyperbaric oxygen therapy to show efficacy, and the fear of exacerbating oxygen free radical injury. The previous trials had several shortcomings, perhaps because they were designed on basis of anecdotal case reports and little preclinical data. Most animal studies concerning oxygen therapy in stroke have been conducted over the last 6 years. Emerging data suggests that hyperbaric and even normobaric oxygen therapy can be effective if used appropriately, and raises the tantalizing possibility that hyperoxia can be used to extend the narrow therapeutic time window for stroke thrombolysis. This article reviews the history, rationale, mechanisms of action and adverse effects of hyperoxia, the key results of previous hyperoxia studies, and the potential role of oxygen therapy in contemporary stroke treatment.", "link"=>"http://www.mendeley.com/research/sos-pilot-study-rct-routine-oxygen-supplementation-early-after-acute-strokeeffect-recovery-neurologi", "reader_count"=>33, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Student > Doctoral Student"=>5, "Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>5, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Student > Doctoral Student"=>5, "Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>5, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>21, "Agricultural and Biological Sciences"=>4, "Neuroscience"=>2, "Psychology"=>2, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>21}, "Neuroscience"=>{"Neuroscience"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Germany"=>1}, "group_count"=>4}

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• http://doi.org/10.1186/s13054-015-0996-4
• http://doi.org/10.1161/STROKEAHA.113.003412

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• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0019113", "share_count"=>1, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>1}

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• {"files"=>["https://ndownloader.figshare.com/files/773375"], "description"=>"<p>SD = Standard deviation</p>", "links"=>[], "tags"=>["characteristics"], "article_id"=>443739, "categories"=>["Neuroscience", "Medicine"], "users"=>["Christine Roffe", "Khalid Ali", "Anushka Warusevitane", "Sheila Sills", "Sarah Pountain", "Martin Allen", "John Hodsoll", "Frank Lally", "Peter Jones", "Peter Crome"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019113.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_the_study_population_/443739", "title"=>"Baseline characteristics of the study population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-05-19 01:02:19"}
• {"files"=>["https://ndownloader.figshare.com/files/773455"], "description"=>"a<p>Mann Whitney U-test; ^bChi-squared test; NS: Not\n significant; ODI 4%: 4% Oxygen Desaturation Index</p>", "links"=>[], "tags"=>["supplementation", "oxygen"], "article_id"=>443819, "categories"=>["Neuroscience", "Medicine"], "users"=>["Christine Roffe", "Khalid Ali", "Anushka Warusevitane", "Sheila Sills", "Sarah Pountain", "Martin Allen", "John Hodsoll", "Frank Lally", "Peter Jones", "Peter Crome"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019113.t002", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effect_of_routine_oxygen_supplementation_on_oxygen____saturation_/443819", "title"=>"The effect of routine oxygen supplementation on oxygen\n saturation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-05-19 01:03:39"}
• {"files"=>["https://ndownloader.figshare.com/files/773282"], "description"=>"<p>The figures in the oxygen and control columns are the number of events\n (NIHSS improvement) followed by the total number in brackets which\n comprises events and non-events. The figure shows that the odds of\n improving with oxygen treatment were similar in all the subgroups\n tested. The apparent adverse effect in the haematoma group is not\n significant, and likely to be due to very small numbers of patients with\n improvement at one week in this subgroup (one improved in the oxygen\n group versus 2 on the control group. COPD: chronic obstructive pulmonary\n disease, CCF: congestive cardiac failure, SSS: Scandinavian Stroke\n Scale, GCS: Glasgow Coma Scale, SpO2: oxygen saturation, Lag SR: time\n lag between stroke onset to recruitment.</p>", "links"=>[], "tags"=>["greater", "the", "institute", "between", "randomization"], "article_id"=>443644, "categories"=>["Neuroscience", "Medicine"], "users"=>["Christine Roffe", "Khalid Ali", "Anushka Warusevitane", "Sheila Sills", "Sarah Pountain", "Martin Allen", "John Hodsoll", "Frank Lally", "Peter Jones", "Peter Crome"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019113.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Forest_plot_of_the_odds_of_a_4_point_or_greater_improvement_of_the____National_Institute_for_Health_Stroke_Scale_NIHSS_score_between____randomization_and_week_1_/443644", "title"=>"Forest plot of the odds of a 4 point or greater improvement of the\n National Institute for Health Stroke Scale (NIHSS) score between\n randomization and week 1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-19 01:00:44"}
• {"files"=>["https://ndownloader.figshare.com/files/388113", "https://ndownloader.figshare.com/files/388181"], "description"=>"<div><p>Mild hypoxia is common after stroke and associated with poor long-term outcome. Oxygen supplementation could prevent hypoxia and improve recovery. A previous study of routine oxygen supplementation showed no significant benefit at 7 and 12 months. This pilot study reports the effects of routine oxygen supplementation for 72 hours on oxygen saturation and neurological outcomes at 1 week after a stroke.</p> <h3>Methods</h3><p>Patients with a clinical diagnosis of acute stroke were recruited within 24 h of hospital admission between October 2004 and April 2008. Participants were randomized to oxygen via nasal cannulae (72 h) or control (room air, oxygen given only if clinically indicated). Clinical outcomes were assessed by research team members at 1 week. Baseline data for oxygen (n = 148) and control (n = 141) did not differ between groups.</p> <h3>Results</h3><p>The median (interquartile range) National Institutes of Health Stroke Scale (NIHSS) score for the groups at baseline was 6 (7) and 5 (7) respectively. The median Nocturnal Oxygen Saturation during treatment was 1.4% (0.3) higher in the oxygen than in the control group (p<0.001) during the intervention. At 1 week, the median NIHSS score had reduced by 2 (3) in the oxygen and by 1 (2) in the control group. 31% of participants in the oxygen group and 14% in the control group had an improvement of ≥4 NIHSS points at 1 week doubling the odds of improvement in the oxygen group (OR: 2.9).</p> <h3>Conclusion</h3><p>Our data show that routine oxygen supplementation started within 24 hours of hospital admission with acute stroke led to a small, but statistically significant, improvement in neurological recovery at 1 week. However, the difference in NIHSS improvement may be due to baseline imbalance in stroke severity between the two groups and needs to be confirmed in a larger study and linked to longer-term clinical outcome.</p> <h3>Trial Registration</h3><p>Controlled-Trials.com <a href=\"http://www.controlled-trials.com/ISRCTN12362720\">ISRCTN12362720</a>; European Clinical Trials Database <a href=\"https://eudract.ema.europa.eu\">2004-001866-41</a></p> </div>", "links"=>[], "tags"=>["sos", "rct", "supplementation", "early", "acute", "neurological", "one"], "article_id"=>136633, "categories"=>["Neuroscience", "Medicine"], "users"=>["Christine Roffe", "Khalid Ali", "Anushka Warusevitane", "Sheila Sills", "Sarah Pountain", "Martin Allen", "John Hodsoll", "Frank Lally", "Peter Jones", "Peter Crome"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0019113.s001", "https://dx.doi.org/10.1371/journal.pone.0019113.s002"], "stats"=>{"downloads"=>17, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_SOS_Pilot_Study_A_RCT_of_Routine_Oxygen_Supplementation_Early___after_Acute_Stroke_Effect_on_Recovery_of_Neurological_Function_at_One___Week/136633", "title"=>"The SOS Pilot Study: A RCT of Routine Oxygen Supplementation Early\n after Acute Stroke—Effect on Recovery of Neurological Function at One\n Week", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-05-19 01:50:33"}
• {"files"=>["https://ndownloader.figshare.com/files/773114"], "description"=>"<p>NOK: Next of Kin.</p>", "links"=>[], "tags"=>["diagram", "illustrating", "the"], "article_id"=>443475, "categories"=>["Neuroscience", "Medicine"], "users"=>["Christine Roffe", "Khalid Ali", "Anushka Warusevitane", "Sheila Sills", "Sarah Pountain", "Martin Allen", "John Hodsoll", "Frank Lally", "Peter Jones", "Peter Crome"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019113.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Consort_diagram_illustrating_the_flow_of_participants_through_the____study_/443475", "title"=>"Consort diagram illustrating the flow of participants through the\n study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-19 00:57:55"}
• {"files"=>["https://ndownloader.figshare.com/files/773414"], "description"=>"<p>There were no data for the one week NIHSS in 5 patients in the oxygen\n group and 8 patients in the control group thus\n n = 143* for oxygen and\n n = 133** for control for the analysis\n of difference between baseline and week 1 NIHSS. NS: not\n significant; ^aMann Whitney U-test;\n ^bChi-squared test.</p>", "links"=>[], "tags"=>["Critical care and emergency medicine", "neurological disorders"], "article_id"=>443777, "categories"=>["Neuroscience", "Medicine"], "users"=>["Christine Roffe", "Khalid Ali", "Anushka Warusevitane", "Sheila Sills", "Sarah Pountain", "Martin Allen", "John Hodsoll", "Frank Lally", "Peter Jones", "Peter Crome"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019113.t003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Neurological_recovery_at_one_week_/443777", "title"=>"Neurological recovery at one week.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-05-19 01:02:57"}

PMC Usage Stats | Further Information

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Relative Metric

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F1000Prime