Analysis of Transcriptional Regulatory Pathways of Photoreceptor Genes by Expression Profiling of the Otx2-Deficient Retina
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Analysis of transcriptional regulatory pathways of photoreceptor genes by expression profiling of the Otx2-deficient retina", "type"=>"journal", "authors"=>[{"first_name"=>"Yoshihiro", "last_name"=>"Omori", "scopus_author_id"=>"36847856600"}, {"first_name"=>"Kimiko", "last_name"=>"Katoh", "scopus_author_id"=>"24468164300"}, {"first_name"=>"Shigeru", "last_name"=>"Sato", "scopus_author_id"=>"36153733700"}, {"first_name"=>"Yuki", "last_name"=>"Muranishi", "scopus_author_id"=>"25230234800"}, {"first_name"=>"Taro", "last_name"=>"Chaya", "scopus_author_id"=>"37094720600"}, {"first_name"=>"Akishi", "last_name"=>"Onishi", "scopus_author_id"=>"7006757293"}, {"first_name"=>"Takashi", "last_name"=>"Minami", "scopus_author_id"=>"35410080600"}, {"first_name"=>"Takashi", "last_name"=>"Fujikado", "scopus_author_id"=>"7006370545"}, {"first_name"=>"Takahisa", "last_name"=>"Furukawa", "scopus_author_id"=>"7403160171"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-79955936417", "sgr"=>"79955936417", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0019685", "pmid"=>"21602925", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"361758776"}, "id"=>"99742e82-8d1e-3379-9298-ce3b2f315d01", "abstract"=>"In the vertebrate retina, the Otx2 transcription factor plays a crucial role in the cell fate determination of both rod and cone photoreceptors. We previously reported that Otx2 conditional knockout (CKO) mice exhibited a total absence of rods and cones in the retina due to their cell fate conversion to amacrine-like cells. In order to investigate the entire transcriptome of the Otx2 CKO retina, we compared expression profile of Otx2 CKO and wild-type retinas at P1 and P12 using microarray. We observed that expression of 101- and 1049-probe sets significantly decreased in the Otx2 CKO retina at P1 and P12, respectively, whereas, expression of 3- and 4149-probe sets increased at P1 and P12, respectively. We found that expression of genes encoding transcription factors involved in photoreceptor development, including Crx, Nrl, Nr2e3, Esrrb, and NeuroD, was markedly down-regulated in the Otx2 CKO at both P1 and P12. Furthermore, we identified three human retinal disease loci mapped in close proximity to certain down-regulated genes in the Otx2 CKO retina including Ccdc126, Tnfsf13 and Pitpnm1, suggesting that these genes are possibly responsible for these diseases. These transcriptome data sets of the Otx2 CKO retina provide a resource on developing rods and cones to further understand the molecular mechanisms underlying photoreceptor development, function and disease.", "link"=>"http://www.mendeley.com/research/analysis-transcriptional-regulatory-pathways-photoreceptor-genes-expression-profiling-otx2deficient", "reader_count"=>43, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>7, "Researcher"=>9, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>5, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>7, "Researcher"=>9, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>5, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>6, "Agricultural and Biological Sciences"=>28, "Medicine and Dentistry"=>6, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>28}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Portugal"=>1, "Germany"=>1}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79955936417"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79955936417?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79955936417&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=79955936417&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/79955936417", "dc:identifier"=>"SCOPUS_ID:79955936417", "eid"=>"2-s2.0-79955936417", "dc:title"=>"Analysis of transcriptional regulatory pathways of photoreceptor genes by expression profiling of the Otx2-deficient retina", "dc:creator"=>"Omori Y.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"6", "prism:issueIdentifier"=>"5", "prism:pageRange"=>nil, "prism:coverDate"=>"2011-05-18", "prism:coverDisplayDate"=>"2011", "prism:doi"=>"10.1371/journal.pone.0019685", "citedby-count"=>"41", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Osaka Bioscience Institute", "affiliation-city"=>"Suita", "affiliation-country"=>"Japan"}, {"@_fa"=>"true", "affilname"=>"Japan Science and Technology Agency", "affiliation-city"=>"Kawaguchi", "affiliation-country"=>"Japan"}, {"@_fa"=>"true", "affilname"=>"PRESTO", "affiliation-city"=>"Suita", "affiliation-country"=>"Japan"}], "pubmed-id"=>"21602925", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e19685", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0019685", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"51", "xml_views"=>"9", "html_views"=>"271"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"86"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"4", "html_views"=>"45"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"5", "html_views"=>"20"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"91"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"48"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"52"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"57"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"50"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"40"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"42"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"84"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"86"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"26"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"3", "html_views"=>"4"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"6"}

Figshare

  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/389248/Table_S1.xls", "https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/389255/Text_S1.doc"], "description"=>"<div><p>In the vertebrate retina, the Otx2 transcription factor plays a crucial role in the cell fate determination of both rod and cone photoreceptors. We previously reported that <em>Otx2</em> conditional knockout (CKO) mice exhibited a total absence of rods and cones in the retina due to their cell fate conversion to amacrine-like cells. In order to investigate the entire transcriptome of the <em>Otx2</em> CKO retina, we compared expression profile of <em>Otx2</em> CKO and wild-type retinas at P1 and P12 using microarray. We observed that expression of 101- and 1049-probe sets significantly decreased in the <em>Otx2</em> CKO retina at P1 and P12, respectively, whereas, expression of 3- and 4149-probe sets increased at P1 and P12, respectively. We found that expression of genes encoding transcription factors involved in photoreceptor development, including <em>Crx, Nrl, Nr2e3, Esrrb,</em> and <em>NeuroD</em>, was markedly down-regulated in the <em>Otx2</em> CKO at both P1 and P12. Furthermore, we identified three human retinal disease loci mapped in close proximity to certain down-regulated genes in the <em>Otx2</em> CKO retina including <em>Ccdc126, Tnfsf13</em> and <em>Pitpnm1</em>, suggesting that these genes are possibly responsible for these diseases. These transcriptome data sets of the <em>Otx2</em> CKO retina provide a resource on developing rods and cones to further understand the molecular mechanisms underlying photoreceptor development, function and disease.</p> </div>", "links"=>[], "tags"=>["transcriptional", "pathways", "photoreceptor", "genes", "profiling", "retina"], "article_id"=>136863, "categories"=>["Neuroscience", "Genetics", "Developmental Biology", "Medicine"], "users"=>["Yoshihiro Omori", "Kimiko Katoh", "Shigeru Sato", "Yuki Muranishi", "Taro Chaya", "Akishi Onishi", "Takashi Minami", "Takashi Fujikado", "Takahisa Furukawa"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0019685"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/Analysis_of_Transcriptional_Regulatory_Pathways_of_Photoreceptor_Genes_by_Expression_Profiling_of_the_Otx2_Deficient_Retina/136863", "title"=>"Analysis of Transcriptional Regulatory Pathways of Photoreceptor Genes by Expression Profiling of the <em>Otx2-</em>Deficient Retina", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-05-13 01:54:23"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/775348/Figure_1.tif"], "description"=>"<p>According to gene ontology (GO) term annotation, the genes differentially expressed in the <i>Otx2</i> CKO retinas at P1 and P12 were categorized into functional groups. We used GO term data on 101 probes with decreased expression in the <i>Otx2</i> CKO at P1 (signal log ratio ≤−1.0, signal intensity ≥50), 36 probes with increased expression in the <i>Otx2</i> CKO at P1 (signal log ratio ≥+0.5, signal intensity ≥50), 241 probes with decreased expression in the <i>Otx2</i> CKO at P12 (signal log ratio ≤−2.5, signal intensity ≥100), and 121 probes with increased expression in the <i>Otx2</i> CKO at P12 (signal log ratio ≥+2.5, signal intensity ≥100).</p>", "links"=>[], "tags"=>["genes", "differentially", "cko"], "article_id"=>445708, "categories"=>["Neuroscience", "Genetics", "Developmental Biology", "Medicine"], "users"=>["Yoshihiro Omori", "Kimiko Katoh", "Shigeru Sato", "Yuki Muranishi", "Taro Chaya", "Akishi Onishi", "Takashi Minami", "Takashi Fujikado", "Takahisa Furukawa"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0019685.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Categorization_of_the_genes_differentially_expressed_in_the_Otx2_CKO_retina_/445708", "title"=>"Categorization of the genes differentially expressed in the <i>Otx2</i> CKO retina.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-13 01:35:08"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/775477/Figure_2.tif"], "description"=>"<p>(A, B) Matrices were visualized as hierarchical clustering of down-regulated (A) and up-regulated (B) genes in the <i>Otx2</i> CKO retina at P1 and P12. Each gene was visualized as a single row of colored squares. The color indicates the relative expression level of a gene. Signal log ratio (SLR) was calculated based on the average of signal intensity of the control retina at P12. The color scale ranges are from signal log ratios of −15 to +15 (A) and −8 to +8 (B) as shown in the scale bar on the bottom of the figure. Gene symbols are indicated in the lists on the right of the matrixes. Hierarchical clustering was performed by the EPCLUST program (<a href=\"http://www.bioinf.ebc.ee/EP/EP/EPCLUST/\" target=\"_blank\">http://www.bioinf.ebc.ee/EP/EP/EPCLUST/</a>).</p>", "links"=>[], "tags"=>["retinal", "profiles", "cko"], "article_id"=>445839, "categories"=>["Neuroscience", "Genetics", "Developmental Biology", "Medicine"], "users"=>["Yoshihiro Omori", "Kimiko Katoh", "Shigeru Sato", "Yuki Muranishi", "Taro Chaya", "Akishi Onishi", "Takashi Minami", "Takashi Fujikado", "Takahisa Furukawa"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0019685.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Clustering_analysis_of_retinal_gene_expression_profiles_in_the_Otx2_CKO_and_control_retinas_/445839", "title"=>"Clustering analysis of retinal gene expression profiles in the <i>Otx2</i> CKO and control retinas.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-13 01:37:19"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/775634/Figure_3.tif"], "description"=>"<p>Expression levels of genes encoding photoreceptor ciliary and ribbon synaptic components in the control, <i>Otx2</i> CKO and <i>Crx</i> KO retinas at P12 were analyzed by Q-PCR. Expression levels of selected genes were normalized to the expression levels of a housekeeping gene, <i>Gapdh</i>. Primer sequences for PCR were shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0019685#pone.0019685.s001\" target=\"_blank\">Table S1</a>. The mean of the value of control at P12 was set as 1.0. Error bars show the SD (n = 3). *, P<0.03.</p>", "links"=>[], "tags"=>["genes", "encoding", "photoreceptor", "ciliary", "synaptic", "components", "cko", "ko"], "article_id"=>445989, "categories"=>["Neuroscience", "Genetics", "Developmental Biology", "Medicine"], "users"=>["Yoshihiro Omori", "Kimiko Katoh", "Shigeru Sato", "Yuki Muranishi", "Taro Chaya", "Akishi Onishi", "Takashi Minami", "Takashi Fujikado", "Takahisa Furukawa"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0019685.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Expression_of_genes_encoding_photoreceptor_ciliary_and_ribbon_synaptic_components_in_the_Otx2_CKO_and_Crx_KO_retina_/445989", "title"=>"Expression of genes encoding photoreceptor ciliary and ribbon synaptic components in the <i>Otx2</i> CKO and <i>Crx</i> KO retina.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-13 01:39:49"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/775771/Figure_4.tif"], "description"=>"<p>(A-C) Microarray analysis datasets from <i>Crx</i> (A), <i>Nrl</i> (B), <i>Nr2e3</i> (C) KO retinas were compared with that from the <i>Otx2</i> CKO retina at P12. We identified 367 down-regulated probes in the <i>Otx2</i> CKO retina (signal log ratio ≤−2.0, signal intensity ≥74). We used datasets from previous microarray analysis of the <i>Crx</i>, <i>Nrl</i> and <i>Nr2e3</i>-null retinas at P21 with the following results: 154 probes down-regulated in the <i>Crx</i> KO retina (signal log ratio ≤−2.0, signal intensity ≥352), 63 probes up-regulated in the <i>Crx</i> KO retina (signal log ratio ≥+2.0, signal intensity ≥345), 95 probes down-regulated in the <i>Nrl</i> KO retina (signal log ratio ≤−2.0, signal intensity ≥354), 186 probes up-regulated in the <i>Nrl</i> KO retina (signal log ratio ≥+2.0, signal intensity ≥347), 9 probes down-regulated in the <i>Nr2e3</i>-null (rd7) retina (signal log ratio ≤−2.0, signal intensity ≥354), 37 probes up-regulated in the <i>Nr2e3</i>-null retina (signal log ratio ≥+2.0, signal intensity ≥358). The numbers of probes in each category were indicated.</p>", "links"=>[], "tags"=>["profiles"], "article_id"=>446139, "categories"=>["Neuroscience", "Genetics", "Developmental Biology", "Medicine"], "users"=>["Yoshihiro Omori", "Kimiko Katoh", "Shigeru Sato", "Yuki Muranishi", "Taro Chaya", "Akishi Onishi", "Takashi Minami", "Takashi Fujikado", "Takahisa Furukawa"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0019685.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Comparison_gene_expression_profiles_with_the_Otx2_CKO_retina_/446139", "title"=>"Comparison gene expression profiles with the <i>Otx2</i>-CKO retina.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-13 01:42:19"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/775931/Figure_5.tif"], "description"=>"<p>Expression levels of selected transcription factor genes in the control (at P1 and P12), <i>Otx2</i> CKO (at P1 and P12) and <i>Crx</i> KO (at P12) retinas were analyzed by Q-PCR. Expression levels of selected genes were normalized to the expression levels of a housekeeping gene, <i>Gapdh</i>. The mean of the value of each control at P12 was set as 1.0. Error bars show the SD (n  =  3). *, P<0.03.</p>", "links"=>[], "tags"=>["regulates", "transcription", "factors", "retinal"], "article_id"=>446286, "categories"=>["Neuroscience", "Genetics", "Developmental Biology", "Medicine"], "users"=>["Yoshihiro Omori", "Kimiko Katoh", "Shigeru Sato", "Yuki Muranishi", "Taro Chaya", "Akishi Onishi", "Takashi Minami", "Takashi Fujikado", "Takahisa Furukawa"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0019685.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Otx2_regulates_expression_of_transcription_factors_involved_in_retinal_development_/446286", "title"=>"<i>Otx2</i> regulates expression of transcription factors involved in retinal development.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-13 01:44:46"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/776092/Figure_6.tif"], "description"=>"<p>Expression of identified candidate genes for human retinal diseases was analyzed by Q-PCR. Expression levels of selected genes were normalized to the expression levels of a housekeeping gene, <i>Gapdh</i>. The mean of the value of control at P12 was set as 1.0. Error bars show the SD (n  =  3). *, P<0.03.</p>", "links"=>[], "tags"=>["genes", "retinal", "diseases", "cko"], "article_id"=>446450, "categories"=>["Neuroscience", "Genetics", "Developmental Biology", "Medicine"], "users"=>["Yoshihiro Omori", "Kimiko Katoh", "Shigeru Sato", "Yuki Muranishi", "Taro Chaya", "Akishi Onishi", "Takashi Minami", "Takashi Fujikado", "Takahisa Furukawa"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0019685.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Expression_of_identified_candidate_genes_for_human_retinal_diseases_in_the_Otx2_CKO_retina_/446450", "title"=>"Expression of identified candidate genes for human retinal diseases in the <i>Otx2</i> CKO retina.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-13 01:47:30"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/776164/Table_3.xls"], "description"=>"<p>Expression of transcription factors involved in retinal development in the <i>Otx2</i> CKO retina.</p>", "links"=>[], "tags"=>["transcription", "factors", "retinal", "cko"], "article_id"=>446528, "categories"=>["Neuroscience", "Genetics", "Developmental Biology", "Medicine"], "users"=>["Yoshihiro Omori", "Kimiko Katoh", "Shigeru Sato", "Yuki Muranishi", "Taro Chaya", "Akishi Onishi", "Takashi Minami", "Takashi Fujikado", "Takahisa Furukawa"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0019685.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Expression_of_transcription_factors_involved_in_retinal_development_in_the_Otx2_CKO_retina_/446528", "title"=>"Expression of transcription factors involved in retinal development in the <i>Otx2</i> CKO retina.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-05-13 01:48:48"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/776208/Table_2.xls"], "description"=>"<p>PR, photoreceptor cell; AM, amacrine cell; BP, bipolar cell; MG, Müller glia; GCL, cells in ganglion cell layer; HC, horizontal cell; INL, cells in inner nuclear layer.</p><p>d, de Melo et al., 2003; W, Wakabayashi et al., 2008; B, Blackshaw et al., 2004; G, GENSAT database.</p>", "links"=>[], "tags"=>["up-regulated", "cko", "retina"], "article_id"=>446576, "categories"=>["Neuroscience", "Genetics", "Developmental Biology", "Medicine"], "users"=>["Yoshihiro Omori", "Kimiko Katoh", "Shigeru Sato", "Yuki Muranishi", "Taro Chaya", "Akishi Onishi", "Takashi Minami", "Takashi Fujikado", "Takahisa Furukawa"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0019685.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Genes_up_regulated_in_the_Otx2_CKO_retina_signal_log_ratio_3_0_/446576", "title"=>"Genes up-regulated in the <i>Otx2</i> CKO retina (signal log ratio ≥+3.0).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-05-13 01:49:36"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/776255/Table_1.xls"], "description"=>"<p>Genes down-regulated in the <i>Otx2</i> CKO retina (signal log ratio ≤−5.0).</p>", "links"=>[], "tags"=>["down-regulated", "cko", "retina"], "article_id"=>446613, "categories"=>["Neuroscience", "Genetics", "Developmental Biology", "Medicine"], "users"=>["Yoshihiro Omori", "Kimiko Katoh", "Shigeru Sato", "Yuki Muranishi", "Taro Chaya", "Akishi Onishi", "Takashi Minami", "Takashi Fujikado", "Takahisa Furukawa"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0019685.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Genes_down_regulated_in_the_Otx2_CKO_retina_signal_log_ratio_5_0_/446613", "title"=>"Genes down-regulated in the <i>Otx2</i> CKO retina (signal log ratio ≤−5.0).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-05-13 01:50:13"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"32", "unique-ip"=>"29", "pdf"=>"19", "year"=>"2011", "figure"=>"26", "scanned-summary"=>"0", "supp-data"=>"5"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"55", "year"=>"2011", "pdf"=>"20", "unique-ip"=>"54", "figure"=>"30", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"7", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "unique-ip"=>"17", "pdf"=>"7", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"8", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"102", "year"=>"2011", "pdf"=>"10", "unique-ip"=>"54", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "unique-ip"=>"21", "pdf"=>"4", "year"=>"2011", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"67", "year"=>"2011", "pdf"=>"14", "unique-ip"=>"47", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "unique-ip"=>"23", "pdf"=>"12", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"23", "year"=>"2011", "pdf"=>"10", "unique-ip"=>"17", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"27", "unique-ip"=>"29", "pdf"=>"22", "year"=>"2012", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"18", "year"=>"2012", "pdf"=>"6", "unique-ip"=>"17", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"21", "unique-ip"=>"23", "pdf"=>"5", "year"=>"2012", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "year"=>"2012", "pdf"=>"7", "unique-ip"=>"18", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"13", "unique-ip"=>"12", "pdf"=>"10", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"4", "year"=>"2012", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"10", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"0", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"7", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"20", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[289, 559, 699, 817, 931, 1031, 1127, 1214, 1297, 1370, 1444, 1515, 1584, 1656, 1726, 1797, 1862, 1930, 1996, 2061, 2125, 2190, 2250, 2311, 2373, 2435, 2496, 2563, 2630, 2692, 2760, 2824, 2898, 2960, 3019, 3089, 3143]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[301, 559, 686, 796, 908, 1013, 1103, 1196, 1281, 1355, 1431, 1507, 1579, 1648, 1711, 1778, 1841, 1910, 1967, 2034, 2087, 2141, 2202, 2261, 2320, 2386, 2444, 2502, 2566, 2632, 2691, 2755, 2812, 2873, 2929, 2997, 3047]}, {"subject_area"=>"/Medicine and health sciences/Ophthalmology", "average_usage"=>[348, 616, 733, 836, 930, 1016, 1092, 1188, 1248, 1305, 1371, 1440, 1491, 1547, 1612, 1677, 1731, 1778, 1833, 1889, 1942, 1987, 2028, 2073, 2136, 2165, 2228, 2272, 2326, 2370, 2416, 2464, 2520, 2565, 2603, 2640, 2671]}]}
Loading … Spinner
There are currently no alerts