Comparative Plasma Lipidome between Human and Cynomolgus Monkey: Are Plasma Polar Lipids Good Biomarkers for Diabetic Monkeys?
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{"title"=>"Comparative plasma lipidome between human and cynomolgus monkey: Are plasma polar lipids good biomarkers for diabetic monkeys?", "type"=>"journal", "authors"=>[{"first_name"=>"Guanghou", "last_name"=>"Shui", "scopus_author_id"=>"14020558700"}, {"first_name"=>"Jeffrey William", "last_name"=>"Stebbins", "scopus_author_id"=>"56250527500"}, {"first_name"=>"Buu Duyen", "last_name"=>"Lam", "scopus_author_id"=>"38961552100"}, {"first_name"=>"Wei Fun", "last_name"=>"Cheong", "scopus_author_id"=>"37046918700"}, {"first_name"=>"Sin Man", "last_name"=>"Lam", "scopus_author_id"=>"38961538500"}, {"first_name"=>"Francine", "last_name"=>"Gregoire", "scopus_author_id"=>"38961194700"}, {"first_name"=>"Jun", "last_name"=>"Kusonoki", "scopus_author_id"=>"37122298000"}, {"first_name"=>"Markus R.", "last_name"=>"Wenk", "scopus_author_id"=>"7006380030"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "sgr"=>"79955780874", "scopus"=>"2-s2.0-79955780874", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"361732857", "doi"=>"10.1371/journal.pone.0019731", "pmid"=>"21573191"}, "id"=>"16cc3992-f017-3e36-afdc-d1e88fac19ee", "abstract"=>"BACKGROUND: Non-human primates (NHP) are now being considered as models for investigating human metabolic diseases including diabetes. Analyses of cholesterol and triglycerides in plasma derived from NHPs can easily be achieved using methods employed in humans. Information pertaining to other lipid species in monkey plasma, however, is lacking and requires comprehensive experimental analysis.\\n\\nMETHODOLOGIES/PRINCIPAL FINDINGS: We examined the plasma lipidome from 16 cynomolgus monkey, Macaca fascicularis, using liquid chromatography coupled with mass spectrometry (LC/MS). We established novel analytical approaches, which are based on a simple gradient elution, to quantify polar lipids in plasma including (i) glycerophospholipids (phosphatidylcholine, PC; phosphatidylethanolamine, PE; phosphatidylinositol, PI; phosphatidylglycerol, PG; phosphatidylserine, PS; phosphatidic acid, PA); (ii) sphingolipids (sphingomyelin, SM; ceramide, Cer; Glucocyl-ceramide, GluCer; ganglioside mannoside 3, GM3). Lipidomic analysis had revealed that the plasma of human and cynomolgus monkey were of similar compositions, with PC, SM, PE, LPC and PI constituting the major polar lipid species present. Human plasma contained significantly higher levels of plasmalogen PE species (p<0.005) and plasmalogen PC species (p<0.0005), while cynomolgus monkey had higher levels of polyunsaturated fatty acyls (PUFA) in PC, PE, PS and PI. Notably, cynomolgus monkey had significantly lower levels of glycosphingolipids, including GluCer (p<0.0005) and GM(3) (p<0.0005), but higher level of Cer (p<0.0005) in plasma than human. We next investigated the biochemical alterations in blood lipids of 8 naturally occurring diabetic cynomolgus monkeys when compared with 8 healthy controls.\\n\\nCONCLUSIONS: For the first time, we demonstrated that the plasma of human and cynomolgus monkey were of similar compositions, but contained different mol distribution of individual molecular species. Diabetic monkeys exhibited decreased levels of sphingolipids, which are microdomain-associated lipids and are thought to be associated with insulin sensitivity. Significant increases in PG species, which are precursors for cardiolipin biosynthesis in mitochondria, were found in fasted diabetic monkeys (n = 8).", "link"=>"http://www.mendeley.com/research/comparative-plasma-lipidome-between-human-cynomolgus-monkey-plasma-polar-lipids-good-biomarkers-diab", "reader_count"=>56, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>27, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>7, "Other"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>27, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>7, "Other"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>10, "Agricultural and Biological Sciences"=>23, "Medicine and Dentistry"=>4, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>11, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>11}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>23}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>10}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Austria"=>1, "Japan"=>1, "Finland"=>1, "United Kingdom"=>1, "Malaysia"=>1, "Spain"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/390037", "https://ndownloader.figshare.com/files/390071", "https://ndownloader.figshare.com/files/390131", "https://ndownloader.figshare.com/files/390163", "https://ndownloader.figshare.com/files/390193", "https://ndownloader.figshare.com/files/390239", "https://ndownloader.figshare.com/files/390277"], "description"=>"<div><h3>Background</h3><p>Non-human primates (NHP) are now being considered as models for investigating human metabolic diseases including diabetes. Analyses of cholesterol and triglycerides in plasma derived from NHPs can easily be achieved using methods employed in humans. Information pertaining to other lipid species in monkey plasma, however, is lacking and requires comprehensive experimental analysis.</p> <h3>Methodologies/Principal Findings</h3><p>We examined the plasma lipidome from 16 cynomolgus monkey, <em>Macaca fascicularis</em>, using liquid chromatography coupled with mass spectrometry (LC/MS). We established novel analytical approaches, which are based on a simple gradient elution, to quantify polar lipids in plasma including (i) glycerophospholipids (phosphatidylcholine, PC; phosphatidylethanolamine, PE; phosphatidylinositol, PI; phosphatidylglycerol, PG; phosphatidylserine, PS; phosphatidic acid, PA); (ii) sphingolipids (sphingomyelin, SM; ceramide, Cer; Glucocyl-ceramide, GluCer; ganglioside mannoside 3, GM3). Lipidomic analysis had revealed that the plasma of human and cynomolgus monkey were of similar compositions, with PC, SM, PE, LPC and PI constituting the major polar lipid species present. Human plasma contained significantly higher levels of plasmalogen PE species (p<0.005) and plasmalogen PC species (p<0.0005), while cynomolgus monkey had higher levels of polyunsaturated fatty acyls (PUFA) in PC, PE, PS and PI. Notably, cynomolgus monkey had significantly lower levels of glycosphingolipids, including GluCer (p<0.0005) and GM<sub>3</sub> (p<0.0005), but higher level of Cer (p<0.0005) in plasma than human. We next investigated the biochemical alterations in blood lipids of 8 naturally occurring diabetic cynomolgus monkeys when compared with 8 healthy controls.</p> <h3>Conclusions</h3><p>For the first time, we demonstrated that the plasma of human and cynomolgus monkey were of similar compositions, but contained different mol distribution of individual molecular species. Diabetic monkeys exhibited decreased levels of sphingolipids, which are microdomain-associated lipids and are thought to be associated with insulin sensitivity. Significant increases in PG species, which are precursors for cardiolipin biosynthesis in mitochondria, were found in fasted diabetic monkeys (n = 8).</p> </div>", "links"=>[], "tags"=>["comparative", "plasma", "lipidome", "cynomolgus", "are", "polar", "lipids", "biomarkers", "diabetic"], "article_id"=>137022, "categories"=>["Chemistry", "Biochemistry", "Physiology"], "users"=>["Guanghou Shui", "Jeffrey William Stebbins", "Buu Duyen Lam", "Wei Fun Cheong", "Sin Man Lam", "Francine Gregoire", "Jun Kusonoki", "Markus R. Wenk"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0019731.s001", "https://dx.doi.org/10.1371/journal.pone.0019731.s002", "https://dx.doi.org/10.1371/journal.pone.0019731.s003", "https://dx.doi.org/10.1371/journal.pone.0019731.s004", "https://dx.doi.org/10.1371/journal.pone.0019731.s005", "https://dx.doi.org/10.1371/journal.pone.0019731.s006", "https://dx.doi.org/10.1371/journal.pone.0019731.s007"], "stats"=>{"downloads"=>39, "page_views"=>35, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Comparative_Plasma_Lipidome_between_Human_and_Cynomolgus_Monkey_Are_Plasma_Polar_Lipids_Good_Biomarkers_for_Diabetic_Monkeys_/137022", "title"=>"Comparative Plasma Lipidome between Human and Cynomolgus Monkey: Are Plasma Polar Lipids Good Biomarkers for Diabetic Monkeys?", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-05-04 01:57:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/777814"], "description"=>"<p>* p<0.05, ** p<0.005, *** p<0.0005.</p>", "links"=>[], "tags"=>["sphingolipid", "plasma", "diabetic", "fasted", "fed", "sm"], "article_id"=>448167, "categories"=>["Chemistry", "Biochemistry", "Physiology"], "users"=>["Guanghou Shui", "Jeffrey William Stebbins", "Buu Duyen Lam", "Wei Fun Cheong", "Sin Man Lam", "Francine Gregoire", "Jun Kusonoki", "Markus R. Wenk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019731.g006", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Individual_sphingolipid_species_in_plasma_of_normal_n_8202_8202_8_and_diabetic_n_8202_8202_8_monkey_under_fasted_and_fed_condition_A_Cer_B_SM_C_GluCer_D_GM3_/448167", "title"=>"Individual sphingolipid species in plasma of normal (n = 8) and diabetic (n = 8) monkey under fasted and fed condition: (A) Cer, (B) SM (C), GluCer, (D) GM3.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-04 02:16:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/777551"], "description"=>"<p>** p<0.005, *** p<0.0005.</p>", "links"=>[], "tags"=>["mol", "plasmalogen", "lipids", "fed", "plasma"], "article_id"=>447912, "categories"=>["Chemistry", "Biochemistry", "Physiology"], "users"=>["Guanghou Shui", "Jeffrey William Stebbins", "Buu Duyen Lam", "Wei Fun Cheong", "Sin Man Lam", "Francine Gregoire", "Jun Kusonoki", "Markus R. Wenk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019731.g003", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_mol_fraction_of_plasmalogen_lipids_in_both_human_n_8202_8202_10_and_normal_fed_Monkey_plasma_n_8202_8202_8_/447912", "title"=>"Comparison of mol fraction of plasmalogen lipids in both human (n = 10) and normal, fed Monkey plasma (n = 8).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-04 02:11:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/777956"], "description"=>"<p>MRM transitions of individual lipid species.</p>", "links"=>[], "tags"=>["transitions", "lipid"], "article_id"=>448318, "categories"=>["Chemistry", "Biochemistry", "Physiology"], "users"=>["Guanghou Shui", "Jeffrey William Stebbins", "Buu Duyen Lam", "Wei Fun Cheong", "Sin Man Lam", "Francine Gregoire", "Jun Kusonoki", "Markus R. Wenk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019731.t001", "stats"=>{"downloads"=>3, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MRM_transitions_of_individual_lipid_species_/448318", "title"=>"MRM transitions of individual lipid species.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-05-04 02:18:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/777435"], "description"=>"<p>* p<0.05, ** p<0.005, *** p<0.0005.</p>", "links"=>[], "tags"=>["polar", "lipids", "fed", "plasma", "phosphatidic", "ganglioside"], "article_id"=>447792, "categories"=>["Chemistry", "Biochemistry", "Physiology"], "users"=>["Guanghou Shui", "Jeffrey William Stebbins", "Buu Duyen Lam", "Wei Fun Cheong", "Sin Man Lam", "Francine Gregoire", "Jun Kusonoki", "Markus R. Wenk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019731.g002", "stats"=>{"downloads"=>2, "page_views"=>34, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heatplots_of_various_polar_lipids_in_normal_human_n_8202_8202_10_and_normal_fed_monkey_plasma_n_8202_8202_8_A_PC_phosphatidylcholine_B_PE_phosphatidylethanolamine_C_PI_phosphatidylinositol_D_PA_phosphatidic_acid_E_PG_phosphatidylglycerol_F_PS_phosphatidy/447792", "title"=>"Heatplots of various polar lipids in normal human (n = 10) and normal, fed monkey plasma (n = 8) (A) PC, phosphatidylcholine; (B) PE, phosphatidylethanolamine; (C) PI, phosphatidylinositol; (D) PA, phosphatidic acid; (E) PG, phosphatidylglycerol; (F) PS, phosphatidylserine; (G) SM, sphingomyelin; (H), Cer, Ceramides; (I) GM3, ganglioside mannoside; (J), Glucer, glucosylceramides.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-04 02:09:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/777617"], "description"=>"<p>(A) Insulin; (B) Glucose; (C) Alanine transaminase (ALT); (D) Aspartate transaminase (AST); (E) Triacylglycerides (TAG); (F) Cholesterol; (D) Low-density lipoprotein cholesterol (LDL-C); (H) High-density lipoprotein cholesterol (HDL-C). * p<0.05, ** p<0.005.</p>", "links"=>[], "tags"=>["plasma", "diabetic", "monkeys"], "article_id"=>447979, "categories"=>["Chemistry", "Biochemistry", "Physiology"], "users"=>["Guanghou Shui", "Jeffrey William Stebbins", "Buu Duyen Lam", "Wei Fun Cheong", "Sin Man Lam", "Francine Gregoire", "Jun Kusonoki", "Markus R. Wenk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019731.g004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Biochemical_analysis_of_plasma_in_diabetic_monkeys_n_8202_8202_8_for_each_group_/447979", "title"=>"Biochemical analysis of plasma in diabetic monkeys (n = 8 for each group).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-04 02:12:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/777730"], "description"=>"<p>* p<0.05, ** p<0.005, *** p<0.0005.</p>", "links"=>[], "tags"=>["lipids", "plasma", "diabetic", "groups", "fasted", "fed"], "article_id"=>448089, "categories"=>["Chemistry", "Biochemistry", "Physiology"], "users"=>["Guanghou Shui", "Jeffrey William Stebbins", "Buu Duyen Lam", "Wei Fun Cheong", "Sin Man Lam", "Francine Gregoire", "Jun Kusonoki", "Markus R. Wenk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019731.g005", "stats"=>{"downloads"=>2, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_total_lipids_in_plasma_of_normal_n_8202_8202_8_and_diabetic_n_8202_8202_8_monkey_groups_under_both_fasted_and_fed_conditions_/448089", "title"=>"Comparison of total lipids in plasma of normal (n = 8) and diabetic (n = 8) monkey groups under both fasted and fed conditions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-04 02:14:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/777334"], "description"=>"<p>(A) Chemical structure of plasma lipids. (B) Comparison of total mol fraction of phospholipid and sphingolipids species in Human (n = 10) and normal, fed Monkey plasma (n = 8). Insert, PG, GM3, Cer, Glucer. * p<0.05, ** p<0.005, *** p<0.0005.</p>", "links"=>[], "tags"=>["lipid"], "article_id"=>447699, "categories"=>["Chemistry", "Biochemistry", "Physiology"], "users"=>["Guanghou Shui", "Jeffrey William Stebbins", "Buu Duyen Lam", "Wei Fun Cheong", "Sin Man Lam", "Francine Gregoire", "Jun Kusonoki", "Markus R. Wenk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019731.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Major_lipid_species_in_human_and_monkey_/447699", "title"=>"Major lipid species in human and monkey.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-04 02:08:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/777901"], "description"=>"<p>* p<0.05, ** p<0.005, *** p<0.0005.</p>", "links"=>[], "tags"=>["pg", "diabetic", "fasted", "fed"], "article_id"=>448260, "categories"=>["Chemistry", "Biochemistry", "Physiology"], "users"=>["Guanghou Shui", "Jeffrey William Stebbins", "Buu Duyen Lam", "Wei Fun Cheong", "Sin Man Lam", "Francine Gregoire", "Jun Kusonoki", "Markus R. Wenk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0019731.g007", "stats"=>{"downloads"=>2, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_individual_PG_species_in_normal_n_8202_8202_8_and_diabetic_n_8202_8202_8_monkey_under_fasted_and_fed_condition_/448260", "title"=>"Comparison of individual PG species in normal (n = 8) and diabetic (n = 8) monkey under fasted and fed condition.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-04 02:17:40"}

PMC Usage Stats | Further Information

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