Effect of Seven-Valent Pneumococcal Conjugate Vaccine on Staphylococcus aureus Colonisation in a Randomised Controlled Trial
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{"title"=>"Effect of seven-valent pneumococcal conjugate vaccine on staphylococcus aureus colonisation in a randomised controlled trial", "type"=>"journal", "authors"=>[{"first_name"=>"Elske J.M.", "last_name"=>"van Gils", "scopus_author_id"=>"8878514900"}, {"first_name"=>"Eelko", "last_name"=>"Hak", "scopus_author_id"=>"7006344929"}, {"first_name"=>"Reinier H.", "last_name"=>"Veenhoven", "scopus_author_id"=>"17037069900"}, {"first_name"=>"Gerwin D.", "last_name"=>"Rodenburg", "scopus_author_id"=>"26040957300"}, {"first_name"=>"Debby", "last_name"=>"Bogaert", "scopus_author_id"=>"55962909800"}, {"first_name"=>"Jacob P.", "last_name"=>"Bruin", "scopus_author_id"=>"8727419100"}, {"first_name"=>"Loek", "last_name"=>"van Alphen", "scopus_author_id"=>"35475176800"}, {"first_name"=>"Elisabeth A.M.", "last_name"=>"Sanders", "scopus_author_id"=>"7102550106"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"79958764530", "doi"=>"10.1371/journal.pone.0020229", "pui"=>"361932877", "pmid"=>"21695210", "scopus"=>"2-s2.0-79958764530", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)"}, "id"=>"dbaef85f-1c57-3313-8899-54406aaebc70", "abstract"=>"BACKGROUND: Heptavalent pneumococcal conjugate vaccine (PCV7) shifts nasopharyngeal colonisation with vaccine serotype pneumococci towards nonvaccine serotypes. Because of the reported negative association of vaccine serotype pneumococci and Staphylococcus aureus in the nasopharynx, we explored the effect of PCV7 on nasopharyngeal colonisation with S. aureus in children and parents.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: This study was part of a randomised controlled trial on the effect of PCV7 on pneumococcal carriage, enrolling healthy newborns who were randomly assigned (1:1:1) to receive PCV7 (1) at 2 and 4 months of age (2) at 2, 4 and 11 months or (3) no PCV7 (controls). Nasopharyngeal colonisation of S. aureus was a planned secondary outcome. Nasopharyngeal swabs were obtained from all children over a 2-year period with 6-months interval and from one parent at the child's age of 12 and 24 months and cultured for Streptococcus pneumoniae and S. aureus. Between July 2005 and February 2006, 1005 children were enrolled and received either 2-doses of PCV7 (n = 336), 2+1-doses (336) or no dose (n = 333) before PCV7 implementation in the Dutch national immunization program. S. aureus colonisation had doubled in children in the 2+1-dose group at 12 months of age compared with unvaccinated controls (10.1% versus 5.0%; p = 0.019). A negative association for co-colonisation of S. pneumoniae and S. aureus was observed for both vaccine serotype (adjusted odds ratio (aOR) 0.53, 95% confidence interval (CI) 0.38-0.74) and nonvaccine serotype pneumococci (aOR 0.67, 95% CI 0.52-0.88).\\n\\nCONCLUSIONS/SIGNIFICANCE: PCV7 induces a temporary increase in S. aureus colonisation in children around 12 months of age after a 2+1-dose PCV7 schedule. The potential clinical consequences are unknown and monitoring is warranted.\\n\\nTRIAL REGISTRATION: ClinicalTrials.gov NCT00189020.", "link"=>"http://www.mendeley.com/research/effect-sevenvalent-pneumococcal-conjugate-vaccine-staphylococcus-aureus-colonisation-randomised-cont", "reader_count"=>53, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>15, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>3, "Student > Master"=>7, "Other"=>4, "Student > Bachelor"=>3, "Lecturer"=>3, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>15, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>3, "Student > Master"=>7, "Other"=>4, "Student > Bachelor"=>3, "Lecturer"=>3, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>8, "Biochemistry, Genetics and Molecular Biology"=>2, "Mathematics"=>1, "Medicine and Dentistry"=>27, "Agricultural and Biological Sciences"=>10, "Psychology"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>27}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>8}}, "reader_count_by_country"=>{"United States"=>1, "United Kingdom"=>1}, "group_count"=>6}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/766735"], "description"=>"a<p>Calculated using a multivariate logistic regression model also including PCV7 vaccination schedule (none, 2-dose, 2+1-dose PCV7 schedule), presence of siblings in the household (no/yes), and sex (male/female).</p>b<p>Calculated using a multivariate logistic regression model also including PCV7 vaccination schedule (none, 2-dose, 2+1-dose PCV7 schedule), day care attendance (no/yes), presence of siblings in the household (no/yes), and sex (male/female).</p>", "links"=>[], "tags"=>["ratios", "colonisation", "adjusted", "co-colonisation"], "article_id"=>437100, "categories"=>["Biotechnology", "Infectious Diseases", "Immunology", "Medicine"], "users"=>["Elske J. M. van Gils", "Eelko Hak", "Reinier H. Veenhoven", "Gerwin D. Rodenburg", "Debby Bogaert", "Jacob P. Bruin", "Loek van Alphen", "Elisabeth A. M. Sanders"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020229.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_and_odds_ratios_of_colonisation_with_S_aureus_adjusted_for_co_colonisation_with_S_pneumoniae_and_other_risk_factors_/437100", "title"=>"Distribution and odds ratios of colonisation with <i>S. aureus</i> adjusted for co-colonisation with <i>S. pneumoniae</i> and other risk factors.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-06-10 01:58:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/766691"], "description"=>"<p>Parents of twins (n = 15 pairs) were excluded. Analyses were performed with Chi-square or 2-sided Fisher Exact test where appropriate.</p>a<p>for the control group: n = 305; for the 2-dose group: n = 318; for the 2+1-dose group: n = 328.</p>b<p>for the control group: n = 296; for the 2-dose group: n = 309; for the 2+1-dose group: n = 321.</p>", "links"=>[], "tags"=>["colonisation", "parents", "unvaccinated", "children", "receiving", "2-dose"], "article_id"=>437050, "categories"=>["Biotechnology", "Infectious Diseases", "Immunology", "Medicine"], "users"=>["Elske J. M. van Gils", "Eelko Hak", "Reinier H. Veenhoven", "Gerwin D. Rodenburg", "Debby Bogaert", "Jacob P. Bruin", "Loek van Alphen", "Elisabeth A. M. Sanders"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020229.t001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nasopharyngeal_colonisation_of_S_pneumoniae_and_S_aureus_in_parents_of_unvaccinated_children_and_of_children_receiving_a_2_dose_or_2_1_dose_PCV7_schedule_/437050", "title"=>"Nasopharyngeal colonisation of <i>S. pneumoniae</i> and <i>S. aureus</i> in parents of unvaccinated children and of children receiving a 2-dose or 2+1-dose PCV7-schedule.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-06-10 01:57:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/766427"], "description"=>"<p>PCV7 indicates 7-valent pneumococcal conjugate vaccine; wks – weeks; m – months.</p>", "links"=>[], "tags"=>["colonisation", "pcv7-unvaccinated", "children"], "article_id"=>436789, "categories"=>["Biotechnology", "Infectious Diseases", "Immunology", "Medicine"], "users"=>["Elske J. M. van Gils", "Eelko Hak", "Reinier H. Veenhoven", "Gerwin D. Rodenburg", "Debby Bogaert", "Jacob P. Bruin", "Loek van Alphen", "Elisabeth A. M. Sanders"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020229.g001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_S_pneumoniae_and_S_aureus_colonisation_in_PCV7_unvaccinated_control_children_in_The_Netherlands_/436789", "title"=>"<i>S. pneumoniae</i> and <i>S aureus</i> colonisation in PCV7-unvaccinated control children in The Netherlands.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-06-10 01:53:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/385099", "https://ndownloader.figshare.com/files/385146", "https://ndownloader.figshare.com/files/385234"], "description"=>"<div><h3>Background</h3><p>Heptavalent pneumococcal conjugate vaccine (PCV7) shifts nasopharyngeal colonisation with vaccine serotype pneumococci towards nonvaccine serotypes. Because of the reported negative association of vaccine serotype pneumococci and <em>Staphylococcus aureus</em> in the nasopharynx, we explored the effect of PCV7 on nasopharyngeal colonisation with <em>S. aureus</em> in children and parents.</p> <h3>Methodology/Principal Findings</h3><p>This study was part of a randomised controlled trial on the effect of PCV7 on pneumococcal carriage, enrolling healthy newborns who were randomly assigned (1∶1∶1) to receive PCV7 (1) at 2 and 4 months of age (2) at 2, 4 and 11 months or (3) no PCV7 (controls). Nasopharyngeal colonisation of <em>S. aureus</em> was a planned secondary outcome. Nasopharyngeal swabs were obtained from all children over a 2-year period with 6-months interval and from one parent at the child's age of 12 and 24 months and cultured for <em>Streptococcus pneumoniae</em> and <em>S. aureus</em>. Between July 2005 and February 2006, 1005 children were enrolled and received either 2-doses of PCV7 (n = 336), 2+1-doses (336) or no dose (n = 333) before PCV7 implementation in the Dutch national immunization program. <em>S. aureus</em> colonisation had doubled in children in the 2+1-dose group at 12 months of age compared with unvaccinated controls (10.1% versus 5.0%; p = 0.019). A negative association for co-colonisation of <em>S. pneumoniae</em> and <em>S. aureus</em> was observed for both vaccine serotype (adjusted odds ratio (aOR) 0.53, 95% confidence interval (CI) 0.38–0.74) and nonvaccine serotype pneumococci (aOR 0.67, 95% CI 0.52–0.88).</p> <h3>Conclusions/Significance</h3><p>PCV7 induces a temporary increase in <em>S. aureus</em> colonisation in children around 12 months of age after a 2+1-dose PCV7 schedule. The potential clinical consequences are unknown and monitoring is warranted.</p> <h3>Trial Registration</h3><p>ClinicalTrials.gov <a href=\"http://clinicaltrials.gov/ct2/show/NCT00189020\">NCT00189020</a></p> </div>", "links"=>[], "tags"=>["seven-valent", "pneumococcal", "conjugate", "colonisation", "randomised", "controlled"], "article_id"=>136017, "categories"=>["Biotechnology", "Cancer", "Immunology", "Medicine"], "users"=>["Elske J. M. van Gils", "Eelko Hak", "Reinier H. Veenhoven", "Gerwin D. Rodenburg", "Debby Bogaert", "Jacob P. Bruin", "Loek van Alphen", "Elisabeth A. M. Sanders"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0020229.s001", "https://dx.doi.org/10.1371/journal.pone.0020229.s002", "https://dx.doi.org/10.1371/journal.pone.0020229.s003"], "stats"=>{"downloads"=>11, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Effect_of_Seven_Valent_Pneumococcal_Conjugate_Vaccine_on_Staphylococcus_aureus_Colonisation_in_a_Randomised_Controlled_Trial/136017", "title"=>"Effect of Seven-Valent Pneumococcal Conjugate Vaccine on <em>Staphylococcus aureus</em> Colonisation in a Randomised Controlled Trial", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-06-10 01:40:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/766783"], "description"=>"<p>OR – Odds ratio; CI – Confidence interval; PCV7 – 7-valent pneumococcal conjugate vaccine.</p>a<p>Calculated using a Generalized Estimating Equations model with <i>S. aureus</i> colonisation as dependent variable and age as within-subject variable with un unstructured correlation structure. Data from all infants at age 6, 12, 18 and 24 months were included in the model; data from age 6 weeks were excluded since day care attendance was not present at this age.</p>", "links"=>[], "tags"=>["factors", "colonisation", "children", "24", "months", "generalized", "estimating"], "article_id"=>437144, "categories"=>["Biotechnology", "Infectious Diseases", "Immunology", "Medicine"], "users"=>["Elske J. M. van Gils", "Eelko Hak", "Reinier H. Veenhoven", "Gerwin D. Rodenburg", "Debby Bogaert", "Jacob P. Bruin", "Loek van Alphen", "Elisabeth A. M. Sanders"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020229.t002", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Risk_factors_for_S_aureus_colonisation_in_children_between_6_and_24_months_of_age_using_a_Generalized_Estimating_Equations_model_/437144", "title"=>"Risk factors for <i>S. aureus</i> colonisation in children between 6 and 24 months of age using a Generalized Estimating Equations-model.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-06-10 01:59:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/766574"], "description"=>"<p>PCV7 indicates 7-valent pneumococcal conjugate vaccine; wks – weeks; m – months * P<0.05 versus control group using Generalised Estimating Equations-model.</p>", "links"=>[], "tags"=>["pcv7", "nasopharyngeal", "colonisation"], "article_id"=>436940, "categories"=>["Biotechnology", "Infectious Diseases", "Immunology", "Medicine"], "users"=>["Elske J. M. van Gils", "Eelko Hak", "Reinier H. Veenhoven", "Gerwin D. Rodenburg", "Debby Bogaert", "Jacob P. Bruin", "Loek van Alphen", "Elisabeth A. M. Sanders"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020229.g002", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_PCV7_on_nasopharyngeal_S_aureus_colonisation_in_children_/436940", "title"=>"Effect of PCV7 on nasopharyngeal <i>S aureus</i> colonisation in children.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-06-10 01:55:40"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
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  • {"unique-ip"=>"5", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
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  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
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  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
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  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
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Relative Metric

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