Autoantibodies against a 43 KDa Muscle Protein in Inclusion Body Myositis
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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/772671"], "description"=>"<p>Images from all immunoblots are shown. Reactivity is present in 13 of 25 different inclusion body myositis (IBM) plasma samples, but in none of 10 dermatomyositis (DM), 10 polymyositis (PM), 5 myasthenia gravis (MG) or 15 normal volunteer (NL) plasma samples.</p>", "links"=>[], "tags"=>["autoantibodies", "43", "kda", "autoantigen", "inclusion", "myositis"], "article_id"=>443042, "categories"=>["Immunology"], "users"=>["Mohammad Salajegheh", "Theresa Lam", "Steven A. Greenberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020266.g001", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Circulating_autoantibodies_against_a_43_kDa_muscle_autoantigen_in_inclusion_body_myositis_IBM_/443042", "title"=>"Circulating autoantibodies against a 43 kDa muscle autoantigen in inclusion body myositis (IBM).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-05-23 00:50:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/387708", "https://ndownloader.figshare.com/files/387726"], "description"=>"<div><h3>Background</h3><p>Inclusion body myositis (IBM) is a poorly understood and refractory autoimmune muscle disease. Though widely believed to have no significant humoral autoimmunity, we sought to identify novel autoantibodies with high specificity for this disease.</p> <h3>Methodology/Principal Findings</h3><p>Plasma autoantibodies from 65 people, including 25 with IBM, were analyzed by immunoblots against normal human muscle. Thirteen of 25 (52%) IBM patient samples recognized an approximately 43 kDa muscle protein. No other disease (N = 25) or healthy volunteer (N = 15) samples recognized this protein.</p> <h3>Conclusions</h3><p>Circulating antibodies against a 43-kDa muscle autoantigen may lead to the discovery of a novel biomarker for IBM. Its high specificity for IBM among patients with autoimmune myopathies furthermore suggests a relationship to disease pathogenesis.</p> </div>", "links"=>[], "tags"=>["autoantibodies", "43", "kda", "inclusion", "myositis"], "article_id"=>136571, "categories"=>["Immunology"], "users"=>["Mohammad Salajegheh", "Theresa Lam", "Steven A. Greenberg"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0020266.s001", "https://dx.doi.org/10.1371/journal.pone.0020266.s002"], "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Autoantibodies_against_a_43_KDa_Muscle_Protein_in_Inclusion_Body_Myositis/136571", "title"=>"Autoantibodies against a 43 KDa Muscle Protein in Inclusion Body Myositis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-05-23 01:49:31"}

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  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
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Relative Metric

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