Early and Late Postnatal Myocardial and Vascular Changes in a Protein Restriction Rat Model of Intrauterine Growth Restriction
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{"title"=>"Early and late postnatal myocardial and vascular changes in a protein restriction rat model of intrauterine growth restriction", "type"=>"journal", "authors"=>[{"first_name"=>"Carlos", "last_name"=>"Menendez-Castro", "scopus_author_id"=>"22035642700"}, {"first_name"=>"Fabian", "last_name"=>"Fahlbusch", "scopus_author_id"=>"26646410900"}, {"first_name"=>"Nada", "last_name"=>"Cordasic", "scopus_author_id"=>"8553894400"}, {"first_name"=>"Kerstin", "last_name"=>"Amann", "scopus_author_id"=>"7005200672"}, {"first_name"=>"Kathrin", "last_name"=>"Münzel", "scopus_author_id"=>"42962019400"}, {"first_name"=>"Christian", "last_name"=>"Plank", "scopus_author_id"=>"57198395420"}, {"first_name"=>"Rainer", "last_name"=>"Wachtveitl", "scopus_author_id"=>"38863320500"}, {"first_name"=>"Wolfgang", "last_name"=>"Rascher", "scopus_author_id"=>"55378838800"}, {"first_name"=>"Karl F.", "last_name"=>"Hilgers", "scopus_author_id"=>"7007122196"}, {"first_name"=>"Andrea", "last_name"=>"Hartner", "scopus_author_id"=>"6603902982"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"79957796725", "pui"=>"361862645", "pmid"=>"21655297", "issn"=>"19326203", "scopus"=>"2-s2.0-79957796725", "doi"=>"10.1371/journal.pone.0020369"}, "id"=>"8884c350-139f-37d2-b4cf-86c9a390bcfa", "abstract"=>"Intrauterine growth restriction (IUGR) is a risk factor for cardiovascular disease in later life. Early structural and functional changes in the cardiovascular system after IUGR may contribute to its pathogenesis. We tested the hypothesis that IUGR leads to primary myocardial and vascular alterations before the onset of hypertension. A rat IUGR model of maternal protein restriction during gestation was used. Dams were fed low protein (LP; casein 8.4%) or isocaloric normal protein diet (NP; casein 17.2%). The offspring was reduced to six males per litter. Immunohistochemical and real-time PCR analyses were performed in myocardial and vascular tissue of neonates and animals at day 70 of life. In the aortas of newborn IUGR rats expression of connective tissue growth factor (CTGF) was induced 3.2-fold. At day 70 of life, the expression of collagen I was increased 5.6-fold in aortas of IUGR rats. In the hearts of neonate IUGR rats, cell proliferation was more prominent compared to controls. At day 70 the expression of osteopontin was induced 7.2-fold. A 3- to 7-fold increase in the expression of the profibrotic cytokines TGF-β and CTGF as well as of microfibrillar matrix molecules was observed. The myocardial expression and deposition of collagens was more prominent in IUGR animals compared to controls at day 70. In the low-protein diet model, IUGR leads to changes in the expression patterns of profibrotic genes and discrete structural abnormalities of vessels and hearts in adolescence, but, with the exception of CTGF, not as early as at the time of birth. Invasive and non-invasive blood pressure measurements confirmed that IUGR rats were normotensive at the time point investigated and that the changes observed occurred independently of an increased blood pressure. Hence, altered matrix composition of the vascular wall and the myocardium may predispose IUGR animals to cardiovascular disease later in life.", "link"=>"http://www.mendeley.com/research/early-late-postnatal-myocardial-vascular-changes-protein-restriction-rat-model-intrauterine-growth-r", "reader_count"=>12, "reader_count_by_academic_status"=>{"Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>2, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}}, "group_count"=>1}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/769208"], "description"=>"<p>A: Birth weights, B: body weights at day 70 of life and C: relative heart weights at day 70 of life of rats with intrauterine growth restriction (LP) and their respective controls (NP). Data are means±sem.</p>", "links"=>[], "tags"=>["Nephrology", "obstetrics", "pediatrics and child health"], "article_id"=>439568, "categories"=>["Cell Biology", "Marine Biology", "Medicine"], "users"=>["Carlos Menendez-Castro", "Fabian Fahlbusch", "Nada Cordasic", "Kerstin Amann", "Kathrin Münzel", "Christian Plank", "Rainer Wachtveitl", "Wolfgang Rascher", "Karl F. Hilgers", "Andrea Hartner"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0020369.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Body_and_relative_heart_weights_/439568", "title"=>"Body and relative heart weights.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:53:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/769280"], "description"=>"<p>Systolic (A), diastolic (B) and mean arterial (C) blood pressure values of two IUGR-rats (LP) and two controls (NP) at the age of 70 days of life obtained by telemetric measurements for one week. Data are means ± sem.</p>", "links"=>[], "tags"=>["Nephrology", "obstetrics", "pediatrics and child health"], "article_id"=>439643, "categories"=>["Cell Biology", "Marine Biology", "Medicine"], "users"=>["Carlos Menendez-Castro", "Fabian Fahlbusch", "Nada Cordasic", "Kerstin Amann", "Kathrin Münzel", "Christian Plank", "Rainer Wachtveitl", "Wolfgang Rascher", "Karl F. Hilgers", "Andrea Hartner"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0020369.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Telemetric_blood_pressure_measurements_/439643", "title"=>"Telemetric blood pressure measurements.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:53:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/769390"], "description"=>"<p>Representative photomicrographs of immunostainings for osteopontin (OPN) in myocardial tissue of neonatal control rats and neonatal rats with intrauterine growth restriction (neo); and in myocardial tissue of control rats and rats with intrauterine growth restriction at day 70 of life (d70). NP, control rats; LP, rats with intrauterine growth restriction. Arrow indicates positive immunoreactivity for OPN in the media of myocardial vessels in LP at day 70.</p>", "links"=>[], "tags"=>["myocardial", "stainings"], "article_id"=>439759, "categories"=>["Cell Biology", "Marine Biology", "Medicine"], "users"=>["Carlos Menendez-Castro", "Fabian Fahlbusch", "Nada Cordasic", "Kerstin Amann", "Kathrin Münzel", "Christian Plank", "Rainer Wachtveitl", "Wolfgang Rascher", "Karl F. Hilgers", "Andrea Hartner"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0020369.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Examples_of_myocardial_stainings_for_osteopontin_/439759", "title"=>"Examples of myocardial stainings for osteopontin.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:54:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/769577"], "description"=>"<p>A: Protein expression of connective tissue growth factor (CTGF) in aortas of newborn rats with intrauterine growth restriction (LP, n = 4) and their respective controls (NP; n = 5). Data are means ± sem. B: Example of Western blot analysis detecting connective tissue growth factor (CTGF). Tubulin was used as a loading control.</p>", "links"=>[], "tags"=>["ctgf"], "article_id"=>439946, "categories"=>["Cell Biology", "Marine Biology", "Medicine"], "users"=>["Carlos Menendez-Castro", "Fabian Fahlbusch", "Nada Cordasic", "Kerstin Amann", "Kathrin Münzel", "Christian Plank", "Rainer Wachtveitl", "Wolfgang Rascher", "Karl F. Hilgers", "Andrea Hartner"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0020369.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Aortal_CTGF_expression_/439946", "title"=>"Aortal CTGF expression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:55:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/769698"], "description"=>"<p>Evaluation of the percentage of positive immunostaining for collagen I (coll I) in myocardial tissue of (A) neonatal control rats and neonatal rats with intrauterine growth restriction (neo) with representative photomicrographs; and in myocardial tissue of (B) control rats and rats with intrauterine growth restriction at day 70 of life (d70) with representative photomicrographs. NP, control rats; LP, rats with intrauterine growth restriction. Data are means ± sem.</p>", "links"=>[], "tags"=>["deposition", "collagen"], "article_id"=>440064, "categories"=>["Cell Biology", "Marine Biology", "Medicine"], "users"=>["Carlos Menendez-Castro", "Fabian Fahlbusch", "Nada Cordasic", "Kerstin Amann", "Kathrin Münzel", "Christian Plank", "Rainer Wachtveitl", "Wolfgang Rascher", "Karl F. Hilgers", "Andrea Hartner"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0020369.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Myocardial_deposition_of_collagen_I_/440064", "title"=>"Myocardial deposition of collagen I.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:55:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/769889"], "description"=>"<p>Evaluation of the percentage of positive immunostaining for collagen IV (coll IV) in myocardial tissue of (A) neonatal control rats and neonatal rats with intrauterine growth restriction (neo) with representative photomicrographs; and in myocardial tissue of (B) control rats and rats with intrauterine growth restriction at day 70 of life (d70) with representative photomicrographs. NP, control rats; LP, rats with intrauterine growth restriction. Data are means ± sem.</p>", "links"=>[], "tags"=>["deposition", "collagen"], "article_id"=>440250, "categories"=>["Cell Biology", "Marine Biology", "Medicine"], "users"=>["Carlos Menendez-Castro", "Fabian Fahlbusch", "Nada Cordasic", "Kerstin Amann", "Kathrin Münzel", "Christian Plank", "Rainer Wachtveitl", "Wolfgang Rascher", "Karl F. Hilgers", "Andrea Hartner"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0020369.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Myocardial_deposition_of_collagen_IV_/440250", "title"=>"Myocardial deposition of collagen IV.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:56:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/770004"], "description"=>"<p>Cell proliferation and areas of medial α-smooth muscle actin stain in aortas and hearts of neonatal rats and of rats at day 70 of life with intrauterine growth restriction (LP) or controls (NP).</p><p>*p<0.05 versus NP.</p>", "links"=>[], "tags"=>["Nephrology", "obstetrics", "pediatrics and child health"], "article_id"=>440367, "categories"=>["Cell Biology", "Marine Biology", "Medicine"], "users"=>["Carlos Menendez-Castro", "Fabian Fahlbusch", "Nada Cordasic", "Kerstin Amann", "Kathrin Münzel", "Christian Plank", "Rainer Wachtveitl", "Wolfgang Rascher", "Karl F. Hilgers", "Andrea Hartner"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0020369.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Markers_of_cell_growth_and_differentiation_/440367", "title"=>"Markers of cell growth and differentiation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 17:57:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/770043"], "description"=>"<p>Macrophage infiltration and expression of the chemotactic peptides MCP-1 and osteopontin in aortas and hearts of neonatal rats and in rats at day 70 of life with intrauterine growth restriction (LP) or controls (NP).</p>a<p>In aortas, MCP-1 and osteopontin expression were below detection limits.</p><p>*p<0.05 versus NP.</p>", "links"=>[], "tags"=>["Nephrology", "obstetrics", "pediatrics and child health"], "article_id"=>440406, "categories"=>["Cell Biology", "Marine Biology", "Medicine"], "users"=>["Carlos Menendez-Castro", "Fabian Fahlbusch", "Nada Cordasic", "Kerstin Amann", "Kathrin Münzel", "Christian Plank", "Rainer Wachtveitl", "Wolfgang Rascher", "Karl F. Hilgers", "Andrea Hartner"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0020369.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Markers_of_inflammation_/440406", "title"=>"Markers of inflammation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 17:57:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/770071"], "description"=>"<p>Designed SYBR Green primer pairs and primer pairs and TaqMan probes used in this study.</p>", "links"=>[], "tags"=>["primer"], "article_id"=>440439, "categories"=>["Cell Biology", "Marine Biology", "Medicine"], "users"=>["Carlos Menendez-Castro", "Fabian Fahlbusch", "Nada Cordasic", "Kerstin Amann", "Kathrin Münzel", "Christian Plank", "Rainer Wachtveitl", "Wolfgang Rascher", "Karl F. Hilgers", "Andrea Hartner"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0020369.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_List_of_primer_pairs_/440439", "title"=>"List of primer pairs.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 17:58:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/770118"], "description"=>"<p>mRNA expression of markers of fibrosis and type I and IV collagen stain in aortas and hearts of neonatal rats and in rats at day 70 of life with intrauterine growth restriction (LP) or controls (NP).</p><p>*p<0.05 versus NP.</p>", "links"=>[], "tags"=>["Nephrology", "obstetrics", "pediatrics and child health"], "article_id"=>440482, "categories"=>["Cell Biology", "Marine Biology", "Medicine"], "users"=>["Carlos Menendez-Castro", "Fabian Fahlbusch", "Nada Cordasic", "Kerstin Amann", "Kathrin Münzel", "Christian Plank", "Rainer Wachtveitl", "Wolfgang Rascher", "Karl F. Hilgers", "Andrea Hartner"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0020369.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Markers_of_fibrosis_/440482", "title"=>"Markers of fibrosis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 17:58:12"}

PMC Usage Stats | Further Information

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