Pirt, a TRPV1 Modulator, Is Required for Histamine-Dependent and -Independent Itch
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{"title"=>"Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch", "type"=>"journal", "authors"=>[{"first_name"=>"Kush N.", "last_name"=>"Patel", "scopus_author_id"=>"24071310800"}, {"first_name"=>"Qin", "last_name"=>"Liu", "scopus_author_id"=>"56182778800"}, {"first_name"=>"Sonya", "last_name"=>"Meeker", "scopus_author_id"=>"6603715544"}, {"first_name"=>"Bradley J.", "last_name"=>"Undem", "scopus_author_id"=>"7006851449"}, {"first_name"=>"Xinzhong", "last_name"=>"Dong", "scopus_author_id"=>"7401796654"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"79957823351", "doi"=>"10.1371/journal.pone.0020559", "issn"=>"19326203", "pui"=>"361862723", "isbn"=>"1932-6203; 1932-6203", "pmid"=>"21655234", "scopus"=>"2-s2.0-79957823351"}, "id"=>"7f032bf2-c8ac-3859-bc77-ea9f7af404b7", "abstract"=>"Itch, or pruritus, is an important clinical problem whose molecular basis has yet to be understood. Recent work has begun to identify genes that contribute to detecting itch at the molecular level. Here we show that Pirt, known to play a vital part in sensing pain through modulation of the transient receptor potential vanilloid 1 (TRPV1) channel, is also necessary for proper itch sensation. Pirt(-/-) mice exhibit deficits in cellular and behavioral responses to various itch-inducing compounds, or pruritogens. Pirt contributes to both histaminergic and nonhistaminergic itch and, crucially, is involved in forms of itch that are both TRPV1-dependent and -independent. Our findings demonstrate that the function of Pirt extends beyond nociception via TRPV1 regulation to its role as a critical component in several itch signaling pathways.", "link"=>"http://www.mendeley.com/research/pirt-trpv1-modulator-required-histaminedependent-independent-itch", "reader_count"=>43, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>18, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>2, "Other"=>1, "Student > Master"=>2, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>18, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>2, "Other"=>1, "Student > Master"=>2, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>13, "Agricultural and Biological Sciences"=>23, "Neuroscience"=>1, "Chemistry"=>2, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>23}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Japan"=>1, "United Kingdom"=>1, "Australia"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/769749"], "description"=>"<p>(<b>A</b>, <b>B</b>) CQ (200 µg) induces significantly less scratching behavior in <i>Pirt<sup>−/−</sup></i> mice (n = 9) than WT controls (n = 8). (<b>C</b>) A smaller percentage of Pirt KO neurons respond to CQ (1 mM) compared to WT (n = 5 per genotype). (<b>D</b>, <b>E</b>) The 5HT<sub>2</sub>-selective agonist α-Me-5HT (30 µg) produces decreased scratching in KO mice (n = 8; WT, n = 13). (<b>F</b>) Responses to 5HT (10 µM) are unchanged in Pirt KO DRG neurons (n = 4 per genotype). * <i>p</i><0.05, ** <i>p</i><0.001, *** <i>p</i><0.0001; two-tailed unpaired <i>t</i>-test.</p>", "links"=>[], "tags"=>["itch", "requires"], "article_id"=>440120, "categories"=>["Neuroscience"], "users"=>["Kush N. Patel", "Qin Liu", "Sonya Meeker", "Bradley J. Undem", "Xinzhong Dong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020559.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nonhistaminergic_itch_requires_Pirt_/440120", "title"=>"Nonhistaminergic itch requires Pirt.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:56:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/769598"], "description"=>"<p>(<b>A</b>) The time course shows scratching bouts, presented as mean ± SEM, in response to histamine injection (10 µmol) over a 30 min period divided into 5 min intervals. (<b>B</b>) Total bouts of scratching over the 30 min observation period show <i>Pirt<sup>−/−</sup></i> mice (n = 7) have decreased behavioral responses to histamine compared to WT mice (n = 8). (<b>C</b>) Ca<sup>2+</sup> imaging shows fewer DRG neurons from Pirt KO mice respond to histamine (50 µM) than WT mice (n = 5 per genotype). (<b>D</b>, <b>E</b>) Pirt mutant mice (n = 10) also scratch less upon injection of the histamine H1 receptor-selective agonist HTMT (0.1 µmol) than WT (n = 9). * <i>p</i><0.05, ** <i>p</i><0.001, *** <i>p</i><0.0001; two-tailed unpaired <i>t</i>-test.</p>", "links"=>[], "tags"=>["contributes", "histaminergic"], "article_id"=>439966, "categories"=>["Neuroscience"], "users"=>["Kush N. Patel", "Qin Liu", "Sonya Meeker", "Bradley J. Undem", "Xinzhong Dong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020559.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pirt_contributes_to_histaminergic_itch_/439966", "title"=>"Pirt contributes to histaminergic itch.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:55:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/769960"], "description"=>"<p>(<b>A</b>, <b>B</b>) In an allergy model, ovalbumin (50 µg) induces less scratching in <i>Pirt<sup>−/−</sup></i> (n = 11) and SASH (n = 7) mice compared to WT controls (n = 8). (<b>C</b>, <b>D</b>) Pirt KO mice (n = 11) show a trend toward decreased scratching compared to WT (n = 13) when injected with compound 48/80 (30 µg), but this difference just misses statistical significance (<i>p</i><0.06). * <i>p</i><0.05, **** <i>p</i><0.00001; two-tailed unpaired <i>t</i>-test.</p>", "links"=>[], "tags"=>["mast", "cell-dependent"], "article_id"=>440334, "categories"=>["Neuroscience"], "users"=>["Kush N. Patel", "Qin Liu", "Sonya Meeker", "Bradley J. Undem", "Xinzhong Dong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020559.g004", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pirt_plays_a_role_in_mast_cell_dependent_itch_/440334", "title"=>"Pirt plays a role in mast cell-dependent itch.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:57:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/770047"], "description"=>"<p>(<b>A</b>, <b>B</b>) Pirt WT (n = 10) and KO (n = 8) mice display comparable formalin-induced (5%) itch behavior. (<b>C</b>) Ca<sup>2+</sup> responses to formalin (0.02%) are unaltered in Pirt mutant DRG neurons (n = 6 per genotype). (<b>D</b>) Saline vehicle induces a similar baseline, i.e. spontaneous, scratching response in <i>Pirt<sup>−/−</sup></i> (n = 5) and WT (n = 7) mice.</p>", "links"=>[], "tags"=>["types"], "article_id"=>440418, "categories"=>["Neuroscience"], "users"=>["Kush N. Patel", "Qin Liu", "Sonya Meeker", "Bradley J. Undem", "Xinzhong Dong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020559.g005", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pirt_is_not_involved_in_all_types_of_itch_/440418", "title"=>"Pirt is not involved in all types of itch.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:57:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/769862"], "description"=>"<p>(<b>A</b>) Cellular responses to SLIGRL (130 µM) are fewer in DRG neurons from <i>Pirt<sup>−/−</sup></i> mice (n = 5 per genotype). (<b>B</b>) Pirt mutants (n = 11) scratch less than WT mice (n = 13) upon SLIGRL injection (0.1 µmol), but the difference is not statistically significant. (<b>C</b>, <b>D</b>) ET-1 (10 pmol) generates a decreased behavioral response in Pirt KO (n = 10) versus WT (n = 9). * <i>p</i><0.05, ** <i>p</i><0.001; two-tailed unpaired <i>t</i>-test.</p>", "links"=>[], "tags"=>["et-1-induced", "responses"], "article_id"=>440239, "categories"=>["Neuroscience"], "users"=>["Kush N. Patel", "Qin Liu", "Sonya Meeker", "Bradley J. Undem", "Xinzhong Dong"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020559.g003", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SLIGRL_and_ET_1_induced_responses_are_Pirt_dependent_/440239", "title"=>"SLIGRL- and ET-1-induced responses are Pirt-dependent.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:56:49"}

PMC Usage Stats | Further Information

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Relative Metric

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