Genomic Polymorphism of the Pandemic A (H1N1) Influenza Viruses Correlates with Viral Replication, Virulence, and Pathogenicity In Vitro and In Vivo
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{"title"=>"Genomic polymorphism of the pandemic A (H1N1) influenza viruses correlates with viral replication, virulence, and pathogenicity in vitro and in vivo", "type"=>"journal", "authors"=>[{"first_name"=>"Lili", "last_name"=>"Xu", "scopus_author_id"=>"55547112139"}, {"first_name"=>"Linlin", "last_name"=>"Bao", "scopus_author_id"=>"35314489100"}, {"first_name"=>"Jianfang", "last_name"=>"Zhou", "scopus_author_id"=>"34871165300"}, {"first_name"=>"Dayan", "last_name"=>"Wang", "scopus_author_id"=>"8345478900"}, {"first_name"=>"Wei", "last_name"=>"Deng", "scopus_author_id"=>"55708608900"}, {"first_name"=>"Qi", "last_name"=>"Lv", "scopus_author_id"=>"36901025600"}, {"first_name"=>"Yila", "last_name"=>"Ma", "scopus_author_id"=>"36668991100"}, {"first_name"=>"Fengdi", "last_name"=>"Li", "scopus_author_id"=>"36437162400"}, {"first_name"=>"Huihui", "last_name"=>"Sun", "scopus_author_id"=>"56125872700"}, {"first_name"=>"Lingjun", "last_name"=>"Zhan", "scopus_author_id"=>"25642040300"}, {"first_name"=>"Hua", "last_name"=>"Zhu", "scopus_author_id"=>"56201637400"}, {"first_name"=>"Chunmei", "last_name"=>"Ma", "scopus_author_id"=>"16834878400"}, {"first_name"=>"Yuelong", "last_name"=>"Shu", "scopus_author_id"=>"7103239481"}, {"first_name"=>"Chuan", "last_name"=>"Qin", "scopus_author_id"=>"7102688076"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"361953007", "doi"=>"10.1371/journal.pone.0020698", "sgr"=>"79958776585", "scopus"=>"2-s2.0-79958776585", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"21698272"}, "id"=>"80da6e1b-02cc-30d2-a160-ad2c40f9c0d7", "abstract"=>"The novel pandemic A (H1N1) virus was first identified in Mexico in April 2009 and quickly spread worldwide. Like all influenzas, the H1N1 strain-specific properties of replication, virulence, and pathogenicity are a result of the particular genomic sequence and concerted expression of multiple genes. Thus, specific mutations may support increased virulence and may be useful as biomarkers of potential threat to human health. We performed comparative genomic analysis of ten strains of the 2009 pandemic A (H1N1) influenza viruses to determine whether genotypes associated with clinical phenotypes, which ranged from mild to severe illness and up to lethal. Virus replication capacity was tested for each strain in vitro using cultured epithelial cells, while virulence and pathogenicity were investigated in vivo using the BALB/c mouse model. The results indicated that A/Sichuan/1/2009 strain had significantly higher replication ability and virulence than the other strains, and five unique non-synonymous mutations were identified in important gene-encoding sequences. These mutations led to amino acid substitutions in HA (L32I), PA (A343T), PB1 (K353R and T566A), and PB2 (T471M), and may be critical molecular determinants for replication, virulence, and pathogenicity. Our results suggested that the replication capacity in vitro and virulence in vivo of the 2009 pandemic A (H1N1) viruses were not associated with the clinical phenotypes. This study offers new insights into the transmission and evolution of the 2009 pandemic A (H1N1) virus.", "link"=>"http://www.mendeley.com/research/genomic-polymorphism-pandemic-h1n1-influenza-viruses-correlates-viral-replication-virulence-pathogen", "reader_count"=>23, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Ph. D. Student"=>8, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>2, "Professor > Associate Professor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Ph. D. Student"=>8, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>2, "Professor > Associate Professor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>1, "Veterinary Science and Veterinary Medicine"=>2, "Social Sciences"=>1, "Computer Science"=>2, "Immunology and Microbiology"=>3, "Materials Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Materials Science"=>{"Materials Science"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/765194"], "description"=>"<p>The numbering of the residues are from the first amino acid in the methionine start site of each gene of influenza viruses.</p>", "links"=>[], "tags"=>["encoding", "sequences", "alignment", "2009", "pandemic", "influenza"], "article_id"=>435546, "categories"=>["Cell Biology", "Microbiology", "Virology", "Infectious Diseases", "Immunology", "Biotechnology", "Biological Sciences", "Genetics"], "users"=>["Lili Xu", "Linlin Bao", "Jianfang Zhou", "Dayan Wang", "Wei Deng", "Qi Lv", "Yila Ma", "Fengdi Li", "Huihui Sun", "Lingjun Zhan", "Hua Zhu", "Chunmei Ma", "Yuelong Shu", "Chuan Qin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020698.t002", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Protein_encoding_sequences_alignment_of_the_ten_2009_pandemic_A_H1N1_influenza_viruses_/435546", "title"=>"Protein encoding sequences alignment of the ten 2009 pandemic A (H1N1) influenza viruses.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 17:31:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/764921"], "description"=>"<p>Ten mice from each group were euthanized at 5 d.p.i. to obtain lung tissue biopsies, and for each lung three 4-µm sections were stained with H&E for pathological investigations. (A) Representative sections of H&E stained lung tissues from 10<sup>6</sup> TCID<sub>50</sub> intranasally challenged mice. (B) Percentage of lesion area in lung tissues.</p>", "links"=>[], "tags"=>["tissues", "challenged"], "article_id"=>435277, "categories"=>["Cell Biology", "Microbiology", "Virology", "Infectious Diseases", "Immunology", "Biotechnology", "Biological Sciences", "Genetics"], "users"=>["Lili Xu", "Linlin Bao", "Jianfang Zhou", "Dayan Wang", "Wei Deng", "Qi Lv", "Yila Ma", "Fengdi Li", "Huihui Sun", "Lingjun Zhan", "Hua Zhu", "Chunmei Ma", "Yuelong Shu", "Chuan Qin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020698.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pathological_analysis_of_the_lung_tissues_of_challenged_BALB_c_mice_/435277", "title"=>"Pathological analysis of the lung tissues of challenged BALB/c mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:29:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/765049"], "description"=>"<p>(A) Affinity to synthetic 3′SL or 3′DI-SL. (B) Affinity to synthetic 6′SLN or 6′DI-SLN.</p>", "links"=>[], "tags"=>["binding", "assay", "synthetic"], "article_id"=>435408, "categories"=>["Cell Biology", "Microbiology", "Virology", "Infectious Diseases", "Immunology", "Biotechnology", "Biological Sciences", "Genetics"], "users"=>["Lili Xu", "Linlin Bao", "Jianfang Zhou", "Dayan Wang", "Wei Deng", "Qi Lv", "Yila Ma", "Fengdi Li", "Huihui Sun", "Lingjun Zhan", "Hua Zhu", "Chunmei Ma", "Yuelong Shu", "Chuan Qin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020698.g004", "stats"=>{"downloads"=>4, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Direct_binding_assay_with_synthetic_sialylglycopolymers_/435408", "title"=>"Direct binding assay with synthetic sialylglycopolymers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:30:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/765135"], "description"=>"#<p>: E, propagated in in the allantoic cavities of chicken embryonated eggs; C, propagated in MDCK cells.</p>", "links"=>[], "tags"=>["2009", "pandemic", "influenza", "viruses", "investigated"], "article_id"=>435485, "categories"=>["Cell Biology", "Microbiology", "Virology", "Infectious Diseases", "Immunology", "Biotechnology", "Biological Sciences", "Genetics"], "users"=>["Lili Xu", "Linlin Bao", "Jianfang Zhou", "Dayan Wang", "Wei Deng", "Qi Lv", "Yila Ma", "Fengdi Li", "Huihui Sun", "Lingjun Zhan", "Hua Zhu", "Chunmei Ma", "Yuelong Shu", "Chuan Qin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020698.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_main_background_information_of_the_ten_2009_pandemic_A_H1N1_influenza_viruses_investigated_in_this_study_/435485", "title"=>"The main background information of the ten 2009 pandemic A (H1N1) influenza viruses investigated in this study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 17:31:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/764793"], "description"=>"<p>Mice were anesthetized and inoculated intranasally with virus (n = 23 per group; 50 µl of 10<sup>6</sup> TCID<sub>50</sub>). Ten randomly selected mice were monitored daily for signs of disease and mortality, up to 14 d.p.i. for (A), (B), and (C) research, whereas ten of the remaining mice from each group were euthanized at 5 d.p.i. to obtain lung tissue biopsies for use in (D). The final three mice were also sacrificed at 5 d.p.i. and their lungs were collected for (E) detection. (A) Survival percentage of mice. (B) Mean survival days for each challenged group. (C) Body weight changes of infected mice. Mean body weight and SD were calculated as percentage of body weight and compared to those at 0 d.p.i. (D) Viral RNA loads in lung tissues at 5 d.p.i. Data are presented as mean viral loads per microgram ± SD. (E) Viral titers in lung tissues at 5 d.p.i. Data are presented as mean log<sub>10</sub> PFU/mg. * <i>P</i><0.05 compared to the values of other viruses (one-way ANOVA).</p>", "links"=>[], "tags"=>["2009", "pandemic", "influenza", "viruses"], "article_id"=>435149, "categories"=>["Cell Biology", "Microbiology", "Virology", "Infectious Diseases", "Immunology", "Biotechnology", "Biological Sciences", "Genetics"], "users"=>["Lili Xu", "Linlin Bao", "Jianfang Zhou", "Dayan Wang", "Wei Deng", "Qi Lv", "Yila Ma", "Fengdi Li", "Huihui Sun", "Lingjun Zhan", "Hua Zhu", "Chunmei Ma", "Yuelong Shu", "Chuan Qin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0020698.g002", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Virulence_comparison_of_the_ten_2009_pandemic_A_H1N1_influenza_viruses_in_BALB_c_mice_/435149", "title"=>"Virulence comparison of the ten 2009 pandemic A (H1N1) influenza viruses in BALB/c mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 17:29:06"}

PMC Usage Stats | Further Information

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Relative Metric

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