The Gut as Reservoir of Antibiotic Resistance: Microbial Diversity of Tetracycline Resistance in Mother and Infant
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{"title"=>"The gut as reservoir of antibiotic resistance: Microbial diversity of tetracycline resistance in mother and infant", "type"=>"journal", "authors"=>[{"first_name"=>"Lisbeth E.", "last_name"=>"de Vries", "scopus_author_id"=>"35094003100"}, {"first_name"=>"Yvonne", "last_name"=>"Vallès", "scopus_author_id"=>"57191359746"}, {"first_name"=>"Yvonne", "last_name"=>"Agersø", "scopus_author_id"=>"6506895457"}, {"first_name"=>"Parag A.", "last_name"=>"Vaishampayan", "scopus_author_id"=>"16023343300"}, {"first_name"=>"Andrea", "last_name"=>"García-Montaner", "scopus_author_id"=>"41761329600"}, {"first_name"=>"Jennifer V.", "last_name"=>"Kuehl", "scopus_author_id"=>"8901056700"}, {"first_name"=>"Henrik", "last_name"=>"Christensen", "scopus_author_id"=>"7401664058"}, {"first_name"=>"Miriam", "last_name"=>"Barlow", "scopus_author_id"=>"7102675818"}, {"first_name"=>"M. Pilar", "last_name"=>"Francino", "scopus_author_id"=>"7801538383"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-79959677612", "sgr"=>"79959677612", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0021644", "pmid"=>"21738748", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "pui"=>"362023037"}, "id"=>"8d720d6f-14aa-36bd-b1fa-37b36b459763", "abstract"=>"The microbiota in the human gastrointestinal tract (GIT) is highly exposed to antibiotics, and may be an important reservoir of resistant strains and transferable resistance genes. Maternal GIT strains can be transmitted to the offspring, and resistances could be acquired from birth. This is a case study using a metagenomic approach to determine the diversity of microorganisms conferring tetracycline resistance (Tc(r)) in the guts of a healthy mother-infant pair one month after childbirth, and to investigate the potential for horizontal transfer and maternal transmission of Tc(r) genes. Fecal fosmid libraries were functionally screened for Tc(r), and further PCR-screened for specific Tc(r) genes. Tc(r) fosmid inserts were sequenced at both ends to establish bacterial diversity. Mother and infant libraries contained Tc(r), although encoded by different genes and organisms. Tc(r) organisms in the mother consisted mainly of Firmicutes and Bacteroidetes, and the main gene detected was tet(O), although tet(W) and tet(X) were also found. Identical Tc(r) gene sequences were present in different bacterial families and even phyla, which may indicate horizontal transfer within the maternal GIT. In the infant library, Tc(r) was present exclusively in streptococci carrying tet(M), tet(L) and erm(T) within a novel composite transposon, Tn6079. This transposon belongs to a family of broad host range conjugative elements, implying a potential for the joint spread of tetracycline and erythromycin resistance within the infant's gut. In addition, although not found in the infant metagenomic library, tet(O) and tet(W) could be detected in the uncloned DNA purified from the infant fecal sample. This is the first study to reveal the diversity of Tc(r) bacteria in the human gut, to detect a likely transmission of antibiotic resistance from mother to infant GITs and to indicate the possible occurrence of gene transfers among distantly related bacteria coinhabiting the GIT of the same individual.", "link"=>"http://www.mendeley.com/research/gut-reservoir-antibiotic-resistance-microbial-diversity-tetracycline-resistance-mother-infant", "reader_count"=>119, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Librarian"=>2, "Researcher"=>33, "Student > Doctoral Student"=>8, "Student > Ph. D. 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  • {"files"=>["https://ndownloader.figshare.com/files/761004"], "description"=>"<p>Modified MEGAN tree (collapsed at Genus level) showing summarized number of reads assigned at different taxonomical levels. The size of each node is proportional to the number of reads assigned to the node. Beneath each node the number and percentage of Tc<sup>r</sup> genes detected in this study are noted. <b>A.</b> The “No hits & removed MGE hits” category contains 13 reads with no BLASTX hits (or hits that did not attain the min score/length of 0.15), 2 removed reads which were predicted to be located in MGE and were initially assigned below order level and 4 reads that mapped to ORFs in the sequenced transposon (Tn<i>6079</i>). <b>B.</b> The “No hits & removed MGE hits” category contains 138 reads with no BLASTX hits (or hits that did not attain the min score/length of 0.15) and 31 removed reads which were predicted to be located in MGE and were initially assigned below order level. The “Not assigned” category contains 2 reads that were assigned by BLASTX hits to uncultured bacteria.</p>", "links"=>[], "tags"=>["fosmid", "clones"], "article_id"=>431370, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Lisbeth E. de Vries", "Yvonne Vallès", "Yvonne Agersø", "Parag A. Vaishampayan", "Andrea García-Montaner", "Jennifer V. Kuehl", "Henrik Christensen", "Miriam Barlow", "M. Pilar Francino"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0021644.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Microbial_diversity_of_Tc_r_fosmid_clones_in_infant_A_and_mother_B_metagenomes_/431370", "title"=>"Microbial diversity of Tc<sup>r</sup> fosmid clones in infant (A) and mother (B) metagenomes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-06-28 00:22:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/761136"], "description"=>"<p>Assignment of end-reads and corresponding fosmids from the infant Tc<sup>r</sup> metagenome at different taxonomical levels.</p>", "links"=>[], "tags"=>["end-reads", "corresponding", "fosmids", "metagenome", "taxonomical"], "article_id"=>431501, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Lisbeth E. de Vries", "Yvonne Vallès", "Yvonne Agersø", "Parag A. Vaishampayan", "Andrea García-Montaner", "Jennifer V. Kuehl", "Henrik Christensen", "Miriam Barlow", "M. Pilar Francino"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0021644.t001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Assignment_of_end_reads_and_corresponding_fosmids_from_the_infant_Tc_r_metagenome_at_different_taxonomical_levels_/431501", "title"=>"Assignment of end-reads and corresponding fosmids from the infant Tc<sup>r</sup> metagenome at different taxonomical levels.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-06-28 00:25:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/761178"], "description"=>"<p>Assignment of end-reads and corresponding fosmids from the mother Tc<sup>r</sup> metagenome at different taxonomical levels.</p>", "links"=>[], "tags"=>["end-reads", "corresponding", "fosmids", "metagenome", "taxonomical"], "article_id"=>431542, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Lisbeth E. de Vries", "Yvonne Vallès", "Yvonne Agersø", "Parag A. Vaishampayan", "Andrea García-Montaner", "Jennifer V. Kuehl", "Henrik Christensen", "Miriam Barlow", "M. Pilar Francino"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0021644.t002", "stats"=>{"downloads"=>4, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Assignment_of_end_reads_and_corresponding_fosmids_from_the_mother_Tc_r_metagenome_at_different_taxonomical_levels_/431542", "title"=>"Assignment of end-reads and corresponding fosmids from the mother Tc<sup>r</sup> metagenome at different taxonomical levels.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-06-28 00:25:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/760864"], "description"=>"<p>Part of the sequenced fosmid-insert in the infant Tc<sup>r</sup> metagenome (GU951538; 1–3095) is compared with the most similar homologous sequences in current databases, from <i>S. gallolyticus</i> subsp. <i>gallolyticus</i> strain UCN34 (FN597254; minus strand 564709–589025 and 52545–55152), <i>S. gallolyticus</i> subsp. <i>pasteurianus</i> NTUH7421 (AY894138; minus strand 1–4107) and <i>S. bovis</i> ATCC700338 (AEEL01000024; 112037–123526, AEEL01000025; 1–6541, AEEL01000026; 1–1578, AEEL01000027; 1–3192, AEEL01000028; 37166–39101). The relationships between sequences are shown as percentage identity at nucleotide level, calculated with the EMBOSS program Needle (<a href=\"http://www.ebi.ac.uk/Tools/emboss/align/index.html\" target=\"_blank\">http://www.ebi.ac.uk/Tools/emboss/align/index.html</a>). <u>Light gray arrows</u> represent ORFs with homology to ORFs from Tn<i>916</i>/Tn<i>1545</i>-like conjugative transposons: <i>orf</i>5–10, <i>orf</i>12–24, <i>tet</i>(M), an excisionase (<i>xis</i>) and an integrase (<i>int</i>) of Tn<i>6079</i>. <u>Dark gray arrows</u> illustrate ORFs thay may be of plasmid origin: <i>tet</i>(L), <i>pre/mob</i> and <i>rep</i>. <u>Black arrows</u> illustrate ORFs that appear to be inserted by the two identical IS<i>1216</i>-like elements: first IS<i>1216</i>, <i>erm</i>(T), <i>erm</i>(T) leader sequence and second IS<i>1216</i>. <i>rmp</i>G and <i>rmp</i>F were predicted to encode L33 and L32 of the 50S ribosomal subunit. The functions of the predicted ORFs, <i>mid12_1</i>, <i>mid12_5</i> and <i>mid12_7</i> are unknown. <i>his</i>S: histidyl-tRNA synthetase. IS<i>Sdy1</i>: putative transposase.</p>", "links"=>[], "tags"=>["transposon", "metagenome", "compared", "corresponding", "sequences"], "article_id"=>431225, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Lisbeth E. de Vries", "Yvonne Vallès", "Yvonne Agersø", "Parag A. Vaishampayan", "Andrea García-Montaner", "Jennifer V. Kuehl", "Henrik Christensen", "Miriam Barlow", "M. Pilar Francino"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0021644.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Composite_transposon_Tn_6079_from_the_infant_metagenome_compared_to_corresponding_sequences_from_S_gallolyticus_strains_/431225", "title"=>"Composite transposon Tn<i>6079</i> from the infant metagenome compared to corresponding sequences from <i>S. gallolyticus</i> strains.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-06-28 00:20:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/383443", "https://ndownloader.figshare.com/files/383487", "https://ndownloader.figshare.com/files/383534", "https://ndownloader.figshare.com/files/383608", "https://ndownloader.figshare.com/files/383658", "https://ndownloader.figshare.com/files/383729", "https://ndownloader.figshare.com/files/383796", "https://ndownloader.figshare.com/files/383853", "https://ndownloader.figshare.com/files/383894", "https://ndownloader.figshare.com/files/383989", "https://ndownloader.figshare.com/files/384031"], "description"=>"<div><p>The microbiota in the human gastrointestinal tract (GIT) is highly exposed to antibiotics, and may be an important reservoir of resistant strains and transferable resistance genes. Maternal GIT strains can be transmitted to the offspring, and resistances could be acquired from birth. This is a case study using a metagenomic approach to determine the diversity of microorganisms conferring tetracycline resistance (Tc<sup>r</sup>) in the guts of a healthy mother-infant pair one month after childbirth, and to investigate the potential for horizontal transfer and maternal transmission of Tc<sup>r</sup> genes. Fecal fosmid libraries were functionally screened for Tc<sup>r</sup>, and further PCR-screened for specific Tc<sup>r</sup> genes. Tc<sup>r</sup> fosmid inserts were sequenced at both ends to establish bacterial diversity. Mother and infant libraries contained Tc<sup>r</sup>, although encoded by different genes and organisms. Tc<sup>r</sup> organisms in the mother consisted mainly of Firmicutes and Bacteroidetes, and the main gene detected was <em>tet</em>(O), although <em>tet</em>(W) and <em>tet</em>(X) were also found. Identical Tc<sup>r</sup> gene sequences were present in different bacterial families and even phyla, which may indicate horizontal transfer within the maternal GIT. In the infant library, Tc<sup>r</sup> was present exclusively in streptococci carrying <em>tet</em>(M), <em>tet</em>(L) and <em>erm</em>(T) within a novel composite transposon, Tn<em>6079</em>. This transposon belongs to a family of broad host range conjugative elements, implying a potential for the joint spread of tetracycline and erythromycin resistance within the infant's gut. In addition, although not found in the infant metagenomic library, <em>tet</em>(O) and <em>tet</em>(W) could be detected in the uncloned DNA purified from the infant fecal sample. This is the first study to reveal the diversity of Tc<sup>r</sup> bacteria in the human gut, to detect a likely transmission of antibiotic resistance from mother to infant GITs and to indicate the possible occurrence of gene transfers among distantly related bacteria coinhabiting the GIT of the same individual.</p> </div>", "links"=>[], "tags"=>["reservoir", "antibiotic", "microbial", "tetracycline"], "article_id"=>135730, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Lisbeth E. de Vries", "Yvonne Vallès", "Yvonne Agersø", "Parag A. Vaishampayan", "Andrea García-Montaner", "Jennifer V. Kuehl", "Henrik Christensen", "Miriam Barlow", "M. Pilar Francino"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0021644.s001", "https://dx.doi.org/10.1371/journal.pone.0021644.s002", "https://dx.doi.org/10.1371/journal.pone.0021644.s003", "https://dx.doi.org/10.1371/journal.pone.0021644.s004", "https://dx.doi.org/10.1371/journal.pone.0021644.s005", "https://dx.doi.org/10.1371/journal.pone.0021644.s006", "https://dx.doi.org/10.1371/journal.pone.0021644.s007", "https://dx.doi.org/10.1371/journal.pone.0021644.s008", "https://dx.doi.org/10.1371/journal.pone.0021644.s009", "https://dx.doi.org/10.1371/journal.pone.0021644.s010", "https://dx.doi.org/10.1371/journal.pone.0021644.s011"], "stats"=>{"downloads"=>28, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_Gut_as_Reservoir_of_Antibiotic_Resistance_Microbial_Diversity_of_Tetracycline_Resistance_in_Mother_and_Infant/135730", "title"=>"The Gut as Reservoir of Antibiotic Resistance: Microbial Diversity of Tetracycline Resistance in Mother and Infant", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-06-28 01:35:30"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[304, 568, 702, 818, 927, 1027, 1118, 1206, 1285, 1357, 1427, 1500, 1564, 1636, 1705, 1773, 1840, 1909, 1974, 2039, 2106, 2170, 2234, 2296, 2358, 2423, 2484, 2546, 2606, 2673, 2734, 2795, 2857, 2921, 2984, 3046, 3100]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[344, 630, 756, 876, 981, 1083, 1179, 1272, 1346, 1421, 1508, 1583, 1659, 1744, 1809, 1891, 1954, 2030, 2105, 2174, 2247, 2324, 2386, 2441, 2502, 2557, 2621, 2685, 2753, 2825, 2882, 2935, 2989, 3052, 3117, 3181, 3242]}]}
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