Multipotent Capacity of Immortalized Human Bronchial Epithelial Cells
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{"title"=>"Multipotent Capacity of Immortalized Human Bronchial Epithelial Cells", "type"=>"journal", "authors"=>[{"first_name"=>"Oliver", "last_name"=>"Delgado"}, {"first_name"=>"Aadil A.", "last_name"=>"Kaisani"}, {"first_name"=>"Monica", "last_name"=>"Spinola"}, {"first_name"=>"Xian-Jin", "last_name"=>"Xie"}, {"first_name"=>"Kimberly G.", "last_name"=>"Batten"}, {"first_name"=>"John D.", "last_name"=>"Minna"}, {"first_name"=>"Woodring E.", "last_name"=>"Wright"}, {"first_name"=>"Jerry W.", "last_name"=>"Shay"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0022023", "pmid"=>"21760947", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"0bb40cb3-37bf-3bd7-a371-f3074b1e8794", "abstract"=>"While the adult murine lung utilizes multiple compartmentally restricted progenitor cells during homeostasis and repair, much less is known about the progenitor cells from the human lung. Translating the murine stem cell model to humans is hindered by anatomical differences between species. Here we show that human bronchial epithelial cells (HBECs) display characteristics of multipotent stem cells of the lung. These HBECs express markers indicative of several epithelial types of the adult lung when experimentally tested in cell culture. When cultured in three different three-dimensional (3D) systems, subtle changes in the microenvironment result in unique responses including the ability of HBECs to differentiate into multiple central and peripheral lung cell types. These new findings indicate that the adult human lung contains a multipotent progenitor cell whose differentiation potential is primarily dictated by the microenvironment. The HBEC system is not only important in understanding mechanisms for specific cell lineage differentiation, but also for examining changes that correlate with human lung diseases including lung cancer.", "link"=>"http://www.mendeley.com/research/multipotent-capacity-immortalized-human-bronchial-epithelial-cells", "reader_count"=>77, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>20, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>5, "Student > Master"=>13, "Other"=>3, "Student > Bachelor"=>9, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>20, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>5, "Student > Master"=>13, "Other"=>3, "Student > Bachelor"=>9, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>4, "Biochemistry, Genetics and Molecular Biology"=>10, "Agricultural and Biological Sciences"=>42, "Medicine and Dentistry"=>11, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Physics and Astronomy"=>2, "Chemistry"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>4}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Chemistry"=>{"Chemistry"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>42}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>10}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "reader_count_by_country"=>{"Norway"=>1, "United States"=>3, "United Kingdom"=>3, "Australia"=>1, "Germany"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/760219"], "description"=>"<p>Cues provided by the microenvironment encompassing each of the anatomical compartments of the adult human lung provide cues that direct the differentiation of activated multipotent progenitor cells <i>in vivo</i>. Differentiation of isolated progenitor cells <i>in vitro</i> is thus largely influenced by the extrinsic signals provided.</p>", "links"=>[], "tags"=>["multipotent", "progenitors", "dictated"], "article_id"=>430584, "categories"=>["Medicine", "Cell Biology", "Developmental Biology"], "users"=>["Oliver Delgado", "Aadil A. Kaisani", "Monica Spinola", "Xian-Jin Xie", "Kimberly G. Batten", "John D. Minna", "Woodring E. Wright", "Jerry W. Shay"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022023.g005", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differentiation_of_Multipotent_Progenitors_of_Adult_Human_Lung_Dictated_by_the_Microenvironment_/430584", "title"=>"Differentiation of Multipotent Progenitors of Adult Human Lung Dictated by the Microenvironment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-07 00:09:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/759930"], "description"=>"<p>Immunofluorescence staining of HBEC3 KTs cultured as 2D monolayer in differentiation media for two days demonstrates capacity of HBEC3 KTs to express markers from multiple lung cell types while actively proliferating. (A) p63. (B) K14. (C) CCSP. (D) SP-A. (E) SP-C. (F) SP-D. (G) FOXJ1. (H) MUC5AC. (I) AQP5. (J) CGRP. DAPI, blue. Scale bars 10 µm. Results are representative of five independent experiments.</p>", "links"=>[], "tags"=>["hbec3s", "markers", "types"], "article_id"=>430296, "categories"=>["Medicine", "Cell Biology", "Developmental Biology"], "users"=>["Oliver Delgado", "Aadil A. Kaisani", "Monica Spinola", "Xian-Jin Xie", "Kimberly G. Batten", "John D. Minna", "Woodring E. Wright", "Jerry W. Shay"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022023.g003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immortalized_HBEC3s_Simultaneously_Express_Markers_of_Multiple_Cell_Types_of_the_Lung_/430296", "title"=>"Immortalized HBEC3s Simultaneously Express Markers of Multiple Cell Types of the Lung.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-07 00:04:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/381477", "https://ndownloader.figshare.com/files/381508", "https://ndownloader.figshare.com/files/381532"], "description"=>"<div><p>While the adult murine lung utilizes multiple compartmentally restricted progenitor cells during homeostasis and repair, much less is known about the progenitor cells from the human lung. Translating the murine stem cell model to humans is hindered by anatomical differences between species. Here we show that human bronchial epithelial cells (HBECs) display characteristics of multipotent stem cells of the lung. These HBECs express markers indicative of several epithelial types of the adult lung when experimentally tested in cell culture. When cultured in three different three-dimensional (3D) systems, subtle changes in the microenvironment result in unique responses including the ability of HBECs to differentiate into multiple central and peripheral lung cell types. These new findings indicate that the adult human lung contains a multipotent progenitor cell whose differentiation potential is primarily dictated by the microenvironment. The HBEC system is not only important in understanding mechanisms for specific cell lineage differentiation, but also for examining changes that correlate with human lung diseases including lung cancer.</p> </div>", "links"=>[], "tags"=>["multipotent", "immortalized", "bronchial", "epithelial", "cells"], "article_id"=>135354, "categories"=>["Medicine", "Cell Biology", "Developmental Biology"], "users"=>["Oliver Delgado", "Aadil A. Kaisani", "Monica Spinola", "Xian-Jin Xie", "Kimberly G. Batten", "John D. Minna", "Woodring E. Wright", "Jerry W. Shay"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022023.s001", "https://dx.doi.org/10.1371/journal.pone.0022023.s002", "https://dx.doi.org/10.1371/journal.pone.0022023.s003"], "stats"=>{"downloads"=>27, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Multipotent_Capacity_of_Immortalized_Human_Bronchial_Epithelial_Cells/135354", "title"=>"Multipotent Capacity of Immortalized Human Bronchial Epithelial Cells", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-07-07 01:29:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/759772"], "description"=>"<p>Quantitative RT-PCR analysis of several genes within pathways critical for progenitor cell maintenance in HBEC3 KT cells five days after varying culture conditions. Transition of HBEC3 KT cells from standard growth media to differentiation media while cultured in 2D results in the significant upregulation of many genes within progenitor-associated pathways (Columns 1 and 2) relative to HBEC3 KT cells cultured within Matrigel™ with differentiation media and IMR90 fibroblast growth stimulus (Columns 3 and 4) (<i>P</i> = 0.00185). Results are from two independent experiments (Columns 1 and 3 and 2 and 4, respectively). Experimental samples normalized to gene expression in HBEC3 KT cells coincidentally maintained in growth media.</p>", "links"=>[], "tags"=>["kt", "cells", "differentially", "genes", "progenitor"], "article_id"=>430139, "categories"=>["Medicine", "Cell Biology", "Developmental Biology"], "users"=>["Oliver Delgado", "Aadil A. Kaisani", "Monica Spinola", "Xian-Jin Xie", "Kimberly G. Batten", "John D. Minna", "Woodring E. Wright", "Jerry W. Shay"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022023.g002", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HBEC3_KT_Cells_Differentially_Regulate_Genes_Associated_with_Progenitor_Maintenance_/430139", "title"=>"HBEC3 KT Cells Differentially Regulate Genes Associated with Progenitor Maintenance.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-07 00:02:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/759612"], "description"=>"<p>HBEC3 KTs were seeded into three different 3D culture models (Figs A, C, and G) and overall response monitored. Culture of the HBEC3 KT cells atop of an IMR-90-embedded collagen type I matrix (Fig A) results in the differentiation into ciliated and/or goblet cells. Scanning electron micrograph (EM) of apical surface of HBEC3 KTs after 3 weeks at an air-liquid interface (Fig B; scale bar 10 µm). Embedding single HBEC3 KT cells within Matrigel™ in the presense of IMR90 fibroblasts (Fig C) results in the formation of organized cyst-like structures comprised of cuboidal cells. Phase contrast image, H&E section, and immunofluorescence staining for E-cadherin (red) in HBEC3 KT cyst-like structures after 5 days of culture (Figs D, E, and F respectively) (scale bar 20 µm; DAPI (blue)). Alternatively, seeding of HBEC3 KT cells on top of Matrigel™ in the presence of IMR90 fibroblasts (Fig G) results in the aggregation into tubular structures from which bud structures emerge over time. Phase contrast images of HBEC3 KTs 24 hours after plating on Matrigel™ (Fig H; scale bar 100 µm), of budding structure (Fig I; scale bar 20 µm), and after 5 days in culture (Fig J; scale bar 200 µm). Results are representative of >20 independent experiments.</p>", "links"=>[], "tags"=>["kts", "distinctly", "cues"], "article_id"=>429978, "categories"=>["Medicine", "Cell Biology", "Developmental Biology"], "users"=>["Oliver Delgado", "Aadil A. Kaisani", "Monica Spinola", "Xian-Jin Xie", "Kimberly G. Batten", "John D. Minna", "Woodring E. Wright", "Jerry W. Shay"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022023.g001", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HBEC3_KTs_Respond_Distinctly_to_Cues_from_Microenvironment_/429978", "title"=>"HBEC3 KTs Respond Distinctly to Cues from Microenvironment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-07 02:46:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/760071"], "description"=>"<p>HBEC3 KT cells were cultured within Matrigel™ for extended periods of time and the potential for differentiation into distal lung cell type monitored. After 7 days in culture, HBEC3 KT cells retain SP-A expression in punctate foci throughout the cytoplasm with subsets of structures containing lamellar bodies. Immunofluorescence staining of SP-A (red) (Fig A; DAPI (blue); scale bar 20 µm) and transmission EM of lamellar bodies (Fig B; scale bar 0.5 µm) in HBEC3 KT cyst-like structures after 7 days of culture. Further culture of HBEC3 KT cells within Matrigel™ results in cyst-like structures comprised of squamous cells surrounding an luminal space in which SP-A is detected. Representative H&E image (Fig C; scale bar 20 µm) and immunofluorescence staining of SP-A (red) (Fig D; DAPI (blue); scale bar 30 µm )in HBEC3 KT cyst-like structures after 9 days of culture. Results are representative of three independent experiments.</p>", "links"=>[], "tags"=>["bodies", "subsets", "hbec3", "kt", "cyst-like", "structures"], "article_id"=>430431, "categories"=>["Medicine", "Cell Biology", "Developmental Biology"], "users"=>["Oliver Delgado", "Aadil A. Kaisani", "Monica Spinola", "Xian-Jin Xie", "Kimberly G. Batten", "John D. Minna", "Woodring E. Wright", "Jerry W. Shay"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022023.g004", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lamellar_Bodies_Detected_in_Subsets_of_HBEC3_KT_Cyst_like_Structures_after_Extended_Culture_/430431", "title"=>"Lamellar Bodies Detected in Subsets of HBEC3 KT Cyst-like Structures after Extended Culture.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-07 00:07:11"}

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Relative Metric

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